iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ptr-091434

Ensembl Protein ID

ENSPTRP00000006946.5

UniProt Accession

H2Q4D0; H2Q4D0_PANTR

Genbank Protein ID

ENSPTRP00000006946

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AACZ03079585

Gene Name

ATG16L2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000004039.5	ENSPTRT00000007529.5	ENSPTRP00000006946.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.60e-28	96.4	335	365
UBD/Beta-Prp	1.50e-46	158.9	333	619

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           H ++v++++f ++  ll++G+ D  i++W++
   Q: 335  HLSEVNAVRFgPNsSLLATGGADRLIHLWNV 365
           99*********7779***************7 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkl..lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkgh 93
           ++h s +++v f p++sllatg++d+ i +w+v    l   ++l+g  + +t+v+f+p+g   + +   +++++w +   +   tl+gh
   Q: 333  DAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLeaNQTLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGH 421
           6899999****************************99988899*****************888888889******************** PP
   S: 94   edsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtds 182
           +d+v++ +f  +++  v+Gs+drt++ wdl   +c++ t ++ +    c  v + + +++sG++D+++r+Wd++   + +      +++
   Q: 422  KDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSR-TINVLS---YCNDVVCGDHIIISGHNDQKIRFWDSRGPHCTQVIP--VQGR 504
           ************************************9.666655...4555555556*************************5..589* PP
   S: 183  vyslsfdsngkelvsgsldgtvklwdlqtgec.....vrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnss 266
           v+sls+++++ +l+s+s+d+t+k+ dl+ +++      + +++ +d++k   fsp+  + + gs+Dg ++iWd+++g+l + lq+++ +
   Q: 505  VTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIrqvfrADGFKCGSDWTK-AVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQGPHCT 592
           ****************************888833334444555556666.8899*********************************77 PP
   S: 267  visvavlsfgdnvlvlgsedskvniwk 293
            +   +++++++++v++++  kv +w+
   Q: 593  AVNAVAWCYSGSHMVSVDQGRKVVLWQ 619
           7777778****************9995 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MAGPGVPGAP AARWKRHIVR QLRLRDRTQK ALFLELVPAY NHLLEKAELL DKFSKKLQPE 60
PNTVTPTTHQ GPWEESELDS DQVPSLVALR VKWQEEEEGL RLVCGEVSWE GVKWGREGKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGGGC CGGGCGTCCC CGGTGCCCCC GCAGCGCGCT GGAAACGCCA CATCGTGCGG 60
CAGCTGCGGC TTCGGGACCG TACGCAAAAG GCGCTTTTCC TGGAGCTGGT GCCGGCCTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR013923--Autophagy-rel_prot_16
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08614--ATG16
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0000421--C:autophagosome membrane
GO:0005654--C:nucleoplasm
GO:0000045--P:autophagosome assembly
GO:0039689--P:negative stranded viral RNA replication

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001470	Ailuropoda melanoleuca	68.62	0.00e+00	744.00
IUUC-Atr-003073	Amborella trichopoda	31.42	8.00e-27	114.00
IUUC-Aca-004664	Anolis carolinensis	72.49	2.00e-99	354.00
IUUC-Ame-011152	Astyanax mexicanus	41.21	7.00e-113	400.00
IUUC-Bta-013118	Bos taurus	83.09	0.00e+00	906.00
IUUC-Cja-020002	Callithrix jacchus	88.08	0.00e+00	976.00
IUUC-Cfa-020878	Canis familiaris	80.65	0.00e+00	890.00
IUUC-Cpo-022476	Cavia porcellus	81.66	0.00e+00	890.00
IUUC-Csa-024134	Chlorocebus sabaeus	92.11	0.00e+00	1028.00
IUUC-Cho-024853	Choloepus hoffmanni	71.22	2.00e-177	615.00
IUUC-Dre-027949	Danio rerio	40.72	6.00e-123	434.00
IUUC-Dno-029683	Dasypus novemcinctus	82.23	0.00e+00	760.00
IUUC-Dor-030897	Dipodomys ordii	76.33	0.00e+00	899.00
IUUC-Ete-032957	Echinops telfairi	92.83	2.00e-130	459.00
IUUC-Eca-033303	Equus caballus	90.12	3.00e-162	564.00
IUUC-Eeu-035336	Erinaceus europaeus	74.01	5.00e-153	534.00
IUUC-Fca-036232	Felis catus	83.28	0.00e+00	969.00
IUUC-Gmo-038880	Gadus morhua	50.00	4.00e-71	262.00
IUUC-Ggo-045130	Gorilla gorilla	99.26	0.00e+00	751.00
IUUC-Hsa-046359	Homo sapiens	96.39	0.00e+00	999.00
IUUC-Itr-048780	Ictidomys tridecemlineatus	84.50	0.00e+00	942.00
IUUC-Lch-050669	Latimeria chalumnae	54.22	6.00e-95	340.00
IUUC-Loc-052789	Lepisosteus oculatus	42.51	9.00e-113	400.00
IUUC-Laf-053699	Loxodonta africana	84.03	0.00e+00	912.00
IUUC-Mcc-055657	Macaca mulatta	89.34	0.00e+00	933.00
IUUC-Meu-056639	Macropus eugenii	49.39	4.00e-103	368.00
IUUC-Mmr-061314	Microcebus murinus	78.53	0.00e+00	819.00
IUUC-Mdo-061841	Monodelphis domestica	62.92	0.00e+00	674.00
IUUC-Mmu-064065	Mus musculus	81.15	0.00e+00	913.00
IUUC-Mpu-066742	Mustela putorius furo	81.19	0.00e+00	870.00
IUUC-Mlu-067019	Myotis lucifugus	88.59	0.00e+00	675.00
IUUC-Nle-069037	Nomascus leucogenys	94.91	0.00e+00	1048.00
IUUC-Opr-071039	Ochotona princeps	79.81	0.00e+00	886.00
IUUC-Oan-073431	Ornithorhynchus anatinus	71.91	2.00e-138	485.00
IUUC-Ocu-074772	Oryctolagus cuniculus	82.02	0.00e+00	822.00
IUUC-Ola-086964	Oryzias latipes	52.61	2.00e-83	301.00
IUUC-Oga-088188	Otolemur garnettii	83.74	0.00e+00	878.00
IUUC-Oar-090231	Ovis aries	77.06	0.00e+00	882.00
IUUC-Pan-091868	Papio anubis	93.05	0.00e+00	1009.00
IUUC-Psi-093652	Pelodiscus sinensis	63.89	1.00e-164	572.00
IUUC-Pab-097776	Pongo abelii	90.15	0.00e+00	972.00
IUUC-Pca-100220	Procavia capensis	64.41	4.00e-172	597.00
IUUC-Pva-103135	Pteropus vampyrus	84.57	0.00e+00	862.00
IUUC-Rno-105529	Rattus norvegicus	79.39	0.00e+00	939.00
IUUC-Sha-107062	Sarcophilus harrisii	62.86	0.00e+00	700.00
IUUC-Sar-113109	Sorex araneus	67.24	1.00e-132	466.00
IUUC-Ssc-115271	Sus scrofa	84.27	0.00e+00	888.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence