iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003299

Ensembl Protein ID

ENSAPLP00000003563.1

UniProt Accession

U3I8J2; U3I8J2_ANAPL

Genbank Protein ID

ENSAPLP00000003563

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01040559

Gene Name

HECW1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000004015.1	ENSAPLT00000004165.1	ENSAPLP00000003563.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.50e-122	408.9	1270	1602

Active Site

Position(s)	Description	Evidence
1570	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  ++hl++F+f Gr+lg+al ++ lld
   Q: 1270 ELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLD 1355
           567899****************************************************985.6************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   +i+++ ldltf+v+ee++g+++e+eLk+gG+n+ Vt++Nk+eY+++
   Q: 1356 AFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDN---NITDI-LDLTFTVNEEVFGQVTERELKSGGANTAVTEKNKKEYIER 1438
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+ea+ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++ + +i+wFw ++e+f++e+r +
   Q: 1439 MVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHIVIRWFWAAVERFNNEQRLR 1525
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s++ l+ekLl+A+eet+ F+l+
   Q: 1526 LLQFVTGTSSVPYEGFAALRgsngLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1602
           ************************999***********************************************985 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

ILSFFFSSQN LYQNRFLGLA AMASPSRNSQ NRRRCKEPLR YSYNPDQFHN MDIRNNSHET 60
VTIPRSTSDT DLVTSDSRST LMVSSSYYSI GHSQDLVIYW DIKEEVDAGD WIGMYLIDEV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCCTTTCTT TTTTTTTTTC TTCACAGAAT CTGTACCAAA ACAGGTTCCT GGGCCTGGCA 60
GCCATGGCGT CTCCATCAAG GAACTCACAA AATCGGCGCC GGTGCAAGGA GCCCCTCAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	83.08	0.00e+00	1687.00
IUUC-Aca-005024	Anolis carolinensis	87.31	0.00e+00	2698.00
IUUC-Bta-012604	Bos taurus	78.69	0.00e+00	2390.00
IUUC-Cja-019880	Callithrix jacchus	74.55	0.00e+00	2004.00
IUUC-Cfa-021216	Canis familiaris	83.05	0.00e+00	1712.00
IUUC-Cpo-021466	Cavia porcellus	81.86	0.00e+00	1706.00
IUUC-Csa-023080	Chlorocebus sabaeus	80.13	0.00e+00	2415.00
IUUC-Cho-024740	Choloepus hoffmanni	90.87	0.00e+00	1125.00
IUUC-Dre-028750	Danio rerio	73.02	0.00e+00	1575.00
IUUC-Dno-030019	Dasypus novemcinctus	80.02	0.00e+00	2405.00
IUUC-Dor-031030	Dipodomys ordii	71.53	0.00e+00	1107.00
IUUC-Ete-032352	Echinops telfairi	92.53	0.00e+00	1245.00
IUUC-Eca-033948	Equus caballus	81.88	0.00e+00	1718.00
IUUC-Eeu-034474	Erinaceus europaeus	68.35	0.00e+00	818.00
IUUC-Fca-036148	Felis catus	84.36	0.00e+00	1721.00
IUUC-Fal-036957	Ficedula albicollis	95.04	0.00e+00	2915.00
IUUC-Gmo-038714	Gadus morhua	68.30	0.00e+00	1014.00
IUUC-Gga-041194	Gallus gallus	95.88	0.00e+00	2980.00
IUUC-Ggo-045442	Gorilla gorilla	70.09	0.00e+00	1813.00
IUUC-Hsa-045730	Homo sapiens	80.27	0.00e+00	2413.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	80.68	0.00e+00	2439.00
IUUC-Lch-050185	Latimeria chalumnae	74.32	0.00e+00	2074.00
IUUC-Loc-052744	Lepisosteus oculatus	77.13	0.00e+00	2289.00
IUUC-Laf-054368	Loxodonta africana	94.58	0.00e+00	1460.00
IUUC-Mcc-055487	Macaca mulatta	80.11	0.00e+00	2422.00
IUUC-Meu-056751	Macropus eugenii	91.34	0.00e+00	728.00
IUUC-Mga-059545	Meleagris gallopavo	95.39	0.00e+00	2943.00
IUUC-Mmr-061078	Microcebus murinus	83.07	0.00e+00	1688.00
IUUC-Mdo-062176	Monodelphis domestica	82.96	0.00e+00	1696.00
IUUC-Mmu-063513	Mus musculus	78.98	0.00e+00	2340.00
IUUC-Mpu-065786	Mustela putorius furo	79.45	0.00e+00	2390.00
IUUC-Mlu-067780	Myotis lucifugus	78.64	0.00e+00	1539.00
IUUC-Nle-069213	Nomascus leucogenys	84.59	0.00e+00	1756.00
IUUC-Opr-070208	Ochotona princeps	93.71	0.00e+00	1444.00
IUUC-Ont-072132	Oreochromis niloticus	70.92	0.00e+00	1432.00
IUUC-Oan-072807	Ornithorhynchus anatinus	87.48	0.00e+00	1779.00
IUUC-Ocu-074745	Oryctolagus cuniculus	82.13	0.00e+00	1727.00
IUUC-Ola-086981	Oryzias latipes	73.61	0.00e+00	1494.00
IUUC-Oga-087965	Otolemur garnettii	84.66	0.00e+00	1718.00
IUUC-Oar-089749	Ovis aries	82.95	0.00e+00	1724.00
IUUC-Ptr-091243	Pan troglodytes	80.05	0.00e+00	2408.00
IUUC-Pan-092201	Papio anubis	79.79	0.00e+00	2412.00
IUUC-Psi-093511	Pelodiscus sinensis	87.85	0.00e+00	2649.00
IUUC-Pfo-097001	Poecilia formosa	65.99	0.00e+00	1606.00
IUUC-Pab-098728	Pongo abelii	77.33	0.00e+00	2302.00
IUUC-Pca-100129	Procavia capensis	77.68	0.00e+00	1202.00
IUUC-Pva-102250	Pteropus vampyrus	71.05	0.00e+00	1722.00
IUUC-Rno-105031	Rattus norvegicus	79.04	0.00e+00	2356.00
IUUC-Tgu-117515	Taeniopygia guttata	94.61	0.00e+00	2910.00
IUUC-Tru-117914	Takifugu rubripes	76.76	0.00e+00	1389.00
IUUC-Tsy-119379	Tarsius syrichta	78.03	0.00e+00	782.00
IUUC-Tni-120178	Tetraodon nigroviridis	76.51	0.00e+00	1405.00
IUUC-Tbe-127762	Tupaia belangeri	80.29	0.00e+00	1613.00
IUUC-Ttr-128806	Tursiops truncatus	87.46	0.00e+00	1628.00
IUUC-Xtr-132903	Xenopus tropicalis	78.64	0.00e+00	1978.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence