iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-048487

Ensembl Protein ID

ENSSTOP00000013113.2

UniProt Accession

I3MNA8; I3MNA8_ICTTR

Genbank Protein ID

ENSSTOP00000013113

Protein Name

Nitric oxide synthase-interacting protein

Genbank Nucleotide ID

AGTP01089713

Gene Name

NOSIP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000014638.2	ENSSTOT00000014636.2	ENSSTOP00000013113.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	2.80e-15	56.2	40	79

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk 41
           v ++ +C +sl++ +dPvv+p+G+ y+r++I +++ +++k
   Q: 40   VKDFDCCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKK 79
           567789*****************************98887 PP

Organism

Ictidomys tridecemlineatus

Functional Description
(View)

Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.

Protein Sequence
(Fasta)

MTRHGKNCTA GAVYTYHEKK KDTAASGYGT QNIRLSRDAV KDFDCCCLSL QPCHDPVVTP 60
DGYLYEREAI LEYILHQKKE IARQMKAYEK QRGAKREEQK KLQRAAAQDQ VRGFLEKEAA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATGACACGG CATGGCAAGA ACTGCACGGC GGGGGCCGTC TACACCTACC ATGAGAAGAA 60
GAAGGACACA GGTACTGAGC TGGGGGCCTG CAGTGTCTCA AAGTCACCTT CTCAGTCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR016818--Nitric_oxide_synth-interacting
IPR031790--Znf-NOSIP
IPR013083--Znf_RING/FYVE/PHD

Pfam

PF15906--zf-NOSIP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003723--F:RNA binding
GO:0051001--P:negative regulation of nitric-oxide synthase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000769	Aegilops tauschii	46.51	1.00e-16	80.90
IUUC-Aml-002069	Ailuropoda melanoleuca	89.81	1.00e-161	561.00
IUUC-Atr-002661	Amborella trichopoda	33.79	5.00e-31	127.00
IUUC-Aca-004630	Anolis carolinensis	75.08	3.00e-135	473.00
IUUC-Aly-006316	Arabidopsis lyrata	30.07	9.00e-29	120.00
IUUC-Ath-007000	Arabidopsis thaliana	29.74	2.00e-28	119.00
IUUC-Acl-008175	Aspergillus clavatus	32.79	9.00e-06	44.30
IUUC-Afl-008440	Aspergillus flavus	33.91	2.00e-05	43.10
IUUC-Afu-009012	Aspergillus fumigatus	33.87	2.00e-06	46.60
IUUC-Ani-009153	Aspergillus nidulans	32.54	4.00e-03	35.40
IUUC-Ang-009556	Aspergillus niger	34.78	1.00e-05	44.30
IUUC-Aor-009892	Aspergillus oryzae	33.05	2.00e-05	43.10
IUUC-Ate-010473	Aspergillus terreus	31.34	4.00e-05	43.50
IUUC-Ame-011874	Astyanax mexicanus	65.26	1.00e-110	392.00
IUUC-Bgr-012090	Blumeria graminis	25.80	1.00e-06	47.00
IUUC-Bta-012956	Bos taurus	94.04	3.00e-168	583.00
IUUC-Bci-013897	Botrytis cinerea	42.50	5.00e-10	58.20
IUUC-Bdi-014968	Brachypodium distachyon	30.51	5.00e-34	137.00
IUUC-Bol-015578	Brassica oleracea	29.93	6.00e-33	134.00
IUUC-Bra-017234	Brassica rapa	29.93	6.00e-33	134.00
IUUC-Cel-018637	Caenorhabditis elegans	41.98	8.00e-59	220.00
IUUC-Cja-019632	Callithrix jacchus	93.36	8.00e-170	588.00
IUUC-Cfa-020192	Canis familiaris	93.02	3.00e-167	580.00
IUUC-Cpo-021939	Cavia porcellus	90.70	3.00e-157	547.00
IUUC-Cre-023005	Chlamydomonas reinhardtii	33.55	1.00e-41	163.00
IUUC-Csa-023802	Chlorocebus sabaeus	93.69	1.00e-169	588.00
IUUC-Cho-024637	Choloepus hoffmanni	76.04	4.00e-81	293.00
IUUC-Cin-025180	Ciona intestinalis	51.99	1.00e-86	312.00
IUUC-Csv-026206	Ciona savignyi	55.10	4.00e-44	170.00
IUUC-Cgl-026696	Colletotrichum gloeosporioides	24.38	1.00e-13	70.50
IUUC-Cne-026827	Cryptococcus neoformans	36.36	8.00e-07	47.80
IUUC-Dre-028092	Danio rerio	65.47	1.00e-117	415.00
IUUC-Dno-029501	Dasypus novemcinctus	87.42	4.00e-142	497.00
IUUC-Dor-030542	Dipodomys ordii	93.07	2.00e-166	577.00
IUUC-Dse-031188	Dothistroma septosporum	24.16	2.00e-15	76.30
IUUC-Dme-031734	Drosophila melanogaster	48.87	2.00e-79	288.00
IUUC-Eca-033577	Equus caballus	94.68	3.00e-170	590.00
IUUC-Fca-035761	Felis catus	94.02	3.00e-168	583.00
IUUC-Fox-037703	Fusarium oxysporum	24.22	7.00e-14	71.20
IUUC-Fso-038208	Fusarium solani	27.43	3.00e-08	52.40
IUUC-Gmo-038523	Gadus morhua	61.46	2.00e-63	234.00
IUUC-Ggr-040087	Gaeumannomyces graminis	41.03	5.00e-10	58.50
IUUC-Gac-042621	Gasterosteus aculeatus	59.57	8.00e-109	386.00
IUUC-Gma-042698	Glycine max	31.51	7.00e-33	134.00
IUUC-Ggo-045357	Gorilla gorilla	94.02	2.00e-170	590.00
IUUC-Hsa-046195	Homo sapiens	94.02	2.00e-170	590.00
IUUC-Hvu-047174	Hordeum vulgare	30.54	8.00e-35	140.00
IUUC-Lch-050569	Latimeria chalumnae	67.64	2.00e-114	404.00
IUUC-Lpe-050992	Leersia perrieri	35.47	1.00e-22	100.00
IUUC-Loc-052522	Lepisosteus oculatus	70.33	4.00e-117	413.00
IUUC-Lma-053254	Leptosphaeria maculans	39.24	1.00e-09	57.40
IUUC-Laf-053397	Loxodonta africana	93.40	8.00e-167	578.00
IUUC-Mcc-054681	Macaca mulatta	93.69	8.00e-170	589.00
IUUC-Meu-056723	Macropus eugenii	83.50	1.00e-150	525.00
IUUC-Mor-056961	Magnaporthe oryzae	25.48	2.00e-11	62.80
IUUC-Mpo-057359	Magnaporthe poae	25.84	4.00e-07	48.10
IUUC-Mtr-058063	Medicago truncatula	31.51	1.00e-33	136.00
IUUC-Mla-059004	Melampsora laricipopulina	30.25	5.00e-25	107.00
IUUC-Mvi-060460	Microbotryum violaceum	29.67	8.00e-26	110.00
IUUC-Mmr-060847	Microcebus murinus	95.02	1.00e-171	594.00
IUUC-Mdo-062480	Monodelphis domestica	84.16	5.00e-151	526.00
IUUC-Mmu-063809	Mus musculus	92.36	5.00e-164	569.00
IUUC-Mac-064870	Musa acuminata	32.76	2.00e-33	135.00
IUUC-Mpu-066322	Mustela putorius furo	94.06	2.00e-168	584.00
IUUC-Mlu-067556	Myotis lucifugus	90.79	3.00e-155	540.00
IUUC-Nfi-068440	Neosartorya fischeri	33.87	2.00e-06	46.60
IUUC-Ncr-068898	Neurospora crassa	38.46	6.00e-08	51.60
IUUC-Nle-070049	Nomascus leucogenys	94.02	3.00e-170	590.00
IUUC-Opr-070972	Ochotona princeps	90.49	3.00e-158	550.00
IUUC-Ont-071682	Oreochromis niloticus	67.22	8.00e-118	416.00
IUUC-Oan-073296	Ornithorhynchus anatinus	98.31	1.00e-32	131.00
IUUC-Ocu-074218	Oryctolagus cuniculus	92.14	2.00e-136	478.00
IUUC-Oba-075284	Oryza barthii	32.19	2.00e-34	139.00
IUUC-Obr-076651	Oryza brachyantha	32.19	2.00e-36	145.00
IUUC-Ogl-077899	Oryza glaberrima	32.19	2.00e-34	139.00
IUUC-Ogu-078477	Oryza glumaepatula	32.53	1.00e-34	139.00
IUUC-Oin-080011	Oryza indica	32.19	2.00e-34	139.00
IUUC-Olo-080545	Oryza longistaminata	31.40	3.00e-27	115.00
IUUC-Ome-081543	Oryza meridionalis	32.19	2.00e-34	139.00
IUUC-Oni-082955	Oryza nivara	32.19	2.00e-34	139.00
IUUC-Opu-083565	Oryza punctata	32.19	7.00e-35	140.00
IUUC-Oru-084474	Oryza rufipogon	32.19	2.00e-34	139.00
IUUC-Osa-085913	Oryza sativa	32.19	2.00e-34	139.00
IUUC-Ola-086851	Oryzias latipes	66.78	1.00e-119	422.00
IUUC-Olu-087724	Ostreococcus lucimarinus	32.04	5.00e-12	64.70
IUUC-Oga-087970	Otolemur garnettii	94.04	2.00e-168	584.00
IUUC-Oar-089756	Ovis aries	90.43	1.00e-156	544.00
IUUC-Ptr-091485	Pan troglodytes	92.69	1.00e-166	578.00
IUUC-Pan-091832	Papio anubis	94.02	3.00e-170	590.00
IUUC-Pma-094551	Petromyzon marinus	61.89	1.00e-106	379.00
IUUC-Pno-094830	Phaeosphaeria nodorum	26.84	5.00e-09	54.70
IUUC-Ppa-095255	Physcomitrella patens	29.43	6.00e-32	130.00
IUUC-Pfo-096373	Poecilia formosa	65.70	7.00e-117	412.00
IUUC-Pab-098247	Pongo abelii	94.02	3.00e-170	590.00
IUUC-Pop-099186	Populus trichocarpa	31.16	5.00e-31	127.00
IUUC-Pca-100677	Procavia capensis	89.82	1.00e-136	478.00
IUUC-Ppe-101403	Prunus persica	30.82	4.00e-32	131.00
IUUC-Pva-103000	Pteropus vampyrus	94.35	1.00e-169	588.00
IUUC-Pgr-103663	Puccinia graminis	30.91	5.00e-31	128.00
IUUC-Ptt-103712	Puccinia triticina	40.00	4.00e-09	54.70
IUUC-Pte-104287	Pyrenophora teres	27.11	2.00e-17	83.20
IUUC-Pyt-104579	Pyrenophora triticirepentis	24.38	1.00e-09	57.00
IUUC-Rno-106069	Rattus norvegicus	92.69	1.00e-164	571.00
IUUC-Sha-106553	Sarcophilus harrisii	83.17	7.00e-150	522.00
IUUC-Smo-108874	Selaginella moellendorffii	32.89	3.00e-36	145.00
IUUC-Sit-110307	Setaria italica	32.19	2.00e-33	135.00
IUUC-Sly-111094	Solanum lycopersicum	31.85	4.00e-32	131.00
IUUC-Stu-112363	Solanum tuberosum	30.58	7.00e-32	130.00
IUUC-Sar-113480	Sorex araneus	93.02	2.00e-155	541.00
IUUC-Sbi-113939	Sorghum bicolor	32.19	3.00e-34	138.00
IUUC-Ssc-115644	Sus scrofa	94.68	2.00e-170	590.00
IUUC-Tru-118781	Takifugu rubripes	65.80	5.00e-119	420.00
IUUC-Tni-119672	Tetraodon nigroviridis	73.56	2.00e-34	136.00
IUUC-Tca-121795	Theobroma cacao	31.27	4.00e-35	141.00
IUUC-Tre-122037	Trichoderma reesei	36.36	2.00e-08	53.10
IUUC-Tvi-122524	Trichoderma virens	26.64	1.00e-17	84.00
IUUC-Tae-122828	Triticum aestivum	30.87	6.00e-35	140.00
IUUC-Tur-126387	Triticum urartu	30.62	6.00e-28	118.00
IUUC-Tme-127111	Tuber melanosporum	40.00	1.00e-09	57.00
IUUC-Ttr-128227	Tursiops truncatus	93.36	7.00e-167	578.00
IUUC-Vda-129924	Verticillium dahliae	26.21	6.00e-15	74.70
IUUC-Vpa-130802	Vicugna pacos	95.51	1.00e-44	172.00
IUUC-Vvi-131105	Vitis vinifera	31.96	1.00e-32	133.00
IUUC-Xtr-132830	Xenopus tropicalis	66.56	2.00e-123	434.00
IUUC-Xma-133618	Xiphophorus maculatus	65.79	2.00e-110	391.00
IUUC-Zma-135389	Zea mays	31.85	6.00e-34	137.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence