iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tru-118782

Ensembl Protein ID

ENSTRUP00000002304.1

UniProt Accession

H2RQ89; H2RQ89_TAKRU

Protein Name

Uncharacterized protein

Gene Name

TLE4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000000978.1	ENSTRUT00000002314.1	ENSTRUP00000002304.1
ENSTRUG00000000978.1	ENSTRUT00000002315.1	ENSTRUP00000002305.1
ENSTRUG00000000978.1	ENSTRUT00000002316.1	ENSTRUP00000002306.1
ENSTRUG00000000978.1	ENSTRUT00000002317.1	ENSTRUP00000002307.1
ENSTRUG00000000978.1	ENSTRUT00000002318.1	ENSTRUP00000002308.1
ENSTRUG00000000978.1	ENSTRUT00000002319.1	ENSTRUP00000002309.1
ENSTRUG00000000978.1	ENSTRUT00000002320.1	ENSTRUP00000002310.1
ENSTRUG00000000978.1	ENSTRUT00000002321.1	ENSTRUP00000002311.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.30e-23	82.0	630	668
UBD/Beta-Prp	3.90e-40	139.1	498	667

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++  +d t l++G+ D+t++ WDlr+g++l+
   Q: 630  GHTDGASCIDIsNDgTKLWTGGLDNTVRSWDLREGRQLQ 668
           8***********999*********************998 PP

UBD/Beta-Prp

   S: 50   gheaevtavkfspdgkilvtgseDrtikvwdls...tgkcvhtlk..ghedsvlslsfspsgdklvsGshdrtirvwdletgqclee.t 132
           gh + v av++s+ +   v ++  + +kvwd+s   + ++v+ l   + +++++s+++ p+g +l++G++ +t+ +wdl t +   +  
   Q: 498  GHGEVVCAVTISNPTR-HVYTGGKGCVKVWDIShpgNKTPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLATPTPRIKaE 585
           6777888999999985.555555579*******999888888888889*********************************99877658 PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecv 215
           l+    +   ++++pd+++++s++ D+ + +Wdl +++l+r+++g htd   +++++ +g+ l +g+ld+tv+ wdl++g+ +
   Q: 586  LTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQG-HTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQL 667
           888888888999********************************9.********************************99754 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MIRDLSKMYP PARHPVPHQP GQPLKFTINE SCDRIKEEFH FLQAQYHSLK LECEKLASEK 60
TEMQRHYVMY YEMSYGLNIE MHKQAEIVKR LNAICAQVVP FLSQEHQQQV VQAVERAKQV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGATTCGTG ATCTGAGCAA GATGTACCCC CCGGCGCGGC ATCCGGTAAG TAAAGAGCCG 60
ATGGAGGCAG CGTGTCCGAC GGCACAGGAA CAACCGCGCG TCTGCTGCGT AATCGCTTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03920--TLE_N
PF00400--WD40

PRINTS

PR01850--GROUCHOFAMLY

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0006355--P:regulation of transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-005279	Anolis carolinensis	85.12	0.00e+00	1169.00
IUUC-Bta-012646	Bos taurus	83.75	0.00e+00	1177.00
IUUC-Cel-018361	Caenorhabditis elegans	58.43	4.00e-121	428.00
IUUC-Cja-019079	Callithrix jacchus	84.74	0.00e+00	1218.00
IUUC-Cfa-020987	Canis familiaris	84.94	0.00e+00	1179.00
IUUC-Cpo-021606	Cavia porcellus	82.93	0.00e+00	1148.00
IUUC-Csa-023445	Chlorocebus sabaeus	84.74	0.00e+00	1194.00
IUUC-Cho-024590	Choloepus hoffmanni	75.15	0.00e+00	1058.00
IUUC-Cin-025767	Ciona intestinalis	58.20	6.00e-170	591.00
IUUC-Dno-028979	Dasypus novemcinctus	84.32	0.00e+00	1146.00
IUUC-Dor-030533	Dipodomys ordii	82.56	0.00e+00	1027.00
IUUC-Ete-032887	Echinops telfairi	75.75	0.00e+00	1066.00
IUUC-Eeu-035237	Erinaceus europaeus	74.97	0.00e+00	1002.00
IUUC-Fca-036030	Felis catus	84.47	0.00e+00	1183.00
IUUC-Fal-037460	Ficedula albicollis	84.83	0.00e+00	1175.00
IUUC-Gga-040416	Gallus gallus	85.12	0.00e+00	1200.00
IUUC-Gac-041739	Gasterosteus aculeatus	81.30	0.00e+00	1129.00
IUUC-Ggo-045633	Gorilla gorilla	83.52	0.00e+00	1186.00
IUUC-Hsa-046461	Homo sapiens	83.46	0.00e+00	1211.00
IUUC-Itr-048974	Ictidomys tridecemlineatus	84.63	0.00e+00	1189.00
IUUC-Lch-049943	Latimeria chalumnae	83.13	0.00e+00	1107.00
IUUC-Loc-052835	Lepisosteus oculatus	85.80	0.00e+00	1147.00
IUUC-Laf-053425	Loxodonta africana	84.83	0.00e+00	1190.00
IUUC-Mcc-055766	Macaca mulatta	83.46	0.00e+00	1210.00
IUUC-Meu-056209	Macropus eugenii	82.43	0.00e+00	1201.00
IUUC-Mmr-061317	Microcebus murinus	84.01	0.00e+00	1211.00
IUUC-Mdo-062956	Monodelphis domestica	84.63	0.00e+00	1189.00
IUUC-Mmu-063576	Mus musculus	84.87	0.00e+00	1187.00
IUUC-Mlu-067456	Myotis lucifugus	81.93	0.00e+00	1118.00
IUUC-Nle-069495	Nomascus leucogenys	84.70	0.00e+00	1167.00
IUUC-Ont-071419	Oreochromis niloticus	90.76	0.00e+00	1206.00
IUUC-Oan-072842	Ornithorhynchus anatinus	82.43	0.00e+00	1176.00
IUUC-Ocu-074453	Oryctolagus cuniculus	83.73	0.00e+00	1176.00
IUUC-Ola-087090	Oryzias latipes	89.85	0.00e+00	1210.00
IUUC-Oga-087939	Otolemur garnettii	84.63	0.00e+00	1190.00
IUUC-Ptr-091048	Pan troglodytes	84.74	0.00e+00	1194.00
IUUC-Pan-091973	Papio anubis	80.33	0.00e+00	1139.00
IUUC-Pfo-097518	Poecilia formosa	87.22	0.00e+00	1157.00
IUUC-Pva-103037	Pteropus vampyrus	80.59	0.00e+00	1200.00
IUUC-Rno-105314	Rattus norvegicus	84.43	0.00e+00	1122.00
IUUC-Sar-113585	Sorex araneus	79.04	0.00e+00	649.00
IUUC-Ssc-116408	Sus scrofa	84.32	0.00e+00	1202.00
IUUC-Tgu-117068	Taeniopygia guttata	84.44	0.00e+00	1167.00
IUUC-Tsy-118884	Tarsius syrichta	76.05	0.00e+00	953.00
IUUC-Tni-120404	Tetraodon nigroviridis	91.01	0.00e+00	1266.00
IUUC-Tbe-128013	Tupaia belangeri	79.29	0.00e+00	1102.00
IUUC-Ttr-129285	Tursiops truncatus	82.39	0.00e+00	1195.00
IUUC-Vpa-130577	Vicugna pacos	71.69	2.00e-156	546.00
IUUC-Xtr-132974	Xenopus tropicalis	83.19	0.00e+00	1130.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence