iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sha-107496

Ensembl Protein ID

ENSSHAP00000010660.1

UniProt Accession

G3W5F5; G3W5F5_SARHA

Genbank Protein ID

ENSSHAP00000010660

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01168488

Gene Name

PHIP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000009200.1	ENSSHAT00000010754.1	ENSSHAP00000010660.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.50e-34	114.5	139	176
UBD/Beta-Prp	2.70e-52	178.0	238	499

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH +sv+c+ f  + +++ +GsdD+ +k+W +++g+ll
   Q: 139  GHLSSVYCVTFdRTgRRIFTGSDDCLVKIWATDDGRLL 176
           8**********955599*****************9987 PP

UBD/Beta-Prp

   S: 19   spdksllatgsrdgtikvwdvttgkl......lrslsgheaevt..avkfspdgkilvtgseDrtikvw..dlstgkcvhtlkghedsv 97
           s +k++l ++++dgti  w ++ g+l       +  +   ++v+  + +fs  g +l+tgs+D++i+v+     +++ ++ l+ h+d+v
   Q: 238  SGSKRYLSSTGADGTICFWLWDAGTLkinqrpTKFTERPRPGVQmiCSSFSAGGMFLATGSTDHIIRVYffGSGQPEKISELEFHTDKV 326
           67899***********999999988866666433335555666611566888888**************777779999*********** PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqclee................tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgk 170
            s++fs +++++vsGs+d t+r+w+ + +++ +                  +++++  v++v+++  +n ++++ ++ t+++W++ tg+
   Q: 327  DSIQFSNTSSRFVSGSRDGTARIWHFKRKEWKSIlldmatrpagqnmqgvEDKITKLKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQ 415
           *******************************999***************888888889******************************* PP
   S: 171  llrtltgghtdsvysls...fdsngkelvsgsldgtvklwdlqtgecvrtlnght.....dnvksvrfspnderlvsgssDgsiriW 249
           l++ l g h+d v  l+   fd+  + l s+++dg v++wdl +g  +r++ +         v + + sp++++++++ s+g + i+
   Q: 416  LIHVLMG-HEDEVFVLEphpFDP--RVLFSAGHDGNVIVWDLARGVKIRSYFNMIegqghGAVFDCKCSPDGQHFACTDSHGHLLIF 499
           ******9.*********999999..89******************999998875544445566667777999999999999988887 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

QLLPRRTDWT GKEHPRTYQN LVKYYRHLAP DHLLQICHRL GPLLEQEIPQ SVPGVQTLLG 60
AGRQSLLRTN KSCKHVVWKG SALAALHCGR PPESPINYGS PPSIADTLFS RRLNGKYRLE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGCTGTTAC CCCGGCGAAC TGACTGGACG GGGAAAGAGC ATCCCAGGAC CTACCAGAAT 60
CTGGTGAGAG ATTCCCATCG CGAAGCGAAA AAACTTTTCC CCGAGTCAAA TAAAAATTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR028738--PHIP
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00439--Bromodomain
PF00400--WD40

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00320--WD40

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0007010--P:cytoskeleton organization
GO:0008286--P:insulin receptor signaling pathway
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0022604--P:regulation of cell morphogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001113	Aegilops tauschii	30.89	1.00e-55	212.00
IUUC-Aml-002299	Ailuropoda melanoleuca	91.43	0.00e+00	3076.00
IUUC-Apl-003700	Anas platyrhynchos	87.79	0.00e+00	2919.00
IUUC-Aca-004474	Anolis carolinensis	83.70	0.00e+00	2812.00
IUUC-Bta-013125	Bos taurus	90.66	0.00e+00	2977.00
IUUC-Cja-018868	Callithrix jacchus	89.03	0.00e+00	3066.00
IUUC-Cfa-021179	Canis familiaris	91.20	0.00e+00	2973.00
IUUC-Cpo-022077	Cavia porcellus	84.93	0.00e+00	2900.00
IUUC-Csa-023618	Chlorocebus sabaeus	91.15	0.00e+00	3098.00
IUUC-Cho-024794	Choloepus hoffmanni	88.15	0.00e+00	854.00
IUUC-Dno-030048	Dasypus novemcinctus	91.28	0.00e+00	3051.00
IUUC-Dor-030195	Dipodomys ordii	87.13	0.00e+00	1424.00
IUUC-Ete-032748	Echinops telfairi	77.03	0.00e+00	1036.00
IUUC-Eca-034274	Equus caballus	91.61	0.00e+00	3031.00
IUUC-Eeu-034688	Erinaceus europaeus	92.08	0.00e+00	1278.00
IUUC-Fca-035451	Felis catus	90.29	0.00e+00	2924.00
IUUC-Fal-037465	Ficedula albicollis	87.72	0.00e+00	2932.00
IUUC-Gmo-039451	Gadus morhua	68.77	0.00e+00	724.00
IUUC-Gga-040798	Gallus gallus	87.93	0.00e+00	2967.00
IUUC-Hsa-046757	Homo sapiens	91.15	0.00e+00	3071.00
IUUC-Hvu-047706	Hordeum vulgare	32.03	4.00e-38	151.00
IUUC-Itr-048843	Ictidomys tridecemlineatus	84.11	0.00e+00	1070.00
IUUC-Laf-054140	Loxodonta africana	91.23	0.00e+00	3073.00
IUUC-Mcc-055061	Macaca mulatta	91.38	0.00e+00	3104.00
IUUC-Mmr-060837	Microcebus murinus	90.79	0.00e+00	3066.00
IUUC-Mdo-061903	Monodelphis domestica	97.02	0.00e+00	3311.00
IUUC-Mmu-063772	Mus musculus	90.77	0.00e+00	3068.00
IUUC-Mpu-066359	Mustela putorius furo	91.12	0.00e+00	2826.00
IUUC-Mlu-067928	Myotis lucifugus	89.82	0.00e+00	3041.00
IUUC-Nle-070094	Nomascus leucogenys	91.32	0.00e+00	3081.00
IUUC-Opr-070971	Ochotona princeps	71.88	0.00e+00	925.00
IUUC-Ont-072221	Oreochromis niloticus	75.78	0.00e+00	1273.00
IUUC-Oan-073185	Ornithorhynchus anatinus	88.63	0.00e+00	2954.00
IUUC-Ocu-074033	Oryctolagus cuniculus	90.39	0.00e+00	2748.00
IUUC-Ogu-078641	Oryza glumaepatula	24.47	3.00e-30	127.00
IUUC-Oin-079669	Oryza indica	31.65	4.00e-53	202.00
IUUC-Olo-080755	Oryza longistaminata	32.49	3.00e-55	211.00
IUUC-Oni-082991	Oryza nivara	27.98	4.00e-40	160.00
IUUC-Oga-088578	Otolemur garnettii	90.54	0.00e+00	3004.00
IUUC-Oar-090247	Ovis aries	90.71	0.00e+00	2980.00
IUUC-Ptr-091266	Pan troglodytes	90.92	0.00e+00	3052.00
IUUC-Pan-092734	Papio anubis	91.32	0.00e+00	3102.00
IUUC-Pfo-096191	Poecilia formosa	73.65	0.00e+00	2039.00
IUUC-Pab-098402	Pongo abelii	91.21	0.00e+00	3075.00
IUUC-Pop-099185	Populus trichocarpa	36.50	1.00e-70	261.00
IUUC-Pca-101128	Procavia capensis	82.43	0.00e+00	2732.00
IUUC-Pva-103058	Pteropus vampyrus	88.50	0.00e+00	1474.00
IUUC-Rno-106013	Rattus norvegicus	89.13	0.00e+00	2994.00
IUUC-Sit-110017	Setaria italica	31.87	7.00e-56	213.00
IUUC-Sar-113520	Sorex araneus	85.23	0.00e+00	1415.00
IUUC-Ssc-115461	Sus scrofa	87.85	0.00e+00	2932.00
IUUC-Tgu-116821	Taeniopygia guttata	87.10	0.00e+00	2924.00
IUUC-Tsy-119132	Tarsius syrichta	79.50	0.00e+00	2439.00
IUUC-Tae-122854	Triticum aestivum	30.49	7.00e-65	243.00
IUUC-Tbe-127479	Tupaia belangeri	83.82	0.00e+00	1335.00
IUUC-Ttr-128427	Tursiops truncatus	87.46	0.00e+00	2909.00
IUUC-Vpa-130160	Vicugna pacos	88.26	0.00e+00	2915.00
IUUC-Xtr-132717	Xenopus tropicalis	75.11	0.00e+00	2514.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence