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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064376
Ensembl Protein ID ENSMUSP00000095747.4
UniProt Accession B1AY10; Q3U2A7; Q3UK95; Q3UMW1; Q7TPT4; Q8CC59; Q9DBC8; Q9JKW7; NFX1_MOUSE
Genbank Protein ID AAF34700.1; BAB23765.1; BAC28494.1; BAE25987.1; BAE26907.1; BAE33235.1; CAM19845.1; CAM19846.1; CAM19847.1; AAH53709.1
Protein Name Transcriptional repressor NF-X1; Nuclear transcription factor, X box-binding protein 1
Genbank Nucleotide ID AF223576; AK005038; AK033850; AK144647; AK146108; AK155387; AL837521; AL837521; AL837521; BC053709
Gene Name Nfx1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000028423.15 ENSMUST00000098143.10 ENSMUSP00000095747.4
ENSMUSG00000028423.15 ENSMUST00000030133.14 ENSMUSP00000030133.8
ENSMUSG00000028423.15 ENSMUST00000091614.6 ENSMUSP00000089203.6
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexHINT
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusUniProt
PHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 88.21 0.00e+00 1897.00 IUUC-Hsa-046870
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Together with PABPC1 or PABPC4, acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination.
 Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Together with PABPC1 or PABPC4, acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination.
Protein Sequence
(Fasta)
MAEAPPVSGT FKFNTDAAEF IPQERKTSGL NCGTQRRLDS SRIGRRNYSS SPPCHLPRHI 60
PYEDISAVHQ HSYASGSKPK SPQGFFQSSN KSLKNHGLQN QPWQKARNEK HQNRNKKAQG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064376|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
GCACCACCCC CTTGGCTGTC CCCGGGCGCG TAGGAGCGAC TAGTCTCTCG GCGCCGGAAA 60
TCCGGGACAC GTGACCAGGT GACAGCCTTC GCTCGGTGGC GGGGCTCGCT TGAGGTGCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064376|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0436--Ligase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR034078--NFX1_fam
IPR001374--R3H_dom
IPR034076--R3H_NF-X1
IPR019786--Zinc_finger_PHD-type_CS
IPR000967--Znf_NFX1
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
PROSITE

PS51061--R3H
PS50089--ZF_RING_2
Pfam

PF01424--R3H
PF01422--zf-NF-X1
SMART

SM00393--R3H
SM00438--ZnF_NFX
Gene Ontology

GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0003723--F:RNA binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0045347--P:negative regulation of MHC class II biosynthetic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
KEGG mmu:74164
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000224 Aegilops tauschii 39.14 1.00e-84 307.00
IUUC-Aml-001716 Ailuropoda melanoleuca 87.86 0.00e+00 1933.00
IUUC-Atr-002895 Amborella trichopoda 39.39 1.00e-134 474.00
IUUC-Apl-003650 Anas platyrhynchos 59.21 0.00e+00 1188.00
IUUC-Aca-004313 Anolis carolinensis 58.66 0.00e+00 1247.00
IUUC-Aly-006515 Arabidopsis lyrata 37.92 4.00e-131 462.00
IUUC-Ath-007056 Arabidopsis thaliana 36.88 6.00e-130 459.00
IUUC-Ago-007777 Ashbya gossypii 31.60 1.00e-84 308.00
IUUC-Acl-008068 Aspergillus clavatus 35.56 4.00e-80 293.00
IUUC-Afl-008499 Aspergillus flavus 36.08 3.00e-46 179.00
IUUC-Afu-009016 Aspergillus fumigatus 34.23 1.00e-107 385.00
IUUC-Ani-009477 Aspergillus nidulans 35.85 4.00e-112 399.00
IUUC-Ang-009605 Aspergillus niger 36.11 3.00e-116 413.00
IUUC-Aor-010166 Aspergillus oryzae 34.62 1.00e-51 198.00
IUUC-Ame-010640 Astyanax mexicanus 62.11 0.00e+00 973.00
IUUC-Bgr-012024 Blumeria graminis 33.42 6.00e-100 359.00
IUUC-Bta-012789 Bos taurus 86.34 0.00e+00 1900.00
IUUC-Bci-013768 Botrytis cinerea 35.35 1.00e-112 401.00
IUUC-Bdi-014723 Brachypodium distachyon 39.67 1.00e-120 428.00
IUUC-Bol-015394 Brassica oleracea 37.73 2.00e-134 474.00
IUUC-Bra-017266 Brassica rapa 37.91 5.00e-133 469.00
IUUC-Cel-018668 Caenorhabditis elegans 39.38 1.00e-152 534.00
IUUC-Cja-019769 Callithrix jacchus 85.85 0.00e+00 1870.00
IUUC-Cfa-020727 Canis familiaris 88.07 0.00e+00 1930.00
IUUC-Cpo-021741 Cavia porcellus 88.03 0.00e+00 1952.00
IUUC-Csa-024054 Chlorocebus sabaeus 88.12 0.00e+00 1922.00
IUUC-Cho-025031 Choloepus hoffmanni 84.31 0.00e+00 1337.00
IUUC-Cin-025164 Ciona intestinalis 47.23 0.00e+00 656.00
IUUC-Csv-026260 Ciona savignyi 46.55 0.00e+00 696.00
IUUC-Cgl-026451 Colletotrichum gloeosporioides 35.91 1.00e-80 295.00
IUUC-Cne-026923 Cryptococcus neoformans 35.89 1.00e-78 288.00
IUUC-Dre-028227 Danio rerio 65.06 0.00e+00 1031.00
IUUC-Dno-029830 Dasypus novemcinctus 82.74 0.00e+00 1810.00
IUUC-Dor-030436 Dipodomys ordii 85.23 0.00e+00 1108.00
IUUC-Dse-031485 Dothistroma septosporum 35.15 2.00e-105 377.00
IUUC-Dme-031875 Drosophila melanogaster 42.02 3.00e-163 569.00
IUUC-Eca-033415 Equus caballus 83.33 0.00e+00 1034.00
IUUC-Eeu-034528 Erinaceus europaeus 87.12 0.00e+00 995.00
IUUC-Fca-036238 Felis catus 91.86 0.00e+00 1316.00
IUUC-Fal-037124 Ficedula albicollis 60.28 0.00e+00 1245.00
IUUC-Fox-038075 Fusarium oxysporum 41.46 1.00e-04 42.70
IUUC-Fso-038310 Fusarium solani 34.11 1.00e-97 351.00
IUUC-Gmo-039506 Gadus morhua 63.41 0.00e+00 955.00
IUUC-Ggr-039984 Gaeumannomyces graminis 36.11 4.00e-120 426.00
IUUC-Gga-040674 Gallus gallus 73.33 0.00e+00 1090.00
IUUC-Gac-041416 Gasterosteus aculeatus 64.38 0.00e+00 972.00
IUUC-Gma-043625 Glycine max 39.08 6.00e-127 449.00
IUUC-Ggo-045017 Gorilla gorilla 87.82 0.00e+00 1920.00
IUUC-Hsa-046870 Homo sapiens 88.21 0.00e+00 1930.00
IUUC-Hvu-047466 Hordeum vulgare 38.60 8.00e-80 291.00
IUUC-Itr-048703 Ictidomys tridecemlineatus 79.62 0.00e+00 670.00
IUUC-Kpa-049244 Komagataella pastoris 30.83 2.00e-72 267.00
IUUC-Lch-050376 Latimeria chalumnae 57.87 0.00e+00 1170.00
IUUC-Lpe-050955 Leersia perrieri 36.74 3.00e-95 343.00
IUUC-Loc-051948 Lepisosteus oculatus 54.28 0.00e+00 1133.00
IUUC-Lma-052950 Leptosphaeria maculans 36.10 5.00e-101 362.00
IUUC-Laf-054206 Loxodonta africana 84.23 0.00e+00 1214.00
IUUC-Mcc-055005 Macaca mulatta 88.04 0.00e+00 1919.00
IUUC-Meu-056120 Macropus eugenii 59.46 0.00e+00 660.00
IUUC-Mor-057238 Magnaporthe oryzae 34.11 2.00e-110 394.00
IUUC-Mpo-057574 Magnaporthe poae 35.14 3.00e-116 413.00
IUUC-Mtr-057823 Medicago truncatula 38.85 2.00e-116 413.00
IUUC-Mla-058822 Melampsora laricipopulina 35.03 2.00e-100 360.00
IUUC-Mga-059785 Meleagris gallopavo 50.14 6.00e-168 584.00
IUUC-Mvi-060543 Microbotryum violaceum 34.40 8.00e-98 352.00
IUUC-Mmr-060611 Microcebus murinus 86.61 0.00e+00 1875.00
IUUC-Mdo-062719 Monodelphis domestica 70.07 0.00e+00 1462.00
IUUC-Mac-064834 Musa acuminata 35.79 9.00e-105 374.00
IUUC-Mpu-066298 Mustela putorius furo 88.11 0.00e+00 1934.00
IUUC-Mlu-067546 Myotis lucifugus 85.70 0.00e+00 1885.00
IUUC-Nfi-068388 Neosartorya fischeri 34.70 3.00e-112 400.00
IUUC-Ncr-068875 Neurospora crassa 34.09 8.00e-104 372.00
IUUC-Nle-069813 Nomascus leucogenys 87.95 0.00e+00 1925.00
IUUC-Opr-070995 Ochotona princeps 76.63 0.00e+00 1337.00
IUUC-Ont-072084 Oreochromis niloticus 66.02 0.00e+00 1025.00
IUUC-Oan-073545 Ornithorhynchus anatinus 56.00 0.00e+00 1122.00
IUUC-Ocu-074092 Oryctolagus cuniculus 83.74 0.00e+00 1849.00
IUUC-Oba-075828 Oryza barthii 38.17 1.00e-100 361.00
IUUC-Obr-076373 Oryza brachyantha 37.08 1.00e-76 280.00
IUUC-Ogl-077043 Oryza glaberrima 39.60 2.00e-111 396.00
IUUC-Ogu-078647 Oryza glumaepatula 39.47 4.00e-109 389.00
IUUC-Oin-079793 Oryza indica 38.38 4.00e-82 299.00
IUUC-Olo-080815 Oryza longistaminata 38.39 2.00e-101 363.00
IUUC-Ome-081650 Oryza meridionalis 39.35 3.00e-112 400.00
IUUC-Oni-082708 Oryza nivara 39.35 8.00e-113 402.00
IUUC-Opu-084078 Oryza punctata 39.87 6.00e-110 392.00
IUUC-Oru-084549 Oryza rufipogon 39.16 1.00e-112 401.00
IUUC-Osa-086095 Oryza sativa 37.58 7.00e-94 338.00
IUUC-Olu-087617 Ostreococcus lucimarinus 32.57 2.00e-11 64.30
IUUC-Oga-088453 Otolemur garnettii 85.09 0.00e+00 1840.00
IUUC-Oar-089769 Ovis aries 86.26 0.00e+00 1893.00
IUUC-Ptr-090803 Pan troglodytes 88.21 0.00e+00 1930.00
IUUC-Pan-092169 Papio anubis 88.04 0.00e+00 1937.00
IUUC-Psi-094065 Pelodiscus sinensis 61.75 0.00e+00 1357.00
IUUC-Pma-094592 Petromyzon marinus 56.20 0.00e+00 867.00
IUUC-Pno-095016 Phaeosphaeria nodorum 31.40 2.00e-14 73.60
IUUC-Ppa-095597 Physcomitrella patens 36.92 1.00e-124 441.00
IUUC-Pfo-096959 Poecilia formosa 61.82 0.00e+00 1043.00
IUUC-Pab-097732 Pongo abelii 93.40 0.00e+00 1246.00
IUUC-Pop-099062 Populus trichocarpa 39.07 7.00e-130 458.00
IUUC-Pca-100219 Procavia capensis 70.63 0.00e+00 1437.00
IUUC-Ppe-101695 Prunus persica 39.56 3.00e-123 436.00
IUUC-Pva-102402 Pteropus vampyrus 79.73 0.00e+00 1689.00
IUUC-Pgr-103317 Puccinia graminis 30.02 2.00e-92 334.00
IUUC-Ptt-103771 Puccinia triticina 30.46 1.00e-83 305.00
IUUC-Pte-104189 Pyrenophora teres 31.25 9.00e-10 58.50
IUUC-Pyt-104801 Pyrenophora triticirepentis 34.76 7.00e-100 358.00
IUUC-Rno-105721 Rattus norvegicus 96.32 0.00e+00 2113.00
IUUC-Sce-106350 Saccharomyces cerevisiae 30.60 1.00e-81 298.00
IUUC-Sha-106801 Sarcophilus harrisii 69.09 0.00e+00 1461.00
IUUC-Sja-107692 Schizosaccharomyces japonicus 34.29 1.00e-121 431.00
IUUC-Spo-108253 Schizosaccharomyces pombe 36.59 1.00e-118 421.00
IUUC-Ssl-108587 Sclerotinia sclerotiorum 34.96 6.00e-65 242.00
IUUC-Smo-108865 Selaginella moellendorffii 39.24 6.00e-114 405.00
IUUC-Sit-110153 Setaria italica 38.65 2.00e-114 407.00
IUUC-Sly-111638 Solanum lycopersicum 37.05 1.00e-125 444.00
IUUC-Stu-112099 Solanum tuberosum 37.23 5.00e-126 446.00
IUUC-Sar-113030 Sorex araneus 81.59 0.00e+00 632.00
IUUC-Sbi-113944 Sorghum bicolor 38.26 7.00e-117 415.00
IUUC-Sre-115206 Sporisorium reilianum 33.38 4.00e-104 373.00
IUUC-Ssc-115729 Sus scrofa 77.46 0.00e+00 674.00
IUUC-Tgu-117520 Taeniopygia guttata 66.50 0.00e+00 991.00
IUUC-Tru-118487 Takifugu rubripes 66.16 0.00e+00 1026.00
IUUC-Tsy-119363 Tarsius syrichta 79.46 0.00e+00 1680.00
IUUC-Tca-121813 Theobroma cacao 37.45 3.00e-123 436.00
IUUC-Tre-122248 Trichoderma reesei 35.55 4.00e-102 365.00
IUUC-Tvi-122462 Trichoderma virens 36.60 2.00e-110 393.00
IUUC-Tae-123637 Triticum aestivum 39.05 3.00e-111 396.00
IUUC-Tur-126173 Triticum urartu 39.20 2.00e-102 367.00
IUUC-Tme-127213 Tuber melanosporum 36.21 3.00e-115 410.00
IUUC-Tbe-127399 Tupaia belangeri 87.90 0.00e+00 811.00
IUUC-Ttr-128798 Tursiops truncatus 90.91 0.00e+00 893.00
IUUC-Uma-129421 Ustilago maydis 31.45 3.00e-103 370.00
IUUC-Vda-129863 Verticillium dahliae 31.47 1.00e-100 361.00
IUUC-Vvi-131615 Vitis vinifera 37.27 1.00e-137 484.00
IUUC-Xtr-132309 Xenopus tropicalis 57.63 0.00e+00 1167.00
IUUC-Xma-133235 Xiphophorus maculatus 64.60 0.00e+00 1004.00
IUUC-Yli-134536 Yarrowia lipolytica 31.59 2.00e-91 330.00
IUUC-Zma-135358 Zea mays 38.49 5.00e-111 395.00
Created Date 25-Jun-2017

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