iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-060052

UUCD1 version

UUC-MeG-00799

Ensembl Protein ID

ENSMGAP00000003011.2

UniProt Accession

G1MWA4; G1MWA4_MELGA

Protein Name

Uncharacterized protein

Gene Name

UBA7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000003255.2	ENSMGAT00000003703.2	ENSMGAP00000003011.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.60e-142	475.3	344	803

Active Site

Position(s)	Description	Evidence
525	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Qi+++G++ qe l+++k+++vGag++GcEllKn++++G+     g itv+Dmdtv  snl rq Lfr+ dvgk+KA+vaa+a++ +
   Q: 344  YDGQIAVFGADFQEELGRQKYFVVGAGAIGCELLKNFAMMGLaagpgGDITVTDMDTVAHSNLHRQLLFREADVGKPKADVAAAAVRLM 432
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqkt 170
           npd++v+ah+ ++ + +e+ +   Ff+++d+Vv+ald + ar ++ + c+  r  l+++gt+G +G+v  +++ l    + s dp++++
   Q: 433  NPDIKVTAHQVQLGPGTEKLFgntFFQRLDGVVSALDTLTARAYLESCCIRSRTALLDTGTEGAKGNVLAMVPPLSQPLEPSSDPTDRS 521
           *******************99*******************************************************9999999****** PP
   S: 171  iPfctlketpnaaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafak 247
           +P+ctl+ +p a+eht+ wa            + +n +l+e +       +       ++  k  +++ +e+++++ +++++a+++++ 
   Q: 522  FPLCTLRFFPCAIEHTLLWArdefeglfqlpaESVNRFLGELP-------DEPVRWEGMVVPKQVQRSLQERPRDWGDCVRWACQHWQL 603
           *********************9998555555555555554444.......4444444566667777888889***************** PP
   S: 248  ttinsikqllksfecdivtkskspfwv.............................................................s 275
           +++nsi+qll++ ++   t+ ++pfw+                                                             +
   Q: 604  RYHNSITQLLHDVPPSHETSPGVPFWSgdrrcphpltfdpsndthlayveaaahllahtyrlpscgdrvatrdvlcnmvlppfvpkdgR 692
           ************************************************************99999999999999999987777777777 PP
   S: 276  fcsnaealqvpekvekdeevvkasaplylllralerfekk...kgrkpgelsfekdddsavdlvtaaanlraeslgiepkldddlikei 361
           +++ a+  ++ e ++++ +          l++ l +++++    ++ ++ + ++kd+d +++++taa+nlrae++gi+p +++   ++i
   Q: 693  YVPTADGMEEVEETLEPGQM-------LELMQELAKWKQElggGTEAMDPIHYDKDSDLHLSFITAASNLRAENYGIPP-ASRLTSQRI 773
           77777777777777777664.......45556666665551116688999*****************************.********* PP
   S: 362  agniipaiattnavvgGlaaqEviKvvsgk 391
           ag+i pai tt+a+v++la++Ev+K+v  +
   Q: 774  AGRILPAIITTTAAVAALACLEVYKLVWRC 803
           **************************9873 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

PKPTSAAAPQ FLQGECSAGQ NGAEASQRLL AALNPDVELS VHSGELSEEF LTAFQVVVLT 60
ECPLEEQLRV GDICHAKGVC FIVADAKGLA GQLFCDFGEH FVVHDPVEGD PLCATVQHIS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCAAGCCCA CGAGTGCCGC TGCCCCACAG TTCCTCCAGG GGGAGTGCAG CGCGGGCCAG 60
AACGGTGCTG AGGCATCCCA GCGGCTGCTG GCCGCACTGA ACCCTGATGT GGAATTGTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR019572--UBA_E1_Cys
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

Gene Ontology

GO:0019782--F:ISG15 activating enzyme activity
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001311	Ailuropoda melanoleuca	50.72	0.00e+00	769.00
IUUC-Aca-004746	Anolis carolinensis	51.81	0.00e+00	786.00
IUUC-Cfa-020622	Canis familiaris	49.70	0.00e+00	739.00
IUUC-Dor-030229	Dipodomys ordii	48.00	0.00e+00	720.00
IUUC-Ete-033124	Echinops telfairi	50.49	1.00e-157	550.00
IUUC-Eeu-034717	Erinaceus europaeus	47.95	1.00e-138	486.00
IUUC-Fal-037445	Ficedula albicollis	66.14	0.00e+00	1010.00
IUUC-Gga-040365	Gallus gallus	90.38	0.00e+00	1466.00
IUUC-Loc-052317	Lepisosteus oculatus	50.18	0.00e+00	763.00
IUUC-Mmr-061405	Microcebus murinus	48.86	0.00e+00	728.00
IUUC-Mdo-062032	Monodelphis domestica	49.76	0.00e+00	744.00
IUUC-Mpu-066409	Mustela putorius furo	50.84	0.00e+00	773.00
IUUC-Nle-070072	Nomascus leucogenys	50.36	0.00e+00	746.00
IUUC-Opr-070715	Ochotona princeps	43.91	1.00e-173	603.00
IUUC-Oan-073306	Ornithorhynchus anatinus	47.04	2.00e-174	605.00
IUUC-Oga-088594	Otolemur garnettii	50.12	0.00e+00	746.00
IUUC-Ptr-090581	Pan troglodytes	47.44	0.00e+00	642.00
IUUC-Pca-100347	Procavia capensis	50.64	0.00e+00	715.00
IUUC-Pva-102584	Pteropus vampyrus	50.60	0.00e+00	785.00
IUUC-Sha-106967	Sarcophilus harrisii	49.39	0.00e+00	738.00
IUUC-Ssc-115777	Sus scrofa	50.60	0.00e+00	772.00
IUUC-Tbe-127587	Tupaia belangeri	52.13	3.00e-172	598.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence