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Tag Content
UUCD2 ID IUUC-Gga-040501
UUCD1 version UUC-GaG-00627
Ensembl Protein ID ENSGALP00000049845.1
UniProt Accession P83038; HDAC4_CHICK
Genbank Protein ID BAB60957.1
Protein Name Histone deacetylase 4
Genbank Nucleotide ID AB052839
Gene Name HDAC4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSGALG00000004288.5 ENSGALT00000033739.4 ENSGALP00000033098.4
ENSGALG00000004288.5 ENSGALT00000064969.1 ENSGALP00000049845.1
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/Other 90.51 0.00e+00 1690.00 IUUC-Hsa-046925
Active Site
Position(s) Description Evidence
799 N/A {ECO:0000250}
Organism Gallus gallus
Functional Description
(View)

Functional Description


     Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).
 Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).
Protein Sequence
(Fasta)
MYRLKHWRLF RATVTCVETD PSQIPSPKDL TLPAMSSQSH PDGLSGRDQP VELLNPPRVN 60
HMPSSVDVST ALPLQVAPTS VPMDLRLDHQ FPMPVTEPTL REQQLQQELL ALKQKQQIQR 120
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Protein Fasta Sequence


>IUUC-Gga-040501|E3,E3 activity/Other|Gallus gallus
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Nucleotide Sequence
(Fasta)
GGATCCCGTC ACGGGCTGAG TCCGTTGGTG GCGCGCGCGC CGCCCGTGTC CGCCGCCGGG 60
CCCTCGCCGC ACGGCTCCAC GCTCCTCCCG CCGTCACCCA GGTCAGTACG CGGCGCCTCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Gga-040501|E3,E3 activity/Other|Gallus gallus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk
Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl
PRINTS

PR01270--HDASUPER
Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0004407--F:histone deacetylase activity
GO:0046872--F:metal ion binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0008134--F:transcription factor binding
GO:0042113--P:B cell activation
GO:0030183--P:B cell differentiation
GO:0006325--P:chromatin organization
GO:0006954--P:inflammatory response
GO:0045843--P:negative regulation of striated muscle tissue development
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0007399--P:nervous system development
GO:0006351--P:transcription, DNA-templated
KEGG gga:374207
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000749 Aegilops tauschii 47.13 1.00e-59 224.00
IUUC-Aml-002279 Ailuropoda melanoleuca 89.95 0.00e+00 1710.00
IUUC-Atr-002745 Amborella trichopoda 39.44 3.00e-70 259.00
IUUC-Apl-003250 Anas platyrhynchos 96.45 0.00e+00 1774.00
IUUC-Aca-004668 Anolis carolinensis 86.88 0.00e+00 1727.00
IUUC-Aly-006432 Arabidopsis lyrata 40.56 1.00e-68 253.00
IUUC-Ath-007355 Arabidopsis thaliana 41.86 4.00e-74 272.00
IUUC-Ago-007972 Ashbya gossypii 38.25 4.00e-68 252.00
IUUC-Acl-008187 Aspergillus clavatus 40.20 3.00e-71 263.00
IUUC-Afl-008399 Aspergillus flavus 44.16 3.00e-40 159.00
IUUC-Afu-008954 Aspergillus fumigatus 35.71 1.00e-58 221.00
IUUC-Ani-009142 Aspergillus nidulans 38.72 3.00e-67 249.00
IUUC-Ang-009522 Aspergillus niger 29.08 4.00e-34 139.00
IUUC-Aor-010069 Aspergillus oryzae 38.38 5.00e-65 242.00
IUUC-Ate-010291 Aspergillus terreus 40.61 4.00e-73 269.00
IUUC-Ame-010780 Astyanax mexicanus 39.85 2.00e-73 270.00
IUUC-Bta-013215 Bos taurus 89.63 0.00e+00 1698.00
IUUC-Bci-013789 Botrytis cinerea 36.96 6.00e-67 248.00
IUUC-Bdi-014007 Brachypodium distachyon 41.13 6.00e-72 265.00
IUUC-Bol-015468 Brassica oleracea 41.22 9.00e-75 274.00
IUUC-Bra-016680 Brassica rapa 41.48 6.00e-75 275.00
IUUC-Cel-018220 Caenorhabditis elegans 36.84 2.00e-66 247.00
IUUC-Cja-019816 Callithrix jacchus 90.02 0.00e+00 1742.00
IUUC-Cfa-020861 Canis familiaris 90.72 0.00e+00 1709.00
IUUC-Cpo-021562 Cavia porcellus 88.97 0.00e+00 1721.00
IUUC-Cre-022561 Chlamydomonas reinhardtii 49.55 7.00e-53 199.00
IUUC-Csa-023612 Chlorocebus sabaeus 90.42 0.00e+00 1729.00
IUUC-Csv-026359 Ciona savignyi 53.04 3.00e-90 324.00
IUUC-Cgl-026709 Colletotrichum gloeosporioides 36.36 1.00e-66 247.00
IUUC-Cne-026978 Cryptococcus neoformans 38.41 2.00e-72 266.00
IUUC-Dre-028284 Danio rerio 86.62 0.00e+00 865.00
IUUC-Dno-029951 Dasypus novemcinctus 86.79 0.00e+00 1558.00
IUUC-Dor-030362 Dipodomys ordii 79.57 0.00e+00 1426.00
IUUC-Dse-031186 Dothistroma septosporum 34.41 2.00e-61 230.00
IUUC-Dme-031766 Drosophila melanogaster 57.30 1.00e-159 557.00
IUUC-Ete-032279 Echinops telfairi 36.81 3.00e-56 213.00
IUUC-Eca-033842 Equus caballus 43.11 4.00e-76 279.00
IUUC-Eeu-034487 Erinaceus europaeus 50.82 4.00e-61 229.00
IUUC-Fca-036187 Felis catus 91.04 0.00e+00 1672.00
IUUC-Fox-038067 Fusarium oxysporum 39.31 4.00e-68 252.00
IUUC-Fso-038263 Fusarium solani 38.33 3.00e-68 253.00
IUUC-Gmo-038473 Gadus morhua 77.13 0.00e+00 760.00
IUUC-Ggr-040062 Gaeumannomyces graminis 40.17 3.00e-65 243.00
IUUC-Gac-042335 Gasterosteus aculeatus 70.10 0.00e+00 1285.00
IUUC-Gma-043738 Glycine max 41.16 2.00e-66 246.00
IUUC-Ggo-045380 Gorilla gorilla 90.11 0.00e+00 1714.00
IUUC-Hsa-046925 Homo sapiens 90.49 0.00e+00 1717.00
IUUC-Hvu-047285 Hordeum vulgare 41.38 2.00e-70 258.00
IUUC-Itr-048036 Ictidomys tridecemlineatus 89.55 0.00e+00 1634.00
IUUC-Kpa-049281 Komagataella pastoris 38.52 3.00e-70 259.00
IUUC-Lch-050325 Latimeria chalumnae 86.19 0.00e+00 1568.00
IUUC-Lpe-051214 Leersia perrieri 41.67 6.00e-75 275.00
IUUC-Loc-052231 Lepisosteus oculatus 82.78 0.00e+00 1493.00
IUUC-Lma-053263 Leptosphaeria maculans 39.70 4.00e-74 273.00
IUUC-Laf-054490 Loxodonta africana 84.00 0.00e+00 1593.00
IUUC-Mcc-055265 Macaca mulatta 90.55 0.00e+00 1765.00
IUUC-Meu-056676 Macropus eugenii 88.31 0.00e+00 778.00
IUUC-Mor-057095 Magnaporthe oryzae 36.98 9.00e-68 251.00
IUUC-Mpo-057389 Magnaporthe poae 38.96 3.00e-64 239.00
IUUC-Mtr-058463 Medicago truncatula 41.16 3.00e-70 259.00
IUUC-Mla-059143 Melampsora laricipopulina 40.33 1.00e-69 257.00
IUUC-Mmr-061633 Microcebus murinus 82.19 0.00e+00 1504.00
IUUC-Mdo-062198 Monodelphis domestica 42.96 2.00e-77 284.00
IUUC-Mmu-063089 Mus musculus 90.33 0.00e+00 1668.00
IUUC-Mac-064630 Musa acuminata 40.79 2.00e-71 263.00
IUUC-Mpu-065887 Mustela putorius furo 90.39 0.00e+00 1706.00
IUUC-Mlu-067470 Myotis lucifugus 90.30 0.00e+00 1695.00
IUUC-Nfi-068404 Neosartorya fischeri 39.44 2.00e-70 259.00
IUUC-Ncr-068672 Neurospora crassa 37.84 6.00e-68 251.00
IUUC-Nle-069099 Nomascus leucogenys 86.96 0.00e+00 1133.00
IUUC-Opr-071074 Ochotona princeps 44.50 1.00e-87 317.00
IUUC-Ont-071613 Oreochromis niloticus 73.02 0.00e+00 1293.00
IUUC-Oan-073275 Ornithorhynchus anatinus 91.68 0.00e+00 1728.00
IUUC-Ocu-074627 Oryctolagus cuniculus 44.84 3.00e-84 306.00
IUUC-Oba-075489 Oryza barthii 41.26 7.00e-73 268.00
IUUC-Obr-076150 Oryza brachyantha 41.55 3.00e-74 273.00
IUUC-Ogl-077437 Oryza glaberrima 41.26 3.00e-73 269.00
IUUC-Ogu-078370 Oryza glumaepatula 41.26 3.00e-73 269.00
IUUC-Oin-079210 Oryza indica 41.26 2.00e-73 270.00
IUUC-Olo-080971 Oryza longistaminata 42.38 5.00e-64 238.00
IUUC-Oni-082031 Oryza nivara 41.26 4.00e-73 269.00
IUUC-Opu-083471 Oryza punctata 41.55 3.00e-73 269.00
IUUC-Oru-084755 Oryza rufipogon 41.26 3.00e-73 269.00
IUUC-Osa-085447 Oryza sativa 41.26 2.00e-73 269.00
IUUC-Ola-087031 Oryzias latipes 68.20 0.00e+00 1216.00
IUUC-Oga-088201 Otolemur garnettii 83.53 0.00e+00 1475.00
IUUC-Oar-089997 Ovis aries 81.75 0.00e+00 1374.00
IUUC-Ptr-091116 Pan troglodytes 90.39 0.00e+00 1751.00
IUUC-Pan-092132 Papio anubis 90.09 0.00e+00 1120.00
IUUC-Psi-093734 Pelodiscus sinensis 94.21 0.00e+00 1709.00
IUUC-Pma-094347 Petromyzon marinus 72.39 0.00e+00 718.00
IUUC-Pno-095131 Phaeosphaeria nodorum 45.85 1.00e-64 240.00
IUUC-Ppa-095550 Physcomitrella patens 43.61 2.00e-72 266.00
IUUC-Pfo-096293 Poecilia formosa 71.05 0.00e+00 1213.00
IUUC-Pab-098491 Pongo abelii 87.59 0.00e+00 1654.00
IUUC-Pop-099174 Populus trichocarpa 40.29 2.00e-70 260.00
IUUC-Pca-101004 Procavia capensis 79.94 0.00e+00 877.00
IUUC-Ppe-101644 Prunus persica 39.77 1.00e-71 263.00
IUUC-Pva-102961 Pteropus vampyrus 66.46 0.00e+00 836.00
IUUC-Ptt-103841 Puccinia triticina 38.56 4.00e-68 252.00
IUUC-Pte-104383 Pyrenophora teres 39.39 4.00e-71 262.00
IUUC-Pyt-104427 Pyrenophora triticirepentis 39.90 6.00e-71 261.00
IUUC-Rno-105005 Rattus norvegicus 90.14 0.00e+00 1639.00
IUUC-Sce-106274 Saccharomyces cerevisiae 36.08 4.00e-65 242.00
IUUC-Sha-107646 Sarcophilus harrisii 68.66 0.00e+00 1036.00
IUUC-Sja-107915 Schizosaccharomyces japonicus 37.66 1.00e-71 263.00
IUUC-Spo-108300 Schizosaccharomyces pombe 39.13 8.00e-74 271.00
IUUC-Smo-109615 Selaginella moellendorffii 42.49 1.00e-76 280.00
IUUC-Sit-110160 Setaria italica 41.09 1.00e-69 257.00
IUUC-Sly-111164 Solanum lycopersicum 42.82 3.00e-77 282.00
IUUC-Stu-112685 Solanum tuberosum 38.85 7.00e-59 221.00
IUUC-Sar-113692 Sorex araneus 35.00 2.00e-45 177.00
IUUC-Sbi-114301 Sorghum bicolor 40.69 1.00e-67 251.00
IUUC-Sre-115013 Sporisorium reilianum 40.56 1.00e-69 257.00
IUUC-Ssc-115428 Sus scrofa 89.82 0.00e+00 1615.00
IUUC-Tgu-116776 Taeniopygia guttata 97.85 0.00e+00 1837.00
IUUC-Tru-118180 Takifugu rubripes 71.34 0.00e+00 1298.00
IUUC-Tsy-119468 Tarsius syrichta 85.66 0.00e+00 737.00
IUUC-Tni-120196 Tetraodon nigroviridis 70.05 0.00e+00 1283.00
IUUC-Tca-121312 Theobroma cacao 42.61 5.00e-75 275.00
IUUC-Tre-121930 Trichoderma reesei 39.36 2.00e-72 266.00
IUUC-Tvi-122373 Trichoderma virens 39.36 5.00e-70 258.00
IUUC-Tae-123064 Triticum aestivum 39.54 7.00e-66 244.00
IUUC-Tme-127027 Tuber melanosporum 44.64 2.00e-60 226.00
IUUC-Tbe-127675 Tupaia belangeri 39.77 6.00e-19 89.70
IUUC-Ttr-128360 Tursiops truncatus 82.03 0.00e+00 963.00
IUUC-Uma-129408 Ustilago maydis 43.53 2.00e-68 253.00
IUUC-Vda-129994 Verticillium dahliae 41.39 3.00e-61 229.00
IUUC-Vpa-130525 Vicugna pacos 57.89 1.00e-16 81.60
IUUC-Vvi-131038 Vitis vinifera 39.61 6.00e-74 271.00
IUUC-Xtr-132956 Xenopus tropicalis 80.59 0.00e+00 1496.00
IUUC-Xma-134265 Xiphophorus maculatus 70.31 0.00e+00 1223.00
IUUC-Yli-134680 Yarrowia lipolytica 40.50 2.00e-68 253.00
IUUC-Zma-135110 Zea mays 40.69 2.00e-69 256.00
Created Date 25-Jun-2017

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