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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063941
UUCD1 version UUC-MuM-00230
Ensembl Protein ID ENSMUSP00000136449.1
UniProt Accession Q69ZR2; HECD1_MOUSE
Genbank Protein ID BAD32384.1
Protein Name E3 ubiquitin-protein ligase HECTD1; HECT domain-containing protein 1; HECT-type E3 ubiquitin transferase HECTD1; Protein open mind
Genbank Nucleotide ID AC159644
Gene Name Hectd1; Kiaa1131; Opm
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000035247.15 ENSMUST00000179265.7 ENSMUSP00000136449.1
ENSMUSG00000035247.15 ENSMUST00000042052.8 ENSMUSP00000046766.8
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
circBasemicroRNATRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 1.20e-120 404.0 2157 2618
Active Site
Position(s) Description Evidence
2587 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysen..dketlqpnpdsglknp..................... 65
           ++d+k++levef+gEeg++l G+t+ef+al+++e+q++dlg +l+++n  d+e+++++   glk+p                     
   Q: 2157 HADRKSVLEVEFLGEEGTGL-GPTLEFYALVAAEFQRTDLGTWLCDDNfpDDESRHVDLGGGLKPPgyyvqrscglftapfpqdsde 2242
           6899****************.******************************************988********************* PP
   S: 66   ..ehlklFeflGrllgkalqdgrlldlplsksfykll.................................................. 100
             + +klF+flG++l+k++qd+rl+dlp+sk+f+kl+                                                  
   Q: 2243 leRITKLFHFLGIFLAKCIQDNRLVDLPISKPFFKLMcmgdiksnmskliyesrgdrdlhctesqseasteeghdslsvgsfeedsk 2329
           *************************************99999999999999999999999999999999999999988888888887 PP
   S: 101  ...............lgkklsledleevdpelykslkeikenaes..................................dieelgld 138
                          ++  l++ed+e v+p+++++lkeik++a +                                  +ie+lgl+
   Q: 2330 sefildppkpkppawFNGILTWEDFELVNPHRARFLKEIKDLAIKrrqilgnkslsedekntklqelvlrnpsgsgpplSIEDLGLN 2416
           7777777777766666668***********************9334455555667777788899999999999************** PP
   S: 139  ltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafr...eGfneviplellslFteeelellicGee 222
           ++f++s++i+g t+++ Lkp+Ge++++t++N+eeYv+l++++++++gi++q+eafr   +Gfn+v+p+e+ls+F++ee+++++cG+ 
   Q: 2417 FQFCPSSRIYGFTAVD-LKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRgnvDGFNKVFPMEKLSSFSHEEVQMILCGN- 2501
           *************999.**************************************97778**************************. PP
   S: 223  eidvedlkket..ky...kggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnT 303
             +++++++e+  +y   k gyt+dsp++ +F++vl+++ss+erkafLqF+Tg+s+lP+gG+a+l+prl+v+rk da+d+++Ps+nT
   Q: 2502 --QSPSWAAEDiiNYtepKLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKvDATDASYPSVNT 2586
           ..6666666665555555********************************************************************* PP
   S: 304  CfnyLkLPeYsskeilkekLlyAieetkgFels 336
           C++yLkLPeYss+ei++e+Ll+A++e kgF+l+
   Q: 2587 CVHYLKLPEYSSEEIMRERLLAATME-KGFHLN 2618
           **************************.****86 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in development of the head mesenchyme and neural tube closure.
 Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in development of the head mesenchyme and neural tube closure.
Protein Sequence
(Fasta)
MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP RTFLPALCKI 60
FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK ALCNRLVVVE LNNRTSRDLA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063941|E3,HECT|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TCCTGCCCCC GCCCGGCTGG CGATGGACGC GGCGTCTCCC CGCTGCCGCC GACGGCCCCG 60
CGCGGACCTG GCTCTGAACC GCAGGGTCTG AGGAGCCGCG TGCTGGGGTC GGGACCCGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063941|E3,HECT|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
PS51416--MIB_HERC2
Pfam

PF12796--Ank_2
PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC
SMART

SM00248--ANK
SM00119--HECTc
Gene Ontology

GO:0046872--F:metal ion binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0035904--P:aorta development
GO:0001892--P:embryonic placenta development
GO:0003170--P:heart valve development
GO:0001779--P:natural killer cell differentiation
GO:1903077--P:negative regulation of protein localization to plasma membrane
GO:0001843--P:neural tube closure
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0060708--P:spongiotrophoblast differentiation
GO:0060707--P:trophoblast giant cell differentiation
GO:0003281--P:ventricular septum development
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001987 Ailuropoda melanoleuca 98.20 0.00e+00 4609.00
IUUC-Apl-003493 Anas platyrhynchos 94.74 0.00e+00 4465.00
IUUC-Aca-004521 Anolis carolinensis 95.53 0.00e+00 2766.00
IUUC-Ame-011258 Astyanax mexicanus 90.26 0.00e+00 2347.00
IUUC-Bta-012835 Bos taurus 98.09 0.00e+00 4617.00
IUUC-Cel-018153 Caenorhabditis elegans 52.47 2.00e-168 588.00
IUUC-Cja-019174 Callithrix jacchus 97.44 0.00e+00 4567.00
IUUC-Cfa-021115 Canis familiaris 97.94 0.00e+00 4558.00
IUUC-Cpo-022382 Cavia porcellus 94.37 0.00e+00 4396.00
IUUC-Csa-023230 Chlorocebus sabaeus 98.32 0.00e+00 4615.00
IUUC-Cho-024711 Choloepus hoffmanni 95.47 0.00e+00 1637.00
IUUC-Cin-025342 Ciona intestinalis 52.98 0.00e+00 1371.00
IUUC-Csv-026031 Ciona savignyi 51.72 0.00e+00 1407.00
IUUC-Dre-027435 Danio rerio 86.88 0.00e+00 4089.00
IUUC-Dno-029954 Dasypus novemcinctus 97.98 0.00e+00 4576.00
IUUC-Dor-030734 Dipodomys ordii 96.89 0.00e+00 1483.00
IUUC-Dme-031739 Drosophila melanogaster 59.54 0.00e+00 1629.00
IUUC-Ete-033192 Echinops telfairi 97.92 0.00e+00 701.00
IUUC-Eca-033434 Equus caballus 98.05 0.00e+00 4608.00
IUUC-Eeu-035031 Erinaceus europaeus 83.38 2.00e-169 589.00
IUUC-Fca-035998 Felis catus 96.49 0.00e+00 4494.00
IUUC-Fal-037468 Ficedula albicollis 94.27 0.00e+00 2765.00
IUUC-Gmo-038495 Gadus morhua 90.72 0.00e+00 1362.00
IUUC-Gga-040736 Gallus gallus 96.19 0.00e+00 2775.00
IUUC-Gac-041777 Gasterosteus aculeatus 90.81 0.00e+00 2387.00
IUUC-Ggo-044677 Gorilla gorilla 94.21 0.00e+00 4364.00
IUUC-Hsa-045879 Homo sapiens 98.32 0.00e+00 4615.00
IUUC-Itr-048664 Ictidomys tridecemlineatus 98.20 0.00e+00 4616.00
IUUC-Lch-050444 Latimeria chalumnae 91.04 0.00e+00 4149.00
IUUC-Loc-051986 Lepisosteus oculatus 87.68 0.00e+00 4125.00
IUUC-Laf-054230 Loxodonta africana 98.17 0.00e+00 4580.00
IUUC-Mcc-054787 Macaca mulatta 98.32 0.00e+00 4615.00
IUUC-Meu-056502 Macropus eugenii 89.20 0.00e+00 1335.00
IUUC-Mga-059409 Meleagris gallopavo 90.43 0.00e+00 2061.00
IUUC-Mmr-061667 Microcebus murinus 97.94 0.00e+00 4593.00
IUUC-Mdo-061960 Monodelphis domestica 96.79 0.00e+00 4565.00
IUUC-Mpu-065939 Mustela putorius furo 98.09 0.00e+00 4608.00
IUUC-Mlu-068112 Myotis lucifugus 97.78 0.00e+00 4566.00
IUUC-Nle-069001 Nomascus leucogenys 98.24 0.00e+00 4614.00
IUUC-Opr-071222 Ochotona princeps 93.57 0.00e+00 2088.00
IUUC-Ont-072101 Oreochromis niloticus 91.97 0.00e+00 2447.00
IUUC-Oan-072814 Ornithorhynchus anatinus 96.45 0.00e+00 4518.00
IUUC-Ocu-074011 Oryctolagus cuniculus 98.20 0.00e+00 4610.00
IUUC-Ola-086412 Oryzias latipes 90.44 0.00e+00 2373.00
IUUC-Oar-089668 Ovis aries 98.13 0.00e+00 4611.00
IUUC-Ptr-090517 Pan troglodytes 98.20 0.00e+00 4600.00
IUUC-Pan-091849 Papio anubis 95.61 0.00e+00 4437.00
IUUC-Psi-093390 Pelodiscus sinensis 93.03 0.00e+00 2678.00
IUUC-Pma-094628 Petromyzon marinus 82.60 0.00e+00 1564.00
IUUC-Pfo-097075 Poecilia formosa 91.20 0.00e+00 2415.00
IUUC-Pab-098176 Pongo abelii 98.32 0.00e+00 4615.00
IUUC-Pca-101123 Procavia capensis 93.00 0.00e+00 2460.00
IUUC-Pva-103008 Pteropus vampyrus 93.61 0.00e+00 1897.00
IUUC-Rno-105885 Rattus norvegicus 98.74 0.00e+00 4632.00
IUUC-Sha-107048 Sarcophilus harrisii 95.43 0.00e+00 4492.00
IUUC-Sar-113071 Sorex araneus 93.19 0.00e+00 1264.00
IUUC-Ssc-115963 Sus scrofa 97.78 0.00e+00 4589.00
IUUC-Tgu-117167 Taeniopygia guttata 92.98 0.00e+00 2601.00
IUUC-Tru-118626 Takifugu rubripes 92.17 0.00e+00 2467.00
IUUC-Tsy-119504 Tarsius syrichta 95.58 0.00e+00 2280.00
IUUC-Tni-119877 Tetraodon nigroviridis 91.34 0.00e+00 2407.00
IUUC-Tbe-127602 Tupaia belangeri 88.89 0.00e+00 1014.00
IUUC-Ttr-128394 Tursiops truncatus 97.48 0.00e+00 3116.00
IUUC-Vpa-130280 Vicugna pacos 97.47 0.00e+00 4402.00
IUUC-Xtr-131787 Xenopus tropicalis 85.61 0.00e+00 2559.00
Created Date 25-Jun-2017

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