iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062257

UUCD1 version

UUC-MoD-00610

Ensembl Protein ID

ENSMODP00000020344.1

UniProt Accession

F7BGQ0; F7BGQ0_MONDO

Protein Name

Ribosome biogenesis protein WDR12; WD repeat-containing protein 12

Gene Name

WDR12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000016275.2	ENSMODT00000020701.2	ENSMODP00000020344.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.20e-45	149.2	255	289
UBD/Beta-Prp	1.60e-45	155.7	246	412

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgv 34
           gH+d ++++ +sd + ++s+s+D+ti+vWD+ +g 
   Q: 255  GHNDAIFSVLWSDaNEICSASWDHTIRVWDVESGS 289
           8**********999*****************9986 PP

UBD/Beta-Prp

   S: 83   tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkl 171
           t+++++tl+gh+d + s+ +s   + + s+s+d tirvwd+e+g+  + tl+g++ + nc++++p ++ l+sG  Dr +rlWd +t++ 
   Q: 246  TRTPIVTLSGHNDAIFSVLWSD-ANEICSASWDHTIRVWDVESGSTKS-TLTGNK-AFNCISYSPLCKRLASGNSDRHIRLWDPRTKDG 331
           67899****************9.999*********************9.****98.779*************************88764 PP
   S: 172  lrtl...tgghtdsvyslsfdsng.kelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
              l   t+ h++ v+s++++++  ++l+sgs d+ vklwd +  +  ++ + +h+d v++v+ + +  +l+sg++D+ ++ +
   Q: 332  SLVLlslTS-HNNWVTSVKWSPSHeQQLISGSFDNMVKLWDTRsCKAPLYDMSAHEDKVLCVDWT-EAGLLLSGGADNKLYTY 412
           444444387.***********9888******************54566****************9.999********998765 PP

Organism

Monodelphis domestica

Functional Description
(View)

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Protein Sequence
(Fasta)

MSQLQTRFFT DNKKYAVDNV PFSIPAASEI SNLSNIINKL LEAKNGVHKY VEFDFLIKGQ 60
FLRMPLIKHM ELENISTEEV VEIEYVEKYT APQPEECIVH DDWISSIEGT EEWILTGSYD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCGCAGC TCCAGACGCG CTTCTTCACA GATAACAAAA AGTAAGTAGC TTGGTTCCCC 60
CCTCACCCCT TTCCCACCCC CTTTCTCGTC TGCTGGAGCC CCCATCCTAC CCCGAGGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0070545--C:PeBoW complex
GO:0030687--C:preribosome, large subunit precursor
GO:0043021--F:ribonucleoprotein complex binding
GO:0000460--P:maturation of 5.8S rRNA
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000470--P:maturation of LSU-rRNA
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

KEGG

mdo:100018440

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000532	Aegilops tauschii	33.65	2.00e-59	223.00
IUUC-Aml-001997	Ailuropoda melanoleuca	85.47	0.00e+00	666.00
IUUC-Atr-002544	Amborella trichopoda	33.33	4.00e-56	212.00
IUUC-Apl-003981	Anas platyrhynchos	82.04	4.00e-178	617.00
IUUC-Aca-004370	Anolis carolinensis	81.32	0.00e+00	682.00
IUUC-Aly-006455	Arabidopsis lyrata	34.13	8.00e-59	221.00
IUUC-Ath-006669	Arabidopsis thaliana	35.34	5.00e-54	204.00
IUUC-Ago-007864	Ashbya gossypii	29.80	2.00e-37	150.00
IUUC-Acl-008177	Aspergillus clavatus	28.64	6.00e-35	142.00
IUUC-Afl-008617	Aspergillus flavus	28.72	1.00e-33	137.00
IUUC-Afu-008752	Aspergillus fumigatus	28.16	2.00e-30	126.00
IUUC-Ani-009136	Aspergillus nidulans	30.10	3.00e-33	135.00
IUUC-Ang-009701	Aspergillus niger	28.46	1.00e-32	134.00
IUUC-Aor-009884	Aspergillus oryzae	28.72	3.00e-33	136.00
IUUC-Ate-010472	Aspergillus terreus	29.46	1.00e-21	97.40
IUUC-Ame-011432	Astyanax mexicanus	74.35	0.00e+00	642.00
IUUC-Bgr-012218	Blumeria graminis	28.44	2.00e-32	133.00
IUUC-Bta-012829	Bos taurus	86.87	0.00e+00	701.00
IUUC-Bci-013953	Botrytis cinerea	28.17	1.00e-32	134.00
IUUC-Bdi-014351	Brachypodium distachyon	35.93	9.00e-58	217.00
IUUC-Bol-016514	Brassica oleracea	34.45	5.00e-54	205.00
IUUC-Bra-016988	Brassica rapa	34.45	1.00e-53	204.00
IUUC-Cel-018569	Caenorhabditis elegans	31.83	7.00e-50	191.00
IUUC-Cja-019468	Callithrix jacchus	84.96	0.00e+00	671.00
IUUC-Cfa-020471	Canis familiaris	85.44	0.00e+00	670.00
IUUC-Cpo-022260	Cavia porcellus	85.68	0.00e+00	681.00
IUUC-Cre-022614	Chlamydomonas reinhardtii	31.14	2.00e-39	156.00
IUUC-Csa-023989	Chlorocebus sabaeus	85.68	0.00e+00	675.00
IUUC-Cho-024426	Choloepus hoffmanni	81.27	2.00e-142	498.00
IUUC-Cin-025789	Ciona intestinalis	42.12	9.00e-96	343.00
IUUC-Cne-027063	Cryptococcus neoformans	24.64	2.00e-22	100.00
IUUC-Dre-027907	Danio rerio	75.77	0.00e+00	659.00
IUUC-Dno-029225	Dasypus novemcinctus	85.20	0.00e+00	691.00
IUUC-Dor-031082	Dipodomys ordii	71.84	2.00e-152	532.00
IUUC-Dse-031308	Dothistroma septosporum	27.97	1.00e-33	137.00
IUUC-Dme-032189	Drosophila melanogaster	40.05	5.00e-91	327.00
IUUC-Ete-032247	Echinops telfairi	79.47	0.00e+00	639.00
IUUC-Eca-034285	Equus caballus	86.40	0.00e+00	697.00
IUUC-Eeu-035322	Erinaceus europaeus	76.88	7.00e-171	593.00
IUUC-Fca-036114	Felis catus	85.44	0.00e+00	691.00
IUUC-Fal-036891	Ficedula albicollis	83.19	2.00e-167	581.00
IUUC-Fox-037965	Fusarium oxysporum	24.77	2.00e-32	133.00
IUUC-Fso-038244	Fusarium solani	25.00	2.00e-31	130.00
IUUC-Gmo-039040	Gadus morhua	73.16	0.00e+00	648.00
IUUC-Gga-040610	Gallus gallus	80.00	0.00e+00	683.00
IUUC-Gac-042117	Gasterosteus aculeatus	74.11	0.00e+00	641.00
IUUC-Gma-043146	Glycine max	35.34	6.00e-64	238.00
IUUC-Ggo-045179	Gorilla gorilla	84.96	0.00e+00	666.00
IUUC-Hsa-046114	Homo sapiens	85.68	0.00e+00	671.00
IUUC-Hvu-047331	Hordeum vulgare	33.76	1.00e-54	206.00
IUUC-Itr-048275	Ictidomys tridecemlineatus	84.96	0.00e+00	687.00
IUUC-Kpa-049304	Komagataella pastoris	29.49	8.00e-42	164.00
IUUC-Lch-050655	Latimeria chalumnae	74.04	1.00e-139	489.00
IUUC-Lpe-051675	Leersia perrieri	36.19	3.00e-60	226.00
IUUC-Loc-052868	Lepisosteus oculatus	79.29	0.00e+00	653.00
IUUC-Lma-053258	Leptosphaeria maculans	28.26	5.00e-35	143.00
IUUC-Laf-053993	Loxodonta africana	84.01	0.00e+00	687.00
IUUC-Mcc-055128	Macaca mulatta	69.45	1.00e-150	525.00
IUUC-Meu-056501	Macropus eugenii	85.52	3.00e-174	603.00
IUUC-Mor-057114	Magnaporthe oryzae	26.08	6.00e-25	108.00
IUUC-Mtr-058367	Medicago truncatula	36.21	2.00e-60	226.00
IUUC-Mla-059107	Melampsora laricipopulina	28.23	1.00e-31	130.00
IUUC-Mga-059745	Meleagris gallopavo	79.28	0.00e+00	657.00
IUUC-Mvi-060362	Microbotryum violaceum	29.09	9.00e-34	138.00
IUUC-Mmu-063546	Mus musculus	82.82	0.00e+00	679.00
IUUC-Mac-065540	Musa acuminata	31.75	2.00e-54	206.00
IUUC-Mpu-066284	Mustela putorius furo	86.40	0.00e+00	696.00
IUUC-Mlu-067241	Myotis lucifugus	85.44	0.00e+00	693.00
IUUC-Nfi-068260	Neosartorya fischeri	27.67	3.00e-33	136.00
IUUC-Ncr-068719	Neurospora crassa	26.11	7.00e-26	111.00
IUUC-Nle-068981	Nomascus leucogenys	85.68	0.00e+00	655.00
IUUC-Opr-071218	Ochotona princeps	78.39	2.00e-176	611.00
IUUC-Ont-071646	Oreochromis niloticus	74.35	0.00e+00	660.00
IUUC-Oan-073453	Ornithorhynchus anatinus	84.52	0.00e+00	724.00
IUUC-Ocu-074008	Oryctolagus cuniculus	85.68	0.00e+00	694.00
IUUC-Oba-075712	Oryza barthii	31.10	9.00e-43	167.00
IUUC-Obr-076721	Oryza brachyantha	34.76	1.00e-61	230.00
IUUC-Ogl-077229	Oryza glaberrima	35.39	8.00e-60	224.00
IUUC-Ogu-078977	Oryza glumaepatula	31.10	4.00e-43	168.00
IUUC-Oin-079683	Oryza indica	35.39	3.00e-60	226.00
IUUC-Olo-080291	Oryza longistaminata	30.07	7.00e-28	117.00
IUUC-Ome-081834	Oryza meridionalis	35.63	6.00e-61	228.00
IUUC-Oni-082507	Oryza nivara	34.29	3.00e-56	212.00
IUUC-Opu-083396	Oryza punctata	35.63	6.00e-61	228.00
IUUC-Oru-085220	Oryza rufipogon	34.29	7.00e-56	211.00
IUUC-Osa-085767	Oryza sativa	35.39	3.00e-60	226.00
IUUC-Ola-087420	Oryzias latipes	75.06	0.00e+00	651.00
IUUC-Olu-087740	Ostreococcus lucimarinus	29.57	7.00e-38	151.00
IUUC-Oga-088264	Otolemur garnettii	85.20	0.00e+00	675.00
IUUC-Oar-089335	Ovis aries	86.40	0.00e+00	696.00
IUUC-Ptr-091320	Pan troglodytes	85.68	0.00e+00	671.00
IUUC-Pan-092833	Papio anubis	86.16	0.00e+00	676.00
IUUC-Psi-093504	Pelodiscus sinensis	83.10	0.00e+00	702.00
IUUC-Pma-094189	Petromyzon marinus	69.05	1.00e-169	589.00
IUUC-Pno-094929	Phaeosphaeria nodorum	29.22	2.00e-35	143.00
IUUC-Ppa-095429	Physcomitrella patens	34.91	9.00e-65	240.00
IUUC-Pfo-096337	Poecilia formosa	73.63	0.00e+00	660.00
IUUC-Pab-097571	Pongo abelii	85.20	0.00e+00	670.00
IUUC-Pop-099977	Populus trichocarpa	37.32	3.00e-67	248.00
IUUC-Pca-100394	Procavia capensis	80.00	4.00e-175	607.00
IUUC-Ppe-101848	Prunus persica	35.82	7.00e-62	231.00
IUUC-Pva-102921	Pteropus vampyrus	86.23	4.00e-105	374.00
IUUC-Pgr-103637	Puccinia graminis	28.63	4.00e-35	142.00
IUUC-Ptt-103781	Puccinia triticina	29.42	4.00e-36	145.00
IUUC-Pte-104135	Pyrenophora teres	27.01	2.00e-35	144.00
IUUC-Pyt-104609	Pyrenophora triticirepentis	26.75	1.00e-34	140.00
IUUC-Rno-105114	Rattus norvegicus	83.05	0.00e+00	681.00
IUUC-Sce-106401	Saccharomyces cerevisiae	28.41	9.00e-39	154.00
IUUC-Sha-107122	Sarcophilus harrisii	91.49	0.00e+00	734.00
IUUC-Sja-107766	Schizosaccharomyces japonicus	31.31	3.00e-47	182.00
IUUC-Spo-108134	Schizosaccharomyces pombe	29.67	3.00e-40	159.00
IUUC-Smo-108761	Selaginella moellendorffii	32.87	8.00e-57	214.00
IUUC-Sit-110311	Setaria italica	36.39	9.00e-60	224.00
IUUC-Sly-111178	Solanum lycopersicum	33.83	4.00e-56	212.00
IUUC-Stu-112778	Solanum tuberosum	35.32	3.00e-60	225.00
IUUC-Sar-113596	Sorex araneus	71.36	5.00e-157	546.00
IUUC-Sbi-114193	Sorghum bicolor	35.03	4.00e-59	221.00
IUUC-Sre-115002	Sporisorium reilianum	24.45	5.00e-10	59.30
IUUC-Ssc-116066	Sus scrofa	86.63	0.00e+00	693.00
IUUC-Tgu-117048	Taeniopygia guttata	82.31	4.00e-179	620.00
IUUC-Tsy-119573	Tarsius syrichta	54.59	2.00e-112	398.00
IUUC-Tni-119820	Tetraodon nigroviridis	75.06	0.00e+00	664.00
IUUC-Tca-121605	Theobroma cacao	35.89	1.00e-61	229.00
IUUC-Tre-121947	Trichoderma reesei	25.00	7.00e-32	131.00
IUUC-Tvi-122481	Trichoderma virens	25.68	7.00e-33	134.00
IUUC-Tae-125861	Triticum aestivum	33.49	9.00e-60	224.00
IUUC-Tur-126586	Triticum urartu	34.02	3.00e-57	215.00
IUUC-Tme-126900	Tuber melanosporum	30.26	3.00e-45	176.00
IUUC-Tbe-127736	Tupaia belangeri	65.33	1.00e-136	479.00
IUUC-Ttr-129041	Tursiops truncatus	76.13	3.00e-172	598.00
IUUC-Vpa-130260	Vicugna pacos	86.16	0.00e+00	696.00
IUUC-Vvi-131009	Vitis vinifera	34.76	3.00e-59	222.00
IUUC-Xtr-132083	Xenopus tropicalis	77.67	0.00e+00	653.00
IUUC-Xma-133094	Xiphophorus maculatus	72.68	0.00e+00	650.00
IUUC-Yli-134531	Yarrowia lipolytica	23.87	1.00e-16	81.60
IUUC-Zma-135509	Zea mays	33.81	7.00e-60	224.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence