iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020462

Ensembl Protein ID

ENSCAFP00000011072.3

UniProt Accession

E2RHV6; E2RHV6_CANLF

Genbank Protein ID

ENSCAFP00000011072

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03013614

Gene Name

NCK1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000007451.3	ENSCAFT00000011939.3	ENSCAFP00000011072.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.90e-46	155.5	192	249

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           +++vq+ly+++++nd+eL+++kGdv++viek e+d +W+k+ ++ +g  Gl+P+n+v+ 
   Q: 192  LHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKC-RKINGMVGLVPKNYVTI 249
           689**************************************.59*************85 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MAEEVVVVAK FDYVAQQEQE LDIKKNERLW LLDDSKSWWR VRNSMNKTGF VPSNYVERKN 60
SARKASIVKN LKDTLGIGKV KRKHSVPDSA SPADDSFVDP GERLYDLNMP AYVKFNYMAE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAGAAG AAGTGGTAGT AGTAGCCAAA TTTGATTATG TGGCCCAACA AGAACAAGAG 60
CTGGACATCA AGAAGAATGA GAGATTATGG CTTCTAGATG ACTCTAAATC CTGGTGGCGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005783--C:endoplasmic reticulum
GO:0000164--C:protein phosphatase type 1 complex
GO:0005840--C:ribosome
GO:0012506--C:vesicle membrane
GO:0004860--F:protein kinase inhibitor activity
GO:0007015--P:actin filament organization
GO:0048013--P:ephrin receptor signaling pathway
GO:0030032--P:lamellipodium assembly
GO:0060548--P:negative regulation of cell death
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0070262--P:peptidyl-serine dephosphorylation
GO:0030838--P:positive regulation of actin filament polymerization
GO:1903676--P:positive regulation of cap-dependent translational initiation
GO:1903679--P:positive regulation of cap-independent translational initiation
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0010976--P:positive regulation of neuron projection development
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress
GO:0030334--P:regulation of cell migration
GO:0051707--P:response to other organism
GO:0006930--P:substrate-dependent cell migration, cell extension
GO:0042110--P:T cell activation

KEGG

cfa:485677

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002115	Ailuropoda melanoleuca	99.73	0.00e+00	743.00
IUUC-Ame-011235	Astyanax mexicanus	78.36	2.00e-180	624.00
IUUC-Bta-013039	Bos taurus	99.20	0.00e+00	740.00
IUUC-Cja-019546	Callithrix jacchus	98.41	0.00e+00	732.00
IUUC-Cpo-022009	Cavia porcellus	98.14	0.00e+00	734.00
IUUC-Csa-023875	Chlorocebus sabaeus	99.20	0.00e+00	741.00
IUUC-Cho-024368	Choloepus hoffmanni	97.67	0.00e+00	652.00
IUUC-Csv-026046	Ciona savignyi	40.60	5.00e-72	265.00
IUUC-Dre-028407	Danio rerio	76.78	2.00e-177	615.00
IUUC-Dno-029593	Dasypus novemcinctus	99.04	2.00e-175	607.00
IUUC-Dor-030730	Dipodomys ordii	97.76	0.00e+00	640.00
IUUC-Dme-031846	Drosophila melanogaster	43.10	1.00e-91	330.00
IUUC-Ete-032906	Echinops telfairi	98.41	0.00e+00	732.00
IUUC-Eca-033378	Equus caballus	99.09	0.00e+00	640.00
IUUC-Eeu-034743	Erinaceus europaeus	88.86	0.00e+00	677.00
IUUC-Fca-035745	Felis catus	99.20	0.00e+00	778.00
IUUC-Gac-042245	Gasterosteus aculeatus	75.84	4.00e-159	553.00
IUUC-Ggo-045487	Gorilla gorilla	99.20	0.00e+00	741.00
IUUC-Hsa-045902	Homo sapiens	99.20	0.00e+00	741.00
IUUC-Itr-047923	Ictidomys tridecemlineatus	98.94	0.00e+00	739.00
IUUC-Lch-050165	Latimeria chalumnae	82.76	2.00e-180	624.00
IUUC-Loc-052523	Lepisosteus oculatus	78.89	1.00e-179	622.00
IUUC-Laf-053845	Loxodonta africana	98.67	0.00e+00	737.00
IUUC-Meu-056139	Macropus eugenii	91.78	0.00e+00	669.00
IUUC-Mmr-061108	Microcebus murinus	87.27	1.00e-174	605.00
IUUC-Mdo-062258	Monodelphis domestica	95.23	0.00e+00	717.00
IUUC-Mmu-063970	Mus musculus	98.67	0.00e+00	777.00
IUUC-Mpu-066093	Mustela putorius furo	99.47	0.00e+00	741.00
IUUC-Mlu-067193	Myotis lucifugus	99.20	0.00e+00	739.00
IUUC-Nle-069611	Nomascus leucogenys	99.20	0.00e+00	741.00
IUUC-Opr-070984	Ochotona princeps	97.34	2.00e-178	617.00
IUUC-Ont-072241	Oreochromis niloticus	75.90	8.00e-172	596.00
IUUC-Oan-072976	Ornithorhynchus anatinus	89.25	2.00e-166	577.00
IUUC-Ocu-073905	Oryctolagus cuniculus	99.20	0.00e+00	740.00
IUUC-Ola-086513	Oryzias latipes	74.62	3.00e-159	554.00
IUUC-Oga-088588	Otolemur garnettii	99.20	0.00e+00	739.00
IUUC-Oar-089973	Ovis aries	99.47	0.00e+00	741.00
IUUC-Ptr-090968	Pan troglodytes	99.20	0.00e+00	741.00
IUUC-Pan-092840	Papio anubis	99.36	3.00e-176	610.00
IUUC-Pfo-096057	Poecilia formosa	74.23	5.00e-169	587.00
IUUC-Pab-097807	Pongo abelii	98.94	0.00e+00	740.00
IUUC-Pca-100522	Procavia capensis	98.40	4.00e-174	603.00
IUUC-Pva-103083	Pteropus vampyrus	99.47	0.00e+00	740.00
IUUC-Rno-104839	Rattus norvegicus	95.76	0.00e+00	739.00
IUUC-Sha-107294	Sarcophilus harrisii	94.16	0.00e+00	707.00
IUUC-Sar-113675	Sorex araneus	97.61	0.00e+00	725.00
IUUC-Ssc-116442	Sus scrofa	98.41	0.00e+00	777.00
IUUC-Tru-118058	Takifugu rubripes	74.55	1.00e-168	585.00
IUUC-Tsy-119184	Tarsius syrichta	91.67	0.00e+00	632.00
IUUC-Tni-119974	Tetraodon nigroviridis	74.23	1.00e-156	545.00
IUUC-Ttr-129155	Tursiops truncatus	97.08	0.00e+00	734.00
IUUC-Vpa-130344	Vicugna pacos	99.20	0.00e+00	741.00
IUUC-Xtr-132372	Xenopus tropicalis	87.77	0.00e+00	657.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence