iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-027554

UUCD1 version

UUC-DaR-01291

Ensembl Protein ID

ENSDARP00000042217.5

UniProt Accession

Q7T394; Q07DR1; LIS1A_DANRE

Genbank Protein ID

ABA29742.1; CAX13814.1; AAH53205.1

Protein Name

Lissencephaly-1 homolog A; Platelet-activating factor acetylhydrolase IB subunit alpha a

Genbank Nucleotide ID

DQ141217; BX324162; BC053205

Gene Name

pafah1b1a; lis1b; si:dkey-95O3.1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000032013.6	ENSDART00000042218.5	ENSDARP00000042217.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.80e-56	186.4	190	228
UBD/Beta-Prp	5.40e-93	312.4	107	410

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH   v+++a  ++ +++vs+s+D+tik+W++ tg ++k
   Q: 190  GHDHNVSSVAImPNgDHIVSASRDKTIKMWEVATGYCVK 228
           899*******99777********************9987 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           h s++t v f+p  s+++++s+d+tikvwd +tg++ r+l+gh++ v++++f+++gk+l+++s D+tik+wd++ ++c++t++gh+++v
   Q: 107  HRSPVTRVIFHPVFSVIVSASEDATIKVWDHETGDFERTLKGHTDSVQDISFDHTGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNV 195
           5668888********************************************************************************** PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
            s++++p+gd++vs+s+d+ti++w++ tg+c++ t++gh+++v++v+ ++dg l++s+s+D+tvr+W ++t+++  +l++ h++ v+++
   Q: 196  SSVAIMPNGDHIVSASRDKTIKMWEVATGYCVK-TFTGHREWVRMVRPNQDGTLIASSSNDQTVRVWVVATKECKAELRE-HEHVVECI 282
           *********************************.*********************************************9.******** PP
   S: 187  sfdsng....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
           s+ +++                    ++l+sgs+d+t+k+wd++ g c++tl gh+++v+ v ++p ++++vs+++D+++riWd++++ 
   Q: 283  SWAPESahptileatgsetkksgkpgPFLLSGSRDKTIKMWDVSIGMCLMTLVGHDNWVRGVLVHPGGKYIVSCADDKTLRIWDYKNKR 371
           ***************************************************************************************** PP
   S: 256  llktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
           ++ktl+ h++ v+s ++ + + +++v+gs d++v++w+++
   Q: 372  CTKTLSAHEHFVTSLDF-HKTAPYVVTGSVDQTVKVWECR 410
           *****************.99*****************985 PP

Organism

Danio rerio

Functional Description
(View)

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.

Protein Sequence
(Fasta)

MVLSQRQRDE LNRAIADYLR SNGYEEAYSV FKKEAELDMN EELDKKYAGL LEKKWTSVIR 60
LQKKVMELES KLNEAKEEIN IGGPIGQKRD PKEWIPRPPE KYALSGHRSP VTRVIFHPVF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCCTGCAGA AGTCAGCCGA TGCGCGCCCC CGTGCCGTGT AGAGGCGAAT GCGGCGCTGC 60
AAGGAGGCAG ACCCCGAGAC TTCAGCCCCC CTTTTCAACA CGAAAATAAC ACTTTTGTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0493--Microtubule
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:1904115--C:axon cytoplasm
GO:0005938--C:cell cortex
GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0000776--C:kinetochore
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0008017--F:microtubule binding
GO:0048854--P:brain morphogenesis
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007281--P:germ cell development
GO:0031023--P:microtubule organizing center organization
GO:0007067--P:mitotic nuclear division
GO:0022008--P:neurogenesis
GO:0007097--P:nuclear migration
GO:2000574--P:regulation of microtubule motor activity
GO:0008090--P:retrograde axonal transport
GO:0047496--P:vesicle transport along microtubule

KEGG

dre:394246

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001589	Ailuropoda melanoleuca	94.49	0.00e+00	794.00
IUUC-Ago-007862	Ashbya gossypii	27.46	2.00e-39	157.00
IUUC-Ang-009873	Aspergillus niger	44.33	7.00e-93	334.00
IUUC-Dor-030222	Dipodomys ordii	86.59	0.00e+00	734.00
IUUC-Dse-031164	Dothistroma septosporum	43.10	6.00e-100	357.00
IUUC-Eca-034288	Equus caballus	93.98	0.00e+00	789.00
IUUC-Fso-038160	Fusarium solani	43.40	2.00e-96	346.00
IUUC-Gmo-038983	Gadus morhua	94.39	0.00e+00	816.00
IUUC-Ggr-040051	Gaeumannomyces graminis	45.35	1.00e-97	350.00
IUUC-Lch-049936	Latimeria chalumnae	94.88	0.00e+00	817.00
IUUC-Loc-052476	Lepisosteus oculatus	96.24	0.00e+00	807.00
IUUC-Lma-053170	Leptosphaeria maculans	45.71	1.00e-97	350.00
IUUC-Mcc-054628	Macaca mulatta	94.15	0.00e+00	813.00
IUUC-Mpo-057583	Magnaporthe poae	45.52	1.00e-93	336.00
IUUC-Mla-058819	Melampsora laricipopulina	48.09	5.00e-118	417.00
IUUC-Mmr-061289	Microcebus murinus	94.49	0.00e+00	793.00
IUUC-Mdo-061912	Monodelphis domestica	93.90	0.00e+00	808.00
IUUC-Mlu-067267	Myotis lucifugus	93.14	0.00e+00	799.00
IUUC-Ncr-068895	Neurospora crassa	48.41	8.00e-104	370.00
IUUC-Nle-069087	Nomascus leucogenys	95.22	0.00e+00	668.00
IUUC-Oga-088219	Otolemur garnettii	92.42	0.00e+00	795.00
IUUC-Pan-092421	Papio anubis	94.15	0.00e+00	813.00
IUUC-Pca-100120	Procavia capensis	70.30	2.00e-158	551.00
IUUC-Pva-102960	Pteropus vampyrus	94.39	0.00e+00	811.00
IUUC-Ptt-103990	Puccinia triticina	42.46	2.00e-44	174.00
IUUC-Sce-106208	Saccharomyces cerevisiae	27.90	5.00e-36	145.00
IUUC-Sha-107010	Sarcophilus harrisii	93.66	0.00e+00	807.00
IUUC-Sja-107899	Schizosaccharomyces japonicus	33.03	2.00e-65	243.00
IUUC-Sar-113309	Sorex araneus	93.73	0.00e+00	785.00
IUUC-Tre-121977	Trichoderma reesei	43.43	3.00e-100	358.00
IUUC-Xtr-131985	Xenopus tropicalis	94.63	0.00e+00	816.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence