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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063438
UUCD1 version UUC-MuM-00711
Ensembl Protein ID ENSMUSP00000108865.3
UniProt Accession Q8C7D2; Q3TVC2; Q5RJV6; Q6IS49; Q80XJ1; Q8BP45; Q8C6B7; Q9JKR4; CRBN_MOUSE
Genbank Protein ID BAC34322.1; BAC36214.1; BAC36970.1; BAE35697.1; AAH46967.1; AAH69905.1; AAH86488.1; AAF35895.1
Protein Name Protein cereblon
Genbank Nucleotide ID AK050557; AK076144; AK077707; AK160219; BC046967; BC069905; BC086488; AF229032
Gene Name Crbn
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000005362.14 ENSMUST00000013882.9 ENSMUSP00000013882.7
ENSMUSG00000005362.14 ENSMUST00000113239.9 ENSMUSP00000108865.3
ENSMUSG00000005362.14 ENSMUST00000151484.6 ENSMUSP00000144723.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDHINT
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/Other 93.48 0.00e+00 855.00 IUUC-Hsa-046888
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (By similarity). May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1 (By similarity).
 Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (By similarity). May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1 (By similarity).
Protein Sequence
(Fasta)
MAGEGDQQDA AHNMGNHLPL LPADSEDEDD EIEMEVEDQD SKEARKPNII NFDTSLPTSH 60
TYLGADMEEF HGRTLHDDDS CQVIPVLPEV LMILIPGQTL PLQLSHPQEV SMVRNLIQKD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063438|E3,E3 activity/Other|Mus musculus
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Nucleotide Sequence
(Fasta)
TCCTTTGCGG GTAAACAGAC ATGGCCGGCG AGGGAGATCA GCAGGACGCT GCGCACAACA 60
TGGGAAACCA CCTGCCGCTT CTGCCTGGTA ACCTCCGGGA CGGGCGCCTG GCCGTGGGTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063438|E3,E3 activity/Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
Interpro

IPR034750--CULT
IPR003111--Lon_substr-bd
IPR015947--PUA-like_domain
IPR004910--Yippee/Mis18/Cereblon
PROSITE

PS51788--CULT
PS51787--LON_N
Pfam

PF02190--LON_substr_bdg
PF03226--Yippee-Mis18
SMART

SM00464--LON
Gene Ontology

GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0034766--P:negative regulation of ion transmembrane transport
GO:0032463--P:negative regulation of protein homooligomerization
GO:0090073--P:positive regulation of protein homodimerization activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
KEGG mmu:58799
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000549 Aegilops tauschii 30.46 6.00e-24 105.00
IUUC-Aml-002159 Ailuropoda melanoleuca 93.27 0.00e+00 857.00
IUUC-Atr-002820 Amborella trichopoda 38.80 1.00e-37 151.00
IUUC-Apl-003508 Anas platyrhynchos 81.43 0.00e+00 741.00
IUUC-Aca-004675 Anolis carolinensis 82.13 0.00e+00 724.00
IUUC-Aly-005404 Arabidopsis lyrata 36.84 6.00e-38 152.00
IUUC-Ath-006819 Arabidopsis thaliana 36.32 2.00e-37 150.00
IUUC-Ani-009423 Aspergillus nidulans 38.60 4.00e-02 33.10
IUUC-Ame-010773 Astyanax mexicanus 67.56 8.00e-174 603.00
IUUC-Bta-012711 Bos taurus 91.69 0.00e+00 843.00
IUUC-Bdi-014416 Brachypodium distachyon 35.53 3.00e-37 149.00
IUUC-Bol-015668 Brassica oleracea 37.24 3.00e-39 156.00
IUUC-Bra-016836 Brassica rapa 37.24 3.00e-39 156.00
IUUC-Cja-019624 Callithrix jacchus 93.48 0.00e+00 858.00
IUUC-Cpo-022319 Cavia porcellus 91.01 0.00e+00 841.00
IUUC-Csa-023791 Chlorocebus sabaeus 93.26 0.00e+00 854.00
IUUC-Cho-024850 Choloepus hoffmanni 95.09 0.00e+00 694.00
IUUC-Csv-025832 Ciona savignyi 43.56 1.00e-88 320.00
IUUC-Cgl-026484 Colletotrichum gloeosporioides 31.82 5.40e-01 29.30
IUUC-Dre-028071 Danio rerio 68.96 7.00e-178 616.00
IUUC-Dno-029431 Dasypus novemcinctus 93.03 0.00e+00 859.00
IUUC-Dor-030571 Dipodomys ordii 78.20 0.00e+00 677.00
IUUC-Dme-031920 Drosophila melanogaster 28.50 7.00e-37 148.00
IUUC-Eca-033462 Equus caballus 92.58 0.00e+00 851.00
IUUC-Fca-036279 Felis catus 92.27 0.00e+00 836.00
IUUC-Fal-037498 Ficedula albicollis 76.61 0.00e+00 710.00
IUUC-Fox-037856 Fusarium oxysporum 42.86 2.50e-01 30.40
IUUC-Gmo-038734 Gadus morhua 70.21 1.00e-179 622.00
IUUC-Gga-040615 Gallus gallus 82.10 0.00e+00 746.00
IUUC-Gac-041426 Gasterosteus aculeatus 71.04 0.00e+00 635.00
IUUC-Gma-043891 Glycine max 40.45 4.00e-39 155.00
IUUC-Ggo-045108 Gorilla gorilla 93.03 0.00e+00 852.00
IUUC-Hsa-046888 Homo sapiens 93.48 0.00e+00 855.00
IUUC-Itr-047937 Ictidomys tridecemlineatus 95.80 0.00e+00 822.00
IUUC-Lch-050189 Latimeria chalumnae 75.37 7.00e-176 609.00
IUUC-Lpe-050808 Leersia perrieri 39.90 2.00e-43 170.00
IUUC-Loc-051762 Lepisosteus oculatus 74.21 0.00e+00 655.00
IUUC-Laf-053882 Loxodonta africana 92.58 0.00e+00 845.00
IUUC-Mcc-054883 Macaca mulatta 93.26 0.00e+00 854.00
IUUC-Mtr-058216 Medicago truncatula 40.45 1.00e-39 157.00
IUUC-Mdo-062260 Monodelphis domestica 82.77 0.00e+00 757.00
IUUC-Mac-064610 Musa acuminata 45.00 3.00e-46 179.00
IUUC-Mpu-066362 Mustela putorius furo 92.58 0.00e+00 854.00
IUUC-Nle-069908 Nomascus leucogenys 93.26 0.00e+00 853.00
IUUC-Ont-072223 Oreochromis niloticus 71.89 0.00e+00 642.00
IUUC-Ocu-074151 Oryctolagus cuniculus 94.53 0.00e+00 801.00
IUUC-Oba-075882 Oryza barthii 42.02 5.00e-43 169.00
IUUC-Obr-076670 Oryza brachyantha 38.38 1.00e-41 164.00
IUUC-Ogl-077753 Oryza glaberrima 42.02 5.00e-43 169.00
IUUC-Ogu-078786 Oryza glumaepatula 42.02 5.00e-43 169.00
IUUC-Oin-079191 Oryza indica 42.02 5.00e-43 169.00
IUUC-Olo-080357 Oryza longistaminata 42.02 5.00e-43 169.00
IUUC-Ome-081227 Oryza meridionalis 29.76 4.00e-19 89.40
IUUC-Oni-082557 Oryza nivara 42.02 5.00e-43 169.00
IUUC-Opu-083920 Oryza punctata 40.70 2.00e-42 167.00
IUUC-Oru-085227 Oryza rufipogon 42.02 5.00e-43 169.00
IUUC-Ola-087321 Oryzias latipes 71.39 2.00e-173 602.00
IUUC-Oga-088413 Otolemur garnettii 93.26 0.00e+00 864.00
IUUC-Oar-089512 Ovis aries 90.67 0.00e+00 834.00
IUUC-Ptr-090764 Pan troglodytes 93.48 0.00e+00 855.00
IUUC-Pan-091942 Papio anubis 93.26 0.00e+00 854.00
IUUC-Psi-092985 Pelodiscus sinensis 85.09 0.00e+00 730.00
IUUC-Ppa-095670 Physcomitrella patens 36.32 2.00e-45 177.00
IUUC-Pfo-097251 Poecilia formosa 76.40 0.00e+00 639.00
IUUC-Pab-097842 Pongo abelii 93.03 0.00e+00 853.00
IUUC-Pop-099118 Populus trichocarpa 37.21 3.00e-42 166.00
IUUC-Pca-101077 Procavia capensis 80.90 0.00e+00 729.00
IUUC-Ppe-101706 Prunus persica 38.03 3.00e-41 162.00
IUUC-Pva-102245 Pteropus vampyrus 79.11 1.00e-145 508.00
IUUC-Rno-105788 Rattus norvegicus 98.88 0.00e+00 882.00
IUUC-Smo-109165 Selaginella moellendorffii 42.58 5.00e-47 182.00
IUUC-Sit-109818 Setaria italica 41.50 1.00e-43 171.00
IUUC-Sly-111062 Solanum lycopersicum 38.58 2.00e-43 169.00
IUUC-Sbi-114298 Sorghum bicolor 39.34 3.00e-44 173.00
IUUC-Ssc-115779 Sus scrofa 91.45 0.00e+00 726.00
IUUC-Tgu-117378 Taeniopygia guttata 79.42 0.00e+00 729.00
IUUC-Tru-118515 Takifugu rubripes 71.85 2.00e-173 602.00
IUUC-Tsy-119555 Tarsius syrichta 84.27 0.00e+00 754.00
IUUC-Tni-119679 Tetraodon nigroviridis 70.83 5.00e-170 590.00
IUUC-Tca-121374 Theobroma cacao 37.64 2.00e-32 133.00
IUUC-Tae-123098 Triticum aestivum 32.60 1.00e-51 197.00
IUUC-Tur-126689 Triticum urartu 30.41 1.00e-16 81.30
IUUC-Vpa-130719 Vicugna pacos 82.70 0.00e+00 726.00
IUUC-Vvi-131014 Vitis vinifera 40.33 3.00e-40 159.00
IUUC-Xtr-131811 Xenopus tropicalis 72.20 0.00e+00 649.00
IUUC-Xma-133238 Xiphophorus maculatus 76.40 0.00e+00 642.00
Created Date 25-Jun-2017

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