iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069865

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01119122

Gene Name

RACK1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000002604.2	ENSNLET00000003576.2	ENSNLEP00000003409.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-43	145.3	180	210
UBD/Beta-Prp	1.50e-58	198.3	87	256

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gHt +v ++af sd + +vsGs+D+tik+W+
   Q: 180  GHTKDVLSVAFsSDnRQIVSGSRDKTIKLWN 210
           8***********88899*************9 PP

UBD/Beta-Prp

   S: 89   tlkghedsvlslsfspsg.dklvsGshdrtirvwdletgqclee....tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkll 172
           tlkgh+  v+ ++  p+  d ++s+s+d+ti +w+l  ++  +      l+gh+++v+ vv+++dg+   sGs D+t+rlWdl tg+  
   Q: 87   TLKGHNGWVTQIATTPQFpDMILSASRDKTIIMWKLTRDETNYGipqrALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTT 175
           78999999999999998889999999999999999876666555666999999999999999999999999999999999999999999 PP
   S: 173  rtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlng..htdnvksvrfs..pnderlvsgssDgsiriWdl 251
           r++ g ht++v s++f+s+ +++vsgs+d+t+klw+   g c +t+++  h+++v++vrfs  + + ++vs++ D+ +++W+l
   Q: 176  RRFVG-HTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT-LGVCKYTVQDesHSEWVSCVRFSpnSSNPIIVSCGWDKLVKVWNL 256
           99998.9999999999999999999999999999998.777888887666999999999995555689999999999999997 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MPYNFPLPFA LHGAAILSRS VSWGSPFCMV ERVFPVPAGG FLSLSLQGGG GSGCGASFSK 60
LSSAILVAAA THALAAAMTE QMTLRGTLKG HNGWVTQIAT TPQFPDMILS ASRDKTIIMW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGAAGCAG CCAGGCGGGC CTCATGGGAA TGTGCCGTAC ACTTCACCTC TTTCGCTTCT 60
CGCTCTACAT CATCCCTGAG AAGTCTTTTT AAACACTTGA ATGTGCTTGT TTCAGAGTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:1990630--C:IRE1-RACK1-PP2A complex
GO:0030496--C:midbody
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0001891--C:phagocytic cup
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0030292--F:protein tyrosine kinase inhibitor activity
GO:0003723--F:RNA binding
GO:0035591--F:signaling adaptor activity
GO:0071333--P:cellular response to glucose stimulus
GO:0071363--P:cellular response to growth factor stimulus
GO:0030308--P:negative regulation of cell growth
GO:0010629--P:negative regulation of gene expression
GO:1903208--P:negative regulation of hydrogen peroxide-induced neuron death
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:0050765--P:negative regulation of phagocytosis
GO:0051898--P:negative regulation of protein kinase B signaling
GO:0030822--P:positive regulation of cAMP catabolic process
GO:0030335--P:positive regulation of cell migration
GO:0051343--P:positive regulation of cyclic-nucleotide phosphodiesterase activity
GO:0042998--P:positive regulation of Golgi to plasma membrane protein transport
GO:0043547--P:positive regulation of GTPase activity
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0051901--P:positive regulation of mitochondrial depolarization
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032464--P:positive regulation of protein homooligomerization
GO:0001934--P:positive regulation of protein phosphorylation
GO:0051726--P:regulation of cell cycle

KEGG

nle:100586801

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000395	Aegilops tauschii	64.44	8.00e-103	366.00
IUUC-Aml-001935	Ailuropoda melanoleuca	100.00	0.00e+00	655.00
IUUC-Atr-002694	Amborella trichopoda	67.73	5.00e-125	440.00
IUUC-Apl-003918	Anas platyrhynchos	100.00	7.00e-167	579.00
IUUC-Aca-004869	Anolis carolinensis	100.00	0.00e+00	655.00
IUUC-Aly-005671	Arabidopsis lyrata	65.43	4.00e-125	440.00
IUUC-Ath-007105	Arabidopsis thaliana	66.25	1.00e-125	442.00
IUUC-Ago-007720	Ashbya gossypii	56.23	1.00e-102	365.00
IUUC-Acl-008156	Aspergillus clavatus	72.44	2.00e-138	484.00
IUUC-Afl-008684	Aspergillus flavus	71.47	4.00e-137	480.00
IUUC-Afu-008867	Aspergillus fumigatus	73.40	8.00e-140	489.00
IUUC-Ani-009221	Aspergillus nidulans	72.44	2.00e-138	484.00
IUUC-Ang-009843	Aspergillus niger	71.47	1.00e-136	478.00
IUUC-Aor-010193	Aspergillus oryzae	71.47	4.00e-137	480.00
IUUC-Ate-010420	Aspergillus terreus	72.44	1.00e-124	438.00
IUUC-Ame-010884	Astyanax mexicanus	96.53	0.00e+00	641.00
IUUC-Bgr-012064	Blumeria graminis	70.19	9.00e-135	472.00
IUUC-Bta-013357	Bos taurus	100.00	0.00e+00	655.00
IUUC-Bci-013862	Botrytis cinerea	71.15	2.00e-137	481.00
IUUC-Bdi-014690	Brachypodium distachyon	62.39	9.00e-114	402.00
IUUC-Bol-016231	Brassica oleracea	66.56	5.00e-127	446.00
IUUC-Bra-016879	Brassica rapa	66.15	1.00e-125	442.00
IUUC-Cel-018335	Caenorhabditis elegans	69.06	2.00e-123	434.00
IUUC-Cja-019914	Callithrix jacchus	100.00	0.00e+00	655.00
IUUC-Cfa-020755	Canis familiaris	100.00	0.00e+00	655.00
IUUC-Cpo-022377	Cavia porcellus	97.60	0.00e+00	659.00
IUUC-Cre-022909	Chlamydomonas reinhardtii	74.60	3.00e-137	480.00
IUUC-Csa-023025	Chlorocebus sabaeus	96.45	0.00e+00	709.00
IUUC-Cin-025647	Ciona intestinalis	77.07	3.00e-146	511.00
IUUC-Csv-026027	Ciona savignyi	76.75	4.00e-144	503.00
IUUC-Cgl-026718	Colletotrichum gloeosporioides	74.91	4.00e-129	453.00
IUUC-Cne-026930	Cryptococcus neoformans	71.15	1.00e-136	478.00
IUUC-Cme-027251	Cyanidioschyzon merolae	63.46	1.00e-121	429.00
IUUC-Dre-028669	Danio rerio	95.58	0.00e+00	637.00
IUUC-Dno-029470	Dasypus novemcinctus	80.05	2.00e-159	555.00
IUUC-Dor-031098	Dipodomys ordii	88.96	3.00e-151	527.00
IUUC-Dse-031255	Dothistroma septosporum	71.15	4.00e-137	480.00
IUUC-Dme-032118	Drosophila melanogaster	77.14	9.00e-148	515.00
IUUC-Ete-033182	Echinops telfairi	83.41	1.00e-105	375.00
IUUC-Eca-033296	Equus caballus	100.00	2.00e-87	313.00
IUUC-Eeu-034771	Erinaceus europaeus	94.64	7.00e-177	612.00
IUUC-Fca-036315	Felis catus	100.00	0.00e+00	655.00
IUUC-Fal-036990	Ficedula albicollis	97.22	4.00e-103	367.00
IUUC-Fox-037702	Fusarium oxysporum	72.44	3.00e-139	487.00
IUUC-Fso-038384	Fusarium solani	73.08	1.00e-139	488.00
IUUC-Gmo-039630	Gadus morhua	94.16	2.00e-176	611.00
IUUC-Ggr-039985	Gaeumannomyces graminis	72.76	1.00e-139	489.00
IUUC-Gga-040540	Gallus gallus	100.00	0.00e+00	655.00
IUUC-Gac-041316	Gasterosteus aculeatus	91.32	4.00e-174	603.00
IUUC-Gma-042872	Glycine max	66.46	6.00e-126	443.00
IUUC-Ggo-045253	Gorilla gorilla	100.00	0.00e+00	655.00
IUUC-Hsa-046809	Homo sapiens	100.00	0.00e+00	655.00
IUUC-Hvu-047683	Hordeum vulgare	63.22	2.00e-115	408.00
IUUC-Itr-048025	Ictidomys tridecemlineatus	100.00	0.00e+00	655.00
IUUC-Kpa-049214	Komagataella pastoris	58.06	1.00e-99	356.00
IUUC-Lch-049634	Latimeria chalumnae	94.32	0.00e+00	629.00
IUUC-Lpe-050762	Leersia perrieri	62.88	2.00e-114	405.00
IUUC-Loc-052163	Lepisosteus oculatus	97.16	0.00e+00	644.00
IUUC-Lma-053113	Leptosphaeria maculans	72.76	3.00e-139	487.00
IUUC-Laf-054422	Loxodonta africana	100.00	0.00e+00	655.00
IUUC-Mcc-055348	Macaca mulatta	96.95	0.00e+00	706.00
IUUC-Meu-056543	Macropus eugenii	100.00	0.00e+00	654.00
IUUC-Mor-057107	Magnaporthe oryzae	72.76	3.00e-140	491.00
IUUC-Mpo-057487	Magnaporthe poae	73.08	3.00e-140	490.00
IUUC-Mtr-058808	Medicago truncatula	66.77	2.00e-126	444.00
IUUC-Mla-058909	Melampsora laricipopulina	73.16	4.00e-139	487.00
IUUC-Mga-059387	Meleagris gallopavo	100.00	0.00e+00	655.00
IUUC-Mvi-060392	Microbotryum violaceum	69.23	7.00e-134	469.00
IUUC-Mmr-061141	Microcebus murinus	89.27	6.00e-139	486.00
IUUC-Mdo-062932	Monodelphis domestica	100.00	0.00e+00	655.00
IUUC-Mmu-064132	Mus musculus	100.00	0.00e+00	655.00
IUUC-Mac-064447	Musa acuminata	61.11	3.00e-109	387.00
IUUC-Mpu-066721	Mustela putorius furo	99.05	0.00e+00	644.00
IUUC-Mlu-068221	Myotis lucifugus	99.37	1.00e-176	612.00
IUUC-Nfi-068344	Neosartorya fischeri	73.40	7.00e-140	489.00
IUUC-Ncr-068722	Neurospora crassa	71.47	2.00e-137	481.00
IUUC-Opr-071100	Ochotona princeps	83.48	4.00e-153	533.00
IUUC-Ont-072287	Oreochromis niloticus	94.32	0.00e+00	632.00
IUUC-Oan-072788	Ornithorhynchus anatinus	100.00	0.00e+00	655.00
IUUC-Ocu-073844	Oryctolagus cuniculus	97.48	0.00e+00	630.00
IUUC-Oba-075981	Oryza barthii	59.94	4.00e-103	367.00
IUUC-Obr-076099	Oryza brachyantha	61.47	4.00e-113	400.00
IUUC-Ogl-077804	Oryza glaberrima	62.69	3.00e-115	407.00
IUUC-Ogu-078035	Oryza glumaepatula	63.38	8.00e-115	406.00
IUUC-Oin-079327	Oryza indica	63.38	8.00e-115	406.00
IUUC-Olo-081084	Oryza longistaminata	63.38	8.00e-115	406.00
IUUC-Ome-081366	Oryza meridionalis	63.00	1.00e-115	409.00
IUUC-Oni-082682	Oryza nivara	63.00	1.00e-115	409.00
IUUC-Opu-084010	Oryza punctata	62.69	6.00e-116	410.00
IUUC-Oru-084358	Oryza rufipogon	63.00	1.00e-115	409.00
IUUC-Osa-085296	Oryza sativa	63.00	1.00e-115	409.00
IUUC-Ola-086400	Oryzias latipes	94.01	0.00e+00	630.00
IUUC-Olu-087817	Ostreococcus lucimarinus	75.79	2.00e-142	498.00
IUUC-Oga-088811	Otolemur garnettii	100.00	0.00e+00	655.00
IUUC-Oar-089962	Ovis aries	100.00	0.00e+00	655.00
IUUC-Ptr-091340	Pan troglodytes	100.00	0.00e+00	655.00
IUUC-Pan-091946	Papio anubis	97.21	0.00e+00	707.00
IUUC-Pma-094535	Petromyzon marinus	94.01	0.00e+00	627.00
IUUC-Pno-095100	Phaeosphaeria nodorum	75.00	5.00e-97	346.00
IUUC-Ppa-095588	Physcomitrella patens	75.08	7.00e-140	489.00
IUUC-Pfo-097311	Poecilia formosa	94.01	0.00e+00	630.00
IUUC-Pab-097863	Pongo abelii	100.00	0.00e+00	656.00
IUUC-Pop-099345	Populus trichocarpa	67.80	5.00e-129	453.00
IUUC-Pca-100594	Procavia capensis	98.15	0.00e+00	652.00
IUUC-Ppe-101743	Prunus persica	65.12	2.00e-123	435.00
IUUC-Pva-102746	Pteropus vampyrus	82.99	1.00e-151	529.00
IUUC-Pgr-103375	Puccinia graminis	57.51	9.00e-97	346.00
IUUC-Ptt-103839	Puccinia triticina	73.16	2.00e-137	481.00
IUUC-Pte-104026	Pyrenophora teres	72.76	3.00e-139	487.00
IUUC-Pyt-104584	Pyrenophora triticirepentis	72.76	4.00e-139	487.00
IUUC-Rno-104964	Rattus norvegicus	100.00	0.00e+00	655.00
IUUC-Sce-106224	Saccharomyces cerevisiae	53.82	6.00e-97	347.00
IUUC-Sha-107409	Sarcophilus harrisii	100.00	0.00e+00	655.00
IUUC-Sja-107971	Schizosaccharomyces japonicus	65.81	3.00e-126	444.00
IUUC-Spo-108297	Schizosaccharomyces pombe	64.22	7.00e-123	433.00
IUUC-Ssl-108479	Sclerotinia sclerotiorum	71.15	2.00e-137	481.00
IUUC-Smo-109017	Selaginella moellendorffii	69.62	8.00e-129	452.00
IUUC-Sit-110680	Setaria italica	62.77	5.00e-115	407.00
IUUC-Sly-111496	Solanum lycopersicum	68.44	3.00e-127	447.00
IUUC-Stu-112757	Solanum tuberosum	66.88	7.00e-123	433.00
IUUC-Sar-113173	Sorex araneus	100.00	0.00e+00	655.00
IUUC-Sbi-114681	Sorghum bicolor	63.38	2.00e-116	411.00
IUUC-Sre-115107	Sporisorium reilianum	70.83	1.00e-138	485.00
IUUC-Ssc-116218	Sus scrofa	95.58	0.00e+00	625.00
IUUC-Tru-118202	Takifugu rubripes	92.74	1.00e-179	622.00
IUUC-Tni-120260	Tetraodon nigroviridis	92.43	5.00e-179	619.00
IUUC-Tca-120951	Theobroma cacao	66.15	3.00e-127	447.00
IUUC-Tre-121961	Trichoderma reesei	73.40	9.00e-141	492.00
IUUC-Tvi-122447	Trichoderma virens	73.08	1.00e-139	488.00
IUUC-Tae-123560	Triticum aestivum	62.61	1.00e-114	405.00
IUUC-Tur-126335	Triticum urartu	67.78	2.00e-104	372.00
IUUC-Tme-127105	Tuber melanosporum	67.96	2.00e-125	441.00
IUUC-Tbe-128021	Tupaia belangeri	79.70	3.00e-86	310.00
IUUC-Ttr-128637	Tursiops truncatus	87.46	4.00e-164	570.00
IUUC-Uma-129634	Ustilago maydis	71.79	2.00e-139	488.00
IUUC-Vda-129923	Verticillium dahliae	72.44	5.00e-139	486.00
IUUC-Vpa-130410	Vicugna pacos	77.62	1.00e-113	402.00
IUUC-Vvi-131115	Vitis vinifera	66.67	2.00e-127	448.00
IUUC-Xtr-132105	Xenopus tropicalis	96.21	0.00e+00	642.00
IUUC-Xma-133875	Xiphophorus maculatus	94.32	0.00e+00	630.00
IUUC-Yli-134624	Yarrowia lipolytica	60.76	2.00e-119	421.00
IUUC-Zma-134711	Zea mays	63.08	3.00e-115	407.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence