iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-027747

UUCD1 version

UUC-DaR-00866

Ensembl Protein ID

ENSDARP00000094129.3

UniProt Accession

P59015; Q5SPB8; VPS18_DANRE

Genbank Protein ID

CAI20654.1; CAI11898.1; AAM34648.1; AAH86828.1

Protein Name

Vacuolar protein sorting-associated protein 18 homolog

Genbank Nucleotide ID

AL929049; BX897725; AF506204; BC086828

Gene Name

vps18

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000070433.3	ENSDART00000103352.3	ENSDARP00000094129.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	65.91	0.00e+00	1353.00	IUUC-Hsa-046635

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Danio rerio

Functional Description
(View)

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a core component of the putative HOPS endosomal tethering complex which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). May be involved in vesicle trafficking to the hepatocyte apical membrane and play a role in development of the intra-hepatic biliary tree. May target endosomes to the pigment granule in melanocytes. Essential for early embryonic development.

Protein Sequence
(Fasta)

MASILDQYED SQNIRQHSRM STANIGITHS GFVNVRLEEE KPIFTKQRID FSPPEKINQF 60
SVCNNQLCMS LGKDTLLRID LGKPDQPNQI ELGRKDDSKV HRLFLDPTGS HLVICLTTNE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CATGATATTC ATCAGCTGAC CCAAGACAGA CATGCAACCA ACACAGCTCG GTTTCTCAGA 60
TCTGTCATTC CTTTTTCATT TATAAAAATT CCCTTGGCGC GTAATTTTGT TTTATTTTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0967--Endosome
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000547--Clathrin_H-chain/VPS_repeat
IPR007810--Pep3_Vps18
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50236--CHCR

Pfam

PF00637--Clathrin
PF05131--Pep3_Vps18

Gene Ontology

GO:0005768--C:endosome
GO:0030897--C:HOPS complex
GO:0031902--C:late endosome membrane
GO:0005765--C:lysosomal membrane
GO:0046872--F:metal ion binding
GO:0030674--F:protein binding, bridging
GO:0045176--P:apical protein localization
GO:0015721--P:bile acid and bile salt transport
GO:0007032--P:endosome organization
GO:0008333--P:endosome to lysosome transport
GO:0043485--P:endosome to pigment granule transport
GO:0048069--P:eye pigmentation
GO:0006886--P:intracellular protein transport
GO:0007040--P:lysosome organization
GO:0060036--P:notochord cell vacuolation
GO:0007634--P:optokinetic behavior
GO:0048757--P:pigment granule maturation
GO:0035542--P:regulation of SNARE complex assembly
GO:0006904--P:vesicle docking involved in exocytosis

KEGG

dre:100005887

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000419	Aegilops tauschii	33.37	7.00e-124	438.00
IUUC-Aml-001240	Ailuropoda melanoleuca	65.71	0.00e+00	1356.00
IUUC-Atr-003125	Amborella trichopoda	33.05	4.00e-133	469.00
IUUC-Apl-004181	Anas platyrhynchos	77.21	0.00e+00	1553.00
IUUC-Aca-004437	Anolis carolinensis	74.85	0.00e+00	1507.00
IUUC-Aly-006046	Arabidopsis lyrata	34.64	3.00e-150	526.00
IUUC-Ath-006932	Arabidopsis thaliana	34.18	9.00e-149	521.00
IUUC-Ago-007800	Ashbya gossypii	24.01	6.00e-60	226.00
IUUC-Acl-008035	Aspergillus clavatus	31.57	6.00e-122	432.00
IUUC-Afl-008714	Aspergillus flavus	31.74	4.00e-121	429.00
IUUC-Afu-009063	Aspergillus fumigatus	31.00	6.00e-123	435.00
IUUC-Ani-009384	Aspergillus nidulans	32.14	2.00e-129	457.00
IUUC-Ang-009507	Aspergillus niger	31.30	1.00e-122	434.00
IUUC-Aor-010094	Aspergillus oryzae	31.74	1.00e-120	428.00
IUUC-Ate-010421	Aspergillus terreus	31.79	3.00e-108	386.00
IUUC-Ame-011797	Astyanax mexicanus	90.18	0.00e+00	1782.00
IUUC-Bgr-012107	Blumeria graminis	31.95	5.00e-116	412.00
IUUC-Bta-012339	Bos taurus	65.81	0.00e+00	1391.00
IUUC-Bci-013895	Botrytis cinerea	32.82	8.00e-129	455.00
IUUC-Bdi-014554	Brachypodium distachyon	34.53	5.00e-143	502.00
IUUC-Bol-015270	Brassica oleracea	34.63	2.00e-152	533.00
IUUC-Bra-017424	Brassica rapa	34.44	4.00e-147	516.00
IUUC-Cel-018455	Caenorhabditis elegans	25.88	6.00e-93	335.00
IUUC-Cja-019629	Callithrix jacchus	65.30	0.00e+00	1353.00
IUUC-Cfa-020425	Canis familiaris	65.81	0.00e+00	1350.00
IUUC-Cpo-021349	Cavia porcellus	65.23	0.00e+00	1332.00
IUUC-Cre-022799	Chlamydomonas reinhardtii	29.43	1.00e-27	119.00
IUUC-Csa-023559	Chlorocebus sabaeus	65.61	0.00e+00	1358.00
IUUC-Cho-024862	Choloepus hoffmanni	59.87	0.00e+00	963.00
IUUC-Cin-025599	Ciona intestinalis	44.02	0.00e+00	689.00
IUUC-Csv-026152	Ciona savignyi	46.19	0.00e+00	857.00
IUUC-Cgl-026551	Colletotrichum gloeosporioides	31.86	2.00e-119	423.00
IUUC-Cne-026907	Cryptococcus neoformans	31.45	5.00e-124	439.00
IUUC-Dno-029668	Dasypus novemcinctus	65.54	0.00e+00	1342.00
IUUC-Dor-030404	Dipodomys ordii	61.60	0.00e+00	1263.00
IUUC-Dse-031345	Dothistroma septosporum	32.79	1.00e-125	444.00
IUUC-Dme-031711	Drosophila melanogaster	33.53	2.00e-157	550.00
IUUC-Ete-032308	Echinops telfairi	64.09	0.00e+00	707.00
IUUC-Eca-033637	Equus caballus	65.71	0.00e+00	1355.00
IUUC-Eeu-035151	Erinaceus europaeus	66.22	0.00e+00	1028.00
IUUC-Fca-035585	Felis catus	65.50	0.00e+00	1348.00
IUUC-Fal-037122	Ficedula albicollis	75.56	0.00e+00	1551.00
IUUC-Fox-038030	Fusarium oxysporum	33.40	7.00e-135	474.00
IUUC-Fso-038426	Fusarium solani	32.73	3.00e-137	483.00
IUUC-Gmo-038784	Gadus morhua	85.66	0.00e+00	1718.00
IUUC-Ggr-039973	Gaeumannomyces graminis	31.86	5.00e-125	442.00
IUUC-Gga-040692	Gallus gallus	77.41	0.00e+00	1578.00
IUUC-Gac-041868	Gasterosteus aculeatus	86.06	0.00e+00	1727.00
IUUC-Gma-044274	Glycine max	35.20	4.00e-153	535.00
IUUC-Ggo-045053	Gorilla gorilla	65.71	0.00e+00	1354.00
IUUC-Hsa-046635	Homo sapiens	65.81	0.00e+00	1357.00
IUUC-Hvu-047361	Hordeum vulgare	35.59	2.00e-140	493.00
IUUC-Itr-048868	Ictidomys tridecemlineatus	66.12	0.00e+00	1349.00
IUUC-Kpa-049270	Komagataella pastoris	25.71	3.00e-77	283.00
IUUC-Lch-050188	Latimeria chalumnae	77.80	0.00e+00	1407.00
IUUC-Lpe-051026	Leersia perrieri	35.83	1.00e-147	517.00
IUUC-Loc-051821	Lepisosteus oculatus	85.70	0.00e+00	1722.00
IUUC-Lma-053178	Leptosphaeria maculans	35.11	1.00e-106	380.00
IUUC-Laf-053552	Loxodonta africana	65.61	0.00e+00	1353.00
IUUC-Mcc-054667	Macaca mulatta	65.61	0.00e+00	1352.00
IUUC-Meu-056422	Macropus eugenii	66.30	0.00e+00	662.00
IUUC-Mor-056981	Magnaporthe oryzae	31.77	2.00e-126	446.00
IUUC-Mtr-058703	Medicago truncatula	34.88	5.00e-145	508.00
IUUC-Mla-059088	Melampsora laricipopulina	36.87	3.00e-116	412.00
IUUC-Mga-059798	Meleagris gallopavo	77.41	0.00e+00	1577.00
IUUC-Mvi-060404	Microbotryum violaceum	33.63	2.00e-138	487.00
IUUC-Mmr-061630	Microcebus murinus	65.81	0.00e+00	1354.00
IUUC-Mdo-062354	Monodelphis domestica	65.20	0.00e+00	1382.00
IUUC-Mmu-063199	Mus musculus	65.20	0.00e+00	1343.00
IUUC-Mac-065595	Musa acuminata	36.96	1.00e-126	447.00
IUUC-Mpu-066596	Mustela putorius furo	65.81	0.00e+00	1360.00
IUUC-Mlu-067455	Myotis lucifugus	65.50	0.00e+00	1348.00
IUUC-Nfi-068565	Neosartorya fischeri	30.90	4.00e-124	439.00
IUUC-Ncr-068748	Neurospora crassa	32.46	9.00e-134	471.00
IUUC-Nle-068979	Nomascus leucogenys	66.59	0.00e+00	1218.00
IUUC-Opr-070711	Ochotona princeps	65.40	0.00e+00	1351.00
IUUC-Ont-072603	Oreochromis niloticus	86.67	0.00e+00	1754.00
IUUC-Oan-073136	Ornithorhynchus anatinus	64.97	0.00e+00	692.00
IUUC-Ocu-074496	Oryctolagus cuniculus	65.81	0.00e+00	1354.00
IUUC-Oba-075933	Oryza barthii	34.10	3.00e-130	459.00
IUUC-Obr-076290	Oryza brachyantha	35.44	6.00e-150	525.00
IUUC-Ogu-078728	Oryza glumaepatula	34.10	2.00e-130	460.00
IUUC-Oin-079954	Oryza indica	33.99	9.00e-140	491.00
IUUC-Olo-081033	Oryza longistaminata	33.01	3.00e-122	433.00
IUUC-Ome-081797	Oryza meridionalis	34.53	8.00e-140	491.00
IUUC-Oni-082802	Oryza nivara	34.10	2.00e-130	460.00
IUUC-Opu-083595	Oryza punctata	36.31	1.00e-146	514.00
IUUC-Oru-084199	Oryza rufipogon	34.10	2.00e-130	460.00
IUUC-Osa-085349	Oryza sativa	34.80	3.00e-147	516.00
IUUC-Ola-087482	Oryzias latipes	83.72	0.00e+00	1702.00
IUUC-Olu-087797	Ostreococcus lucimarinus	25.36	1.00e-71	265.00
IUUC-Oga-088817	Otolemur garnettii	65.81	0.00e+00	1365.00
IUUC-Oar-090350	Ovis aries	64.48	0.00e+00	1068.00
IUUC-Ptr-090999	Pan troglodytes	65.61	0.00e+00	1353.00
IUUC-Pan-092704	Papio anubis	65.61	0.00e+00	1352.00
IUUC-Psi-093529	Pelodiscus sinensis	75.77	0.00e+00	1522.00
IUUC-Pma-094400	Petromyzon marinus	60.51	0.00e+00	1221.00
IUUC-Pno-094875	Phaeosphaeria nodorum	33.83	8.00e-130	458.00
IUUC-Ppa-095231	Physcomitrella patens	33.27	1.00e-145	510.00
IUUC-Pfo-096967	Poecilia formosa	85.15	0.00e+00	1709.00
IUUC-Pab-098300	Pongo abelii	65.71	0.00e+00	1354.00
IUUC-Pop-098966	Populus trichocarpa	35.17	1.00e-153	537.00
IUUC-Pca-100643	Procavia capensis	65.40	0.00e+00	1268.00
IUUC-Ppe-101589	Prunus persica	34.56	9.00e-150	524.00
IUUC-Pva-102766	Pteropus vampyrus	65.09	0.00e+00	1306.00
IUUC-Pgr-103330	Puccinia graminis	31.30	3.00e-123	436.00
IUUC-Ptt-103809	Puccinia triticina	33.19	1.00e-109	391.00
IUUC-Pte-104319	Pyrenophora teres	32.93	1.00e-125	444.00
IUUC-Pyt-104798	Pyrenophora triticirepentis	31.00	4.00e-114	406.00
IUUC-Rno-105817	Rattus norvegicus	65.61	0.00e+00	1343.00
IUUC-Sce-106255	Saccharomyces cerevisiae	24.61	3.00e-51	197.00
IUUC-Sha-107479	Sarcophilus harrisii	64.88	0.00e+00	1369.00
IUUC-Sja-107976	Schizosaccharomyces japonicus	25.60	4.00e-76	280.00
IUUC-Spo-108146	Schizosaccharomyces pombe	27.50	6.00e-87	315.00
IUUC-Ssl-108663	Sclerotinia sclerotiorum	32.70	2.00e-118	420.00
IUUC-Smo-109585	Selaginella moellendorffii	33.40	3.00e-128	452.00
IUUC-Sit-110275	Setaria italica	35.24	1.00e-144	507.00
IUUC-Sly-111073	Solanum lycopersicum	34.81	5.00e-147	515.00
IUUC-Stu-112392	Solanum tuberosum	25.41	3.00e-14	71.60
IUUC-Sar-113718	Sorex araneus	63.90	0.00e+00	1304.00
IUUC-Sbi-114080	Sorghum bicolor	35.75	6.00e-152	531.00
IUUC-Sre-115160	Sporisorium reilianum	31.19	4.00e-130	459.00
IUUC-Ssc-115997	Sus scrofa	65.61	0.00e+00	1352.00
IUUC-Tgu-116904	Taeniopygia guttata	78.75	0.00e+00	1427.00
IUUC-Tru-117946	Takifugu rubripes	83.83	0.00e+00	1694.00
IUUC-Tni-119692	Tetraodon nigroviridis	83.93	0.00e+00	1690.00
IUUC-Tca-121455	Theobroma cacao	34.50	2.00e-152	533.00
IUUC-Tre-122128	Trichoderma reesei	33.26	1.00e-128	454.00
IUUC-Tvi-122657	Trichoderma virens	33.09	5.00e-132	465.00
IUUC-Tae-125953	Triticum aestivum	34.69	1.00e-141	497.00
IUUC-Tur-126110	Triticum urartu	32.41	9.00e-114	404.00
IUUC-Tme-127173	Tuber melanosporum	31.15	8.00e-114	404.00
IUUC-Ttr-128420	Tursiops truncatus	65.40	0.00e+00	1376.00
IUUC-Uma-129580	Ustilago maydis	30.68	5.00e-129	456.00
IUUC-Vda-129790	Verticillium dahliae	30.72	4.00e-115	409.00
IUUC-Vvi-131095	Vitis vinifera	34.46	2.00e-149	523.00
IUUC-Xtr-131906	Xenopus tropicalis	73.41	0.00e+00	1472.00
IUUC-Xma-134197	Xiphophorus maculatus	85.25	0.00e+00	1723.00
IUUC-Yli-134617	Yarrowia lipolytica	27.68	1.00e-101	365.00
IUUC-Zma-134979	Zea mays	32.88	5.00e-117	415.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence