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Tag Content
iUUCD ID IUUC-Ont-072432
Ensembl Protein ID ENSONIP00000010247.1
UniProt Accession I3JN03; I3JN03_ORENI
Genbank Protein ID ENSONIP00000010247
Protein Name Lissencephaly-1 homolog
Genbank Nucleotide ID AERX01052037
Gene Name pafah1b1b (1 of many); LOC106098161; LIS1; PAFAH1B1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSONIG00000008138.1 ENSONIT00000010256.1 ENSONIP00000010247.1
ENSONIG00000008138.1 ENSONIT00000010257.1 ENSONIP00000010248.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.80e-59 194.8 336 374
UBD/Beta-Prp 9.80e-95 317.6 107 410
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
    gH ++v+++ f ++ +++v+++dD+t+++WD++ ++ k
   Q: 336 GHDNWVRGILFhPGgKFIVTCADDKTLRIWDYKNKRCMK 374
    8***********999****************99998876 PP
   


   UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
    h s++t v f+p s+++++s+d+tikvwd++tg++ r+l+gh++ v++++f+++gk+l+++s D+tik+wd++ ++c++t++gh+++v
   Q: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHTGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNV 195
    5668888********************************************************************************** PP
   S: 98 lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
    s++++p+gd++vs+s+d+ti++w++ tg+c++ t++gh+++v++v+ ++dg l++s+s+D+tvr+W ++++++ +l++ h++ v+++
   Q: 196 SSVAIMPNGDHIVSASRDKTIKMWEVATGYCVK-TFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVASKECKAELRE-HEHVVECI 282
    *********************************.*********************************************9.******** PP
   S: 187 sfdsng....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
    s+ +++ ++l+sgs+d+t+k+wd++tg c++tl gh+++v+ + f+p ++++v++++D+++riWd++++
   Q: 283 SWAPESaystildatgseskksgkpgPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGILFHPGGKFIVTCADDKTLRIWDYKNKR 371
    ***************************************************************************************** PP
   S: 256 llktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
    ++ktl+ h++ v+s ++ + +++v+gs d++v++w+++
   Q: 372 CMKTLSAHEHFVTSLDF-HKAAPYVVTGSVDQTVKVWECR 410
    *****************.999****************985 PP
   

Organism Oreochromis niloticus
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.
Protein Sequence
(Fasta)
MVLSQRQRDE LNRAIADYLR SNGYEEAYST FKKEAELDNN EELDKKYAGL LEKKWTSVIR 60
LQKKVMELES KLNEAKDELT LGGPVTQKRD PKEWIPRPPE KYALSGHRSP VTRVIFHPVF 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Ont-072432|E3,WD_repeat;UBD,Beta-Prp|Oreochromis niloticus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCGTGAACG CGAATTCCGT GCGCGTACCC GGCCGAAGTC GAATGCGGTA GTGTACGAAA 60
AAAAAAAACA AGCGAGCGGA GCCGACAGGA GACAAGACGG CCACAGTTTA CCTCCACATC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Ont-072432|E3,WD_repeat;UBD,Beta-Prp|Oreochromis niloticus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0493--Microtubule
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0005815--C:microtubule organizing center
GO:0030154--P:cell differentiation
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007067--P:mitotic nuclear division
GO:0007399--P:nervous system development
GO:0006810--P:transport

Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 94.49 0.00e+00 799.00
IUUC-Apl-004024 Anas platyrhynchos 94.63 0.00e+00 821.00
IUUC-Aca-004564 Anolis carolinensis 93.90 0.00e+00 813.00
IUUC-Acl-008360 Aspergillus clavatus 46.55 3.00e-104 372.00
IUUC-Afl-008502 Aspergillus flavus 45.17 1.00e-93 336.00
IUUC-Afu-008848 Aspergillus fumigatus 46.48 3.00e-106 379.00
IUUC-Ani-009173 Aspergillus nidulans 42.93 3.00e-91 328.00
IUUC-Ang-009873 Aspergillus niger 44.33 1.00e-93 336.00
IUUC-Aor-009973 Aspergillus oryzae 43.69 2.00e-91 329.00
IUUC-Ate-010523 Aspergillus terreus 42.61 5.00e-91 328.00
IUUC-Ame-010969 Astyanax mexicanus 95.37 0.00e+00 826.00
IUUC-Bgr-011972 Blumeria graminis 47.26 2.00e-104 373.00
IUUC-Bta-013106 Bos taurus 94.63 0.00e+00 822.00
IUUC-Bci-013615 Botrytis cinerea 44.82 1.00e-98 353.00
IUUC-Cel-018459 Caenorhabditis elegans 56.69 2.00e-148 519.00
IUUC-Cja-018755 Callithrix jacchus 92.20 0.00e+00 801.00
IUUC-Cfa-020749 Canis familiaris 94.63 0.00e+00 822.00
IUUC-Cpo-022371 Cavia porcellus 94.63 0.00e+00 822.00
IUUC-Csa-023524 Chlorocebus sabaeus 93.62 0.00e+00 690.00
IUUC-Cho-024764 Choloepus hoffmanni 84.37 0.00e+00 650.00
IUUC-Cin-025753 Ciona intestinalis 71.78 0.00e+00 628.00
IUUC-Csv-025817 Ciona savignyi 70.24 0.00e+00 639.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 46.32 4.00e-97 348.00
IUUC-Dre-028314 Danio rerio 94.15 0.00e+00 820.00
IUUC-Dno-029050 Dasypus novemcinctus 94.39 0.00e+00 821.00
IUUC-Dor-030222 Dipodomys ordii 86.59 0.00e+00 739.00
IUUC-Dse-031164 Dothistroma septosporum 43.34 3.00e-101 362.00
IUUC-Ete-032508 Echinops telfairi 78.78 0.00e+00 662.00
IUUC-Eca-034288 Equus caballus 93.98 0.00e+00 795.00
IUUC-Eeu-034984 Erinaceus europaeus 86.34 0.00e+00 736.00
IUUC-Fca-036498 Felis catus 94.63 0.00e+00 822.00
IUUC-Fal-036920 Ficedula albicollis 94.63 0.00e+00 821.00
IUUC-Fox-037996 Fusarium oxysporum 45.93 1.00e-104 373.00
IUUC-Gmo-038983 Gadus morhua 95.61 0.00e+00 824.00
IUUC-Gga-040623 Gallus gallus 94.63 0.00e+00 821.00
IUUC-Gac-041613 Gasterosteus aculeatus 95.85 0.00e+00 829.00
IUUC-Ggo-045410 Gorilla gorilla 84.21 0.00e+00 692.00
IUUC-Hsa-046358 Homo sapiens 94.63 0.00e+00 821.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 94.63 0.00e+00 822.00
IUUC-Lch-049936 Latimeria chalumnae 93.66 0.00e+00 812.00
IUUC-Loc-052476 Lepisosteus oculatus 95.74 0.00e+00 805.00
IUUC-Lma-053170 Leptosphaeria maculans 46.19 8.00e-100 357.00
IUUC-Laf-053713 Loxodonta africana 92.67 0.00e+00 802.00
IUUC-Mcc-054628 Macaca mulatta 94.15 0.00e+00 818.00
IUUC-Meu-055927 Macropus eugenii 81.23 9.00e-135 472.00
IUUC-Mpo-057583 Magnaporthe poae 45.02 8.00e-94 337.00
IUUC-Mga-059945 Meleagris gallopavo 94.39 0.00e+00 820.00
IUUC-Mvi-060403 Microbotryum violaceum 50.45 4.00e-130 457.00
IUUC-Mmr-061289 Microcebus murinus 94.49 0.00e+00 799.00
IUUC-Mdo-061912 Monodelphis domestica 93.90 0.00e+00 814.00
IUUC-Mmu-063253 Mus musculus 94.63 0.00e+00 822.00
IUUC-Mpu-066638 Mustela putorius furo 94.63 0.00e+00 822.00
IUUC-Mlu-067267 Myotis lucifugus 92.89 0.00e+00 803.00
IUUC-Ncr-068895 Neurospora crassa 48.77 2.00e-105 376.00
IUUC-Nle-069087 Nomascus leucogenys 95.22 0.00e+00 671.00
IUUC-Opr-070579 Ochotona princeps 94.39 0.00e+00 821.00
IUUC-Oan-073072 Ornithorhynchus anatinus 94.63 0.00e+00 822.00
IUUC-Ocu-074180 Oryctolagus cuniculus 94.39 0.00e+00 821.00
IUUC-Ola-086772 Oryzias latipes 97.07 0.00e+00 836.00
IUUC-Oga-088219 Otolemur garnettii 92.42 0.00e+00 801.00
IUUC-Oar-090394 Ovis aries 94.63 0.00e+00 822.00
IUUC-Ptr-091517 Pan troglodytes 94.63 0.00e+00 822.00
IUUC-Pan-092421 Papio anubis 94.15 0.00e+00 818.00
IUUC-Psi-093370 Pelodiscus sinensis 94.39 0.00e+00 820.00
IUUC-Pno-094815 Phaeosphaeria nodorum 46.78 1.00e-103 370.00
IUUC-Pfo-097089 Poecilia formosa 97.07 0.00e+00 839.00
IUUC-Pab-098421 Pongo abelii 94.63 0.00e+00 822.00
IUUC-Pca-100120 Procavia capensis 70.05 5.00e-158 550.00
IUUC-Pva-102960 Pteropus vampyrus 94.39 0.00e+00 817.00
IUUC-Ptt-103990 Puccinia triticina 44.31 5.00e-46 179.00
IUUC-Pte-104261 Pyrenophora teres 47.02 9.00e-104 370.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 47.26 4.00e-104 371.00
IUUC-Rno-105123 Rattus norvegicus 94.63 0.00e+00 822.00
IUUC-Sha-107010 Sarcophilus harrisii 93.66 0.00e+00 812.00
IUUC-Sja-107899 Schizosaccharomyces japonicus 33.49 5.00e-67 248.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 44.95 6.00e-99 354.00
IUUC-Sar-113309 Sorex araneus 93.73 0.00e+00 789.00
IUUC-Sre-115003 Sporisorium reilianum 49.54 4.00e-125 441.00
IUUC-Ssc-116148 Sus scrofa 94.63 0.00e+00 822.00
IUUC-Tgu-117299 Taeniopygia guttata 94.39 0.00e+00 818.00
IUUC-Tru-117721 Takifugu rubripes 95.85 0.00e+00 827.00
IUUC-Tsy-119493 Tarsius syrichta 93.66 0.00e+00 808.00
IUUC-Tni-120355 Tetraodon nigroviridis 96.83 0.00e+00 808.00
IUUC-Tre-121977 Trichoderma reesei 43.01 1.00e-100 360.00
IUUC-Tvi-122661 Trichoderma virens 43.41 5.00e-100 358.00
IUUC-Tme-127031 Tuber melanosporum 48.17 2.00e-102 366.00
IUUC-Tbe-127492 Tupaia belangeri 78.46 8.00e-112 397.00
IUUC-Ttr-128929 Tursiops truncatus 94.63 0.00e+00 819.00
IUUC-Uma-129347 Ustilago maydis 48.63 1.00e-124 439.00
IUUC-Vda-129837 Verticillium dahliae 45.43 6.00e-100 357.00
IUUC-Vpa-130532 Vicugna pacos 80.57 0.00e+00 635.00
IUUC-Xtr-131985 Xenopus tropicalis 94.39 0.00e+00 820.00
IUUC-Xma-133314 Xiphophorus maculatus 97.07 0.00e+00 839.00
Created Date 25-Jun-2017

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