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Tag Content
UUCD2 ID IUUC-Bta-012851
UUCD1 version UUC-BoT-00939
Ensembl Protein ID ENSBTAP00000007758.5
UniProt Accession Q3MHL3; A5D9B1; RBBP4_BOVIN
Genbank Protein ID ABQ12970.1; AAI05196.1
Protein Name Histone-binding protein RBBP4; Nucleosome-remodeling factor subunit RBAP48; Retinoblastoma-binding protein 4
Genbank Nucleotide ID BT030530; BC105195
Gene Name RBBP4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000005904.5 ENSBTAT00000007758.5 ENSBTAP00000007758.5
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.60e-37 124.9 272 306
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf...sdtllvsGsdDgtikvWDlrtg 33
           Ht++v+cl+f   s+ +l++Gs D+t+ +WDlr  
   Q: 272  HTAEVNCLSFnpySEFILATGSADKTVALWDLRNL 306
           **********96554568*************9875 PP
   
Organism Bos taurus
Functional Description
(View)

Functional Description


     Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex (By similarity).
 Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex (By similarity).
Protein Sequence
(Fasta)
MADKEAAFDD AVEERVINEE YKIWKKNTPF LYDLVMTHAL EWPSLTAQWL PDVTRPEGKD 60
FSIHRLVLGT HTSDEQNHLV IASVQLPNDD AQFDASHYDS EKGEFGGFGS VSGKIEIEIK 120
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Protein Fasta Sequence


>IUUC-Bta-012851|E3,WD_repeat|Bos taurus
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Nucleotide Sequence
(Fasta)
GCCTACCCGC CATGGCCGAC AAGGAAGGTG AGGGTTCCGG GGCGGCCCCA GGAGAGTGGG 60
GGGTGCCGGG GTTGCGTAGC GGCCTCGAAA CGGCCTAACA GTGAGGACAG GCCAGACTCA 120
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Nucleotide Fasta Sequence


>IUUC-Bta-012851|E3,WD_repeat|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0131--Cell cycle
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0235--DNA replication
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR022052--Histone-bd_RBBP4_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12265--CAF1C_H4-bd
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0033186--C:CAF-1 complex
GO:0005829--C:cytosol
GO:0035098--C:ESC/E(Z) complex
GO:0000790--C:nuclear chromatin
GO:0016581--C:NuRD complex
GO:0016589--C:NURF complex
GO:0008094--F:DNA-dependent ATPase activity
GO:0031492--F:nucleosomal DNA binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980--F:RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0043044--P:ATP-dependent chromatin remodeling
GO:0007049--P:cell cycle
GO:0031497--P:chromatin assembly
GO:0016569--P:covalent chromatin modification
GO:0006260--P:DNA replication
GO:0006335--P:DNA replication-dependent nucleosome assembly
GO:0006336--P:DNA replication-independent nucleosome assembly
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG bta:767940
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000757 Aegilops tauschii 60.29 8.00e-141 493.00
IUUC-Aml-001339 Ailuropoda melanoleuca 99.29 0.00e+00 855.00
IUUC-Atr-003075 Amborella trichopoda 67.87 3.00e-171 594.00
IUUC-Apl-003952 Anas platyrhynchos 100.00 0.00e+00 868.00
IUUC-Aca-004508 Anolis carolinensis 98.82 0.00e+00 870.00
IUUC-Aly-006342 Arabidopsis lyrata 68.00 7.00e-166 576.00
IUUC-Ath-006855 Arabidopsis thaliana 68.25 3.00e-166 577.00
IUUC-Ago-007892 Ashbya gossypii 38.77 1.00e-79 290.00
IUUC-Acl-008163 Aspergillus clavatus 53.03 3.00e-125 441.00
IUUC-Afl-008645 Aspergillus flavus 52.99 4.00e-124 437.00
IUUC-Afu-009091 Aspergillus fumigatus 53.28 3.00e-125 441.00
IUUC-Ani-009478 Aspergillus nidulans 48.74 1.00e-103 369.00
IUUC-Ang-009707 Aspergillus niger 52.53 2.00e-120 425.00
IUUC-Aor-010028 Aspergillus oryzae 52.99 4.00e-124 437.00
IUUC-Ate-010416 Aspergillus terreus 51.34 3.00e-124 438.00
IUUC-Ame-010598 Astyanax mexicanus 96.93 0.00e+00 856.00
IUUC-Bgr-012001 Blumeria graminis 49.51 6.00e-108 384.00
IUUC-Bci-013815 Botrytis cinerea 50.12 2.00e-125 441.00
IUUC-Bdi-014926 Brachypodium distachyon 68.06 5.00e-164 570.00
IUUC-Bol-015856 Brassica oleracea 68.15 1.00e-165 576.00
IUUC-Bra-016725 Brassica rapa 63.00 1.00e-161 562.00
IUUC-Cel-018587 Caenorhabditis elegans 72.51 0.00e+00 631.00
IUUC-Cja-019884 Callithrix jacchus 100.00 0.00e+00 879.00
IUUC-Cfa-020343 Canis familiaris 100.00 0.00e+00 879.00
IUUC-Cpo-021591 Cavia porcellus 100.00 0.00e+00 879.00
IUUC-Cre-022563 Chlamydomonas reinhardtii 62.08 3.00e-157 548.00
IUUC-Cho-024506 Choloepus hoffmanni 99.53 0.00e+00 870.00
IUUC-Cin-025589 Ciona intestinalis 89.18 0.00e+00 802.00
IUUC-Csv-026216 Ciona savignyi 90.19 0.00e+00 806.00
IUUC-Cgl-026564 Colletotrichum gloeosporioides 48.55 1.00e-118 419.00
IUUC-Cne-026792 Cryptococcus neoformans 55.64 1.00e-134 472.00
IUUC-Cme-027307 Cyanidioschyzon merolae 52.20 7.00e-129 454.00
IUUC-Dre-028742 Danio rerio 97.41 0.00e+00 858.00
IUUC-Dno-029114 Dasypus novemcinctus 100.00 0.00e+00 879.00
IUUC-Dse-031282 Dothistroma septosporum 47.15 2.00e-102 366.00
IUUC-Dme-032126 Drosophila melanogaster 91.93 0.00e+00 800.00
IUUC-Ete-032731 Echinops telfairi 100.00 0.00e+00 879.00
IUUC-Eca-033533 Equus caballus 98.57 0.00e+00 850.00
IUUC-Eeu-034644 Erinaceus europaeus 100.00 2.00e-130 459.00
IUUC-Fca-036202 Felis catus 100.00 0.00e+00 879.00
IUUC-Fal-037084 Ficedula albicollis 100.00 0.00e+00 869.00
IUUC-Fox-037974 Fusarium oxysporum 50.12 2.00e-123 435.00
IUUC-Fso-038246 Fusarium solani 48.32 5.00e-111 394.00
IUUC-Gmo-039214 Gadus morhua 97.16 0.00e+00 848.00
IUUC-Ggr-039741 Gaeumannomyces graminis 50.36 5.00e-119 421.00
IUUC-Gga-040396 Gallus gallus 100.00 0.00e+00 879.00
IUUC-Gac-041389 Gasterosteus aculeatus 95.75 0.00e+00 840.00
IUUC-Gma-042791 Glycine max 68.17 8.00e-164 569.00
IUUC-Ggo-045422 Gorilla gorilla 91.59 0.00e+00 782.00
IUUC-Hsa-045683 Homo sapiens 100.00 0.00e+00 879.00
IUUC-Hvu-047457 Hordeum vulgare 67.18 3.00e-76 277.00
IUUC-Itr-047950 Ictidomys tridecemlineatus 100.00 0.00e+00 879.00
IUUC-Kpa-049119 Komagataella pastoris 37.19 3.00e-72 265.00
IUUC-Lch-050545 Latimeria chalumnae 93.38 0.00e+00 824.00
IUUC-Lpe-051337 Leersia perrieri 68.55 7.00e-165 573.00
IUUC-Loc-052473 Lepisosteus oculatus 97.88 0.00e+00 863.00
IUUC-Lma-053275 Leptosphaeria maculans 45.33 3.00e-69 254.00
IUUC-Laf-054114 Loxodonta africana 100.00 0.00e+00 879.00
IUUC-Mcc-055648 Macaca mulatta 99.76 0.00e+00 872.00
IUUC-Meu-056490 Macropus eugenii 100.00 0.00e+00 879.00
IUUC-Mor-056947 Magnaporthe oryzae 50.96 2.00e-117 416.00
IUUC-Mpo-057602 Magnaporthe poae 49.64 3.00e-118 418.00
IUUC-Mtr-057853 Medicago truncatula 67.00 1.00e-161 562.00
IUUC-Mla-058884 Melampsora laricipopulina 52.67 6.00e-128 450.00
IUUC-Mga-059452 Meleagris gallopavo 100.00 0.00e+00 869.00
IUUC-Mvi-060450 Microbotryum violaceum 57.52 4.00e-137 481.00
IUUC-Mmr-060678 Microcebus murinus 99.75 0.00e+00 830.00
IUUC-Mdo-062450 Monodelphis domestica 99.51 0.00e+00 838.00
IUUC-Mmu-063282 Mus musculus 100.00 0.00e+00 879.00
IUUC-Mac-065480 Musa acuminata 67.25 5.00e-162 563.00
IUUC-Mpu-066529 Mustela putorius furo 99.06 0.00e+00 872.00
IUUC-Mlu-068072 Myotis lucifugus 100.00 0.00e+00 879.00
IUUC-Nfi-068374 Neosartorya fischeri 53.28 7.00e-122 430.00
IUUC-Ncr-068794 Neurospora crassa 48.04 3.00e-115 408.00
IUUC-Nle-069577 Nomascus leucogenys 100.00 0.00e+00 879.00
IUUC-Opr-070245 Ochotona princeps 84.47 0.00e+00 697.00
IUUC-Ont-071809 Oreochromis niloticus 96.70 0.00e+00 855.00
IUUC-Oan-072839 Ornithorhynchus anatinus 99.76 0.00e+00 864.00
IUUC-Ocu-074515 Oryctolagus cuniculus 94.12 0.00e+00 764.00
IUUC-Oba-075719 Oryza barthii 57.82 8.00e-137 480.00
IUUC-Obr-076859 Oryza brachyantha 68.14 6.00e-163 566.00
IUUC-Ogl-077920 Oryza glaberrima 68.06 1.00e-164 572.00
IUUC-Ogu-078048 Oryza glumaepatula 57.82 6.00e-136 478.00
IUUC-Oin-079960 Oryza indica 56.27 2.00e-124 439.00
IUUC-Olo-080553 Oryza longistaminata 55.45 2.00e-132 466.00
IUUC-Ome-081835 Oryza meridionalis 68.06 3.00e-165 575.00
IUUC-Oni-082494 Oryza nivara 57.58 5.00e-135 474.00
IUUC-Opu-083913 Oryza punctata 65.36 1.00e-153 535.00
IUUC-Oru-084666 Oryza rufipogon 68.06 1.00e-164 572.00
IUUC-Osa-085884 Oryza sativa 68.06 1.00e-164 572.00
IUUC-Ola-086664 Oryzias latipes 96.47 0.00e+00 849.00
IUUC-Olu-087579 Ostreococcus lucimarinus 63.43 1.00e-145 509.00
IUUC-Oga-088364 Otolemur garnettii 91.10 0.00e+00 791.00
IUUC-Oar-089652 Ovis aries 100.00 0.00e+00 879.00
IUUC-Psi-093300 Pelodiscus sinensis 100.00 0.00e+00 806.00
IUUC-Pma-094307 Petromyzon marinus 93.78 0.00e+00 824.00
IUUC-Pno-095153 Phaeosphaeria nodorum 48.43 2.00e-109 389.00
IUUC-Ppa-095800 Physcomitrella patens 68.17 1.00e-169 589.00
IUUC-Pfo-097376 Poecilia formosa 96.47 0.00e+00 850.00
IUUC-Pab-097697 Pongo abelii 100.00 0.00e+00 879.00
IUUC-Pop-099709 Populus trichocarpa 65.70 2.00e-166 578.00
IUUC-Pca-100642 Procavia capensis 89.85 0.00e+00 737.00
IUUC-Ppe-101212 Prunus persica 66.50 6.00e-165 573.00
IUUC-Pva-102253 Pteropus vampyrus 100.00 0.00e+00 879.00
IUUC-Pgr-103441 Puccinia graminis 54.22 4.00e-123 434.00
IUUC-Pte-104332 Pyrenophora teres 48.90 5.00e-112 397.00
IUUC-Pyt-104516 Pyrenophora triticirepentis 48.90 6.00e-112 397.00
IUUC-Rno-105678 Rattus norvegicus 100.00 0.00e+00 879.00
IUUC-Sce-106364 Saccharomyces cerevisiae 37.84 2.00e-71 262.00
IUUC-Sha-106663 Sarcophilus harrisii 100.00 0.00e+00 869.00
IUUC-Sja-108001 Schizosaccharomyces japonicus 47.79 1.00e-106 379.00
IUUC-Spo-108145 Schizosaccharomyces pombe 52.22 1.00e-119 423.00
IUUC-Smo-109159 Selaginella moellendorffii 65.45 3.00e-164 571.00
IUUC-Sit-110144 Setaria italica 68.00 2.00e-155 542.00
IUUC-Sly-111680 Solanum lycopersicum 66.18 3.00e-166 578.00
IUUC-Stu-111931 Solanum tuberosum 65.94 6.00e-165 573.00
IUUC-Sbi-114637 Sorghum bicolor 68.25 5.00e-163 567.00
IUUC-Sre-114980 Sporisorium reilianum 54.29 1.00e-137 482.00
IUUC-Ssc-115711 Sus scrofa 100.00 0.00e+00 806.00
IUUC-Tgu-116925 Taeniopygia guttata 99.76 0.00e+00 868.00
IUUC-Tru-117549 Takifugu rubripes 96.01 0.00e+00 844.00
IUUC-Tni-120398 Tetraodon nigroviridis 96.01 0.00e+00 848.00
IUUC-Tca-121841 Theobroma cacao 68.25 1.00e-165 575.00
IUUC-Tre-122190 Trichoderma reesei 50.36 2.00e-115 409.00
IUUC-Tvi-122304 Trichoderma virens 49.64 1.00e-123 436.00
IUUC-Tae-124648 Triticum aestivum 67.32 8.00e-156 543.00
IUUC-Tur-126850 Triticum urartu 63.55 4.00e-117 414.00
IUUC-Tme-126949 Tuber melanosporum 54.89 2.00e-129 455.00
IUUC-Uma-129424 Ustilago maydis 53.15 2.00e-137 482.00
IUUC-Vda-129873 Verticillium dahliae 49.88 5.00e-125 441.00
IUUC-Vpa-130079 Vicugna pacos 99.53 0.00e+00 873.00
IUUC-Vvi-131585 Vitis vinifera 67.25 2.00e-163 568.00
IUUC-Xma-133066 Xiphophorus maculatus 96.70 0.00e+00 855.00
IUUC-Yli-134334 Yarrowia lipolytica 39.43 9.00e-81 293.00
IUUC-Zma-135710 Zea mays 67.50 5.00e-156 543.00
Created Date 25-Jun-2017

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