iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-036610

Ensembl Protein ID

ENSFALP00000008700.1

UniProt Accession

U3K0Z6; U3K0Z6_FICAL

Genbank Protein ID

ENSFALP00000008700

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AGTO01020411

Gene Name

USP13

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000008348.1	ENSFALT00000008738.1	ENSFALP00000008700.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.00e-55	188.9	271	798
UBD/Alpha-Helix/UBA	2.50e-19	68.4	665	702

Active Site

Position(s)	Description	Evidence
280	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
761	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tG+kNlgN+CY+N+v+Q++++ipe+++++  + ++ ++ + p +p++++ ++++kl + l                       k +++ 
   Q: 271  TGMKNLGNSCYLNAVMQAIFSIPEFQRAYVGNLPRIFDYS-PLDPTQDFNTQMAKLGHGLlsgqyskpplkselieqvmkeeHKPQHNG 358
           7******************************777777765.79***************998888888888877777665443377777* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           +spr++++ ++k ++efs+++qqDaqEf+ +l++ +e++                               +++  sd+F++ ++++++c
   Q: 359  ISPRMFKAFISKGHPEFSSNRQQDAQEFFLHLINLVERNP-----------------------------VGSENPSDVFRFLVEERTQC 418
           ************************************9998.............................788899************** PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeae 218
            + ++v  +e   + ++lpv ++  t+ke                            ++ cL++f+++ ++e+   ++++  ++k+  +
   Q: 419  CQSRKVRYTERVDYIMQLPVAMEAATNKEeliayelkrreaeaarrplpelvrakiPFRACLQAFSEPSNVED---FWSSALQAKSAGV 504
           *********************999999999******************************************7...************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................ 267
           k+ ++ ++Pe+L++++k+f+f  + + ++k++ ++++p+ Ld+s+  ++                                        
   Q: 505  KTSRFASFPEYLVVQIKKFTFGLD-WIPKKLDVSIDMPDFLDISHLRARglqpgeeelpdiappivipddpkdhmanhfvesldidess 592
           *********************997.*******************999889999999999999999999988888888888888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 593  vmqlaemgfpleacrkavyytgnlgaevafnwiiahmeepdfaeplvtpafgevassgaaalgavgldnqppeemvaiiismgfqrnla 681
           88888888888888887777777777777777777777777777777777777777777777777777777666666666666666666 PP
   S: 268  .....................peekqke....................................kkkYeLiavvvHsG.slssGHYvay 298
                                p     +                                    + +YeL++ ++H+G s+ sGHYv++
   Q: 682  iqalkatnnnleraldwifshP-----DpeeesdlaldtmdmennananiladtgsegprikdgPGRYELFGFISHMGtSTMSGHYVCH 765
           6666665555555555555550.....0555555666666666677777888888888999999************************* PP
   S: 299  vknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
            ++ +g+W+ ++D +V ++  e+  +   + +Y++fY+r
   Q: 766  LRK-EGRWVIYNDLRVCAS--ERPPK---DLGYIYFYHR 798
           ***.9***********999..78888...89******97 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e++++ +++MGF r++a+qaL a+nnnle+A+++++++
   Q: 665  EEMVAIIISMGFQRNLAIQALKATNNNLERALDWIFSH 702
           89**********************************97 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MNTFLGFGRE HIERHYRKTG QCVYLHLKRH VIEKVPGASG GALPKRRNAK LFLDLEISSD 60
LNNDDFEYED EAKLVIFPDH YEISLPNIEE LPALVTIACD ALLSAKSPYR KQESDSWEEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTGCTGGGT CCTTCCTGTC CTGTTCAGCT CCTTCCCTGC TGTAACTGTT TGTGTCATTG 60
CTTGTAGGAT TCAGAAGGAG GTCTCTATGT GTGCATGAAC ACGTTTCTGG GATTTGGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904454--F:ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0035523--P:protein K29-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

fab:101805743

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001356	Ailuropoda melanoleuca	83.50	0.00e+00	1327.00
IUUC-Apl-003712	Anas platyrhynchos	94.39	0.00e+00	1492.00
IUUC-Aca-004634	Anolis carolinensis	86.89	0.00e+00	1371.00
IUUC-Ame-011470	Astyanax mexicanus	75.62	0.00e+00	1251.00
IUUC-Bta-013349	Bos taurus	84.02	0.00e+00	1347.00
IUUC-Cja-019021	Callithrix jacchus	83.40	0.00e+00	1325.00
IUUC-Cfa-020614	Canis familiaris	83.75	0.00e+00	1329.00
IUUC-Cpo-022484	Cavia porcellus	83.15	0.00e+00	1326.00
IUUC-Csa-024078	Chlorocebus sabaeus	83.77	0.00e+00	1332.00
IUUC-Cho-024522	Choloepus hoffmanni	69.04	0.00e+00	1034.00
IUUC-Cme-027335	Cyanidioschyzon merolae	26.97	3.00e-54	206.00
IUUC-Dre-027651	Danio rerio	75.89	0.00e+00	1320.00
IUUC-Dno-028975	Dasypus novemcinctus	83.44	0.00e+00	1321.00
IUUC-Dor-030130	Dipodomys ordii	60.80	0.00e+00	904.00
IUUC-Ete-032251	Echinops telfairi	71.04	0.00e+00	1115.00
IUUC-Eca-033568	Equus caballus	83.77	0.00e+00	1331.00
IUUC-Eeu-034612	Erinaceus europaeus	67.17	0.00e+00	1016.00
IUUC-Fca-036280	Felis catus	83.88	0.00e+00	1332.00
IUUC-Gmo-038906	Gadus morhua	72.00	0.00e+00	1194.00
IUUC-Gga-041215	Gallus gallus	93.64	0.00e+00	1473.00
IUUC-Gac-042441	Gasterosteus aculeatus	72.99	0.00e+00	1226.00
IUUC-Ggo-044446	Gorilla gorilla	83.65	0.00e+00	1331.00
IUUC-Hsa-046546	Homo sapiens	83.52	0.00e+00	1327.00
IUUC-Itr-048147	Ictidomys tridecemlineatus	79.61	0.00e+00	1267.00
IUUC-Lch-050425	Latimeria chalumnae	79.02	0.00e+00	1330.00
IUUC-Loc-052072	Lepisosteus oculatus	76.56	0.00e+00	1256.00
IUUC-Laf-053909	Loxodonta africana	82.84	0.00e+00	1309.00
IUUC-Mcc-054686	Macaca mulatta	83.77	0.00e+00	1333.00
IUUC-Meu-056361	Macropus eugenii	76.53	0.00e+00	1205.00
IUUC-Mga-059972	Meleagris gallopavo	87.38	0.00e+00	1398.00
IUUC-Mmr-060916	Microcebus murinus	83.02	0.00e+00	1326.00
IUUC-Mdo-062302	Monodelphis domestica	85.52	0.00e+00	1393.00
IUUC-Mmu-063639	Mus musculus	83.77	0.00e+00	1351.00
IUUC-Mpu-066533	Mustela putorius furo	83.75	0.00e+00	1330.00
IUUC-Mlu-067786	Myotis lucifugus	77.95	0.00e+00	1261.00
IUUC-Nle-069997	Nomascus leucogenys	83.40	0.00e+00	1333.00
IUUC-Ont-071859	Oreochromis niloticus	71.94	0.00e+00	1218.00
IUUC-Oan-072959	Ornithorhynchus anatinus	86.19	3.00e-127	446.00
IUUC-Ocu-074265	Oryctolagus cuniculus	83.27	0.00e+00	1324.00
IUUC-Ola-087344	Oryzias latipes	72.15	0.00e+00	1231.00
IUUC-Oga-088734	Otolemur garnettii	83.40	0.00e+00	1329.00
IUUC-Oar-089636	Ovis aries	83.90	0.00e+00	1379.00
IUUC-Ptr-090982	Pan troglodytes	83.65	0.00e+00	1330.00
IUUC-Pan-091991	Papio anubis	83.77	0.00e+00	1333.00
IUUC-Psi-093509	Pelodiscus sinensis	90.26	0.00e+00	1439.00
IUUC-Pfo-096029	Poecilia formosa	74.33	0.00e+00	1265.00
IUUC-Pab-098672	Pongo abelii	79.28	0.00e+00	1231.00
IUUC-Pca-100860	Procavia capensis	65.30	0.00e+00	934.00
IUUC-Pva-102545	Pteropus vampyrus	78.15	0.00e+00	1207.00
IUUC-Rno-105210	Rattus norvegicus	83.52	0.00e+00	1336.00
IUUC-Sar-113733	Sorex araneus	84.56	0.00e+00	687.00
IUUC-Tgu-116591	Taeniopygia guttata	96.25	0.00e+00	1500.00
IUUC-Tru-118627	Takifugu rubripes	71.46	0.00e+00	1236.00
IUUC-Tsy-119278	Tarsius syrichta	75.41	0.00e+00	1190.00
IUUC-Tni-120804	Tetraodon nigroviridis	74.08	0.00e+00	1263.00
IUUC-Tbe-127699	Tupaia belangeri	69.62	0.00e+00	793.00
IUUC-Ttr-128295	Tursiops truncatus	75.69	0.00e+00	1189.00
IUUC-Vpa-130170	Vicugna pacos	74.66	0.00e+00	1155.00
IUUC-Xtr-132809	Xenopus tropicalis	74.41	0.00e+00	1210.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence