iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Vvi-131059

UUCD1 version

UUC-ViV-01042

Ensembl Protein ID

VIT_12s0059g00610.t01

UniProt Accession

D7TE75; D7TE75_VITVI

Genbank Protein ID

CBI28798.3

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

FN595765

Gene Name

VIT_12s0059g00610

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
VIT_12s0059g00610	VIT_12s0059g00610.t01	VIT_12s0059g00610.t01

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	5.20e-119	398.7	8	514

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdv 88
           YDRQ+r+wGe++qe+l++a+++l+++g++G+E+lKnLvl+G+gsitv+D+++ve+ +l+++F+++++++g+sKA++++++l+eln+ v
   Q: 8    YDRQLRIWGEQGQEALEKASICLLNCGPTGSETLKNLVLGGIGSITVIDGSKVELGDLGNNFMVDESSIGQSKAKCVCASLQELNDAV 95
           **************************************************************************************** PP
   S: 89   nveaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiP 172
           ++++ ee +++l e+++ Ff++f++V++++  ++++ k++r+c++a+v li ++++Gl G+vr+++k++ +++s++d   d++++++P
   Q: 96   KAKFIEEYPEALIETNPsFFSQFTLVIATQLVEDSMIKLDRICREANVMLIFARSYGLTGFVRISLKEHAVIESKPDhflDDLRLNNP 183
           **************************************************************************************** PP
   S: 173  fctlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttin 251
           +++l+ + +         +++++++++v++ k++e+++++++++ ++++eek+e+kd+ ks++ ++de+n++eaie+++k fa++ i+
   Q: 184  WPELRGFAEtidlnvsdpVVHKHTPYVVILVKMAEQWTKSHDGKLPSTREEKKEFKDLLKSKMIAMDEDNYKEAIEASFKVFAPRGIS 271
           *******98899999999********************************************************************** PP
   S: 252  s.ikqllksfecdivtkskspfwv................................................................ 274
           s  +q++++ +   v +s+s+fwv                                                                
   Q: 272  SnLQQIIDDSRA-DVDSSSSNFWVmvaslkefianegggeaplegsipdmtsstehyvnlqkiyqakaeadflvieqrvrnilkkigr 358
           *99999999555.77************************************************************************* PP
   S: 275  ...........sfcsnaealq...........vpekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekdddsavdl 335
                      sf +na++l              +   + +++++++++     +y+llra++rf++++++ pg+++  +d+d + +l
   Q: 359  dpdsiskanikSFSKNARKLTvcryrlleeefNSPIQPELQKYLTDEDYsvavgFYILLRAVDRFAANYNSFPGQFDGGMDED-ISRL 445
           ********9999999999999665555555543366666666777777788899*****************************.**** PP
   S: 336  vtaaanlraeslgiep.kldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
           +t+a +l  ++lg+++  l++dli e++++++++++ ++a++gG+a+qEviK+++++f+p+  +f+f+++
   Q: 446  KTTAVSLL-SDLGCNGsTLTEDLINEMCRFGAAELHAVAAFIGGIASQEVIKLITKQFVPMSGTFIFNGI 514
           *****999.**********************************************************986 PP

Organism

Vitis vinifera

Functional Description
(View)

Regulatory subunit of the dimeric E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1.

Protein Sequence
(Fasta)

MAEPKTKYDR QLRIWGEQGQ EALEKASICL LNCGPTGSET LKNLVLGGIG SITVIDGSKV 60
ELGDLGNNFM VDESSIGQSK AKCVCASLQE LNDAVKAKFI EEYPEALIET NPSFFSQFTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGAAC CCAAAACGAA ATATGATCGT CAGCTCAGGT ACTCTGACAA TGAACTATTT 60
TCCCTCCAAT ATTTCCGCAG TTTCCGTTTT TGCCATCTCC TTACCCTAAC TCTCTACTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

KEGG

vvi:100251665

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	69.77	0.00e+00	774.00
IUUC-Aml-002333	Ailuropoda melanoleuca	41.19	6.00e-125	440.00
IUUC-Atr-002644	Amborella trichopoda	78.59	0.00e+00	830.00
IUUC-Apl-003446	Anas platyrhynchos	40.61	1.00e-115	409.00
IUUC-Aca-004450	Anolis carolinensis	38.97	3.00e-120	424.00
IUUC-Aly-005466	Arabidopsis lyrata	79.58	0.00e+00	890.00
IUUC-Ath-006692	Arabidopsis thaliana	80.53	0.00e+00	899.00
IUUC-Ago-007900	Ashbya gossypii	25.56	7.00e-37	147.00
IUUC-Acl-008333	Aspergillus clavatus	31.51	5.00e-68	251.00
IUUC-Afl-008529	Aspergillus flavus	32.91	5.00e-75	274.00
IUUC-Afu-009071	Aspergillus fumigatus	32.60	2.00e-70	258.00
IUUC-Ani-009443	Aspergillus nidulans	30.59	2.00e-65	242.00
IUUC-Ang-009669	Aspergillus niger	31.65	1.00e-73	269.00
IUUC-Aor-009914	Aspergillus oryzae	32.21	2.00e-73	268.00
IUUC-Ate-010450	Aspergillus terreus	31.75	2.00e-71	262.00
IUUC-Ame-011183	Astyanax mexicanus	40.56	1.00e-121	429.00
IUUC-Bgr-012111	Blumeria graminis	32.09	2.00e-62	233.00
IUUC-Bta-012583	Bos taurus	41.53	2.00e-127	448.00
IUUC-Bci-013892	Botrytis cinerea	30.95	2.00e-57	215.00
IUUC-Bdi-014592	Brachypodium distachyon	69.87	0.00e+00	774.00
IUUC-Bol-016399	Brassica oleracea	81.07	0.00e+00	903.00
IUUC-Bra-017506	Brassica rapa	76.00	0.00e+00	850.00
IUUC-Cel-018456	Caenorhabditis elegans	31.72	3.00e-73	268.00
IUUC-Cja-020007	Callithrix jacchus	40.93	3.00e-125	441.00
IUUC-Cfa-020324	Canis familiaris	41.34	4.00e-127	447.00
IUUC-Cpo-022248	Cavia porcellus	35.84	5.00e-67	247.00
IUUC-Csa-023149	Chlorocebus sabaeus	38.02	3.00e-96	345.00
IUUC-Cho-024537	Choloepus hoffmanni	34.05	2.00e-83	302.00
IUUC-Cin-025763	Ciona intestinalis	40.41	5.00e-112	397.00
IUUC-Csv-026113	Ciona savignyi	39.78	4.00e-108	384.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	30.60	2.00e-57	215.00
IUUC-Cne-026884	Cryptococcus neoformans	33.08	1.00e-70	259.00
IUUC-Dre-028140	Danio rerio	41.04	9.00e-126	442.00
IUUC-Dno-030033	Dasypus novemcinctus	40.87	5.00e-107	380.00
IUUC-Dor-030513	Dipodomys ordii	51.82	3.00e-26	112.00
IUUC-Dse-031536	Dothistroma septosporum	31.16	4.00e-68	251.00
IUUC-Dme-031683	Drosophila melanogaster	39.40	7.00e-101	360.00
IUUC-Ete-032420	Echinops telfairi	36.75	8.00e-108	383.00
IUUC-Eca-033992	Equus caballus	38.65	4.00e-96	343.00
IUUC-Eeu-034713	Erinaceus europaeus	31.52	2.00e-35	142.00
IUUC-Fca-036548	Felis catus	40.97	4.00e-126	444.00
IUUC-Fal-037600	Ficedula albicollis	40.54	2.00e-114	404.00
IUUC-Fox-038037	Fusarium oxysporum	31.47	2.00e-65	242.00
IUUC-Fso-038387	Fusarium solani	32.19	8.00e-66	243.00
IUUC-Gmo-038562	Gadus morhua	39.77	3.00e-119	421.00
IUUC-Ggr-040005	Gaeumannomyces graminis	35.82	7.00e-58	217.00
IUUC-Gga-041129	Gallus gallus	40.15	2.00e-117	415.00
IUUC-Gac-042558	Gasterosteus aculeatus	40.71	2.00e-121	428.00
IUUC-Gma-043610	Glycine max	84.13	0.00e+00	912.00
IUUC-Ggo-045611	Gorilla gorilla	41.40	6.00e-124	436.00
IUUC-Hsa-046563	Homo sapiens	41.63	4.00e-125	440.00
IUUC-Hvu-047790	Hordeum vulgare	68.89	2.00e-162	564.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	41.15	1.00e-125	442.00
IUUC-Kpa-049309	Komagataella pastoris	34.11	2.00e-75	275.00
IUUC-Lch-050038	Latimeria chalumnae	39.47	3.00e-118	417.00
IUUC-Lpe-051535	Leersia perrieri	68.02	0.00e+00	689.00
IUUC-Loc-051917	Lepisosteus oculatus	37.52	5.00e-109	387.00
IUUC-Lma-053112	Leptosphaeria maculans	31.96	3.00e-76	278.00
IUUC-Laf-053690	Loxodonta africana	41.34	3.00e-126	444.00
IUUC-Mcc-055117	Macaca mulatta	40.11	1.00e-120	426.00
IUUC-Meu-056761	Macropus eugenii	33.64	8.00e-91	327.00
IUUC-Mor-057230	Magnaporthe oryzae	31.69	6.00e-65	240.00
IUUC-Mpo-057514	Magnaporthe poae	32.04	2.00e-66	246.00
IUUC-Mtr-058551	Medicago truncatula	78.11	0.00e+00	845.00
IUUC-Mla-059183	Melampsora laricipopulina	35.17	8.00e-87	313.00
IUUC-Mga-060144	Meleagris gallopavo	39.96	5.00e-114	404.00
IUUC-Mvi-060221	Microbotryum violaceum	33.21	6.00e-73	267.00
IUUC-Mmr-061325	Microcebus murinus	40.19	8.00e-121	426.00
IUUC-Mdo-062532	Monodelphis domestica	41.25	1.00e-125	442.00
IUUC-Mmu-063956	Mus musculus	40.97	2.00e-126	445.00
IUUC-Mac-064521	Musa acuminata	75.34	0.00e+00	838.00
IUUC-Mpu-066716	Mustela putorius furo	40.79	4.00e-116	410.00
IUUC-Mlu-067459	Myotis lucifugus	41.92	3.00e-127	447.00
IUUC-Nfi-068245	Neosartorya fischeri	32.66	7.00e-70	257.00
IUUC-Ncr-068910	Neurospora crassa	33.46	2.00e-69	255.00
IUUC-Nle-070034	Nomascus leucogenys	40.19	3.00e-119	421.00
IUUC-Opr-070552	Ochotona princeps	37.30	5.00e-96	343.00
IUUC-Ont-071426	Oreochromis niloticus	39.74	9.00e-123	432.00
IUUC-Oan-073389	Ornithorhynchus anatinus	38.20	3.00e-89	321.00
IUUC-Ocu-074911	Oryctolagus cuniculus	41.71	1.00e-127	449.00
IUUC-Oba-075437	Oryza barthii	71.59	0.00e+00	750.00
IUUC-Obr-076684	Oryza brachyantha	70.91	0.00e+00	707.00
IUUC-Ogl-077170	Oryza glaberrima	71.59	0.00e+00	750.00
IUUC-Ogu-078844	Oryza glumaepatula	70.36	0.00e+00	696.00
IUUC-Oin-079105	Oryza indica	71.40	0.00e+00	747.00
IUUC-Olo-080943	Oryza longistaminata	68.62	0.00e+00	675.00
IUUC-Oni-082891	Oryza nivara	69.29	0.00e+00	722.00
IUUC-Opu-083457	Oryza punctata	71.59	0.00e+00	750.00
IUUC-Oru-084960	Oryza rufipogon	68.55	0.00e+00	677.00
IUUC-Osa-085358	Oryza sativa	71.21	0.00e+00	743.00
IUUC-Ola-086420	Oryzias latipes	37.50	1.00e-77	281.00
IUUC-Olu-087625	Ostreococcus lucimarinus	31.42	2.00e-62	232.00
IUUC-Oga-088810	Otolemur garnettii	41.34	2.00e-126	445.00
IUUC-Oar-089196	Ovis aries	41.30	9.00e-126	442.00
IUUC-Ptr-090617	Pan troglodytes	41.63	2.00e-125	441.00
IUUC-Pan-092761	Papio anubis	41.34	2.00e-126	444.00
IUUC-Psi-093191	Pelodiscus sinensis	38.85	2.00e-118	418.00
IUUC-Pma-094380	Petromyzon marinus	40.73	4.00e-110	390.00
IUUC-Pno-095084	Phaeosphaeria nodorum	31.67	5.00e-64	239.00
IUUC-Ppa-095798	Physcomitrella patens	54.70	0.00e+00	629.00
IUUC-Pfo-096467	Poecilia formosa	40.26	2.00e-119	421.00
IUUC-Pab-098255	Pongo abelii	41.61	3.00e-104	371.00
IUUC-Pop-099722	Populus trichocarpa	85.85	0.00e+00	946.00
IUUC-Pca-100807	Procavia capensis	49.20	2.00e-51	195.00
IUUC-Ppe-101280	Prunus persica	88.53	0.00e+00	973.00
IUUC-Pva-102333	Pteropus vampyrus	40.00	4.00e-118	417.00
IUUC-Pgr-103401	Puccinia graminis	29.15	1.00e-73	269.00
IUUC-Ptt-103889	Puccinia triticina	28.45	4.00e-64	238.00
IUUC-Pte-104355	Pyrenophora teres	33.15	1.00e-72	266.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	33.63	7.00e-73	267.00
IUUC-Rno-105810	Rattus norvegicus	40.68	4.00e-124	437.00
IUUC-Sce-106397	Saccharomyces cerevisiae	30.03	6.00e-32	130.00
IUUC-Sha-106770	Sarcophilus harrisii	46.69	8.00e-72	262.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	32.76	3.00e-79	288.00
IUUC-Spo-108276	Schizosaccharomyces pombe	32.63	5.00e-83	300.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	31.44	2.00e-56	212.00
IUUC-Smo-109296	Selaginella moellendorffii	54.53	1.00e-166	578.00
IUUC-Sit-110157	Setaria italica	71.89	0.00e+00	816.00
IUUC-Sly-111105	Solanum lycopersicum	80.45	0.00e+00	912.00
IUUC-Stu-112469	Solanum tuberosum	81.01	0.00e+00	920.00
IUUC-Sar-113083	Sorex araneus	32.30	1.00e-82	299.00
IUUC-Sbi-113813	Sorghum bicolor	70.75	0.00e+00	807.00
IUUC-Sre-115058	Sporisorium reilianum	34.53	1.00e-66	246.00
IUUC-Tgu-116772	Taeniopygia guttata	40.94	6.00e-115	406.00
IUUC-Tru-118686	Takifugu rubripes	38.61	1.00e-120	426.00
IUUC-Tsy-119111	Tarsius syrichta	42.49	6.00e-61	227.00
IUUC-Tni-120231	Tetraodon nigroviridis	36.82	1.00e-104	372.00
IUUC-Tca-121491	Theobroma cacao	88.91	0.00e+00	937.00
IUUC-Tre-122103	Trichoderma reesei	32.09	2.00e-71	261.00
IUUC-Tvi-122672	Trichoderma virens	32.77	3.00e-68	251.00
IUUC-Tae-125316	Triticum aestivum	70.63	0.00e+00	782.00
IUUC-Tur-126487	Triticum urartu	69.05	0.00e+00	751.00
IUUC-Tme-127097	Tuber melanosporum	34.25	1.00e-76	279.00
IUUC-Ttr-128465	Tursiops truncatus	39.26	3.00e-112	397.00
IUUC-Uma-129645	Ustilago maydis	30.55	9.00e-72	263.00
IUUC-Vda-129989	Verticillium dahliae	29.79	8.00e-40	157.00
IUUC-Vpa-130529	Vicugna pacos	40.19	3.00e-115	408.00
IUUC-Xtr-132002	Xenopus tropicalis	41.06	3.00e-125	441.00
IUUC-Xma-133930	Xiphophorus maculatus	40.19	7.00e-123	433.00
IUUC-Yli-134505	Yarrowia lipolytica	33.53	2.00e-82	299.00
IUUC-Zma-135619	Zea mays	70.36	0.00e+00	762.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence