iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-045250

UUCD1 version

UUC-GoG-00228

Ensembl Protein ID

ENSGGOP00000005561.2

UniProt Accession

G3QSC8; G3QSC8_GORGO

Protein Name

Uncharacterized protein

Gene Name

AIRE

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000005672.2	ENSGGOT00000005706.2	ENSGGOP00000005561.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	4.40e-18	65.6	297	342

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrs 53
           + C+vC++gge    l++C+ C ++fH aCl+++  +e p+ + w C++C +
   Q: 297  DECAVCRDGGE----LICCDGCPRAFHLACLSPP-LREIPSGT-WRCSSCLQ 342
           57*********....*******************.*******6.******76 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MAADAALRRL LRLHRTEIAV AVDSAFPLLH ALADHDVVPE DKFQETLHLK EKEGCPQAFH 60
ALLSWLLTQD STAILDFWRV LFKDYNLERY GRLQPILDSF PKDVDLSQPR KGRKPSAVPK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGACGGGCGG GCGCACAGCC GGCGCGGAGG CCCCACAGCC CCGCCAGGAC CCGAGGCCAA 60
GCGAGGGGCT GCCAGTGTCC CGGGACCCAC CGCGTCCGCC CCAGCCCCGG GTCCCCGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008087--AIRE
IPR004865--HSR_dom
IPR000770--SAND_dom
IPR010919--SAND_dom-like
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51414--HSR
PS50864--SAND
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF03172--HSR
PF00628--PHD
PF01342--SAND

PRINTS

PR01711--AIREGULATOR

SMART

SM00249--PHD
SM00258--SAND

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0003682--F:chromatin binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0045182--F:translation regulator activity
GO:0008270--F:zinc ion binding
GO:0002509--P:central tolerance induction to self antigen
GO:0032602--P:chemokine production
GO:0006959--P:humoral immune response
GO:0045060--P:negative thymic T cell selection
GO:0002458--P:peripheral T cell tolerance induction
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000410--P:regulation of thymocyte migration
GO:0097536--P:thymus epithelium morphogenesis

KEGG

ggo:101130778

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001612	Ailuropoda melanoleuca	75.56	4.00e-171	594.00
IUUC-Aca-004543	Anolis carolinensis	70.97	4.00e-25	105.00
IUUC-Bta-012988	Bos taurus	73.67	0.00e+00	635.00
IUUC-Bci-013636	Botrytis cinerea	26.36	1.00e-10	62.80
IUUC-Bdi-014663	Brachypodium distachyon	46.34	3.00e-14	74.70
IUUC-Cja-019486	Callithrix jacchus	84.29	1.00e-117	415.00
IUUC-Cfa-021069	Canis familiaris	74.02	1.00e-172	599.00
IUUC-Cpo-021649	Cavia porcellus	69.78	8.00e-157	546.00
IUUC-Csa-023960	Chlorocebus sabaeus	92.12	0.00e+00	741.00
IUUC-Dre-028583	Danio rerio	40.00	4.00e-55	209.00
IUUC-Dno-029869	Dasypus novemcinctus	65.08	8.00e-132	463.00
IUUC-Dor-030263	Dipodomys ordii	86.17	1.00e-45	176.00
IUUC-Ete-032778	Echinops telfairi	92.86	7.00e-50	191.00
IUUC-Eca-034328	Equus caballus	74.39	6.00e-168	583.00
IUUC-Fca-035400	Felis catus	70.60	9.00e-164	570.00
IUUC-Fal-036644	Ficedula albicollis	52.91	1.00e-69	256.00
IUUC-Hsa-046603	Homo sapiens	98.68	0.00e+00	823.00
IUUC-Hvu-047073	Hordeum vulgare	58.70	2.00e-13	72.40
IUUC-Itr-048977	Ictidomys tridecemlineatus	73.20	8.00e-173	600.00
IUUC-Lch-050310	Latimeria chalumnae	40.68	4.00e-94	338.00
IUUC-Lpe-051272	Leersia perrieri	47.92	8.00e-10	60.50
IUUC-Loc-052508	Lepisosteus oculatus	37.34	4.00e-86	311.00
IUUC-Laf-054028	Loxodonta africana	67.45	2.00e-154	539.00
IUUC-Mcc-054935	Macaca mulatta	90.99	0.00e+00	783.00
IUUC-Mga-059318	Meleagris gallopavo	43.56	3.00e-56	212.00
IUUC-Mmr-061557	Microcebus murinus	65.06	1.00e-143	503.00
IUUC-Mdo-062475	Monodelphis domestica	51.80	6.00e-123	434.00
IUUC-Mmu-063994	Mus musculus	70.28	0.00e+00	670.00
IUUC-Mpu-066347	Mustela putorius furo	75.83	0.00e+00	660.00
IUUC-Mlu-068239	Myotis lucifugus	63.44	6.00e-89	320.00
IUUC-Nle-069544	Nomascus leucogenys	93.10	3.00e-28	118.00
IUUC-Opr-071199	Ochotona princeps	76.67	6.00e-73	268.00
IUUC-Ont-072571	Oreochromis niloticus	32.14	2.00e-34	140.00
IUUC-Oan-073739	Ornithorhynchus anatinus	54.63	1.00e-142	499.00
IUUC-Ogl-077865	Oryza glaberrima	56.52	1.00e-12	68.90
IUUC-Olo-080499	Oryza longistaminata	56.52	1.00e-12	69.70
IUUC-Opu-083209	Oryza punctata	56.52	2.00e-12	69.30
IUUC-Oru-084558	Oryza rufipogon	56.00	2.80e-02	35.00
IUUC-Ola-086528	Oryzias latipes	35.21	2.00e-42	167.00
IUUC-Oga-088353	Otolemur garnettii	78.53	0.00e+00	677.00
IUUC-Oar-090065	Ovis aries	77.66	2.00e-146	512.00
IUUC-Ptr-091347	Pan troglodytes	98.11	0.00e+00	787.00
IUUC-Pan-092423	Papio anubis	92.09	0.00e+00	778.00
IUUC-Psi-093798	Pelodiscus sinensis	53.99	3.00e-134	472.00
IUUC-Pfo-096145	Poecilia formosa	71.70	2.00e-20	93.60
IUUC-Pab-098369	Pongo abelii	92.40	9.00e-138	483.00
IUUC-Pca-100537	Procavia capensis	72.93	2.00e-178	618.00
IUUC-Ppe-101215	Prunus persica	60.42	3.00e-14	73.90
IUUC-Pva-102639	Pteropus vampyrus	76.59	8.00e-176	609.00
IUUC-Rno-105285	Rattus norvegicus	69.98	0.00e+00	652.00
IUUC-Sha-107159	Sarcophilus harrisii	51.33	6.00e-127	447.00
IUUC-Sit-110355	Setaria italica	50.00	9.00e-14	73.20
IUUC-Sbi-113930	Sorghum bicolor	42.70	3.00e-14	74.70
IUUC-Ssc-115773	Sus scrofa	73.39	1.00e-179	622.00
IUUC-Tgu-116922	Taeniopygia guttata	50.30	2.00e-66	245.00
IUUC-Tru-118263	Takifugu rubripes	31.19	2.00e-60	226.00
IUUC-Tsy-119270	Tarsius syrichta	73.14	5.00e-92	331.00
IUUC-Tni-120138	Tetraodon nigroviridis	30.83	3.00e-56	212.00
IUUC-Tca-121757	Theobroma cacao	57.14	1.00e-13	73.20
IUUC-Tae-124715	Triticum aestivum	54.72	2.00e-13	72.40
IUUC-Tur-126422	Triticum urartu	53.19	1.00e-11	66.20
IUUC-Tme-127204	Tuber melanosporum	55.32	9.00e-14	72.80
IUUC-Tbe-128077	Tupaia belangeri	71.03	0.00e+00	638.00
IUUC-Ttr-128781	Tursiops truncatus	80.43	1.00e-73	270.00
IUUC-Xma-133054	Xiphophorus maculatus	30.68	9.00e-56	211.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence