iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-133232

Ensembl Protein ID

ENSXMAP00000017210.1

UniProt Accession

M4ARW5; M4ARW5_XIPMA

Genbank Protein ID

ENSXMAP00000017210

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

AGAJ01022223

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000017166.1	ENSXMAT00000017234.1	ENSXMAP00000017210.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	1.60e-159	531.0	3	727

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 5    vkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakq 93
           +k+wleLesdPglftllvedfgvk++ qvee+y+L++++      pv+g+++lFk++e+r+s+rk+++++++++v+de+i++ +ffa+q
   Q: 3    NKGWLELESDPGLFTLLVEDFGVKGV-QVEEIYDLQSKC----HSPVYGFIFLFKWIEERRSRRKVNTLVDETSVIDEEIVNDMFFAHQ 86
           69************************.************....9********************************************* PP
   S: 94   vigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvs 182
           +i+NsCat+Allsvllnc+ +  +lGttlsr+k +tk++spe+k++a+gn+++l+ +hns+ar+e+r++pe+q++ ++++t+eafhfvs
   Q: 87   LIPNSCATHALLSVLLNCSGV--ELGTTLSRIKAFTKGFSPESKGYAIGNAPELARAHNSHARPEPRHLPEKQNGISAVRTMEAFHFVS 173
           *******************99..9***************************************************************** PP
   S: 183  yvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesde....irfnllaivadrrviktlrlnvlkid........ 259
           yv+i++rl+eldglk++P+d+g+++e+ee++dk+++v+  +eri+l++++e    irfnl+a+v+drr++++ +l++lk +        
   Q: 174  YVPIKDRLFELDGLKAYPIDHGPWGEDEEWTDKARRVI--MERIGLATAGEpyhdIRFNLMAVVPDRRMKYESKLEILKRNrqiilegl 260
           **************************************..************************************************* PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 261  qkmirltqpevvhdkkqqntsspdentikkeadadsvdesgvqskdgagpsgsskvmgkpaaptgggaqqvnpivqrlpafldnhnyak 349
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 350  spmqeeedlaagvgrartagppqppfsddedefdedeeeaagsasassrfrrkaslrsrkgrvgtgmesqialnvlaeklkkeaqrkdg 438
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 439  vntplsvrtegrtggicitsasqpsptpsnestdtaseigsafnsplrsparsqaatrpsspvashlsrvlfgedemlrldsrhnravr 527
           ***************************************************************************************** PP
   S: 260  ......................................................................................... 259
                                                                                                    
   Q: 528  elgpsvsasllhlqddgviyalppsgdsaegtklctlekvklkvkedekdpikegdegpsvavkkedenedgaelkpgkeklnvtesga 616
           ***************************************************************************************** PP
   S: 260  ...........keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefgvneg 337
                      keLl+Llk++e+ ++++e  l++e+ekrkkfkidd+rRt+nydefic+fi++la+eg+l+ lve++is++r++gv++g
   Q: 617  dskppgdkyspKELLALLKCVEADIANYEVFLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLASLVEQNISVRRRQGVSIG 705
           ***************************************************************************************** PP
   S: 338  rlakqrkqgrekkirplkrkrk 359
           rl+kqrk++r+k++rp+k+kr+
   Q: 706  RLHKQRKPDRRKRSRPYKAKRQ 727
           ********************97 PP

Organism

Xiphophorus maculatus

Protein Sequence
(Fasta)

MNNKGWLELE SDPGLFTLLV EDFGVKGVQV EEIYDLQSKC HSPVYGFIFL FKWIEERRSR 60
RKVNTLVDET SVIDEEIVND MFFAHQLIPN SCATHALLSV LLNCSGVELG TTLSRIKAFT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAGTCTGCGA CCAGTTTTGC CTATTGTGTT TATGTTGATC TGTTTTCGTT TGTTACGCGA 60
GAGGAAGCTG AGTTCAGCTG TAAAACATCT TCCACCGCCT CTGGACATGG ACTGGAATGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005622--C:intracellular
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001263	Ailuropoda melanoleuca	63.55	0.00e+00	866.00
IUUC-Apl-003405	Anas platyrhynchos	52.87	9.00e-126	443.00
IUUC-Aca-004836	Anolis carolinensis	66.13	0.00e+00	913.00
IUUC-Ame-011946	Astyanax mexicanus	70.13	0.00e+00	992.00
IUUC-Bta-013131	Bos taurus	60.14	0.00e+00	732.00
IUUC-Cja-019599	Callithrix jacchus	66.05	0.00e+00	899.00
IUUC-Cfa-021003	Canis familiaris	64.85	0.00e+00	872.00
IUUC-Cpo-022143	Cavia porcellus	65.34	0.00e+00	883.00
IUUC-Csa-023477	Chlorocebus sabaeus	65.10	0.00e+00	887.00
IUUC-Cho-024734	Choloepus hoffmanni	47.39	2.00e-120	426.00
IUUC-Csv-025842	Ciona savignyi	61.65	4.00e-94	338.00
IUUC-Dre-027793	Danio rerio	74.70	0.00e+00	1053.00
IUUC-Dno-029253	Dasypus novemcinctus	64.20	0.00e+00	875.00
IUUC-Dor-030891	Dipodomys ordii	60.66	0.00e+00	812.00
IUUC-Dme-031796	Drosophila melanogaster	62.64	2.00e-93	335.00
IUUC-Ete-032646	Echinops telfairi	84.30	9.00e-119	421.00
IUUC-Eca-033805	Equus caballus	64.39	0.00e+00	884.00
IUUC-Eeu-035216	Erinaceus europaeus	63.46	1.00e-94	340.00
IUUC-Fca-035611	Felis catus	63.65	0.00e+00	843.00
IUUC-Fal-037186	Ficedula albicollis	65.77	0.00e+00	786.00
IUUC-Gmo-038824	Gadus morhua	81.74	0.00e+00	748.00
IUUC-Gga-040875	Gallus gallus	65.82	0.00e+00	897.00
IUUC-Gac-042226	Gasterosteus aculeatus	84.55	0.00e+00	1164.00
IUUC-Ggo-045122	Gorilla gorilla	65.28	0.00e+00	894.00
IUUC-Hsa-045882	Homo sapiens	65.70	0.00e+00	894.00
IUUC-Itr-048185	Ictidomys tridecemlineatus	65.70	0.00e+00	890.00
IUUC-Lch-049960	Latimeria chalumnae	63.44	0.00e+00	842.00
IUUC-Loc-052408	Lepisosteus oculatus	71.65	7.00e-177	613.00
IUUC-Laf-054187	Loxodonta africana	64.90	0.00e+00	900.00
IUUC-Mcc-055273	Macaca mulatta	64.40	0.00e+00	868.00
IUUC-Meu-056267	Macropus eugenii	63.32	0.00e+00	872.00
IUUC-Mga-059958	Meleagris gallopavo	90.27	2.00e-143	501.00
IUUC-Mmr-061280	Microcebus murinus	65.13	0.00e+00	881.00
IUUC-Mdo-062625	Monodelphis domestica	66.10	0.00e+00	927.00
IUUC-Mmu-063853	Mus musculus	64.20	0.00e+00	880.00
IUUC-Mlu-067771	Myotis lucifugus	65.34	0.00e+00	885.00
IUUC-Opr-070741	Ochotona princeps	64.99	0.00e+00	888.00
IUUC-Ont-072172	Oreochromis niloticus	87.99	0.00e+00	1273.00
IUUC-Oan-073167	Ornithorhynchus anatinus	60.16	0.00e+00	827.00
IUUC-Ocu-074176	Oryctolagus cuniculus	64.48	0.00e+00	876.00
IUUC-Ola-087203	Oryzias latipes	91.63	1.00e-143	502.00
IUUC-Oga-089153	Otolemur garnettii	63.25	0.00e+00	873.00
IUUC-Oar-090008	Ovis aries	63.83	0.00e+00	879.00
IUUC-Ptr-091234	Pan troglodytes	65.41	0.00e+00	896.00
IUUC-Pan-092005	Papio anubis	64.97	0.00e+00	894.00
IUUC-Psi-093995	Pelodiscus sinensis	74.47	2.00e-164	572.00
IUUC-Pma-094110	Petromyzon marinus	45.51	1.00e-115	410.00
IUUC-Pfo-097418	Poecilia formosa	98.62	0.00e+00	1368.00
IUUC-Pab-098267	Pongo abelii	65.28	0.00e+00	870.00
IUUC-Pca-101084	Procavia capensis	63.01	0.00e+00	835.00
IUUC-Pva-102292	Pteropus vampyrus	65.33	9.00e-178	617.00
IUUC-Rno-105251	Rattus norvegicus	63.41	0.00e+00	871.00
IUUC-Sha-107100	Sarcophilus harrisii	65.74	0.00e+00	914.00
IUUC-Sar-113559	Sorex araneus	61.00	0.00e+00	771.00
IUUC-Ssc-115688	Sus scrofa	65.74	0.00e+00	889.00
IUUC-Tgu-117424	Taeniopygia guttata	67.29	0.00e+00	909.00
IUUC-Tru-118585	Takifugu rubripes	82.51	0.00e+00	1169.00
IUUC-Tsy-119299	Tarsius syrichta	54.31	2.00e-174	606.00
IUUC-Tni-120808	Tetraodon nigroviridis	81.97	0.00e+00	1154.00
IUUC-Tbe-127705	Tupaia belangeri	72.78	2.00e-144	504.00
IUUC-Ttr-128225	Tursiops truncatus	63.84	0.00e+00	866.00
IUUC-Vpa-130193	Vicugna pacos	68.72	3.00e-90	325.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence