iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000019744.2	ENSPPYT00000023052.2	ENSPPYP00000022143.2
ENSPPYG00000019744.2	ENSPPYT00000023051.1	ENSPPYP00000022142.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.10e-17	63.8	717	768

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 8    vlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           + y++ a +  eL+l++Gdvv++ +    d+gW+kg  e++g+ G fP+ +ve+
   Q: 717  ARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKG--ETNGRIGWFPSTYVEE 768
           67**********************************..9*************86 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

FLCLKNIRTF LKVCHDKFGL RNSELFDPFD LFDVRDFGKV ISAVSRLSLH SIAQNKGIRL 60
SPAQHCAEQR DQTLHLLPVL SCEHDLGEDI YDCVPCEDGG DDIYEDIIKV EVQQPMKMGM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNACC 60
TCTCCCCCGG CTCCATCGAC CTCAAGGACA TCAACTTCCG GCCGCACATT TACCCAGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF00307--CH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0016477--P:cell migration
GO:0030032--P:lamellipodium assembly
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0030193--P:regulation of blood coagulation
GO:0008361--P:regulation of cell size
GO:0010468--P:regulation of gene expression
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001437	Ailuropoda melanoleuca	76.23	0.00e+00	1130.00
IUUC-Apl-003262	Anas platyrhynchos	74.44	0.00e+00	1119.00
IUUC-Ath-007352	Arabidopsis thaliana	39.22	9.00e-04	38.90
IUUC-Ame-011608	Astyanax mexicanus	68.95	0.00e+00	1038.00
IUUC-Bta-013147	Bos taurus	76.00	0.00e+00	1036.00
IUUC-Cja-018877	Callithrix jacchus	76.10	0.00e+00	1100.00
IUUC-Cfa-020315	Canis familiaris	81.87	0.00e+00	1038.00
IUUC-Cpo-021543	Cavia porcellus	74.20	0.00e+00	1002.00
IUUC-Csa-024204	Chlorocebus sabaeus	78.68	0.00e+00	1170.00
IUUC-Dre-028308	Danio rerio	65.89	0.00e+00	1016.00
IUUC-Dno-029584	Dasypus novemcinctus	76.85	0.00e+00	939.00
IUUC-Dor-031014	Dipodomys ordii	69.17	0.00e+00	964.00
IUUC-Eca-033448	Equus caballus	75.94	0.00e+00	1162.00
IUUC-Eeu-035182	Erinaceus europaeus	80.43	1.00e-126	447.00
IUUC-Fca-035460	Felis catus	77.55	0.00e+00	1065.00
IUUC-Fal-036684	Ficedula albicollis	72.53	0.00e+00	1101.00
IUUC-Gmo-038816	Gadus morhua	65.98	0.00e+00	876.00
IUUC-Gga-040999	Gallus gallus	77.09	0.00e+00	1137.00
IUUC-Gac-041353	Gasterosteus aculeatus	67.52	0.00e+00	928.00
IUUC-Ggo-044558	Gorilla gorilla	80.05	0.00e+00	1174.00
IUUC-Hsa-046208	Homo sapiens	80.42	0.00e+00	1181.00
IUUC-Itr-047931	Ictidomys tridecemlineatus	75.11	0.00e+00	953.00
IUUC-Loc-052827	Lepisosteus oculatus	65.61	0.00e+00	1010.00
IUUC-Laf-054009	Loxodonta africana	77.36	0.00e+00	1167.00
IUUC-Mcc-055054	Macaca mulatta	80.17	0.00e+00	1177.00
IUUC-Meu-056269	Macropus eugenii	72.43	7.00e-173	600.00
IUUC-Mga-060106	Meleagris gallopavo	74.07	0.00e+00	1110.00
IUUC-Mmr-061118	Microcebus murinus	77.42	0.00e+00	1140.00
IUUC-Mdo-062380	Monodelphis domestica	76.87	0.00e+00	1038.00
IUUC-Mmu-063135	Mus musculus	78.66	0.00e+00	1177.00
IUUC-Mpu-066135	Mustela putorius furo	80.31	0.00e+00	1183.00
IUUC-Nle-069465	Nomascus leucogenys	75.87	0.00e+00	1096.00
IUUC-Ont-071945	Oreochromis niloticus	66.34	0.00e+00	981.00
IUUC-Oan-073384	Ornithorhynchus anatinus	72.80	0.00e+00	954.00
IUUC-Ola-087499	Oryzias latipes	67.96	0.00e+00	880.00
IUUC-Oga-088444	Otolemur garnettii	80.17	0.00e+00	1059.00
IUUC-Oar-089576	Ovis aries	73.94	0.00e+00	976.00
IUUC-Ptr-090507	Pan troglodytes	81.51	0.00e+00	1187.00
IUUC-Pan-092325	Papio anubis	84.06	0.00e+00	1205.00
IUUC-Psi-094021	Pelodiscus sinensis	77.06	0.00e+00	1125.00
IUUC-Pfo-096732	Poecilia formosa	66.14	0.00e+00	984.00
IUUC-Pca-100295	Procavia capensis	76.85	0.00e+00	1155.00
IUUC-Rno-105332	Rattus norvegicus	76.92	0.00e+00	1112.00
IUUC-Sha-106529	Sarcophilus harrisii	74.75	0.00e+00	983.00
IUUC-Ssc-116176	Sus scrofa	76.42	0.00e+00	1133.00
IUUC-Tgu-116917	Taeniopygia guttata	74.32	0.00e+00	1114.00
IUUC-Tru-118398	Takifugu rubripes	62.88	0.00e+00	725.00
IUUC-Tni-120819	Tetraodon nigroviridis	64.38	0.00e+00	910.00
IUUC-Xtr-132747	Xenopus tropicalis	67.81	0.00e+00	994.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence