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Tag Content
iUUCD ID IUUC-Bta-012778
Ensembl Protein ID ENSBTAP00000008224.4
UniProt Accession Q95KU9; A2VDM3; Q5E9T0; Q5EA16; NEMO_BOVIN
Genbank Protein ID CAC93688.1; AAX08857.1; AAX08770.1; AAX08784.1; AAX08889.1; AAI33307.1
Protein Name NF-kappa-B essential modulator; IkB kinase-associated protein 1; Inhibitor of nuclear factor kappa-B kinase subunit gamma; NF-kappa-B essential modifier
Genbank Nucleotide ID AJ414557; BT020840; BT020753; BT020767; BT020872; BC133306
Gene Name IKBKG; NEMO
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000006268.5 ENSBTAT00000008224.4 ENSBTAP00000008224.4
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/Alpha-Helix/UBAN 6.90e-26 90.1 291 350
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBAN
   S: 1    keelletvevLkqQveiYkeDFqaERadRErlneekeeLqeqveklqkqvsklndslkas 60
           +++++etv+vLk+Q++iYk+DFqaER++RE+l+e+ke Lqeq+e+lq+++s+l+ s+++s
   Q: 291  HKIVMETVPVLKAQADIYKADFQAERQAREKLAEKKEFLQEQLEQLQREYSRLKTSCQES 350
           899*******************************************************98 PP
   
Organism Bos taurus
Functional Description
(View)

Functional Description


     Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (By similarity).
 Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination (By similarity).
Protein Sequence
(Fasta)
MSRPPWKSPL CEMVQPSGSP AGDQDMLGEE SSLGKPAMLH VPSEQGTPET FQRCLEENQE 60
LRDAIRQSNQ MLRERCEELQ HFQGNQREEK AFLMQKFQEA RDLVVRLSLE KRELRQQREQ 120
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Protein Fasta Sequence


>IUUC-Bta-012778|UBD,UBAN|Bos taurus
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Nucleotide Sequence
(Fasta)
CGCCGGAGCA GGTCAAACCA GCCCTATTAG ATAATAGCCT CGTTGTGGTT CCAACCCTAG 60
CGGGAGGGGG GACGGCCCTG CCGGAGAGAC AAGAGGGAAT GCAGGTCGCA ACGCTAATTA 120
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Nucleotide Fasta Sequence


>IUUC-Bta-012778|UBD,UBAN|Bos taurus
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Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1015--Disulfide bond
KW-0227--DNA damage
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR032419--CC2-LZ_dom
IPR021063--NEMO_N
IPR034735--ZF_CCHC_NOA
PROSITE

PS51801--ZF_CCHC_NOA
Pfam

PF16516--CC2-LZ
PF11577--NEMO
Gene Ontology

GO:0008385--C:IkappaB kinase complex
GO:0072686--C:mitotic spindle
GO:0005634--C:nucleus
GO:0000922--C:spindle pole
GO:0000151--C:ubiquitin ligase complex
GO:0070530--F:K63-linked polyubiquitin binding
GO:0046872--F:metal ion binding
GO:0046982--F:protein heterodimerization activity
GO:0042803--F:protein homodimerization activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0051650--P:establishment of vesicle localization
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated
KEGG bta:281855
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002336 Ailuropoda melanoleuca 89.74 0.00e+00 630.00
IUUC-Aca-004653 Anolis carolinensis 57.11 2.00e-94 338.00
IUUC-Cja-018954 Callithrix jacchus 85.92 2.00e-174 605.00
IUUC-Cfa-020778 Canis familiaris 88.31 0.00e+00 683.00
IUUC-Cpo-022327 Cavia porcellus 81.86 6.00e-143 500.00
IUUC-Csa-023340 Chlorocebus sabaeus 86.86 2.00e-150 525.00
IUUC-Dre-028819 Danio rerio 49.14 6.00e-55 208.00
IUUC-Dno-029566 Dasypus novemcinctus 82.90 2.00e-161 561.00
IUUC-Dor-031122 Dipodomys ordii 86.30 3.00e-30 125.00
IUUC-Eca-033895 Equus caballus 82.10 1.00e-149 522.00
IUUC-Eeu-034478 Erinaceus europaeus 77.33 3.00e-140 491.00
IUUC-Fca-035990 Felis catus 89.20 1.00e-128 453.00
IUUC-Gmo-038622 Gadus morhua 44.60 6.00e-61 228.00
IUUC-Gac-041917 Gasterosteus aculeatus 45.66 8.00e-61 228.00
IUUC-Ggo-045478 Gorilla gorilla 85.92 1.00e-158 553.00
IUUC-Hsa-046243 Homo sapiens 85.68 3.00e-158 551.00
IUUC-Itr-048520 Ictidomys tridecemlineatus 85.20 3.00e-174 604.00
IUUC-Lch-050187 Latimeria chalumnae 56.60 1.00e-99 356.00
IUUC-Loc-052627 Lepisosteus oculatus 54.05 2.00e-59 223.00
IUUC-Laf-054387 Loxodonta africana 82.42 3.00e-138 484.00
IUUC-Mcc-054611 Macaca mulatta 86.40 7.00e-160 556.00
IUUC-Meu-056530 Macropus eugenii 61.33 8.00e-91 327.00
IUUC-Mmr-061028 Microcebus murinus 84.36 4.00e-173 600.00
IUUC-Mdo-062520 Monodelphis domestica 62.84 7.00e-116 410.00
IUUC-Mmu-063925 Mus musculus 83.05 3.00e-153 534.00
IUUC-Mpu-066392 Mustela putorius furo 85.68 9.00e-163 566.00
IUUC-Mlu-067374 Myotis lucifugus 84.11 2.00e-163 568.00
IUUC-Nle-069085 Nomascus leucogenys 83.24 6.00e-77 279.00
IUUC-Ont-071385 Oreochromis niloticus 45.03 1.00e-56 214.00
IUUC-Oan-073347 Ornithorhynchus anatinus 70.74 3.00e-149 521.00
IUUC-Ocu-074929 Oryctolagus cuniculus 82.34 2.00e-172 598.00
IUUC-Ola-086340 Oryzias latipes 48.00 3.00e-65 243.00
IUUC-Oga-088042 Otolemur garnettii 86.16 1.00e-175 609.00
IUUC-Oar-090051 Ovis aries 94.92 0.00e+00 641.00
IUUC-Ptr-090498 Pan troglodytes 84.96 7.00e-156 543.00
IUUC-Psi-093840 Pelodiscus sinensis 55.58 6.00e-84 305.00
IUUC-Pfo-097140 Poecilia formosa 43.41 7.00e-51 195.00
IUUC-Pab-097707 Pongo abelii 86.16 5.00e-159 553.00
IUUC-Pca-100427 Procavia capensis 72.41 1.00e-129 456.00
IUUC-Pva-102328 Pteropus vampyrus 82.58 1.00e-143 503.00
IUUC-Rno-105231 Rattus norvegicus 82.82 2.00e-173 601.00
IUUC-Sha-106676 Sarcophilus harrisii 71.66 5.00e-150 523.00
IUUC-Sar-113027 Sorex araneus 77.58 2.00e-70 258.00
IUUC-Ssc-116284 Sus scrofa 89.50 4.00e-160 557.00
IUUC-Tru-117790 Takifugu rubripes 42.47 2.00e-50 193.00
IUUC-Tbe-127949 Tupaia belangeri 88.78 8.00e-66 244.00
IUUC-Ttr-128663 Tursiops truncatus 91.13 0.00e+00 634.00
Created Date 25-Jun-2017

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