iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-106879

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01009387

Gene Name

USP8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000012085.1	ENSSHAT00000014258.1	ENSSHAP00000014141.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.80e-108	362.9	759	1092

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaee 83
           tGl+NlgNtCYmNS+LQcL n p l++++++     + ++l+++n  ++kge+++++  ++++lw+++ +++sp++++ +++k++ +
   Q: 759  TGLRNLGNTCYMNSILQCLCNAPHLADYFNRnfyqDDINSLQRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQ 845
           7******************************877777778888888***************************************** PP
   S: 84   fsgyeqqDaqEflaflldqleeelkkeknkpkeeeeee...dkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssree 167
           fsgy+qqD+qE+l fl+d+l+e+l+k +n ++++ee++   d+ ++ ++a++k+k+ n+s+i+ lFqgq+ks+++cl+c+++s ++e
   Q: 846  FSGYSQQDSQELLLFLMDGLHEDLNKADNRKRHKEENNdhlDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFE 932
           ************************9855555555444411145566667************************************** PP
   S: 168  pfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkve 254
            f++lslp+ + +++   +lqdcL+ f+kee+l+++n++yc++ck ++++ kk++++klP+vL +hLkRfs++ + ++ +k++++v+
   Q: 933  AFMYLSLPLASTSKC---TLQDCLRLFSKEEKLTDNNRFYCSHCKTRRDSMKKIEIWKLPPVLLVHLKRFSYDGR-WK-QKLQTSVD 1014
           **************9...******************************************************996.55.6******* PP
   S: 255  fple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYk 336
           fple Ldls++++ p+++    k+Y+L++v +H+G+l++GHY+ay+kn  ++ W++fdD++V+ ++ ++v +   s aY+lfY+
   Q: 1015 FPLEnLDLSQYVIGPKNN---LKRYNLFSVSNHYGGLDGGHYTAYCKNAARQrWFKFDDHEVSDISVSSVRS---SAAYILFYT 1092
           **************9988...69*************************88888*******************...********8 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MPAVASVPKE LYLGSSLKEL NKKTEVKADK ISTKNYVQSA LKIFRTAEES RLDRDEEKAY 60
VLYMKYVSVY NLIKKRPDFK QQQEYFHSML GPGNIKKAIE EAERLSESLK LRYEEAEVRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGACATCACG GGGGCCGGCT CGCTCCCGGA GTGCGTAGCT TGGAGCGCGC GCACGTGCCT 60
GAGGGGAGTG GGAGTGGGAG TGGGAGTAGG AGTGGGGGTG GGGGGAAGCG CGCCCTCTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR001763--Rhodanese-like_dom
IPR015063--USP8_dimer
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50206--RHODANESE_3
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00581--Rhodanese
PF00443--UCH
PF08969--USP8_dimer

SMART

SM00450--RHOD

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0019897--C:extrinsic component of plasma membrane
GO:0030496--C:midbody
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007032--P:endosome organization
GO:0000281--P:mitotic cytokinesis
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001661	Ailuropoda melanoleuca	86.90	0.00e+00	1009.00
IUUC-Apl-003226	Anas platyrhynchos	68.63	0.00e+00	1458.00
IUUC-Aca-004936	Anolis carolinensis	65.62	0.00e+00	1281.00
IUUC-Ago-007959	Ashbya gossypii	35.87	2.00e-53	204.00
IUUC-Acl-008102	Aspergillus clavatus	31.06	4.00e-50	193.00
IUUC-Afl-008604	Aspergillus flavus	30.52	5.00e-49	189.00
IUUC-Afu-009001	Aspergillus fumigatus	31.34	2.00e-49	191.00
IUUC-Ani-009291	Aspergillus nidulans	31.18	2.00e-49	191.00
IUUC-Ang-009844	Aspergillus niger	32.14	2.00e-48	187.00
IUUC-Aor-010098	Aspergillus oryzae	30.52	2.00e-48	187.00
IUUC-Ate-010585	Aspergillus terreus	30.55	2.00e-48	187.00
IUUC-Ame-010960	Astyanax mexicanus	77.78	3.00e-85	306.00
IUUC-Bta-013008	Bos taurus	78.04	0.00e+00	1561.00
IUUC-Bol-015281	Brassica oleracea	37.87	3.00e-47	182.00
IUUC-Bra-017228	Brassica rapa	39.05	2.00e-49	189.00
IUUC-Cel-018482	Caenorhabditis elegans	34.39	2.00e-51	197.00
IUUC-Cja-019173	Callithrix jacchus	86.50	0.00e+00	1002.00
IUUC-Cfa-021243	Canis familiaris	79.95	0.00e+00	1627.00
IUUC-Cpo-021522	Cavia porcellus	74.87	0.00e+00	1546.00
IUUC-Cre-022582	Chlamydomonas reinhardtii	44.83	7.00e-81	293.00
IUUC-Csa-023616	Chlorocebus sabaeus	87.91	0.00e+00	1008.00
IUUC-Cho-024381	Choloepus hoffmanni	67.60	0.00e+00	1364.00
IUUC-Cin-025287	Ciona intestinalis	50.00	3.00e-97	350.00
IUUC-Csv-026253	Ciona savignyi	47.80	2.00e-85	310.00
IUUC-Cne-026821	Cryptococcus neoformans	39.84	4.00e-73	270.00
IUUC-Dre-028440	Danio rerio	71.57	0.00e+00	738.00
IUUC-Dno-029039	Dasypus novemcinctus	78.32	0.00e+00	1668.00
IUUC-Dor-031043	Dipodomys ordii	93.97	2.00e-129	456.00
IUUC-Dse-031463	Dothistroma septosporum	28.90	1.00e-40	161.00
IUUC-Dme-032089	Drosophila melanogaster	44.13	1.00e-83	304.00
IUUC-Ete-033040	Echinops telfairi	72.81	0.00e+00	1401.00
IUUC-Eca-033449	Equus caballus	85.71	0.00e+00	1001.00
IUUC-Eeu-034693	Erinaceus europaeus	93.53	4.00e-129	456.00
IUUC-Fca-035794	Felis catus	95.19	0.00e+00	903.00
IUUC-Fal-037322	Ficedula albicollis	82.49	0.00e+00	909.00
IUUC-Gmo-038584	Gadus morhua	66.93	0.00e+00	668.00
IUUC-Gga-041188	Gallus gallus	84.84	0.00e+00	940.00
IUUC-Gac-041850	Gasterosteus aculeatus	70.31	0.00e+00	734.00
IUUC-Ggo-045565	Gorilla gorilla	88.08	0.00e+00	1014.00
IUUC-Hsa-046438	Homo sapiens	88.26	0.00e+00	1015.00
IUUC-Itr-048883	Ictidomys tridecemlineatus	75.22	0.00e+00	1560.00
IUUC-Kpa-049321	Komagataella pastoris	33.24	1.00e-47	184.00
IUUC-Lch-050485	Latimeria chalumnae	82.64	0.00e+00	876.00
IUUC-Loc-052769	Lepisosteus oculatus	74.76	0.00e+00	793.00
IUUC-Laf-053432	Loxodonta africana	94.11	0.00e+00	934.00
IUUC-Mcc-055823	Macaca mulatta	88.08	0.00e+00	1015.00
IUUC-Meu-056099	Macropus eugenii	98.51	6.00e-166	578.00
IUUC-Mla-059089	Melampsora laricipopulina	40.12	2.00e-70	261.00
IUUC-Mga-059739	Meleagris gallopavo	84.81	0.00e+00	932.00
IUUC-Mvi-060559	Microbotryum violaceum	39.50	5.00e-76	279.00
IUUC-Mmr-061158	Microcebus murinus	85.71	0.00e+00	988.00
IUUC-Mdo-061801	Monodelphis domestica	92.22	0.00e+00	1786.00
IUUC-Mmu-063665	Mus musculus	71.47	0.00e+00	1495.00
IUUC-Mpu-066738	Mustela putorius furo	80.02	0.00e+00	1627.00
IUUC-Mlu-067307	Myotis lucifugus	78.79	0.00e+00	1624.00
IUUC-Nfi-068410	Neosartorya fischeri	31.13	1.00e-49	191.00
IUUC-Nle-069314	Nomascus leucogenys	88.26	0.00e+00	1018.00
IUUC-Opr-070378	Ochotona princeps	64.14	1.00e-146	513.00
IUUC-Ont-071545	Oreochromis niloticus	76.01	0.00e+00	758.00
IUUC-Oan-073537	Ornithorhynchus anatinus	76.95	0.00e+00	1513.00
IUUC-Ocu-074193	Oryctolagus cuniculus	75.88	0.00e+00	1577.00
IUUC-Ola-086622	Oryzias latipes	57.73	0.00e+00	1064.00
IUUC-Oga-088271	Otolemur garnettii	85.00	0.00e+00	978.00
IUUC-Oar-090431	Ovis aries	78.18	0.00e+00	1573.00
IUUC-Ptr-091339	Pan troglodytes	77.59	0.00e+00	1687.00
IUUC-Pan-091783	Papio anubis	75.16	0.00e+00	692.00
IUUC-Psi-093187	Pelodiscus sinensis	66.81	1.00e-154	540.00
IUUC-Pma-094626	Petromyzon marinus	57.14	1.00e-143	502.00
IUUC-Pfo-096463	Poecilia formosa	75.20	0.00e+00	751.00
IUUC-Pab-097645	Pongo abelii	88.54	0.00e+00	1015.00
IUUC-Pva-103222	Pteropus vampyrus	91.22	0.00e+00	730.00
IUUC-Pgr-103408	Puccinia graminis	35.75	1.00e-52	201.00
IUUC-Ptt-103699	Puccinia triticina	45.33	6.00e-66	246.00
IUUC-Pte-104348	Pyrenophora teres	29.13	5.00e-40	159.00
IUUC-Pyt-104711	Pyrenophora triticirepentis	31.68	2.00e-50	194.00
IUUC-Rno-105510	Rattus norvegicus	74.48	0.00e+00	1505.00
IUUC-Sce-106166	Saccharomyces cerevisiae	34.70	2.00e-49	191.00
IUUC-Sja-107836	Schizosaccharomyces japonicus	35.19	3.00e-48	186.00
IUUC-Sar-113019	Sorex araneus	71.86	0.00e+00	1517.00
IUUC-Sre-115031	Sporisorium reilianum	34.41	1.00e-66	248.00
IUUC-Ssc-116334	Sus scrofa	75.20	0.00e+00	1587.00
IUUC-Tgu-117062	Taeniopygia guttata	83.03	0.00e+00	915.00
IUUC-Tru-117908	Takifugu rubripes	56.54	0.00e+00	1125.00
IUUC-Tsy-118867	Tarsius syrichta	79.79	0.00e+00	890.00
IUUC-Tni-120206	Tetraodon nigroviridis	74.45	0.00e+00	741.00
IUUC-Tme-127144	Tuber melanosporum	39.94	7.00e-77	282.00
IUUC-Tbe-127877	Tupaia belangeri	94.12	9.00e-81	295.00
IUUC-Ttr-128580	Tursiops truncatus	85.49	0.00e+00	974.00
IUUC-Uma-129340	Ustilago maydis	36.25	1.00e-69	258.00
IUUC-Vpa-130541	Vicugna pacos	78.79	0.00e+00	1608.00
IUUC-Xtr-132161	Xenopus tropicalis	74.25	0.00e+00	816.00
IUUC-Xma-134271	Xiphophorus maculatus	74.80	0.00e+00	746.00
IUUC-Yli-134561	Yarrowia lipolytica	36.17	1.00e-58	221.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence