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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063669
UUCD1 version UUC-MuM-00574
Ensembl Protein ID ENSMUSP00000110972.2
UniProt Accession Q80TF4; A2AL86; A2AL87; A2AL88; A2AL89; Q9DBY7; KLH13_MOUSE
Genbank Protein ID BAC65773.1; BAB23465.1; CAM13384.1; CAM13385.1; CAM13386.1; CAM13387.1
Protein Name Kelch-like protein 13; BTB and kelch domain-containing protein 2
Genbank Nucleotide ID AK122491; AK004677; AL773552; AL773552; AL773552; AL773552
Gene Name Klhl13; Bklhd2; Kiaa1309
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000036782.13 ENSMUST00000115319.8 ENSMUSP00000110974.2
ENSMUSG00000036782.13 ENSMUST00000115316.8 ENSMUSP00000110971.2
ENSMUSG00000036782.13 ENSMUST00000115317.8 ENSMUSP00000110972.2
ENSMUSG00000036782.13 ENSMUST00000035973.4 ENSMUSP00000041190.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDHINT
Post-translational Modifications (PTMs)
PhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 4.20e-14 53.8 91 159
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 2.50e-06 26.8 192 222
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvg..geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +Dv+l  g  +  +++h++++a++S++F+a+f+++++e++   ++++++v+   +r +++F+Yt kl++n
   Q: 91   CDVTLMPGdtDDAYPVHRVMMASASDYFKAMFTGGMKEQE-LMCIKLHGVSRVGLRKIIDFIYTAKLSLN 159
           8******999****************************98.**************************987 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           l+Nc+++ r+A++y ++++ +++++f+lk+F
   Q: 192  LDNCVEVGRIANTYHLTEVDKYVNSFVLKNF 222
           69****************************9 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis (By similarity).
 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis (By similarity).
Protein Sequence
(Fasta)
MPLKWKTSSP AIWKFPVPVL KTSRSTPLSP AYISLVEEED QHLKLCLGSE MGLSSHLQSC 60
KAGSTRIFTS NSHSSVVLQG FDQLRLDGLL CDVTLMPGDT DDAYPVHRVM MASASDYFKA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063669|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTATCCCCCA CCCCCTGGTG AGGTCAGGCG GAGGCTCTGC CGCTGCGGCC GCAGCAGCTC 60
AGCTCCCATT CCCAGGCAGC TTGGAACAGG GACTTTGGCA AATAACTGGA GCGGCGTTCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063669|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0030496--C:midbody
GO:0000910--P:cytokinesis
GO:0007067--P:mitotic nuclear division
GO:0016567--P:protein ubiquitination
KEGG mmu:67455
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001184 Ailuropoda melanoleuca 94.20 0.00e+00 1224.00
IUUC-Aca-005013 Anolis carolinensis 90.08 0.00e+00 1224.00
IUUC-Ame-011461 Astyanax mexicanus 83.55 0.00e+00 1174.00
IUUC-Bta-012481 Bos taurus 94.35 0.00e+00 1224.00
IUUC-Cja-019972 Callithrix jacchus 94.05 0.00e+00 1222.00
IUUC-Cfa-021230 Canis familiaris 94.05 0.00e+00 1156.00
IUUC-Cpo-022428 Cavia porcellus 93.74 0.00e+00 1219.00
IUUC-Csa-023027 Chlorocebus sabaeus 94.20 0.00e+00 1222.00
IUUC-Dre-028137 Danio rerio 84.60 0.00e+00 1180.00
IUUC-Dno-029077 Dasypus novemcinctus 94.81 0.00e+00 1133.00
IUUC-Dor-030975 Dipodomys ordii 95.11 0.00e+00 1249.00
IUUC-Ete-032431 Echinops telfairi 94.19 0.00e+00 1251.00
IUUC-Eca-033771 Equus caballus 94.35 0.00e+00 1224.00
IUUC-Fca-036060 Felis catus 92.44 0.00e+00 1162.00
IUUC-Fal-037167 Ficedula albicollis 85.54 0.00e+00 970.00
IUUC-Ggo-045388 Gorilla gorilla 94.20 0.00e+00 1222.00
IUUC-Hsa-046694 Homo sapiens 94.20 0.00e+00 1222.00
IUUC-Lch-050402 Latimeria chalumnae 89.77 0.00e+00 1223.00
IUUC-Laf-054306 Loxodonta africana 93.89 0.00e+00 1223.00
IUUC-Mcc-055150 Macaca mulatta 93.89 0.00e+00 1156.00
IUUC-Mga-060174 Meleagris gallopavo 90.38 0.00e+00 1233.00
IUUC-Mmr-061476 Microcebus murinus 94.05 0.00e+00 1158.00
IUUC-Mpu-066379 Mustela putorius furo 93.73 0.00e+00 1185.00
IUUC-Mlu-067214 Myotis lucifugus 94.20 0.00e+00 1222.00
IUUC-Nle-069858 Nomascus leucogenys 93.89 0.00e+00 1155.00
IUUC-Ocu-074431 Oryctolagus cuniculus 94.05 0.00e+00 1223.00
IUUC-Oga-089132 Otolemur garnettii 94.20 0.00e+00 1223.00
IUUC-Oar-090227 Ovis aries 94.35 0.00e+00 1224.00
IUUC-Pan-092417 Papio anubis 94.20 0.00e+00 1222.00
IUUC-Pma-094341 Petromyzon marinus 73.95 0.00e+00 813.00
IUUC-Pca-100332 Procavia capensis 89.62 0.00e+00 1162.00
IUUC-Pva-102590 Pteropus vampyrus 94.05 0.00e+00 1210.00
IUUC-Rno-105802 Rattus norvegicus 99.36 0.00e+00 1296.00
IUUC-Sha-107055 Sarcophilus harrisii 86.26 0.00e+00 1181.00
IUUC-Sar-113034 Sorex araneus 90.38 0.00e+00 1170.00
IUUC-Tgu-117014 Taeniopygia guttata 90.38 0.00e+00 1233.00
IUUC-Tsy-119600 Tarsius syrichta 88.85 0.00e+00 1143.00
IUUC-Tbe-127718 Tupaia belangeri 79.14 0.00e+00 915.00
IUUC-Ttr-128975 Tursiops truncatus 94.35 0.00e+00 1224.00
IUUC-Vpa-130756 Vicugna pacos 90.08 0.00e+00 1146.00
IUUC-Xtr-132681 Xenopus tropicalis 89.16 0.00e+00 1217.00
Created Date 25-Jun-2017

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