iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tre-122103

Ensembl Protein ID

EGR51836

UniProt Accession

G0RAC8; G0RAC8_HYPJQ

Genbank Protein ID

EGR51836.1

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

GL985057

Gene Name

TRIREDRAFT_55891

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
TRIREDRAFT_55891	EGR51836	EGR51836

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	6.30e-60	202.4	23	522

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGag..glGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveaheesite 99
           YDRQ+rlw +e+q++l+sa++ll++ g  + G+E+lKnLvl G+g++t+ D +tv+ ++l+ +F+++++  gk++A ++ e l elnp v+++  ++++  
   Q: 23   YDRQLRLWAAEGQAALESANILLINSGpgTAGVETLKNLVLPGIGKFTIADSATVQDEDLGVNFFLDESCLGKPRARCCTELLLELNPEVEGVWTSKDPAS 123
           ***********************98752279********************************************************************** PP
   S: 100  leeeivFfkkfdvVvlaldnrearr.kvnrlclnarvpliesgtlGllGqvrviikgltecyscsd.....dppqktiPfctlketpn...........aa 183
           l+e     + f++V+  l     ++  +    +++r pl+ + + G++++ r+ ++g   + + ++      ++++ +P+++l ++ +            +
   Q: 124  LQELLDSPEVFTMVMYSLPLHPGMLeAIEAYGRQHRTPLVAIHSVGFYSYFRITLPGTFPIVDTHPdetatTDLRLLAPWPELSQFARemtkdidnldhHD 224
           *999889999*****99987777753699***************************9755555554499999**************998888899988899 PP
   S: 184  ehtiewavlfnklleeeageeevlekldseekeegkdkvkselks....edeenfeeaieiavkafakttins.ikqllksfecdivtkskspfwv..... 274
           + +i+++v++ ++l+ ++++++++ +l+++ek+++++ v ++++       eenfeea+++++k+ +  + +s  +++++++++d+ ++ ks+fw+     
   Q: 225  HGHIPMVVILLHYLDIWKQQHDGAYPLSYSEKTAFRQMVADAMRRdnpeGGEENFEEAVAAVMKHVNLPQVPSsLTEVFEYDHKDE-QQAKSSFWIiaeam 324
           9999999************************************9966655689***************999999*******99999.9************* PP
   S: 275  ...............................................................sfcsnaealq..........vpekvekdeevvkasap. 301
                                                                           fc+na+ ++          + e ++++e  ++ +a+ 
   Q: 325  kqfyaehqrlpvagglpdmkaessvyiklqniykdkarqdandvlarvrklpggenvdlveveLFCKNARFIKlintrtetplSLEQIIERELSNDNTAAv 425
           ************************************************************************98888766655334444444433333335 PP
   S: 302  ........lylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfep 394
                   l    +al+ +++++  +          d   ++ +a++++     g e  l+ ++ +e+++ + ++++ ++av gG++aqEviK+++++++p
   Q: 426  vgpempfsLIPIYLALSVLSHNPMASA---------D---EITAAVCAMAPALKGNER-LT-QVAQELSRAAGGELHNISAVTGGMVAQEVIKIITKQYVP 512
           665667664444555555555555532.........3...444444533334444444.54.56667999999**************************** PP
   S: 395  lknfflfdae 404
           ++n+ +fd+ 
   Q: 513  IDNTCIFDGV 522
           *******985 PP

Organism

Trichoderma reesei

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.

Protein Sequence
(Fasta)

MTDILAQQTP LSLLGPSDKE KKYDRQLRLW AAEGQAALES ANILLINSGP GTAGVETLKN 60
LVLPGIGKFT IADSATVQDE DLGVNFFLDE SCLGKPRARC CTELLLELNP EVEGVWTSKD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACAGACA TCCTGGCACA GCAAACACCT CTCTCACTCC TCGGCCCCTC AGACAAGGAA 60
AAGAAGTATG ACCGCCAGCT CAGGCTGTGG GCGGCCGAGG GCCAGGCTGC CTTGGAGTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

KEGG

tre:TRIREDRAFT_55891

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	32.71	9.00e-75	272.00
IUUC-Aml-002333	Ailuropoda melanoleuca	37.18	7.00e-84	302.00
IUUC-Atr-002644	Amborella trichopoda	31.55	6.00e-65	239.00
IUUC-Apl-003446	Anas platyrhynchos	35.06	3.00e-72	264.00
IUUC-Aca-004450	Anolis carolinensis	35.88	2.00e-83	301.00
IUUC-Aly-005466	Arabidopsis lyrata	32.77	8.00e-68	249.00
IUUC-Ath-007600	Arabidopsis thaliana	32.52	5.00e-69	253.00
IUUC-Ago-007900	Ashbya gossypii	26.48	4.00e-40	157.00
IUUC-Acl-008333	Aspergillus clavatus	46.50	3.00e-128	450.00
IUUC-Afl-008529	Aspergillus flavus	46.42	6.00e-130	456.00
IUUC-Afu-009071	Aspergillus fumigatus	45.99	1.00e-127	448.00
IUUC-Ani-009443	Aspergillus nidulans	44.89	2.00e-121	427.00
IUUC-Ang-009669	Aspergillus niger	46.14	3.00e-136	476.00
IUUC-Aor-009914	Aspergillus oryzae	46.43	1.00e-130	458.00
IUUC-Ate-010450	Aspergillus terreus	46.57	3.00e-130	456.00
IUUC-Ame-011183	Astyanax mexicanus	31.99	6.00e-74	270.00
IUUC-Bgr-012111	Blumeria graminis	54.74	2.00e-155	540.00
IUUC-Bta-012583	Bos taurus	35.98	5.00e-83	300.00
IUUC-Bci-013892	Botrytis cinerea	57.77	5.00e-163	565.00
IUUC-Bdi-014592	Brachypodium distachyon	32.65	2.00e-72	264.00
IUUC-Bol-015487	Brassica oleracea	32.84	2.00e-70	258.00
IUUC-Bra-017506	Brassica rapa	33.39	4.00e-71	260.00
IUUC-Cel-018456	Caenorhabditis elegans	30.22	6.00e-60	223.00
IUUC-Cja-020007	Callithrix jacchus	36.15	5.00e-82	296.00
IUUC-Cfa-020324	Canis familiaris	37.50	2.00e-84	304.00
IUUC-Cpo-022248	Cavia porcellus	33.15	4.00e-44	170.00
IUUC-Csa-023149	Chlorocebus sabaeus	32.49	1.00e-56	212.00
IUUC-Cho-024537	Choloepus hoffmanni	28.99	4.00e-41	160.00
IUUC-Cin-025763	Ciona intestinalis	36.92	1.00e-83	302.00
IUUC-Csv-026113	Ciona savignyi	35.96	8.00e-81	292.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	60.29	0.00e+00	636.00
IUUC-Cne-026884	Cryptococcus neoformans	29.37	7.00e-52	196.00
IUUC-Dre-028140	Danio rerio	34.00	3.00e-79	287.00
IUUC-Dno-030033	Dasypus novemcinctus	40.44	2.00e-75	274.00
IUUC-Dor-030513	Dipodomys ordii	56.86	3.00e-25	107.00
IUUC-Dse-031536	Dothistroma septosporum	42.16	2.00e-117	414.00
IUUC-Dme-031683	Drosophila melanogaster	37.02	4.00e-74	270.00
IUUC-Ete-032420	Echinops telfairi	31.61	8.00e-61	226.00
IUUC-Eca-033992	Equus caballus	32.83	2.00e-54	204.00
IUUC-Eeu-034713	Erinaceus europaeus	55.45	3.00e-26	111.00
IUUC-Fca-036548	Felis catus	37.18	3.00e-83	300.00
IUUC-Fal-037600	Ficedula albicollis	35.78	3.00e-72	264.00
IUUC-Fox-038037	Fusarium oxysporum	66.29	0.00e+00	724.00
IUUC-Fso-038387	Fusarium solani	68.54	0.00e+00	764.00
IUUC-Gmo-038562	Gadus morhua	34.57	7.00e-78	283.00
IUUC-Ggr-040005	Gaeumannomyces graminis	60.44	0.00e+00	668.00
IUUC-Gga-041129	Gallus gallus	35.48	3.00e-76	277.00
IUUC-Gac-042558	Gasterosteus aculeatus	33.88	2.00e-77	281.00
IUUC-Gma-043610	Glycine max	33.08	2.00e-68	251.00
IUUC-Ggo-045611	Gorilla gorilla	36.98	3.00e-83	300.00
IUUC-Hsa-046563	Homo sapiens	37.00	2.00e-84	304.00
IUUC-Hvu-047790	Hordeum vulgare	29.43	1.00e-42	165.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	36.40	4.00e-83	300.00
IUUC-Kpa-049309	Komagataella pastoris	33.08	5.00e-66	243.00
IUUC-Lch-050038	Latimeria chalumnae	34.13	1.00e-76	278.00
IUUC-Lpe-051535	Leersia perrieri	30.84	2.00e-54	204.00
IUUC-Loc-051917	Lepisosteus oculatus	31.48	1.00e-65	242.00
IUUC-Lma-053112	Leptosphaeria maculans	44.64	1.00e-133	468.00
IUUC-Laf-053690	Loxodonta africana	36.81	9.00e-85	305.00
IUUC-Mcc-055117	Macaca mulatta	35.95	2.00e-78	285.00
IUUC-Meu-056761	Macropus eugenii	30.36	2.00e-53	202.00
IUUC-Mor-057230	Magnaporthe oryzae	58.02	0.00e+00	654.00
IUUC-Mpo-057514	Magnaporthe poae	63.08	0.00e+00	665.00
IUUC-Mtr-058551	Medicago truncatula	32.49	4.00e-65	240.00
IUUC-Mla-059183	Melampsora laricipopulina	35.08	6.00e-78	283.00
IUUC-Mga-060144	Meleagris gallopavo	34.07	5.00e-72	263.00
IUUC-Mvi-060221	Microbotryum violaceum	32.61	9.00e-70	256.00
IUUC-Mmr-061325	Microcebus murinus	35.60	4.00e-79	287.00
IUUC-Mdo-062532	Monodelphis domestica	36.50	8.00e-83	299.00
IUUC-Mmu-063956	Mus musculus	37.02	2.00e-84	304.00
IUUC-Mac-064521	Musa acuminata	33.83	3.00e-73	267.00
IUUC-Mpu-066716	Mustela putorius furo	40.50	2.00e-74	271.00
IUUC-Mlu-067459	Myotis lucifugus	36.95	4.00e-83	300.00
IUUC-Nfi-068245	Neosartorya fischeri	46.23	2.00e-128	450.00
IUUC-Ncr-068910	Neurospora crassa	60.55	0.00e+00	670.00
IUUC-Nle-070034	Nomascus leucogenys	34.25	3.00e-74	270.00
IUUC-Opr-070552	Ochotona princeps	37.34	3.00e-62	230.00
IUUC-Ont-071426	Oreochromis niloticus	34.57	4.00e-80	290.00
IUUC-Oan-073389	Ornithorhynchus anatinus	32.04	2.00e-51	194.00
IUUC-Ocu-074911	Oryctolagus cuniculus	36.72	8.00e-83	299.00
IUUC-Oba-075437	Oryza barthii	32.65	9.00e-65	239.00
IUUC-Obr-076684	Oryza brachyantha	31.84	2.00e-60	225.00
IUUC-Ogl-077170	Oryza glaberrima	32.65	9.00e-65	239.00
IUUC-Ogu-078844	Oryza glumaepatula	31.84	2.00e-56	211.00
IUUC-Oin-079105	Oryza indica	32.65	1.00e-64	239.00
IUUC-Olo-080943	Oryza longistaminata	30.45	2.00e-49	188.00
IUUC-Oni-082891	Oryza nivara	31.34	5.00e-58	217.00
IUUC-Opu-083457	Oryza punctata	32.84	8.00e-65	239.00
IUUC-Oru-084960	Oryza rufipogon	30.45	2.00e-49	188.00
IUUC-Osa-085358	Oryza sativa	32.65	1.00e-64	239.00
IUUC-Ola-086420	Oryzias latipes	32.45	4.00e-49	186.00
IUUC-Olu-087625	Ostreococcus lucimarinus	25.95	3.00e-39	154.00
IUUC-Oga-088810	Otolemur garnettii	36.40	2.00e-82	298.00
IUUC-Oar-089196	Ovis aries	36.01	3.00e-81	293.00
IUUC-Ptr-090617	Pan troglodytes	37.00	3.00e-84	304.00
IUUC-Pan-092761	Papio anubis	36.95	1.00e-83	301.00
IUUC-Psi-093191	Pelodiscus sinensis	33.46	1.00e-73	268.00
IUUC-Pma-094380	Petromyzon marinus	37.50	5.00e-67	246.00
IUUC-Pno-095084	Phaeosphaeria nodorum	42.28	9.00e-117	413.00
IUUC-Ppa-095875	Physcomitrella patens	31.88	1.00e-64	239.00
IUUC-Pfo-096467	Poecilia formosa	35.24	2.00e-79	288.00
IUUC-Pab-098255	Pongo abelii	39.45	2.00e-73	267.00
IUUC-Pop-099871	Populus trichocarpa	33.15	9.00e-71	259.00
IUUC-Pca-100807	Procavia capensis	40.70	6.00e-29	120.00
IUUC-Ppe-101280	Prunus persica	31.60	3.00e-68	250.00
IUUC-Pva-102333	Pteropus vampyrus	35.78	2.00e-75	274.00
IUUC-Pgr-103401	Puccinia graminis	29.75	8.00e-66	243.00
IUUC-Ptt-103889	Puccinia triticina	27.88	6.00e-58	216.00
IUUC-Pte-104355	Pyrenophora teres	45.21	1.00e-135	474.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	45.92	6.00e-135	472.00
IUUC-Rno-105810	Rattus norvegicus	36.65	4.00e-83	300.00
IUUC-Sce-106397	Saccharomyces cerevisiae	24.24	8.00e-25	106.00
IUUC-Sha-106770	Sarcophilus harrisii	40.91	1.00e-50	191.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	32.22	3.00e-64	237.00
IUUC-Spo-108276	Schizosaccharomyces pombe	33.64	1.00e-69	255.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	59.07	1.00e-179	621.00
IUUC-Smo-109296	Selaginella moellendorffii	33.64	2.00e-73	268.00
IUUC-Sit-110157	Setaria italica	33.21	6.00e-77	280.00
IUUC-Sly-111105	Solanum lycopersicum	31.56	3.00e-66	244.00
IUUC-Stu-112469	Solanum tuberosum	30.84	5.00e-67	246.00
IUUC-Sar-113083	Sorex araneus	27.29	9.00e-42	162.00
IUUC-Sbi-113813	Sorghum bicolor	33.58	5.00e-76	276.00
IUUC-Sre-115058	Sporisorium reilianum	36.78	2.00e-56	211.00
IUUC-Tgu-116772	Taeniopygia guttata	35.78	2.00e-72	265.00
IUUC-Tru-118686	Takifugu rubripes	34.07	1.00e-79	289.00
IUUC-Tsy-119111	Tarsius syrichta	37.19	3.00e-41	161.00
IUUC-Tni-120231	Tetraodon nigroviridis	31.51	5.00e-67	246.00
IUUC-Tca-121491	Theobroma cacao	33.96	1.00e-64	238.00
IUUC-Tvi-122672	Trichoderma virens	82.11	0.00e+00	895.00
IUUC-Tae-125684	Triticum aestivum	32.84	6.00e-75	273.00
IUUC-Tur-126487	Triticum urartu	31.52	5.00e-70	256.00
IUUC-Tme-127097	Tuber melanosporum	42.12	3.00e-100	357.00
IUUC-Ttr-128465	Tursiops truncatus	34.37	2.00e-69	254.00
IUUC-Uma-129645	Ustilago maydis	36.94	1.00e-57	215.00
IUUC-Vda-129989	Verticillium dahliae	53.32	8.00e-154	535.00
IUUC-Vpa-130529	Vicugna pacos	34.86	2.00e-73	268.00
IUUC-Vvi-131059	Vitis vinifera	32.09	1.00e-69	255.00
IUUC-Xtr-132002	Xenopus tropicalis	36.89	5.00e-83	300.00
IUUC-Xma-133930	Xiphophorus maculatus	34.26	5.00e-79	286.00
IUUC-Yli-134505	Yarrowia lipolytica	36.69	3.00e-92	330.00
IUUC-Zma-135619	Zea mays	32.96	3.00e-74	271.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence