iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000016641.2	ENSMMUT00000023389.2	ENSMMUP00000021885.2
ENSMMUG00000016641.2	ENSMMUT00000068944.1	ENSMMUP00000060298.1
ENSMMUG00000016641.2	ENSMMUT00000064048.1	ENSMMUP00000050841.1
ENSMMUG00000016641.2	ENSMMUT00000063574.1	ENSMMUP00000047367.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	2.50e-54	183.9	31	165

Active Site

Position(s)	Description	Evidence
111	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkee 89
           Rl++++k+l++dpp g+s  p+++ ++++w+++i+Gpe+tp+e+g+Fkl ief+e+YP kPP+v+fl+k+fhPnvy++G++Cl+il+  
   Q: 31   RLMRDFKRLQEDPPVGVSGAPSEN-NIMQWNAVIFGPEGTPFEDGTFKLVIEFSEEYPNKPPTVRFLSKMFHPNVYADGSICLDILQ-- 116
           9**********************9.9************************************************************9.. PP
   S: 90   ekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           ++Wsp+++v+s+l+siqsll+epnp+sp+n++aa+l+++n++ey+k+v+
   Q: 117  NRWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKRVS 165
           **********************************************996 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

AQEEPRPAEG LRERALTAGQ LRSMSTPARR RLMRDFKRLQ EDPPVGVSGA PSENNIMQWN 60
AVIFGPEGTP FEDGTFKLVI EFSEEYPNKP PTVRFLSKMF HPNVYADGSI CLDILQNRWS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCCAGGAAG AACCACGCCC CGCTGAAGGG CTCAGGGAAC GCGCGCTCCC CCGTCCCGCC 60
CCCTCCTCCC CCAGCACTCA CTCTGTGGTA GCGGCGGAGG GCGGAGGGAT CCGGAGGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0033503--C:HULC complex
GO:0000790--C:nuclear chromatin
GO:0005657--C:replication fork
GO:0001741--C:XY body
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0060070--P:canonical Wnt signaling pathway
GO:0051026--P:chiasma assembly
GO:0033522--P:histone H2A ubiquitination
GO:0070076--P:histone lysine demethylation
GO:0001701--P:in utero embryonic development
GO:0006344--P:maintenance of chromatin silencing
GO:0045141--P:meiotic telomere clustering
GO:0043066--P:negative regulation of apoptotic process
GO:0043951--P:negative regulation of cAMP-mediated signaling
GO:0033128--P:negative regulation of histone phosphorylation
GO:0010845--P:positive regulation of reciprocal meiotic recombination
GO:0006301--P:postreplication repair
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0006513--P:protein monoubiquitination
GO:0050821--P:protein stabilization
GO:0042493--P:response to drug
GO:0009411--P:response to UV
GO:0007288--P:sperm axoneme assembly
GO:0070193--P:synaptonemal complex organization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002120	Ailuropoda melanoleuca	100.00	2.00e-88	317.00
IUUC-Apl-004063	Anas platyrhynchos	92.62	6.00e-77	279.00
IUUC-Aca-005001	Anolis carolinensis	99.34	3.00e-88	316.00
IUUC-Ago-007745	Ashbya gossypii	69.80	6.00e-63	233.00
IUUC-Acl-008139	Aspergillus clavatus	68.87	5.00e-64	236.00
IUUC-Afl-008551	Aspergillus flavus	68.87	8.00e-64	235.00
IUUC-Afu-008980	Aspergillus fumigatus	68.87	8.00e-64	235.00
IUUC-Ang-009554	Aspergillus niger	68.87	8.00e-64	235.00
IUUC-Aor-010242	Aspergillus oryzae	68.87	8.00e-64	235.00
IUUC-Ate-010390	Aspergillus terreus	68.87	8.00e-64	235.00
IUUC-Ame-010743	Astyanax mexicanus	96.71	4.00e-85	306.00
IUUC-Bta-012840	Bos taurus	100.00	2.00e-88	317.00
IUUC-Bci-013919	Botrytis cinerea	69.08	1.00e-64	238.00
IUUC-Cja-019737	Callithrix jacchus	100.00	2.00e-88	317.00
IUUC-Cfa-020244	Canis familiaris	100.00	2.00e-88	317.00
IUUC-Cpo-022192	Cavia porcellus	100.00	2.00e-88	317.00
IUUC-Cre-022822	Chlamydomonas reinhardtii	75.97	4.00e-58	216.00
IUUC-Csa-023430	Chlorocebus sabaeus	100.00	2.00e-88	317.00
IUUC-Cho-024773	Choloepus hoffmanni	79.61	7.00e-65	239.00
IUUC-Cgl-026381	Colletotrichum gloeosporioides	68.87	2.00e-64	237.00
IUUC-Cme-027284	Cyanidioschyzon merolae	66.67	2.00e-54	205.00
IUUC-Dno-029661	Dasypus novemcinctus	100.00	2.00e-88	317.00
IUUC-Dor-030452	Dipodomys ordii	100.00	7.00e-79	285.00
IUUC-Dse-031487	Dothistroma septosporum	68.87	4.00e-64	236.00
IUUC-Ete-032595	Echinops telfairi	96.71	1.00e-85	307.00
IUUC-Eca-033377	Equus caballus	100.00	2.00e-88	317.00
IUUC-Fca-036336	Felis catus	100.00	2.00e-88	317.00
IUUC-Fox-037808	Fusarium oxysporum	68.87	3.00e-64	237.00
IUUC-Fso-038232	Fusarium solani	68.87	3.00e-64	236.00
IUUC-Ggr-039875	Gaeumannomyces graminis	69.13	1.00e-63	234.00
IUUC-Gga-040494	Gallus gallus	100.00	2.00e-88	317.00
IUUC-Hsa-046239	Homo sapiens	100.00	2.00e-88	317.00
IUUC-Itr-048960	Ictidomys tridecemlineatus	100.00	2.00e-88	317.00
IUUC-Kpa-049225	Komagataella pastoris	69.33	9.00e-63	232.00
IUUC-Lch-050283	Latimeria chalumnae	97.35	6.00e-86	308.00
IUUC-Loc-051962	Lepisosteus oculatus	98.03	1.00e-86	311.00
IUUC-Laf-053380	Loxodonta africana	100.00	2.00e-88	317.00
IUUC-Mor-057087	Magnaporthe oryzae	67.16	8.00e-55	205.00
IUUC-Mpo-057498	Magnaporthe poae	69.13	1.00e-63	236.00
IUUC-Mla-058876	Melampsora laricipopulina	72.85	9.00e-59	218.00
IUUC-Mga-059863	Meleagris gallopavo	98.57	1.00e-79	287.00
IUUC-Mmr-060630	Microcebus murinus	100.00	2.00e-88	317.00
IUUC-Mdo-062676	Monodelphis domestica	100.00	2.00e-88	317.00
IUUC-Mmu-063491	Mus musculus	100.00	2.00e-88	317.00
IUUC-Mpu-065803	Mustela putorius furo	100.00	2.00e-88	317.00
IUUC-Mlu-067147	Myotis lucifugus	100.00	2.00e-88	317.00
IUUC-Nfi-068580	Neosartorya fischeri	68.87	8.00e-64	235.00
IUUC-Ncr-068913	Neurospora crassa	68.87	1.00e-64	238.00
IUUC-Nle-070105	Nomascus leucogenys	100.00	2.00e-88	317.00
IUUC-Opr-070935	Ochotona princeps	100.00	2.00e-88	317.00
IUUC-Oan-072706	Ornithorhynchus anatinus	94.63	7.00e-81	292.00
IUUC-Ocu-074130	Oryctolagus cuniculus	100.00	2.00e-88	317.00
IUUC-Oga-088836	Otolemur garnettii	100.00	2.00e-88	317.00
IUUC-Oar-090141	Ovis aries	100.00	2.00e-88	317.00
IUUC-Ptr-091453	Pan troglodytes	100.00	2.00e-88	317.00
IUUC-Pan-092511	Papio anubis	100.00	2.00e-88	317.00
IUUC-Psi-093968	Pelodiscus sinensis	99.34	3.00e-88	316.00
IUUC-Pno-094935	Phaeosphaeria nodorum	68.87	1.00e-64	238.00
IUUC-Pab-098121	Pongo abelii	100.00	2.00e-88	317.00
IUUC-Pgr-103611	Puccinia graminis	72.19	4.00e-59	219.00
IUUC-Ptt-103971	Puccinia triticina	72.88	9.00e-45	171.00
IUUC-Pte-104378	Pyrenophora teres	69.54	8.00e-65	238.00
IUUC-Pyt-104757	Pyrenophora triticirepentis	69.54	8.00e-65	238.00
IUUC-Rno-105772	Rattus norvegicus	94.89	8.00e-95	338.00
IUUC-Sce-106283	Saccharomyces cerevisiae	69.80	5.00e-63	233.00
IUUC-Sha-107650	Sarcophilus harrisii	98.68	1.00e-86	311.00
IUUC-Ssl-108432	Sclerotinia sclerotiorum	69.08	1.00e-64	238.00
IUUC-Sar-113429	Sorex araneus	100.00	2.00e-88	317.00
IUUC-Sre-115106	Sporisorium reilianum	74.17	3.00e-60	223.00
IUUC-Ssc-115257	Sus scrofa	98.03	3.00e-86	310.00
IUUC-Tgu-116604	Taeniopygia guttata	93.83	5.00e-86	309.00
IUUC-Tru-118576	Takifugu rubripes	94.74	6.00e-84	302.00
IUUC-Tsy-119000	Tarsius syrichta	100.00	2.00e-88	317.00
IUUC-Tni-119745	Tetraodon nigroviridis	94.74	4.00e-84	303.00
IUUC-Tre-122002	Trichoderma reesei	68.87	4.00e-64	236.00
IUUC-Tvi-122331	Trichoderma virens	68.87	4.00e-64	236.00
IUUC-Tbe-127921	Tupaia belangeri	98.03	7.00e-84	302.00
IUUC-Ttr-129121	Tursiops truncatus	100.00	2.00e-88	317.00
IUUC-Uma-129561	Ustilago maydis	74.17	2.00e-60	224.00
IUUC-Vda-129711	Verticillium dahliae	68.87	2.00e-64	237.00
IUUC-Vpa-130570	Vicugna pacos	93.43	8.00e-72	261.00
IUUC-Xtr-131824	Xenopus tropicalis	98.68	4.00e-87	313.00
IUUC-Yli-134660	Yarrowia lipolytica	66.23	3.00e-63	233.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence