iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013131

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

DAAA02054377

Gene Name

BAP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000045817.1	ENSBTAT00000064109.1	ENSBTAP00000054730.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	5.20e-135	450.4	3	664

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 6    kewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakqv 94
           k+wleLesdPglftllvedfgvk++ qvee+y+L++++    q+pv+g+++lFk++e+r+s+rk++++++d++v+d+di++++ffa+q+
   Q: 3    KGWLELESDPGLFTLLVEDFGVKGV-QVEEIYDLQSKC----QGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQL 86
           89***********************.************....*********************************************** PP
   S: 95   igNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvsy 183
           i+NsCat+Allsvllnc+++  dlG+tlsr+k++tk++spe+k++a+gn+++l+++hns+ar+e+r++pe+q+++++++t+eafhfvsy
   Q: 87   IPNSCATHALLSVLLNCSNV--DLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSY 173
           ******************99..******************************************************************* PP
   S: 184  vningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesde...irfnllaivadrrviktlrlnvlkid.......... 259
           v+i+grl+eldglk++P+d+g+++e+ee++dk+++v+  +eri+l++++     r  +l++    + + ++  ++ ++           
   Q: 174  VPITGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVI--MERIGLATAGIkyeARLHVLKVNR--QTVLEALQQLIRVTqpeliqthks 258
           *************************************..*******99854334444444433..334455555555559********* PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 259  qesqlpeeskpassksplaletsrapvasesthtdgveevagscpqapthsppskpklvvkppgsningvppnptpivqrlpafldnhn 347
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 348  yakspmqeeedlaagvgrsrvpvrppqqysddeddyedeeeddaqstssairykrkgpgkpgplsssgdgqlsvlqpntinvlaeklke 436
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 437  sqkdlsiplsiktssgagspavavpthsqpsptpsnestdtaseigsafnsplrspirsanptrpsspvtshisvlfgeddsllrvdci 525
           ***************************************************************************************** PP
   S: 260  ..................................................................................keLlkLl 266
                                                                                             keLl+Ll
   Q: 526  rynravrdlvltgllhlaedgvlsplaltesgkgsspsirpsqgsqgsgspeekevveavdsrekpglvrpseslngekyspKELLALL 614
           ***************************************************************************************** PP
   S: 267  kdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlareg 316
           k++e+e++++ea+l++e+ekrkkfkidd+rRt+nydefic+fi++la+eg
   Q: 615  KCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEG 664
           ************************************************97 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCQ GPVYGFIFLF KWIEERRSRR 60
KVSTLVDDTS VIDDDIVNNM FFAHQLIPNS CATHALLSVL LNCSNVDLGP TLSRMKDFTK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGTGGGGTT AGGGGCCCCC GGGGCGGAGG GGGCTCCCGG CAGGGAGGCG GCGGGTGGGT 60
CGGGAGGGCC TGGACATGGC GCTGAGGGCC CGCCCCGCGG GAAGATGAAT AAGGGCTGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0035517--C:PR-DUB complex
GO:0003682--F:chromatin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0061519--P:macrophage homeostasis
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0071108--P:protein K48-linked deubiquitination
GO:0051726--P:regulation of cell cycle
GO:0001558--P:regulation of cell growth
GO:1900015--P:regulation of cytokine production involved in inflammatory response
GO:0010035--P:response to inorganic substance
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001263	Ailuropoda melanoleuca	90.33	0.00e+00	1054.00
IUUC-Apl-003405	Anas platyrhynchos	62.32	1.00e-136	479.00
IUUC-Aca-004836	Anolis carolinensis	76.06	0.00e+00	993.00
IUUC-Ame-011946	Astyanax mexicanus	59.89	0.00e+00	748.00
IUUC-Cja-019599	Callithrix jacchus	92.57	0.00e+00	1181.00
IUUC-Cfa-021003	Canis familiaris	92.71	0.00e+00	1055.00
IUUC-Cpo-022143	Cavia porcellus	91.55	0.00e+00	1144.00
IUUC-Csa-023477	Chlorocebus sabaeus	91.84	0.00e+00	1139.00
IUUC-Cho-024734	Choloepus hoffmanni	78.12	0.00e+00	693.00
IUUC-Csv-025842	Ciona savignyi	54.45	5.00e-84	304.00
IUUC-Dre-027793	Danio rerio	61.13	0.00e+00	765.00
IUUC-Dno-029253	Dasypus novemcinctus	90.72	0.00e+00	1128.00
IUUC-Dor-030891	Dipodomys ordii	85.26	0.00e+00	1068.00
IUUC-Dme-031796	Drosophila melanogaster	55.85	7.00e-82	297.00
IUUC-Ete-032646	Echinops telfairi	84.15	3.00e-142	498.00
IUUC-Eca-033805	Equus caballus	92.27	0.00e+00	1112.00
IUUC-Eeu-035216	Erinaceus europaeus	90.84	7.00e-120	424.00
IUUC-Fca-035611	Felis catus	92.00	0.00e+00	1000.00
IUUC-Fal-037186	Ficedula albicollis	75.82	0.00e+00	848.00
IUUC-Gmo-038824	Gadus morhua	65.49	1.00e-164	573.00
IUUC-Gga-040875	Gallus gallus	77.73	0.00e+00	969.00
IUUC-Gac-042226	Gasterosteus aculeatus	64.12	0.00e+00	788.00
IUUC-Ggo-045122	Gorilla gorilla	91.11	0.00e+00	1169.00
IUUC-Hsa-045882	Homo sapiens	91.11	0.00e+00	1169.00
IUUC-Itr-048185	Ictidomys tridecemlineatus	92.57	0.00e+00	1158.00
IUUC-Lch-049960	Latimeria chalumnae	67.72	0.00e+00	855.00
IUUC-Loc-052408	Lepisosteus oculatus	71.94	6.00e-176	610.00
IUUC-Laf-054187	Loxodonta africana	92.71	0.00e+00	1095.00
IUUC-Mcc-055273	Macaca mulatta	90.52	0.00e+00	1135.00
IUUC-Meu-056267	Macropus eugenii	78.13	0.00e+00	1017.00
IUUC-Mga-059958	Meleagris gallopavo	83.33	6.00e-141	493.00
IUUC-Mmr-061280	Microcebus murinus	92.58	0.00e+00	1129.00
IUUC-Mdo-062625	Monodelphis domestica	86.15	0.00e+00	1130.00
IUUC-Mmu-063853	Mus musculus	89.21	0.00e+00	1119.00
IUUC-Mlu-067771	Myotis lucifugus	91.69	0.00e+00	1085.00
IUUC-Opr-070741	Ochotona princeps	89.94	0.00e+00	1129.00
IUUC-Ont-072172	Oreochromis niloticus	62.17	0.00e+00	795.00
IUUC-Oan-073167	Ornithorhynchus anatinus	75.66	0.00e+00	986.00
IUUC-Ocu-074176	Oryctolagus cuniculus	90.96	0.00e+00	1075.00
IUUC-Ola-087203	Oryzias latipes	78.41	8.00e-120	423.00
IUUC-Oga-089153	Otolemur garnettii	91.31	0.00e+00	1134.00
IUUC-Oar-090008	Ovis aries	92.71	0.00e+00	1117.00
IUUC-Ptr-091234	Pan troglodytes	91.40	0.00e+00	1174.00
IUUC-Pan-092005	Papio anubis	91.55	0.00e+00	1163.00
IUUC-Psi-093995	Pelodiscus sinensis	80.31	7.00e-177	613.00
IUUC-Pma-094110	Petromyzon marinus	41.40	1.00e-83	304.00
IUUC-Pfo-097418	Poecilia formosa	61.45	0.00e+00	778.00
IUUC-Pab-098267	Pongo abelii	91.25	0.00e+00	1148.00
IUUC-Pca-101084	Procavia capensis	90.80	0.00e+00	1136.00
IUUC-Pva-102292	Pteropus vampyrus	92.62	0.00e+00	864.00
IUUC-Rno-105251	Rattus norvegicus	87.70	0.00e+00	1089.00
IUUC-Sha-107100	Sarcophilus harrisii	84.64	0.00e+00	1120.00
IUUC-Sar-113559	Sorex araneus	83.10	0.00e+00	926.00
IUUC-Ssc-115688	Sus scrofa	91.98	0.00e+00	1146.00
IUUC-Tgu-117424	Taeniopygia guttata	76.61	0.00e+00	973.00
IUUC-Tru-118585	Takifugu rubripes	63.85	0.00e+00	791.00
IUUC-Tsy-119299	Tarsius syrichta	80.33	0.00e+00	905.00
IUUC-Tni-120808	Tetraodon nigroviridis	63.39	0.00e+00	786.00
IUUC-Tbe-127705	Tupaia belangeri	90.86	6.00e-169	586.00
IUUC-Ttr-128225	Tursiops truncatus	92.71	0.00e+00	1100.00
IUUC-Vpa-130193	Vicugna pacos	94.22	4.00e-124	438.00
IUUC-Xtr-132449	Xenopus tropicalis	65.88	0.00e+00	794.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence