iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033776

UUCD1 version

UUC-EqC-01015

Ensembl Protein ID

ENSECAP00000010880.1

UniProt Accession

F6R0H0; F6R0H0_HORSE

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Gene Name

UCHL5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000012988.1	ENSECAT00000013687.1	ENSECAP00000010880.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	3.80e-89	299.5	1	296

Active Site

Position(s)	Description	Evidence
63	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
139	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 26   gvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqvigNsCatyAllsvllncedk 114
           g+++  qvee++sL+pen++++ +pv+gl++lFk+++ +e +          +vv+++ ++tiffakqvi+N+Cat+A++svllnc+++
   Q: 1    GCRGA-QVEEIWSLEPENFEKL-KPVHGLIFLFKWQPGEEPAG---------SVVQDSRLDTIFFAKQVINNACATQAIVSVLLNCTHQ 78
           78899.****************.********************.........899********************************** PP
   S: 115  lldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsyvningrlyeldglkpfPldl 203
            ++lG+tls++ke+++++++ +k+lal+n++v++++hns+ar+++++ + +++++    +++afhfvsyv++ngrlyeldgl++ P+dl
   Q: 79   DVHLGETLSEFKEFSQSFDAAMKGLALSNSDVIRQVHNSFARQQMFEFDAKTSAK----EEDAFHFVSYVPVNGRLYELDGLREGPIDL 163
           ***************************************************9887....79**************************** PP
   S: 204  gkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid.........keLlkLlkdieseeekieaqldde 283
           g+ ++++++ ++++ v+   +ri++++++eirfnl+aiv+dr++i+++++  l+ +          +  ++l++i+se++k++  +++e
   Q: 164  GA-CNQDDWISAVRPVI--EKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIAELQRQlaeeepmdtDQGNNMLSAIQSEVAKNQLLIEEE 249
           *9.78999*********..******************************9766665778888887444589****************** PP
   S: 284  kekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefg 333
           ++k k++ki++irR++ny  fi++++k+la++++l  lve+    + +++
   Q: 250  VQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKA---KEKQN 296
           ***************************************993...33344 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

GCRGAQVEEI WSLEPENFEK LKPVHGLIFL FKWQPGEEPA GSVVQDSRLD TIFFAKQVIN 60
NACATQAIVS VLLNCTHQDV HLGETLSEFK EFSQSFDAAM KGLALSNSDV IRQVHNSFAR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTTGCCGAG GAGCTCAAGT AGAAGAAATA TGGAGTTTAG AACCTGAGAA TTTTGAAAAA 60
TTAAAGTAAG TATAACTTCA ATTGTGTTAA AAATAATGTC TGTATCTAAG CAAACTTTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031011--C:Ino80 complex
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0004866--F:endopeptidase inhibitor activity
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0048853--P:forebrain morphogenesis
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0016579--P:protein deubiquitination
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	45.17	8.00e-76	276.00
IUUC-Aml-001866	Ailuropoda melanoleuca	99.65	2.00e-172	597.00
IUUC-Atr-002966	Amborella trichopoda	47.66	2.00e-76	279.00
IUUC-Apl-003306	Anas platyrhynchos	87.35	7.00e-168	582.00
IUUC-Aca-004763	Anolis carolinensis	95.14	6.00e-165	573.00
IUUC-Aly-005581	Arabidopsis lyrata	47.25	8.00e-71	260.00
IUUC-Ath-007283	Arabidopsis thaliana	47.57	7.00e-74	270.00
IUUC-Acl-008231	Aspergillus clavatus	42.47	2.00e-45	175.00
IUUC-Afl-008557	Aspergillus flavus	36.27	4.00e-47	181.00
IUUC-Afu-008988	Aspergillus fumigatus	44.50	3.00e-47	181.00
IUUC-Ani-009420	Aspergillus nidulans	36.45	3.00e-46	178.00
IUUC-Aor-010145	Aspergillus oryzae	36.27	4.00e-47	181.00
IUUC-Ate-010347	Aspergillus terreus	40.95	7.00e-46	177.00
IUUC-Ame-010791	Astyanax mexicanus	90.46	6.00e-167	579.00
IUUC-Bgr-012298	Blumeria graminis	37.40	1.00e-42	166.00
IUUC-Bta-013251	Bos taurus	98.61	2.00e-169	588.00
IUUC-Bci-013786	Botrytis cinerea	37.42	1.00e-51	196.00
IUUC-Bdi-014132	Brachypodium distachyon	47.87	6.00e-73	267.00
IUUC-Bol-015611	Brassica oleracea	48.54	1.00e-75	276.00
IUUC-Bra-017769	Brassica rapa	48.54	1.00e-75	276.00
IUUC-Cel-018604	Caenorhabditis elegans	45.21	6.00e-69	253.00
IUUC-Cja-019768	Callithrix jacchus	89.56	2.00e-165	574.00
IUUC-Cfa-020207	Canis familiaris	99.65	2.00e-172	597.00
IUUC-Cpo-021925	Cavia porcellus	95.14	7.00e-163	565.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	43.81	1.00e-65	243.00
IUUC-Csa-023958	Chlorocebus sabaeus	98.61	4.00e-169	587.00
IUUC-Cho-024928	Choloepus hoffmanni	100.00	9.00e-43	167.00
IUUC-Cin-025771	Ciona intestinalis	52.67	8.00e-88	316.00
IUUC-Csv-026149	Ciona savignyi	56.23	1.00e-90	326.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	37.23	2.00e-51	196.00
IUUC-Cne-026955	Cryptococcus neoformans	37.38	2.00e-47	182.00
IUUC-Cme-027104	Cyanidioschyzon merolae	32.44	1.00e-39	156.00
IUUC-Dre-027409	Danio rerio	89.47	7.00e-164	569.00
IUUC-Dno-028921	Dasypus novemcinctus	98.96	5.00e-171	593.00
IUUC-Dse-031170	Dothistroma septosporum	38.31	2.00e-51	196.00
IUUC-Dme-031677	Drosophila melanogaster	58.44	1.00e-102	366.00
IUUC-Ete-032707	Echinops telfairi	72.43	6.00e-107	380.00
IUUC-Eeu-035305	Erinaceus europaeus	76.69	9.00e-68	249.00
IUUC-Fca-035846	Felis catus	91.11	3.00e-167	580.00
IUUC-Fal-037597	Ficedula albicollis	95.49	2.00e-159	554.00
IUUC-Fox-037670	Fusarium oxysporum	51.85	4.00e-49	187.00
IUUC-Fso-038243	Fusarium solani	42.86	8.00e-49	187.00
IUUC-Gmo-038499	Gadus morhua	83.68	2.00e-146	511.00
IUUC-Ggr-039975	Gaeumannomyces graminis	41.67	1.00e-41	163.00
IUUC-Gga-040904	Gallus gallus	94.74	7.00e-173	599.00
IUUC-Gac-042058	Gasterosteus aculeatus	88.89	9.00e-156	542.00
IUUC-Gma-043763	Glycine max	47.80	2.00e-76	279.00
IUUC-Ggo-044699	Gorilla gorilla	92.55	2.00e-154	537.00
IUUC-Hsa-046227	Homo sapiens	98.96	3.00e-171	593.00
IUUC-Hvu-047359	Hordeum vulgare	45.69	2.00e-74	271.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	89.34	9.00e-166	575.00
IUUC-Lch-049829	Latimeria chalumnae	93.06	1.00e-160	558.00
IUUC-Lpe-050899	Leersia perrieri	47.32	8.00e-70	256.00
IUUC-Loc-052264	Lepisosteus oculatus	91.00	2.00e-158	551.00
IUUC-Lma-053110	Leptosphaeria maculans	37.21	3.00e-43	169.00
IUUC-Laf-053639	Loxodonta africana	99.65	2.00e-172	597.00
IUUC-Mcc-055506	Macaca mulatta	98.61	4.00e-169	587.00
IUUC-Mor-057001	Magnaporthe oryzae	46.30	6.00e-49	187.00
IUUC-Mpo-057608	Magnaporthe poae	39.76	2.00e-26	112.00
IUUC-Mtr-057731	Medicago truncatula	48.42	2.00e-76	279.00
IUUC-Mla-059016	Melampsora laricipopulina	42.62	3.00e-37	147.00
IUUC-Mga-060178	Meleagris gallopavo	95.07	5.00e-174	603.00
IUUC-Mvi-060353	Microbotryum violaceum	37.74	1.00e-47	182.00
IUUC-Mmr-060738	Microcebus murinus	98.96	2.00e-171	594.00
IUUC-Mdo-062266	Monodelphis domestica	97.84	2.00e-108	384.00
IUUC-Mmu-063619	Mus musculus	96.53	8.00e-168	582.00
IUUC-Mac-065301	Musa acuminata	49.83	3.00e-79	288.00
IUUC-Mpu-066058	Mustela putorius furo	99.31	8.00e-172	595.00
IUUC-Mlu-067292	Myotis lucifugus	97.57	1.00e-167	582.00
IUUC-Nfi-068275	Neosartorya fischeri	37.24	4.00e-48	184.00
IUUC-Ncr-068713	Neurospora crassa	38.18	3.00e-51	195.00
IUUC-Nle-069013	Nomascus leucogenys	98.26	7.00e-169	586.00
IUUC-Opr-070628	Ochotona princeps	88.85	1.00e-163	568.00
IUUC-Ont-072688	Oreochromis niloticus	89.66	4.00e-156	543.00
IUUC-Oan-073004	Ornithorhynchus anatinus	97.53	5.00e-143	499.00
IUUC-Ocu-074303	Oryctolagus cuniculus	99.31	3.00e-172	598.00
IUUC-Oba-075002	Oryza barthii	47.44	3.00e-73	268.00
IUUC-Obr-076392	Oryza brachyantha	48.01	5.00e-71	260.00
IUUC-Ogl-077271	Oryza glaberrima	47.44	3.00e-73	268.00
IUUC-Ogu-078493	Oryza glumaepatula	47.28	1.00e-73	270.00
IUUC-Oin-080084	Oryza indica	47.28	1.00e-73	270.00
IUUC-Olo-080803	Oryza longistaminata	46.96	2.00e-73	268.00
IUUC-Ome-081146	Oryza meridionalis	46.33	2.00e-72	265.00
IUUC-Oni-082146	Oryza nivara	47.28	1.00e-73	270.00
IUUC-Opu-083633	Oryza punctata	47.99	7.00e-70	257.00
IUUC-Oru-084789	Oryza rufipogon	47.28	1.00e-73	270.00
IUUC-Osa-086196	Oryza sativa	47.28	1.00e-73	270.00
IUUC-Ola-087126	Oryzias latipes	89.58	1.00e-152	532.00
IUUC-Olu-087665	Ostreococcus lucimarinus	40.15	3.00e-60	224.00
IUUC-Oga-089140	Otolemur garnettii	89.84	6.00e-166	576.00
IUUC-Oar-090296	Ovis aries	98.96	1.00e-171	595.00
IUUC-Ptr-090566	Pan troglodytes	98.96	3.00e-171	593.00
IUUC-Pan-092052	Papio anubis	98.61	5.00e-169	587.00
IUUC-Psi-093723	Pelodiscus sinensis	95.14	1.00e-165	575.00
IUUC-Pma-094568	Petromyzon marinus	61.46	2.00e-107	381.00
IUUC-Pno-095120	Phaeosphaeria nodorum	38.31	2.00e-44	172.00
IUUC-Ppa-095761	Physcomitrella patens	46.44	1.00e-75	276.00
IUUC-Pfo-096210	Poecilia formosa	89.58	5.00e-157	546.00
IUUC-Pab-098463	Pongo abelii	98.96	2.00e-171	594.00
IUUC-Pop-099423	Populus trichocarpa	48.26	4.00e-76	277.00
IUUC-Pca-100108	Procavia capensis	97.74	2.00e-127	448.00
IUUC-Ppe-101176	Prunus persica	50.85	2.00e-77	282.00
IUUC-Pva-102629	Pteropus vampyrus	95.78	4.00e-133	467.00
IUUC-Pgr-103419	Puccinia graminis	39.35	4.00e-49	187.00
IUUC-Pte-104207	Pyrenophora teres	43.24	2.00e-26	111.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	38.38	1.00e-50	192.00
IUUC-Rno-105579	Rattus norvegicus	86.38	1.00e-162	565.00
IUUC-Sha-106894	Sarcophilus harrisii	93.84	9.00e-156	542.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	37.81	3.00e-52	198.00
IUUC-Spo-108371	Schizosaccharomyces pombe	40.70	4.00e-52	197.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	38.41	2.00e-47	182.00
IUUC-Smo-109396	Selaginella moellendorffii	50.33	9.00e-80	290.00
IUUC-Sit-110630	Setaria italica	48.38	3.00e-77	281.00
IUUC-Sly-110972	Solanum lycopersicum	50.48	8.00e-81	293.00
IUUC-Stu-112185	Solanum tuberosum	50.16	1.00e-80	292.00
IUUC-Sar-113294	Sorex araneus	81.76	2.00e-152	531.00
IUUC-Sbi-113951	Sorghum bicolor	48.70	1.00e-77	283.00
IUUC-Ssc-115501	Sus scrofa	99.31	4.00e-172	596.00
IUUC-Tgu-117152	Taeniopygia guttata	95.14	2.00e-159	554.00
IUUC-Tru-118388	Takifugu rubripes	88.54	6.00e-156	543.00
IUUC-Tsy-119109	Tarsius syrichta	99.31	7.00e-172	595.00
IUUC-Tni-120048	Tetraodon nigroviridis	88.54	1.00e-156	545.00
IUUC-Tca-121750	Theobroma cacao	48.11	1.00e-79	290.00
IUUC-Tre-122130	Trichoderma reesei	38.35	1.00e-48	186.00
IUUC-Tvi-122284	Trichoderma virens	39.00	2.00e-46	179.00
IUUC-Tae-125344	Triticum aestivum	46.91	3.00e-73	268.00
IUUC-Tur-126366	Triticum urartu	42.90	1.00e-64	240.00
IUUC-Tme-127187	Tuber melanosporum	40.78	2.00e-51	195.00
IUUC-Tbe-127619	Tupaia belangeri	90.24	1.00e-145	508.00
IUUC-Ttr-128867	Tursiops truncatus	88.16	7.00e-125	439.00
IUUC-Vda-129912	Verticillium dahliae	36.59	3.00e-46	178.00
IUUC-Vpa-130552	Vicugna pacos	100.00	3.00e-110	391.00
IUUC-Vvi-130881	Vitis vinifera	49.84	9.00e-76	276.00
IUUC-Xtr-131934	Xenopus tropicalis	85.53	7.00e-159	552.00
IUUC-Xma-133312	Xiphophorus maculatus	89.58	6.00e-157	546.00
IUUC-Zma-135462	Zea mays	43.28	1.00e-64	239.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence