iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000008720.1	ENSSHAT00000010172.1	ENSSHAP00000010083.1
ENSSHAG00000008720.1	ENSSHAT00000010173.1	ENSSHAP00000010084.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	3.00e-46	157.4	79	267

Active Site

Position(s)	Description	Evidence
85	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
88	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
261		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 3    ilktkgDGnCLlrAvsqs..........................................................llgvfdddslsda 33
            +ktkgDGnC++rA+++s                                                          ll+vf+d+s sd 
   Q: 79   LRKTKGDGNCFYRALGYSyleslignsreilrfkervlqtpkdllaagfeehkfrnffnafyslvemvekdgsvsnLLKVFNDQSFSDR 167
           689************************************************************************************** PP
   S: 34   lveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklkk 121
           +v++Lr+lts+++++++dff++fi+e++d+k+fc ++vep+a+ +++++i+aL+q+L++p++v++vd++++    +l++++f e++ ++
   Q: 168  IVQFLRLLTSAFIKNRADFFRHFIDEEMDVKDFCAQEVEPMATeCDHVQITALSQALNIPLQVEYVDEMDT----ALNHHVFSEAA-CP 251
           *********************************************************************95....9**********.** PP
   S: 122  pivLlYrsgHYdaLva 137
           +++LlY+++HY++L+a
   Q: 252  SVYLLYKTSHYNILYA 267
           **************95 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

LAALEKSDQE GKKLGKKKEG YSLLTVNCSI YLSVFIFQSE SSFNLISEKC DILSILCDHP 60
ENRIYQRKIQ ELSKRFSALR KTKGDGNCFY RALGYSYLES LIGNSREILR FKERVLQTPK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CATCGTTTTA CGTTTTATTT TTTAAAAGAC ACAAGTTCAT TCAGCGTTTC AAAATGGGAC 60
CAGTCCTTTG AGATTTTTAA CTCTTATAGT TGAGGTTTCT GTCTTTTTAA AAAAAGGTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR003323--OTU_dom
IPR030299--OTUB2
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002059	Ailuropoda melanoleuca	89.57	2.00e-123	434.00
IUUC-Bta-012766	Bos taurus	90.83	1.00e-124	437.00
IUUC-Cja-019480	Callithrix jacchus	88.65	1.00e-121	428.00
IUUC-Cfa-021106	Canis familiaris	90.00	5.00e-124	436.00
IUUC-Cpo-022187	Cavia porcellus	89.18	3.00e-124	436.00
IUUC-Csa-023493	Chlorocebus sabaeus	89.22	7.00e-124	436.00
IUUC-Cho-024411	Choloepus hoffmanni	73.17	3.00e-81	293.00
IUUC-Dno-029346	Dasypus novemcinctus	92.14	4.00e-125	439.00
IUUC-Dor-031012	Dipodomys ordii	90.39	6.00e-124	436.00
IUUC-Ete-032266	Echinops telfairi	83.41	2.00e-112	397.00
IUUC-Eca-033356	Equus caballus	90.87	3.00e-124	437.00
IUUC-Eeu-034775	Erinaceus europaeus	89.08	3.00e-122	430.00
IUUC-Fca-035363	Felis catus	89.57	5.00e-123	432.00
IUUC-Ggo-045023	Gorilla gorilla	88.65	2.00e-121	427.00
IUUC-Hsa-046984	Homo sapiens	89.08	4.00e-122	429.00
IUUC-Itr-048012	Ictidomys tridecemlineatus	89.96	3.00e-123	433.00
IUUC-Lch-050514	Latimeria chalumnae	58.67	1.00e-79	289.00
IUUC-Loc-052003	Lepisosteus oculatus	49.55	4.00e-62	230.00
IUUC-Laf-054382	Loxodonta africana	91.30	7.00e-125	439.00
IUUC-Mcc-055516	Macaca mulatta	88.70	3.00e-122	430.00
IUUC-Meu-056038	Macropus eugenii	98.94	4.00e-110	389.00
IUUC-Mmr-060918	Microcebus murinus	91.27	1.00e-124	437.00
IUUC-Mdo-062638	Monodelphis domestica	100.00	2.00e-135	474.00
IUUC-Mmu-063973	Mus musculus	90.04	3.00e-123	434.00
IUUC-Mpu-066013	Mustela putorius furo	89.96	2.00e-123	434.00
IUUC-Mlu-067509	Myotis lucifugus	87.39	1.00e-119	421.00
IUUC-Nle-069673	Nomascus leucogenys	89.08	4.00e-122	429.00
IUUC-Opr-070761	Ochotona princeps	81.21	2.00e-75	274.00
IUUC-Oan-072922	Ornithorhynchus anatinus	84.65	2.00e-114	404.00
IUUC-Ocu-074643	Oryctolagus cuniculus	89.52	6.00e-123	432.00
IUUC-Oni-082026	Oryza nivara	31.53	2.00e-17	84.00
IUUC-Oru-084761	Oryza rufipogon	31.53	2.00e-17	84.00
IUUC-Ola-086603	Oryzias latipes	45.83	3.00e-51	194.00
IUUC-Oga-088936	Otolemur garnettii	88.70	1.00e-122	431.00
IUUC-Oar-089460	Ovis aries	90.56	9.00e-127	445.00
IUUC-Ptr-090805	Pan troglodytes	88.65	1.00e-121	428.00
IUUC-Pan-091969	Papio anubis	89.08	4.00e-122	429.00
IUUC-Pab-098476	Pongo abelii	89.22	2.00e-123	434.00
IUUC-Pca-100252	Procavia capensis	87.00	4.00e-50	190.00
IUUC-Pva-102204	Pteropus vampyrus	87.77	3.00e-121	427.00
IUUC-Pgr-103552	Puccinia graminis	75.00	3.00e-02	31.20
IUUC-Rno-105062	Rattus norvegicus	89.96	7.00e-123	432.00
IUUC-Sar-113295	Sorex araneus	90.39	1.00e-121	428.00
IUUC-Ssc-115288	Sus scrofa	89.52	1.00e-122	431.00
IUUC-Tni-120440	Tetraodon nigroviridis	40.09	2.00e-41	162.00
IUUC-Tbe-127717	Tupaia belangeri	89.19	4.00e-74	269.00
IUUC-Ttr-128221	Tursiops truncatus	72.49	1.00e-92	332.00
IUUC-Uma-129443	Ustilago maydis	34.56	8.00e-24	103.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence