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Basic Information Integrated Annotations

Tag Content
UUCD2 ID IUUC-Rno-105120
UUCD1 version UUC-RaN-00377
Ensembl Protein ID ENSRNOP00000042091.5
UniProt Accession F1M589; F1M589_RAT
Genbank Protein ID ENSRNOP00000042091
Protein Name Promyelocytic leukemia
Genbank Nucleotide ID AABR07070273
Gene Name Pml
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000008400.8 ENSRNOT00000043434.6 ENSRNOP00000042091.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
RAID2
Protein-protein Interaction
iRefIndexPINAHINT
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 69.06 0.00e+00 1167.00 IUUC-Hsa-045861
E3 activity/RING/RING 82.17 0.00e+00 1416.00 IUUC-Mmu-063118
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Rattus norvegicus
Protein Sequence
(Fasta)
MPPPEEPSED HEHSQSPAEQ AIKEEFQFLR CPGCQTQAKC PKLLPCLHTL CSGCLEAPGL 60
QCPICQAPGS ANANAEALDN VFFESLQRRL AVFRQIVDAQ AACTRCKELA DFWCFECEQL 120
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Protein Fasta Sequence



>IUUC-Rno-105120|E3,RING|Rattus norvegicus
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Nucleotide Sequence
(Fasta)
GCAGCTCACT TTTCTGGCTC AAGTCTGGGA CGCATTTCCC GCCCTCACAG ACCCAATCCA 60
GAAATCGAAA CTGAACCAGG CTCTACGCAG AAGGCGCCTG CACCCTCTGG ATCTCTCTGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Rno-105120|E3,RING|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR021978--DUF3583
IPR012337--RNaseH-like_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF12126--DUF3583
PF00643--zf-B_box

SMART

SM00336--BBOX
SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0042406--C:extrinsic component of endoplasmic reticulum membrane
GO:0000784--C:nuclear chromosome, telomeric region
GO:0016363--C:nuclear matrix
GO:0031965--C:nuclear membrane
GO:0005730--C:nucleolus
GO:0016605--C:PML body
GO:0008270--F:zinc ion binding
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0060444--P:branching involved in mammary gland duct morphogenesis
GO:0007050--P:cell cycle arrest
GO:0045165--P:cell fate commitment
GO:0071353--P:cellular response to interleukin-4
GO:0090398--P:cellular senescence
GO:0032922--P:circadian regulation of gene expression
GO:0007182--P:common-partner SMAD protein phosphorylation
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0032469--P:endoplasmic reticulum calcium ion homeostasis
GO:0043153--P:entrainment of circadian clock by photoperiod
GO:0097191--P:extrinsic apoptotic signaling pathway
GO:0010761--P:fibroblast migration
GO:0045087--P:innate immune response
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0008631--P:intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0051457--P:maintenance of protein location in nucleus
GO:0030099--P:myeloid cell differentiation
GO:0016525--P:negative regulation of angiogenesis
GO:0030308--P:negative regulation of cell growth
GO:0008285--P:negative regulation of cell proliferation
GO:0050713--P:negative regulation of interleukin-1 beta secretion
GO:2000059--P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:1902187--P:negative regulation of viral release from host cell
GO:0030578--P:PML body organization
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0045345--P:positive regulation of MHC class I biosynthetic process
GO:0032206--P:positive regulation of telomere maintenance
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006461--P:protein complex assembly
GO:0010522--P:regulation of calcium ion transport into cytosol
GO:0030155--P:regulation of cell adhesion
GO:2000779--P:regulation of double-strand break repair
GO:0001932--P:regulation of protein phosphorylation
GO:0010332--P:response to gamma radiation
GO:0001666--P:response to hypoxia
GO:0009411--P:response to UV
GO:0048384--P:retinoic acid receptor signaling pathway
GO:0007184--P:SMAD protein import into nucleus
GO:0007179--P:transforming growth factor beta receptor signaling pathway

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001901 Ailuropoda melanoleuca 67.29 0.00e+00 1014.00
IUUC-Bta-012427 Bos taurus 63.72 0.00e+00 1033.00
IUUC-Cja-019029 Callithrix jacchus 69.28 0.00e+00 1070.00
IUUC-Cfa-021127 Canis familiaris 65.67 0.00e+00 1026.00
IUUC-Cpo-022553 Cavia porcellus 61.79 0.00e+00 927.00
IUUC-Csa-023187 Chlorocebus sabaeus 64.55 0.00e+00 716.00
IUUC-Cho-024937 Choloepus hoffmanni 67.02 5.00e-71 262.00
IUUC-Dno-029326 Dasypus novemcinctus 64.84 0.00e+00 976.00
IUUC-Dor-030808 Dipodomys ordii 55.78 0.00e+00 659.00
IUUC-Ete-032746 Echinops telfairi 48.64 3.00e-151 529.00
IUUC-Eca-033234 Equus caballus 66.36 0.00e+00 982.00
IUUC-Fca-035648 Felis catus 68.35 0.00e+00 1075.00
IUUC-Ggo-044927 Gorilla gorilla 68.97 0.00e+00 1109.00
IUUC-Hsa-045861 Homo sapiens 68.81 0.00e+00 1109.00
IUUC-Itr-047861 Ictidomys tridecemlineatus 69.19 0.00e+00 1131.00
IUUC-Loc-052276 Lepisosteus oculatus 32.15 7.00e-48 185.00
IUUC-Laf-054059 Loxodonta africana 64.87 0.00e+00 1004.00
IUUC-Meu-056495 Macropus eugenii 51.55 3.00e-96 346.00
IUUC-Mga-059224 Meleagris gallopavo 40.37 8.00e-35 142.00
IUUC-Mmr-061507 Microcebus murinus 64.12 0.00e+00 1019.00
IUUC-Mdo-062196 Monodelphis domestica 41.93 4.00e-169 588.00
IUUC-Mmu-063118 Mus musculus 83.39 0.00e+00 1440.00
IUUC-Mpu-066024 Mustela putorius furo 61.95 0.00e+00 962.00
IUUC-Mlu-066980 Myotis lucifugus 64.35 0.00e+00 978.00
IUUC-Nle-069779 Nomascus leucogenys 68.79 0.00e+00 1053.00
IUUC-Ocu-074016 Oryctolagus cuniculus 59.17 0.00e+00 907.00
IUUC-Oga-089085 Otolemur garnettii 58.87 0.00e+00 905.00
IUUC-Oar-089980 Ovis aries 62.50 0.00e+00 993.00
IUUC-Ptr-091681 Pan troglodytes 68.69 0.00e+00 1101.00
IUUC-Pan-091965 Papio anubis 67.96 0.00e+00 1032.00
IUUC-Psi-093577 Pelodiscus sinensis 34.99 4.00e-102 365.00
IUUC-Pab-098215 Pongo abelii 63.30 4.00e-157 548.00
IUUC-Pca-100883 Procavia capensis 60.76 0.00e+00 709.00
IUUC-Pva-102465 Pteropus vampyrus 60.16 0.00e+00 662.00
IUUC-Sar-113320 Sorex araneus 58.70 3.00e-81 296.00
IUUC-Ssc-116042 Sus scrofa 63.90 0.00e+00 1015.00
IUUC-Tbe-127880 Tupaia belangeri 66.57 1.00e-122 434.00
Created Date 25-Jun-2017

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