iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Gac-041761

Ensembl Protein ID

ENSGACP00000001881.1

UniProt Accession

G3N991; G3N991_GASAC

Protein Name

tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; WD repeat-containing protein 4

Gene Name

wdr4; WDR4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000001454.1	ENSGACT00000001884.1	ENSGACP00000001881.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.30e-08	33.1	203	227

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 14   tllvsGsdDgtikvWDlrtgvllks 38
           + l+sGs+Dgt+k+W++ +g++l+s
   Q: 203  HWLLSGSGDGTMKLWEYESGRKLQS 227
           569******************9986 PP

Organism

Gasterosteus aculeatus

Functional Description
(View)

Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

Protein Sequence
(Fasta)

MHTTSMTAVG FCGEWLIVTC DKKLVAINTK QARERFVFDC STAEKKPADG NDAGASEEVG 60
RDKVLAFAVS SSGKLVALTD DSKRLVLFRC EPSWQCISIR WVVRRCTSLM FNKAEDALLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTCGCGTGG GCCGCCGTTG CGTGTCCCAT GCACACAACA AGCATGACTG CCGTTGGTTT 60
CTGTGGAGAG TGGTTGATCG TCACATGCGA CAAGAAGCTC GTAGCCATCA ACACCAAACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0819--tRNA processing
KW-0853--WD repeat

Interpro

IPR028884--Trm82
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0036265--P:RNA (guanine-N7)-methylation
GO:0030488--P:tRNA methylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000556	Aegilops tauschii	27.14	5.00e-09	55.50
IUUC-Atr-002431	Amborella trichopoda	36.71	8.00e-09	52.80
IUUC-Apl-003975	Anas platyrhynchos	44.02	4.00e-80	291.00
IUUC-Aca-005170	Anolis carolinensis	44.61	2.00e-72	266.00
IUUC-Aly-005769	Arabidopsis lyrata	27.30	5.00e-23	102.00
IUUC-Ath-006733	Arabidopsis thaliana	27.11	3.00e-24	106.00
IUUC-Acl-008151	Aspergillus clavatus	43.43	2.00e-15	77.00
IUUC-Afl-008518	Aspergillus flavus	30.08	2.00e-18	86.70
IUUC-Afu-009102	Aspergillus fumigatus	26.92	7.00e-17	82.00
IUUC-Ani-009442	Aspergillus nidulans	27.31	5.00e-15	75.90
IUUC-Aor-010133	Aspergillus oryzae	25.06	3.00e-19	89.70
IUUC-Ate-010465	Aspergillus terreus	28.45	2.00e-15	77.40
IUUC-Ame-010613	Astyanax mexicanus	51.83	1.00e-110	392.00
IUUC-Bgr-012067	Blumeria graminis	32.50	6.00e-18	85.50
IUUC-Bta-012788	Bos taurus	43.09	4.00e-80	291.00
IUUC-Bdi-014458	Brachypodium distachyon	34.41	3.00e-13	69.70
IUUC-Bol-016398	Brassica oleracea	32.09	1.00e-24	107.00
IUUC-Bra-016644	Brassica rapa	36.22	2.00e-23	104.00
IUUC-Cpo-021963	Cavia porcellus	42.89	5.00e-79	287.00
IUUC-Csa-024148	Chlorocebus sabaeus	42.02	7.00e-69	254.00
IUUC-Cne-026834	Cryptococcus neoformans	34.78	2.00e-21	97.40
IUUC-Dre-028427	Danio rerio	53.45	1.00e-115	409.00
IUUC-Dno-028881	Dasypus novemcinctus	38.14	3.00e-64	239.00
IUUC-Dor-030522	Dipodomys ordii	43.30	4.00e-84	305.00
IUUC-Dme-032136	Drosophila melanogaster	34.60	6.00e-22	98.60
IUUC-Fca-035833	Felis catus	47.52	1.00e-78	286.00
IUUC-Fal-037497	Ficedula albicollis	43.36	6.00e-81	294.00
IUUC-Gga-040547	Gallus gallus	43.31	3.00e-79	288.00
IUUC-Gma-043722	Glycine max	33.00	2.00e-19	90.10
IUUC-Ggo-045340	Gorilla gorilla	43.88	2.00e-74	273.00
IUUC-Hsa-046403	Homo sapiens	44.41	5.00e-76	278.00
IUUC-Hvu-047643	Hordeum vulgare	29.02	3.00e-17	82.80
IUUC-Itr-048103	Ictidomys tridecemlineatus	44.41	3.00e-87	315.00
IUUC-Kpa-049283	Komagataella pastoris	31.58	9.00e-16	77.80
IUUC-Lch-050682	Latimeria chalumnae	44.70	3.00e-85	308.00
IUUC-Lpe-050712	Leersia perrieri	31.10	1.00e-21	97.80
IUUC-Loc-052599	Lepisosteus oculatus	50.79	2.00e-111	395.00
IUUC-Laf-054390	Loxodonta africana	45.21	2.00e-85	309.00
IUUC-Mcc-054747	Macaca mulatta	44.41	3.00e-74	272.00
IUUC-Mtr-058600	Medicago truncatula	35.26	3.00e-23	102.00
IUUC-Mla-059129	Melampsora laricipopulina	28.41	1.00e-13	70.10
IUUC-Mga-059876	Meleagris gallopavo	43.90	1.00e-81	296.00
IUUC-Mvi-060359	Microbotryum violaceum	32.12	6.00e-13	69.30
IUUC-Mmr-061518	Microcebus murinus	43.43	2.00e-81	296.00
IUUC-Mac-065625	Musa acuminata	31.79	2.00e-19	90.10
IUUC-Nfi-068402	Neosartorya fischeri	28.84	4.00e-15	76.30
IUUC-Nle-069914	Nomascus leucogenys	42.82	1.00e-68	253.00
IUUC-Ont-071555	Oreochromis niloticus	66.58	1.00e-142	499.00
IUUC-Oan-072951	Ornithorhynchus anatinus	45.76	1.00e-84	306.00
IUUC-Ocu-074679	Oryctolagus cuniculus	43.16	2.00e-75	276.00
IUUC-Oba-075355	Oryza barthii	24.19	7.00e-10	58.50
IUUC-Obr-076769	Oryza brachyantha	28.75	2.00e-23	103.00
IUUC-Ogl-077168	Oryza glaberrima	28.94	2.00e-23	103.00
IUUC-Ogu-078275	Oryza glumaepatula	23.87	2.00e-09	57.40
IUUC-Oin-079207	Oryza indica	28.94	2.00e-23	103.00
IUUC-Oni-082437	Oryza nivara	22.83	3.00e-09	56.60
IUUC-Opu-084031	Oryza punctata	29.90	2.00e-23	103.00
IUUC-Oru-084380	Oryza rufipogon	23.87	2.00e-09	57.40
IUUC-Osa-085327	Oryza sativa	28.62	4.00e-23	102.00
IUUC-Ola-086716	Oryzias latipes	55.15	8.00e-117	413.00
IUUC-Olu-087708	Ostreococcus lucimarinus	28.30	1.00e-14	74.30
IUUC-Oar-090239	Ovis aries	43.57	2.00e-80	292.00
IUUC-Ptr-090851	Pan troglodytes	43.88	7.00e-75	274.00
IUUC-Pan-092558	Papio anubis	42.55	2.00e-69	256.00
IUUC-Psi-093792	Pelodiscus sinensis	39.68	4.00e-78	285.00
IUUC-Ppa-095757	Physcomitrella patens	30.71	7.00e-22	98.20
IUUC-Pfo-096465	Poecilia formosa	60.26	1.00e-136	479.00
IUUC-Pab-097722	Pongo abelii	46.35	3.00e-77	281.00
IUUC-Pop-098979	Populus trichocarpa	33.68	3.00e-20	93.20
IUUC-Pca-100753	Procavia capensis	42.86	1.00e-51	196.00
IUUC-Ppe-101515	Prunus persica	29.13	4.00e-21	95.50
IUUC-Sja-107780	Schizosaccharomyces japonicus	26.64	3.00e-12	66.20
IUUC-Spo-108251	Schizosaccharomyces pombe	27.76	3.00e-13	69.30
IUUC-Smo-108938	Selaginella moellendorffii	29.55	6.00e-22	98.60
IUUC-Sit-110020	Setaria italica	28.78	2.00e-20	93.20
IUUC-Sly-111543	Solanum lycopersicum	29.18	1.00e-22	100.00
IUUC-Stu-111925	Solanum tuberosum	28.85	5.00e-22	99.00
IUUC-Sbi-114061	Sorghum bicolor	26.83	2.00e-20	93.60
IUUC-Tgu-117321	Taeniopygia guttata	43.11	2.00e-74	272.00
IUUC-Tru-118454	Takifugu rubripes	63.03	3.00e-131	461.00
IUUC-Tni-119894	Tetraodon nigroviridis	58.22	2.00e-111	395.00
IUUC-Tca-121746	Theobroma cacao	34.54	1.00e-21	97.80
IUUC-Tae-124459	Triticum aestivum	29.02	2.00e-18	87.00
IUUC-Tur-126254	Triticum urartu	25.53	2.00e-10	59.70
IUUC-Tbe-127683	Tupaia belangeri	30.58	8.00e-27	114.00
IUUC-Ttr-129056	Tursiops truncatus	43.05	3.00e-75	275.00
IUUC-Vvi-131428	Vitis vinifera	31.37	4.00e-21	95.50
IUUC-Xma-133605	Xiphophorus maculatus	60.00	2.00e-136	478.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence