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Tag Content
iUUCD ID IUUC-Nfi-068571
Ensembl Protein ID CADNFIAP00004828
UniProt Accession A1DP19; LIS1_NEOFI
Genbank Protein ID EAW16540.1
Protein Name Nuclear distribution protein nudF; Lissencephaly-1 homolog
Genbank Nucleotide ID DS027698
Gene Name NFIA_058910; nudF; lis1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
CADNFIAG00004956 CADNFIAT00004956 CADNFIAP00004828
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 6.50e-50 164.0 174 221
UBD/Beta-Prp 2.90e-66 222.7 87 381
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..........sdtllvsGsdDgtikvWDlrtgvllks 38
    gH sv++++f s++llvs+s+D+t+++WD++tg ++k+
   Q: 174 GHDHSVSSVRFipsgaagspmSGNLLVSASRDKTLRIWDVTTGYCVKT 221
    8*****************976669*******************99875 PP
   


   UBD/Beta-Prp

   S: 8    hhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk..ilvtgseDrtikvwdls.tgkcvhtlkghedsv 97
    h +++tcv+f+p s la+gs+d tik+wd++ g l r+++gh+++v +v++ + +l+++s+D tik+wd+s ++k ++tl gh++sv
   Q: 87 GHREPVTCVAFHPVFSSLASGSDDTTIKIWDWELGELERTVKGHTKAVLDVDYGGPRGgtLLASCSSDLTIKLWDPSdNYKNIRTLPGHDHSV 179
    466799***********************************************7544446**************88779************** PP
   S: 98 lslsfsp........sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtds 182
    s++f p sg+ lvs+s+d+t+r+wd+ tg+c++ tlsgh ++v+ v+ + dg+ l+++++Dr+ rlWdl++++ t+ g h++
   Q: 180 SSVRFIPsgaagspmSGNLLVSASRDKTLRIWDVTTGYCVK-TLSGHVDWVRAVAPSLDGRFLFAAGDDRIPRLWDLSSAETKSTFLG-HEHV 270
    *****999999999999************************.******************9999999********************9.**** PP
   S: 183 vysls.....................fdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsg 254
    +++++ ++s+ +++++gs+d+t++lwd +g+ ++tl gh+++v+ ++f+p +++l+s+++D++ir+Wdl++
   Q: 271 IECVAiapaasyphlavlsglkkpppVSSSAEFFATGSRDKTIRLWDS-RGNLIKTLVGHDNWVRALAFHPGGKHLLSVADDKTIRCWDLTQE 362
    *****66666666666666666666655555****************8.7889************************************9765 PP
   S: 255 .dllktlqlhn.......s 265
    +++++++ +
   Q: 363 cKCVRVISDAHghfvtclR 381
    4899999998854444440 PP
   

Organism Neosartorya fischeri
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
Protein Sequence
(Fasta)
MSQLLTARQA EELHKSIIAY LASVNLTESS AALRAELGDS VSIDDATLKK YEGLLEKKWT 60
SVVRLQKKNQ DPTSWLPRSP ARHILEGHRE PVTCVAFHPV FSSLASGSDD TTIKIWDWEL 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Nfi-068571|E3,WD_repeat;UBD,Beta-Prp|Neosartorya fischeri
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAGCCAGC TACTCACGGC GCGGCAGGCA GAGGAGCTGT ACGTCATTGC TCCTGGGTTA 60
CAATAACTGA AAAAGACTGA GGAGGAAAGG GTGTGACGCT GACATCGCTC AAAATGTTCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Nfi-068571|E3,WD_repeat;UBD,Beta-Prp|Neosartorya fischeri
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0000922--C:spindle pole
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0006810--P:transport

KEGG nfi:NFIA_058910
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 45.45 2.00e-96 343.00
IUUC-Apl-004024 Anas platyrhynchos 45.57 1.00e-99 354.00
IUUC-Aca-004564 Anolis carolinensis 45.07 3.00e-97 347.00
IUUC-Ago-007862 Ashbya gossypii 29.73 1.00e-33 135.00
IUUC-Acl-008360 Aspergillus clavatus 86.30 0.00e+00 762.00
IUUC-Afl-008502 Aspergillus flavus 58.81 1.00e-145 508.00
IUUC-Afu-008848 Aspergillus fumigatus 92.29 0.00e+00 871.00
IUUC-Ani-009173 Aspergillus nidulans 57.08 1.00e-150 524.00
IUUC-Ang-009873 Aspergillus niger 54.53 7.00e-146 508.00
IUUC-Aor-009973 Aspergillus oryzae 62.08 1.00e-154 537.00
IUUC-Ate-010523 Aspergillus terreus 56.34 2.00e-152 530.00
IUUC-Ame-010969 Astyanax mexicanus 45.81 4.00e-100 356.00
IUUC-Bgr-011972 Blumeria graminis 65.10 4.00e-180 622.00
IUUC-Bta-013106 Bos taurus 45.57 1.00e-99 354.00
IUUC-Bci-013615 Botrytis cinerea 70.30 0.00e+00 642.00
IUUC-Cel-018459 Caenorhabditis elegans 41.00 1.00e-86 311.00
IUUC-Cja-018755 Callithrix jacchus 45.10 4.00e-97 346.00
IUUC-Cfa-020749 Canis familiaris 45.57 1.00e-99 354.00
IUUC-Cpo-022371 Cavia porcellus 45.57 1.00e-99 354.00
IUUC-Csa-023524 Chlorocebus sabaeus 48.90 3.00e-87 313.00
IUUC-Cho-024764 Choloepus hoffmanni 43.10 1.00e-81 294.00
IUUC-Cin-025753 Ciona intestinalis 42.57 1.00e-88 318.00
IUUC-Csv-025817 Ciona savignyi 42.23 2.00e-92 330.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 69.91 0.00e+00 632.00
IUUC-Cne-027087 Cryptococcus neoformans 50.73 5.00e-109 385.00
IUUC-Dre-028314 Danio rerio 45.57 4.00e-100 356.00
IUUC-Dno-029050 Dasypus novemcinctus 45.57 1.00e-99 354.00
IUUC-Dor-030222 Dipodomys ordii 42.00 5.00e-90 322.00
IUUC-Dse-031164 Dothistroma septosporum 63.69 9.00e-172 594.00
IUUC-Dme-031745 Drosophila melanogaster 43.68 9.00e-92 328.00
IUUC-Ete-032508 Echinops telfairi 47.79 2.00e-70 257.00
IUUC-Eca-034288 Equus caballus 44.95 8.00e-96 342.00
IUUC-Eeu-034984 Erinaceus europaeus 41.75 8.00e-89 318.00
IUUC-Fca-036498 Felis catus 45.57 1.00e-99 354.00
IUUC-Fal-036920 Ficedula albicollis 45.57 1.00e-99 354.00
IUUC-Fox-037996 Fusarium oxysporum 64.68 2.00e-178 616.00
IUUC-Fso-038160 Fusarium solani 65.87 6.00e-177 611.00
IUUC-Gmo-038983 Gadus morhua 44.66 6.00e-100 355.00
IUUC-Ggr-040051 Gaeumannomyces graminis 60.92 3.00e-162 562.00
IUUC-Gga-040623 Gallus gallus 45.57 1.00e-99 354.00
IUUC-Gac-041613 Gasterosteus aculeatus 44.74 9.00e-100 355.00
IUUC-Ggo-045410 Gorilla gorilla 42.78 1.00e-79 288.00
IUUC-Hsa-046358 Homo sapiens 45.57 9.00e-100 355.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 45.57 1.00e-99 354.00
IUUC-Kpa-049351 Komagataella pastoris 29.50 8.00e-42 162.00
IUUC-Lch-049936 Latimeria chalumnae 44.18 1.00e-99 355.00
IUUC-Loc-052476 Lepisosteus oculatus 45.71 2.00e-96 344.00
IUUC-Lma-053170 Leptosphaeria maculans 70.66 0.00e+00 630.00
IUUC-Laf-053713 Loxodonta africana 44.72 1.00e-97 347.00
IUUC-Mcc-054628 Macaca mulatta 45.57 2.00e-99 353.00
IUUC-Meu-055927 Macropus eugenii 38.97 7.00e-51 192.00
IUUC-Mor-056962 Magnaporthe oryzae 62.90 7.00e-173 598.00
IUUC-Mpo-057583 Magnaporthe poae 61.52 6.00e-157 545.00
IUUC-Mla-058819 Melampsora laricipopulina 43.46 3.00e-104 370.00
IUUC-Mga-059945 Meleagris gallopavo 45.32 3.00e-99 353.00
IUUC-Mvi-060403 Microbotryum violaceum 47.88 5.00e-118 416.00
IUUC-Mmr-061289 Microcebus murinus 45.05 1.00e-96 344.00
IUUC-Mdo-061912 Monodelphis domestica 45.07 1.00e-98 351.00
IUUC-Mmu-063253 Mus musculus 45.57 1.00e-99 354.00
IUUC-Mpu-066638 Mustela putorius furo 45.57 1.00e-99 354.00
IUUC-Mlu-067267 Myotis lucifugus 44.69 9.00e-97 345.00
IUUC-Ncr-068895 Neurospora crassa 66.45 3.00e-174 602.00
IUUC-Nle-069087 Nomascus leucogenys 43.63 3.00e-81 293.00
IUUC-Opr-070579 Ochotona princeps 45.57 1.00e-99 354.00
IUUC-Ont-071905 Oreochromis niloticus 45.81 4.00e-100 356.00
IUUC-Oan-073072 Ornithorhynchus anatinus 45.57 1.00e-99 354.00
IUUC-Ocu-074180 Oryctolagus cuniculus 45.57 1.00e-99 354.00
IUUC-Ola-086772 Oryzias latipes 45.39 2.00e-100 357.00
IUUC-Oga-088219 Otolemur garnettii 44.72 2.00e-97 347.00
IUUC-Oar-090394 Ovis aries 45.57 1.00e-99 354.00
IUUC-Ptr-091517 Pan troglodytes 45.57 1.00e-99 354.00
IUUC-Pan-092421 Papio anubis 45.57 2.00e-99 353.00
IUUC-Psi-093370 Pelodiscus sinensis 45.57 2.00e-99 354.00
IUUC-Pma-094319 Petromyzon marinus 48.01 2.00e-86 310.00
IUUC-Pno-094815 Phaeosphaeria nodorum 70.02 0.00e+00 647.00
IUUC-Pfo-097089 Poecilia formosa 45.39 5.00e-101 359.00
IUUC-Pab-098421 Pongo abelii 45.57 1.00e-99 354.00
IUUC-Pca-100120 Procavia capensis 37.86 8.00e-61 225.00
IUUC-Pva-102960 Pteropus vampyrus 45.32 2.00e-98 350.00
IUUC-Pgr-103538 Puccinia graminis 47.06 6.00e-112 395.00
IUUC-Ptt-103990 Puccinia triticina 42.34 2.00e-38 152.00
IUUC-Pte-104261 Pyrenophora teres 70.51 0.00e+00 644.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 70.30 0.00e+00 643.00
IUUC-Rno-105123 Rattus norvegicus 45.57 1.00e-99 354.00
IUUC-Sce-106208 Saccharomyces cerevisiae 25.74 4.00e-28 117.00
IUUC-Sha-107010 Sarcophilus harrisii 45.07 2.00e-98 350.00
IUUC-Sja-107899 Schizosaccharomyces japonicus 35.39 5.00e-64 236.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 70.72 2.00e-177 613.00
IUUC-Sar-113309 Sorex araneus 44.70 1.00e-93 335.00
IUUC-Sre-115003 Sporisorium reilianum 48.39 8.00e-118 415.00
IUUC-Ssc-116148 Sus scrofa 45.57 1.00e-99 354.00
IUUC-Tgu-117299 Taeniopygia guttata 45.57 2.00e-99 354.00
IUUC-Tru-117721 Takifugu rubripes 45.59 9.00e-100 355.00
IUUC-Tsy-119493 Tarsius syrichta 45.57 2.00e-98 350.00
IUUC-Tni-120355 Tetraodon nigroviridis 44.50 9.00e-99 352.00
IUUC-Tre-121977 Trichoderma reesei 60.29 2.00e-156 543.00
IUUC-Tvi-122661 Trichoderma virens 61.39 3.00e-154 536.00
IUUC-Tme-127031 Tuber melanosporum 62.23 1.00e-171 593.00
IUUC-Tbe-127492 Tupaia belangeri 40.07 9.00e-48 182.00
IUUC-Ttr-128929 Tursiops truncatus 45.57 3.00e-99 353.00
IUUC-Uma-129347 Ustilago maydis 48.50 4.00e-115 406.00
IUUC-Vda-129837 Verticillium dahliae 68.38 3.00e-174 602.00
IUUC-Vpa-130532 Vicugna pacos 38.75 7.00e-79 285.00
IUUC-Xtr-131985 Xenopus tropicalis 45.81 3.00e-100 356.00
IUUC-Xma-133314 Xiphophorus maculatus 45.39 5.00e-101 359.00
IUUC-Yli-134403 Yarrowia lipolytica 40.78 3.00e-99 353.00
Created Date 25-Jun-2017

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