iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Rno-105818

Ensembl Protein ID

ENSRNOP00000065542.1

UniProt Accession

M0R7V5; M0R7V5_RAT

Genbank Protein ID

ENSRNOP00000065542

Protein Name

TNF alpha-induced protein 3

Genbank Nucleotide ID

AABR07000482

Gene Name

Tnfaip3; LOC683206

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000049517.1	ENSRNOT00000074583.1	ENSRNOP00000065542.1

Annotation

mRNA Expression
GEO
DNA & RNA Element
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	1.10e-38	133.2	130	299
UBD/ZnF/ZnF_A20	6.10e-25	87.3	781	814

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseyl....qkesdffsefieek........edekefcqklvepe... 74
           ++lkt+gDGnCL++A+ q+++gv+d+d+ l++al ++L+e+ ++++    q es + +ef+e++        +de++++ k+++ +   
   Q: 130  VALKTNGDGNCLMHAACQYMWGVQDTDLvLRKALCSTLKETDTRNFkfrwQLESLKSQEFVETGlcydtrnwNDEWDNLVKMASADtpa 218
           789**********************************************9**********************************99665 PP
   S: 75   akg.......eeihifaLaqiLsrpiivvdvdsles..........kvggillpllfpeek.lkkpivLlYrsgHYdaLva 137
           a++       eeihif+L++iL+rpiiv+++++l+s          kvggi+lpl++p+++ +++pivL+Y+s H+ +Lv+
   Q: 219  ARSglqynslEEIHIFVLSNILRRPIIVISDKMLRSlesgsnfaplKVGGIYLPLHWPAQEcYRYPIVLGYDSQHFVPLVT 299
           5526999************************************************************************97 PP

UBD/ZnF/ZnF_A20

   S: 2    pskllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           p+k++C++ +C+++Gn+++ngyC++Cy+++++++
   Q: 781  PPKQRCRApACDHFGNAKCNGYCNECYQFKQMYG 814
           9*******************************96 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MTRSNTGVSC RQVYGSSVKG RLTEWAFPLP LQALSRTMAE QLLPQALYLS NMRKAVKIRE 60
RTPEDIFKPS NGIIHHFKTM HRYTLEMFRT CQFCPQFREI IHKALIDRSV QASLESQKKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACAAGAT CAAACACTGG GGTTTCCTGC CGGCAGGTAT ATGGGAGCAG TGTAAAAGGC 60
AGGCTAACGG AATGGGCTTT TCCCCTTCCT CTTCAGGCCT TGTCGAGGAC CATGGCTGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR033478--A20
IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0001922--P:B-1 B cell homeostasis
GO:0070301--P:cellular response to hydrogen peroxide
GO:0072666--P:establishment of protein localization to vacuole
GO:0006955--P:immune response
GO:0050869--P:negative regulation of B cell activation
GO:2000349--P:negative regulation of CD40 signaling pathway
GO:0002677--P:negative regulation of chronic inflammatory response
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824--P:negative regulation of innate immune response
GO:0032691--P:negative regulation of interleukin-1 beta production
GO:0032703--P:negative regulation of interleukin-2 production
GO:0032715--P:negative regulation of interleukin-6 production
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0070429--P:negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433--P:negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0031397--P:negative regulation of protein ubiquitination
GO:0048662--P:negative regulation of smooth muscle cell proliferation
GO:0034140--P:negative regulation of toll-like receptor 3 signaling pathway
GO:0034148--P:negative regulation of toll-like receptor 5 signaling pathway
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:1903364--P:positive regulation of cellular protein catabolic process
GO:2000347--P:positive regulation of hepatocyte proliferation
GO:0071947--P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0002634--P:regulation of germinal center formation
GO:0050727--P:regulation of inflammatory response
GO:0045088--P:regulation of innate immune response
GO:0032495--P:response to muramyl dipeptide
GO:0072573--P:tolerance induction to lipopolysaccharide

KEGG

rno:683206

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001825	Ailuropoda melanoleuca	86.85	0.00e+00	1415.00
IUUC-Apl-003501	Anas platyrhynchos	65.49	0.00e+00	1029.00
IUUC-Aca-004245	Anolis carolinensis	63.84	0.00e+00	1050.00
IUUC-Ame-011789	Astyanax mexicanus	46.15	0.00e+00	703.00
IUUC-Bta-012664	Bos taurus	84.59	0.00e+00	1349.00
IUUC-Cja-019895	Callithrix jacchus	87.48	0.00e+00	1421.00
IUUC-Cfa-020754	Canis familiaris	87.74	0.00e+00	1430.00
IUUC-Cpo-021780	Cavia porcellus	86.38	0.00e+00	1404.00
IUUC-Csa-023568	Chlorocebus sabaeus	88.50	0.00e+00	1451.00
IUUC-Cho-024300	Choloepus hoffmanni	88.34	0.00e+00	642.00
IUUC-Dre-028577	Danio rerio	49.62	0.00e+00	694.00
IUUC-Dno-029382	Dasypus novemcinctus	80.38	0.00e+00	1305.00
IUUC-Dor-030874	Dipodomys ordii	84.96	0.00e+00	1367.00
IUUC-Ete-032721	Echinops telfairi	90.67	0.00e+00	796.00
IUUC-Eca-033596	Equus caballus	82.81	0.00e+00	1353.00
IUUC-Eeu-035159	Erinaceus europaeus	83.78	0.00e+00	1069.00
IUUC-Fca-035847	Felis catus	87.74	0.00e+00	1428.00
IUUC-Fal-036681	Ficedula albicollis	64.53	0.00e+00	1041.00
IUUC-Gmo-038521	Gadus morhua	58.72	6.00e-146	511.00
IUUC-Gga-040975	Gallus gallus	63.74	0.00e+00	1046.00
IUUC-Gac-042216	Gasterosteus aculeatus	61.84	8.00e-154	537.00
IUUC-Ggo-045258	Gorilla gorilla	88.13	0.00e+00	1444.00
IUUC-Hsa-046071	Homo sapiens	87.86	0.00e+00	1442.00
IUUC-Itr-048386	Ictidomys tridecemlineatus	89.38	0.00e+00	1447.00
IUUC-Lch-050326	Latimeria chalumnae	57.52	0.00e+00	919.00
IUUC-Loc-051945	Lepisosteus oculatus	44.32	4.00e-178	618.00
IUUC-Laf-053722	Loxodonta africana	85.46	0.00e+00	1388.00
IUUC-Mcc-055503	Macaca mulatta	88.24	0.00e+00	1445.00
IUUC-Meu-056481	Macropus eugenii	73.72	0.00e+00	1150.00
IUUC-Mga-059690	Meleagris gallopavo	62.52	0.00e+00	984.00
IUUC-Mmr-061233	Microcebus murinus	86.38	0.00e+00	1392.00
IUUC-Mdo-062446	Monodelphis domestica	78.20	0.00e+00	1254.00
IUUC-Mmu-063436	Mus musculus	94.59	0.00e+00	1489.00
IUUC-Mpu-066808	Mustela putorius furo	87.10	0.00e+00	1418.00
IUUC-Mlu-067339	Myotis lucifugus	85.88	0.00e+00	1399.00
IUUC-Nle-069888	Nomascus leucogenys	87.74	0.00e+00	1439.00
IUUC-Opr-070303	Ochotona princeps	86.13	0.00e+00	1412.00
IUUC-Ont-072283	Oreochromis niloticus	59.04	7.00e-149	521.00
IUUC-Oan-072925	Ornithorhynchus anatinus	75.50	0.00e+00	1218.00
IUUC-Ocu-073889	Oryctolagus cuniculus	87.29	0.00e+00	1390.00
IUUC-Ola-087417	Oryzias latipes	59.56	4.00e-149	522.00
IUUC-Oga-088708	Otolemur garnettii	84.32	0.00e+00	1318.00
IUUC-Oar-089271	Ovis aries	84.71	0.00e+00	1363.00
IUUC-Ptr-091296	Pan troglodytes	87.86	0.00e+00	1442.00
IUUC-Pan-092474	Papio anubis	87.78	0.00e+00	1459.00
IUUC-Psi-093447	Pelodiscus sinensis	67.79	0.00e+00	1092.00
IUUC-Pfo-096511	Poecilia formosa	59.52	1.00e-150	526.00
IUUC-Pab-098700	Pongo abelii	87.74	0.00e+00	1437.00
IUUC-Pca-100246	Procavia capensis	73.20	0.00e+00	1150.00
IUUC-Pva-102606	Pteropus vampyrus	76.90	4.00e-177	614.00
IUUC-Sha-106559	Sarcophilus harrisii	78.09	0.00e+00	1246.00
IUUC-Sit-110516	Setaria italica	41.86	3.30e-02	34.70
IUUC-Sar-113454	Sorex araneus	92.07	0.00e+00	638.00
IUUC-Ssc-116064	Sus scrofa	85.75	0.00e+00	1372.00
IUUC-Tgu-117212	Taeniopygia guttata	63.84	0.00e+00	1023.00
IUUC-Tru-118230	Takifugu rubripes	59.56	1.00e-151	530.00
IUUC-Tsy-119066	Tarsius syrichta	85.91	0.00e+00	1395.00
IUUC-Tni-119825	Tetraodon nigroviridis	47.83	0.00e+00	681.00
IUUC-Tur-126383	Triticum urartu	50.00	1.20e-02	31.20
IUUC-Tbe-127601	Tupaia belangeri	95.43	0.00e+00	665.00
IUUC-Ttr-128930	Tursiops truncatus	85.24	0.00e+00	1366.00
IUUC-Vpa-130450	Vicugna pacos	94.01	0.00e+00	790.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence