iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-048863

Ensembl Protein ID

ENSSTOP00000006063.2

UniProt Accession

I3M8I7; I3M8I7_ICTTR

Genbank Protein ID

ENSSTOP00000006063

Protein Name

Estrogen receptor; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1

Genbank Nucleotide ID

AGTP01021798

Gene Name

ESR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000006748.2	ENSSTOT00000006781.2	ENSSTOP00000006063.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UMI	90.79	0.00e+00	979.00	IUUC-Hsa-046944

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ictidomys tridecemlineatus

Functional Description
(View)

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Protein Sequence
(Fasta)

MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKMPLERPLG EVYVDSSKPA VFNYPEGAAY 60
EFNASAASAP VYGQSGIAYG PGSEATFGAN NLGGFPQLNS VSPSPLMPPH PPPQLSPFLH 120

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Nucleotide Sequence
(Fasta)

ATGACCATGA CTCTCCACAC CAAAGCATCA GGAATGGCCT TGCTGCACCA GATCCAAGGG 60
AACGAGCTGG AGCCCCTAAA CCGCCCGCAG CTCAAGATGC CCTTGGAGCG GCCCCTGGGT 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0754--Steroid-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001292--Oestr_rcpt
IPR024736--Oestrogen-typ_rcpt_final_C_dom
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF12743--ESR1_C
PF00104--Hormone_recep
PF02159--Oest_recep
PF00105--zf-C4

PRINTS

PR00543--OESTROGENR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000790--C:nuclear chromatin
GO:0005886--C:plasma membrane
GO:0035327--C:transcriptionally active chromatin
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0034056--F:estrogen response element binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0038052--F:RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0008209--P:androgen metabolic process
GO:0001547--P:antral ovarian follicle growth
GO:0071392--P:cellular response to estradiol stimulus
GO:0071391--P:cellular response to estrogen stimulus
GO:0002064--P:epithelial cell development
GO:0060750--P:epithelial cell proliferation involved in mammary gland duct elongation
GO:0008584--P:male gonad development
GO:0060749--P:mammary gland alveolus development
GO:0060745--P:mammary gland branching involved in pregnancy
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:1903799--P:negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060527--P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523--P:prostate epithelial cord elongation
GO:0071168--P:protein localization to chromatin
GO:0042981--P:regulation of apoptotic process
GO:0060687--P:regulation of branching involved in prostate gland morphogenesis
GO:0050727--P:regulation of inflammatory response
GO:0034121--P:regulation of toll-like receptor signaling pathway
GO:0060065--P:uterus development
GO:0060068--P:vagina development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001925	Ailuropoda melanoleuca	92.87	0.00e+00	802.00
IUUC-Apl-003688	Anas platyrhynchos	80.30	0.00e+00	806.00
IUUC-Aca-005222	Anolis carolinensis	77.80	0.00e+00	874.00
IUUC-Ame-010731	Astyanax mexicanus	59.01	1.00e-134	473.00
IUUC-Bta-013112	Bos taurus	84.45	0.00e+00	947.00
IUUC-Cja-019408	Callithrix jacchus	90.95	0.00e+00	994.00
IUUC-Cfa-020694	Canis familiaris	87.12	0.00e+00	955.00
IUUC-Cpo-021426	Cavia porcellus	87.12	0.00e+00	946.00
IUUC-Csa-023736	Chlorocebus sabaeus	92.74	0.00e+00	861.00
IUUC-Dre-027698	Danio rerio	56.11	3.00e-129	455.00
IUUC-Dno-029477	Dasypus novemcinctus	90.06	0.00e+00	756.00
IUUC-Dor-030572	Dipodomys ordii	92.60	0.00e+00	771.00
IUUC-Ete-032849	Echinops telfairi	70.16	0.00e+00	645.00
IUUC-Eca-033605	Equus caballus	85.43	0.00e+00	930.00
IUUC-Eeu-034683	Erinaceus europaeus	90.65	1.00e-108	386.00
IUUC-Fca-035928	Felis catus	91.76	0.00e+00	783.00
IUUC-Fal-036754	Ficedula albicollis	77.68	0.00e+00	883.00
IUUC-Gmo-038872	Gadus morhua	59.06	2.00e-110	392.00
IUUC-Gga-040988	Gallus gallus	78.52	0.00e+00	873.00
IUUC-Gac-042015	Gasterosteus aculeatus	62.44	9.00e-125	440.00
IUUC-Ggo-044749	Gorilla gorilla	91.29	0.00e+00	996.00
IUUC-Hsa-046944	Homo sapiens	90.79	0.00e+00	990.00
IUUC-Loc-052414	Lepisosteus oculatus	59.40	0.00e+00	641.00
IUUC-Mcc-054781	Macaca mulatta	91.12	0.00e+00	994.00
IUUC-Meu-056232	Macropus eugenii	84.54	0.00e+00	930.00
IUUC-Mga-059319	Meleagris gallopavo	79.03	0.00e+00	878.00
IUUC-Mmr-061636	Microcebus murinus	90.44	1.00e-172	598.00
IUUC-Mdo-062661	Monodelphis domestica	85.38	0.00e+00	941.00
IUUC-Mmu-063330	Mus musculus	91.51	0.00e+00	973.00
IUUC-Mpu-065757	Mustela putorius furo	87.48	0.00e+00	989.00
IUUC-Mlu-067712	Myotis lucifugus	88.93	0.00e+00	853.00
IUUC-Nle-069283	Nomascus leucogenys	89.78	0.00e+00	956.00
IUUC-Opr-070391	Ochotona princeps	88.40	0.00e+00	995.00
IUUC-Ont-071369	Oreochromis niloticus	56.03	7.00e-117	414.00
IUUC-Oan-073734	Ornithorhynchus anatinus	72.75	3.00e-129	454.00
IUUC-Ocu-074292	Oryctolagus cuniculus	90.33	0.00e+00	988.00
IUUC-Oba-075103	Oryza barthii	27.85	2.00e-03	37.40
IUUC-Ogu-079042	Oryza glumaepatula	27.85	3.00e-04	39.70
IUUC-Olo-080944	Oryza longistaminata	24.77	7.00e-04	37.00
IUUC-Oni-082560	Oryza nivara	27.85	1.00e-03	37.40
IUUC-Ola-087052	Oryzias latipes	49.06	1.00e-126	446.00
IUUC-Oga-088586	Otolemur garnettii	90.13	0.00e+00	974.00
IUUC-Oar-090156	Ovis aries	91.28	0.00e+00	823.00
IUUC-Ptr-091321	Pan troglodytes	91.29	0.00e+00	996.00
IUUC-Pan-092851	Papio anubis	90.95	0.00e+00	992.00
IUUC-Psi-093434	Pelodiscus sinensis	78.15	0.00e+00	911.00
IUUC-Pfo-097379	Poecilia formosa	53.68	2.00e-130	459.00
IUUC-Pab-097735	Pongo abelii	91.12	0.00e+00	993.00
IUUC-Pva-102125	Pteropus vampyrus	87.42	0.00e+00	965.00
IUUC-Rno-106121	Rattus norvegicus	91.36	0.00e+00	972.00
IUUC-Sha-107547	Sarcophilus harrisii	85.88	0.00e+00	942.00
IUUC-Sar-113650	Sorex araneus	81.16	4.00e-179	620.00
IUUC-Tgu-117175	Taeniopygia guttata	78.19	0.00e+00	888.00
IUUC-Tru-117545	Takifugu rubripes	50.00	4.00e-132	465.00
IUUC-Tsy-119586	Tarsius syrichta	86.87	0.00e+00	736.00
IUUC-Tni-120121	Tetraodon nigroviridis	48.62	8.00e-132	463.00
IUUC-Tbe-127548	Tupaia belangeri	81.17	7.00e-180	623.00
IUUC-Ttr-128374	Tursiops truncatus	81.41	0.00e+00	865.00
IUUC-Vpa-130464	Vicugna pacos	81.25	5.00e-153	533.00
IUUC-Xtr-132171	Xenopus tropicalis	70.25	0.00e+00	736.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence