iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028262

UUCD1 version

UUC-DaR-00140

Ensembl Protein ID

ENSDARP00000085530.4

UniProt Accession

B0EVP6; B0EVP6_DANRE

Genbank Protein ID

ABM68035.1; CBY83941.1

Protein Name

Suppressor of cytokine signaling 5-like; Suppressor of cytokine signaling 5b; Suppressor of cytokine-signaling 5b

Genbank Nucleotide ID

BX004962; FR750005

Gene Name

socs5b; SOCS5L

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000062745.7	ENSDART00000091097.5	ENSDARP00000085530.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.50e-13	51.3	494	540

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 4    lwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
           ++l r+ p+SLqhL R +I+r+++++++    +LPLP+ ++d+L++++y+
   Q: 494  APLHRTFPFSLQHLARSSICRHTTYDGI---GALPLPPTMQDFLKEYHYK 540
           6778999*********************...****************985 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MWGNLRSRCQ ALFHSDGSES HLCSQDLDCA HCVLDLDRGA HAEPYETRSS TPSRNLSPLP 60
LATGGRRSHN CVADIPQIVE ISIDKESEDA RRGPLVRRDS YSRHAPWGGK KKHSCSTKTQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CATTAATCAT TCATCCCTTG GCACTCATGC ATTATCTCGA GTCTCCACGT TTTCAGGGTG 60
GCAACGGAGG CAACGCTCTC TCAACTTGCA ATCTGATTGG TTGGCCAGCA CGCTCGTCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR022252--SOCS4/SOCS5_dom
IPR028420--SOCS5
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF12610--SOCS
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007259--P:JAK-STAT cascade
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination

KEGG

dre:559639

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000371	Aegilops tauschii	35.85	1.60e-01	29.30
IUUC-Aml-001789	Ailuropoda melanoleuca	51.74	7.00e-99	354.00
IUUC-Apl-003815	Anas platyrhynchos	64.18	0.00e+00	646.00
IUUC-Aca-004504	Anolis carolinensis	62.32	8.00e-179	620.00
IUUC-Ame-010677	Astyanax mexicanus	79.17	0.00e+00	819.00
IUUC-Bta-012338	Bos taurus	64.32	0.00e+00	640.00
IUUC-Bol-016597	Brassica oleracea	36.59	1.00e-01	32.00
IUUC-Cja-019828	Callithrix jacchus	64.08	0.00e+00	632.00
IUUC-Cfa-020369	Canis familiaris	63.73	0.00e+00	642.00
IUUC-Cpo-021397	Cavia porcellus	64.48	0.00e+00	648.00
IUUC-Csa-023856	Chlorocebus sabaeus	64.50	0.00e+00	643.00
IUUC-Cho-024700	Choloepus hoffmanni	48.28	2.00e-102	366.00
IUUC-Dno-029019	Dasypus novemcinctus	64.15	0.00e+00	648.00
IUUC-Dor-030273	Dipodomys ordii	51.75	8.00e-100	357.00
IUUC-Dme-031965	Drosophila melanogaster	65.34	2.00e-70	260.00
IUUC-Ete-032972	Echinops telfairi	54.01	2.00e-94	339.00
IUUC-Eca-033867	Equus caballus	64.67	0.00e+00	650.00
IUUC-Eeu-035208	Erinaceus europaeus	48.79	1.00e-87	316.00
IUUC-Fca-035806	Felis catus	64.36	0.00e+00	637.00
IUUC-Fal-037117	Ficedula albicollis	63.83	0.00e+00	641.00
IUUC-Gmo-039066	Gadus morhua	92.17	2.00e-120	426.00
IUUC-Gga-040876	Gallus gallus	63.10	0.00e+00	637.00
IUUC-Gac-042149	Gasterosteus aculeatus	74.96	0.00e+00	724.00
IUUC-Ggo-045169	Gorilla gorilla	63.38	0.00e+00	640.00
IUUC-Hsa-045805	Homo sapiens	64.50	0.00e+00	643.00
IUUC-Hvu-047122	Hordeum vulgare	44.83	1.10e-01	30.40
IUUC-Itr-049048	Ictidomys tridecemlineatus	64.08	0.00e+00	647.00
IUUC-Lch-049686	Latimeria chalumnae	63.59	1.00e-176	612.00
IUUC-Loc-051745	Lepisosteus oculatus	70.37	0.00e+00	659.00
IUUC-Laf-054124	Loxodonta africana	65.25	0.00e+00	655.00
IUUC-Mcc-055175	Macaca mulatta	64.50	0.00e+00	643.00
IUUC-Meu-056557	Macropus eugenii	64.07	0.00e+00	647.00
IUUC-Mtr-057670	Medicago truncatula	37.50	3.90e-01	29.30
IUUC-Mga-059214	Meleagris gallopavo	64.30	0.00e+00	644.00
IUUC-Mvi-060418	Microbotryum violaceum	30.86	2.20e-01	29.30
IUUC-Mmr-060613	Microcebus murinus	51.76	2.00e-130	459.00
IUUC-Mdo-062788	Monodelphis domestica	63.89	0.00e+00	631.00
IUUC-Mmu-064333	Mus musculus	64.72	0.00e+00	639.00
IUUC-Mpu-066048	Mustela putorius furo	63.73	0.00e+00	639.00
IUUC-Mlu-067430	Myotis lucifugus	63.59	0.00e+00	627.00
IUUC-Nle-069086	Nomascus leucogenys	64.85	0.00e+00	654.00
IUUC-Opr-070312	Ochotona princeps	66.13	0.00e+00	634.00
IUUC-Ont-072299	Oreochromis niloticus	74.78	0.00e+00	751.00
IUUC-Ocu-074123	Oryctolagus cuniculus	65.48	0.00e+00	626.00
IUUC-Ola-086934	Oryzias latipes	76.24	0.00e+00	756.00
IUUC-Oga-088535	Otolemur garnettii	64.36	0.00e+00	645.00
IUUC-Oar-089875	Ovis aries	64.15	0.00e+00	641.00
IUUC-Ptr-090541	Pan troglodytes	64.50	0.00e+00	643.00
IUUC-Pan-092416	Papio anubis	64.50	0.00e+00	643.00
IUUC-Psi-092960	Pelodiscus sinensis	64.11	0.00e+00	649.00
IUUC-Pma-094222	Petromyzon marinus	81.76	5.00e-84	305.00
IUUC-Pfo-096930	Poecilia formosa	75.35	0.00e+00	744.00
IUUC-Pab-098659	Pongo abelii	64.50	0.00e+00	643.00
IUUC-Pca-100222	Procavia capensis	65.36	0.00e+00	655.00
IUUC-Pva-102387	Pteropus vampyrus	63.80	0.00e+00	639.00
IUUC-Rno-105698	Rattus norvegicus	64.72	0.00e+00	645.00
IUUC-Sha-107234	Sarcophilus harrisii	63.44	0.00e+00	627.00
IUUC-Sar-113698	Sorex araneus	63.96	6.00e-179	620.00
IUUC-Ssc-115985	Sus scrofa	64.23	0.00e+00	643.00
IUUC-Tgu-116676	Taeniopygia guttata	64.06	0.00e+00	645.00
IUUC-Tru-118441	Takifugu rubripes	66.61	4.00e-171	594.00
IUUC-Tsy-119163	Tarsius syrichta	61.52	1.00e-173	603.00
IUUC-Tni-120436	Tetraodon nigroviridis	75.58	0.00e+00	754.00
IUUC-Tca-121131	Theobroma cacao	29.49	1.30e-01	30.80
IUUC-Tvi-122265	Trichoderma virens	45.83	4.80e-01	30.40
IUUC-Tae-124846	Triticum aestivum	35.85	2.00e-01	28.90
IUUC-Tbe-127353	Tupaia belangeri	64.01	0.00e+00	638.00
IUUC-Ttr-128907	Tursiops truncatus	63.80	0.00e+00	628.00
IUUC-Vpa-130140	Vicugna pacos	63.62	0.00e+00	638.00
IUUC-Xtr-132817	Xenopus tropicalis	60.25	0.00e+00	627.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence