iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-048328

Ensembl Protein ID

ENSSTOP00000013171.2

UniProt Accession

I3MNE6; I3MNE6_ICTTR

Genbank Protein ID

ENSSTOP00000013171

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01054077

Gene Name

MDM2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000014702.2	ENSSTOT00000014704.2	ENSSTOP00000013171.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	92.51	0.00e+00	764.00	IUUC-Hsa-046376
E3 activity/RING/RING	79.32	0.00e+00	640.00	IUUC-Mmu-063207
E3 activity/RING/RING	82.96	0.00e+00	667.00	IUUC-Rno-105641

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

SPTCRPMCNT NMSVSTDGAV STSQIPASEQ ETLVRPKPLL LKLLKSVGAQ KDTYTMKEVI 60
FYLGQYIMTK RLYDEKQQHI VYCSNDLLGD LFGVPSFSVK EHRKIYTMIY KNLVVVNQQE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCCCTACTT GTAGGCCAAT GTGCAATACC AACATGTCTG TGTCTACTGA TGGTGCTGTA 60
AGCACCTCAC AGATTCCAGC TTCGGAACAA GAGACCCTGG TTGGTATTTC TGTCTAAAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR028340--Mdm2
IPR015459--MDM2_E3_ligase
IPR016495--p53_neg-reg_MDM_2/4
IPR003121--SWIB_MDM2_domain
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS50089--ZF_RING_2

Pfam

PF02201--SWIB
PF00641--zf-RanBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0005730--C:nucleolus
GO:0043234--C:protein complex
GO:0016874--F:ligase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0003283--P:atrial septum development
GO:0003181--P:atrioventricular valve morphogenesis
GO:0001568--P:blood vessel development
GO:0001974--P:blood vessel remodeling
GO:0060411--P:cardiac septum morphogenesis
GO:0071456--P:cellular response to hypoxia
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0003203--P:endocardial cushion morphogenesis
GO:0045184--P:establishment of protein localization
GO:0043066--P:negative regulation of apoptotic process
GO:0071157--P:negative regulation of cell cycle arrest
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0018205--P:peptidyl-lysine modification
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0006461--P:protein complex assembly
GO:0031648--P:protein destabilization
GO:0034504--P:protein localization to nucleus
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0002027--P:regulation of heart rate
GO:0046677--P:response to antibiotic
GO:0007089--P:traversing start control point of mitotic cell cycle
GO:0003281--P:ventricular septum development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002039	Ailuropoda melanoleuca	91.16	0.00e+00	792.00
IUUC-Apl-003193	Anas platyrhynchos	63.78	2.00e-155	542.00
IUUC-Aca-004305	Anolis carolinensis	58.91	3.00e-118	418.00
IUUC-Ame-010675	Astyanax mexicanus	44.75	1.00e-83	303.00
IUUC-Bta-013270	Bos taurus	91.68	0.00e+00	760.00
IUUC-Cja-019744	Callithrix jacchus	91.87	0.00e+00	790.00
IUUC-Cfa-020807	Canis familiaris	89.75	0.00e+00	729.00
IUUC-Cpo-022182	Cavia porcellus	89.27	0.00e+00	744.00
IUUC-Cre-022828	Chlamydomonas reinhardtii	35.42	1.00e-05	40.80
IUUC-Csa-023541	Chlorocebus sabaeus	92.68	0.00e+00	772.00
IUUC-Cho-024831	Choloepus hoffmanni	98.20	3.00e-55	207.00
IUUC-Cin-025448	Ciona intestinalis	30.14	1.00e-21	95.90
IUUC-Csv-026151	Ciona savignyi	31.17	2.00e-11	62.40
IUUC-Dre-028419	Danio rerio	42.54	1.00e-51	196.00
IUUC-Dno-028950	Dasypus novemcinctus	89.84	0.00e+00	773.00
IUUC-Dor-031048	Dipodomys ordii	78.23	9.00e-106	377.00
IUUC-Ete-032264	Echinops telfairi	71.64	1.00e-104	373.00
IUUC-Eca-033301	Equus caballus	79.48	0.00e+00	686.00
IUUC-Eeu-035005	Erinaceus europaeus	78.46	2.00e-179	621.00
IUUC-Fca-035454	Felis catus	91.46	0.00e+00	778.00
IUUC-Fal-036720	Ficedula albicollis	60.60	1.00e-71	262.00
IUUC-Gmo-039296	Gadus morhua	41.44	2.00e-46	178.00
IUUC-Gga-040251	Gallus gallus	63.97	2.00e-151	528.00
IUUC-Gac-041528	Gasterosteus aculeatus	37.80	7.00e-36	144.00
IUUC-Ggo-044948	Gorilla gorilla	84.35	0.00e+00	703.00
IUUC-Hsa-046376	Homo sapiens	92.51	0.00e+00	776.00
IUUC-Lch-050037	Latimeria chalumnae	56.59	2.00e-116	412.00
IUUC-Loc-051837	Lepisosteus oculatus	50.10	9.00e-116	410.00
IUUC-Laf-053483	Loxodonta africana	83.00	0.00e+00	703.00
IUUC-Mcc-055294	Macaca mulatta	92.71	0.00e+00	778.00
IUUC-Mga-060007	Meleagris gallopavo	63.52	1.00e-142	499.00
IUUC-Mmr-060673	Microcebus murinus	91.87	0.00e+00	791.00
IUUC-Mdo-063057	Monodelphis domestica	71.66	0.00e+00	637.00
IUUC-Mmu-063207	Mus musculus	77.31	0.00e+00	630.00
IUUC-Mpu-065836	Mustela putorius furo	89.63	0.00e+00	780.00
IUUC-Mlu-068193	Myotis lucifugus	86.57	0.00e+00	769.00
IUUC-Nle-069927	Nomascus leucogenys	92.91	0.00e+00	780.00
IUUC-Opr-070590	Ochotona princeps	83.77	0.00e+00	678.00
IUUC-Ont-071984	Oreochromis niloticus	43.73	7.00e-54	204.00
IUUC-Oan-072744	Ornithorhynchus anatinus	70.50	2.00e-161	561.00
IUUC-Ocu-074071	Oryctolagus cuniculus	92.51	0.00e+00	793.00
IUUC-Oba-075400	Oryza barthii	35.19	1.00e-06	47.80
IUUC-Ogl-077249	Oryza glaberrima	42.11	2.00e-06	47.80
IUUC-Oin-080213	Oryza indica	42.11	2.00e-06	47.80
IUUC-Olo-080683	Oryza longistaminata	35.19	1.00e-06	47.80
IUUC-Ome-081101	Oryza meridionalis	35.19	2.00e-06	47.80
IUUC-Oni-082539	Oryza nivara	42.11	2.00e-06	47.80
IUUC-Opu-083826	Oryza punctata	42.11	2.00e-06	47.40
IUUC-Oru-084786	Oryza rufipogon	42.11	1.00e-06	48.10
IUUC-Osa-085344	Oryza sativa	35.19	2.00e-06	47.80
IUUC-Ola-087329	Oryzias latipes	39.92	3.00e-72	265.00
IUUC-Oga-088135	Otolemur garnettii	83.23	0.00e+00	724.00
IUUC-Oar-089726	Ovis aries	90.95	0.00e+00	807.00
IUUC-Ptr-091399	Pan troglodytes	92.91	0.00e+00	780.00
IUUC-Pan-092720	Papio anubis	92.71	0.00e+00	778.00
IUUC-Psi-093591	Pelodiscus sinensis	66.23	3.00e-126	444.00
IUUC-Pma-094500	Petromyzon marinus	31.48	2.00e-26	112.00
IUUC-Pfo-096316	Poecilia formosa	42.60	3.00e-51	195.00
IUUC-Pab-097696	Pongo abelii	92.51	0.00e+00	769.00
IUUC-Pca-100974	Procavia capensis	80.04	0.00e+00	712.00
IUUC-Pva-102488	Pteropus vampyrus	85.43	0.00e+00	680.00
IUUC-Rno-105641	Rattus norvegicus	82.56	0.00e+00	666.00
IUUC-Sha-107314	Sarcophilus harrisii	73.08	0.00e+00	657.00
IUUC-Sar-112938	Sorex araneus	84.35	0.00e+00	726.00
IUUC-Ssc-115495	Sus scrofa	91.06	0.00e+00	763.00
IUUC-Tgu-116623	Taeniopygia guttata	63.27	2.00e-148	518.00
IUUC-Tru-117820	Takifugu rubripes	40.06	3.00e-48	186.00
IUUC-Tsy-119162	Tarsius syrichta	63.69	5.00e-79	287.00
IUUC-Tni-119793	Tetraodon nigroviridis	43.30	1.00e-45	176.00
IUUC-Tvi-122445	Trichoderma virens	28.42	2.40e-01	29.60
IUUC-Tbe-127816	Tupaia belangeri	89.82	2.00e-118	419.00
IUUC-Ttr-129194	Tursiops truncatus	79.96	3.00e-180	624.00
IUUC-Vpa-130326	Vicugna pacos	84.94	0.00e+00	700.00
IUUC-Xtr-132216	Xenopus tropicalis	53.36	6.00e-113	400.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence