iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-021639

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02019346

Gene Name

TRIP12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000007990.3	ENSCPOT00000008065.2	ENSCPOP00000007191.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.50e-95	320.4	1663	2042

Active Site

Position(s)	Description	Evidence
2009	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlq..pnpdsglknp.....................ehlk 69
           ++ le+++++E g++l G+t+ef+al+s+elq++dlgl++ +e   ++ +   + +++                         ++  
   Q: 1663 RAMLEIQYENEVGTGL-GPTLEFYALVSQELQRADLGLWRGEEVTLSNPKgsQEGTKY---IqnlqglfalpfgrtakpahiaKVKM 1745
           56899***********.**********************6665533332200222333...14458888999**********9999* PP
   S: 70   lFeflGrllgkalqdgrlldlplsksfyklllgkklsl..edleevdpelykslkeikena......es.................. 130
            F+flG+l++ka++d rl+dlpl  +fyk +l+++ sl  +dl +vdp +++s+  +++ +      e+                  
   Q: 1746 KFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLtsHDLFDVDPVVARSVCHLEDIVrqkkrlEQdksqtkeslqyaletltm 1832
           **********************************654444******************99865555511555666666554444444 PP
   S: 131  ...dieelgldltfsvseei.....lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslF 209
              ++e+            +     l+   + eLk gG++ipVt+ N+eeY +lv+ + l+eg+ +q+++fr+Gf++v+pl++l++F
   Q: 1833 ngcSVED------------LgldftLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYF 1907
           4444444............25555578999********************************************************* PP
   S: 210  teeelellicGe..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk... 291
            +eel++l+cG+  +++d+++l + ++ ++gyt+ds+a+++++e+l++f++e+++ fLqFvTgs+rlP+gGf++l+p l+++rk   
   Q: 1908 YPEELDQLLCGSkaDTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSGFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKtfe 1994
           ************7778999999999999*********************************************************** PP
   S: 292  ..dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFels 336
             ++ dd lPs++TC+nyLkLP+Yss ei+++kLl+A +e+ ++F+ls
   Q: 1995 stENPDDFLPSVMTCVNYLKLPDYSSIEIMRDKLLIAAREGqQSFHLS 2042
           988888***************************************985 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MSNRPNNNPG GSLRRSQRNT AGAQLQDDSI GGRSHLGQAK HKRYSPPESR KSNSKAPKVQ 60
SNTTSELSRG HLCKRSCSTS SAVTVPQPED SDRANTSERQ KTGQVPKKDN SRGVKRSASP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCAACC GGCCTAATAA CAATCCAGGG GGGTCACTGC GACGTTCACA GAGGAACACT 60
GCCGGGGCCC AACTACAAGA CGACTCGATA GGAGGAAGGT ATGTATTTCA TGGTAGTTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom
IPR004170--WWE-dom

PROSITE

PS50237--HECT
PS50918--WWE

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0016607--C:nuclear speck
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0009790--P:embryo development
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000750	Aegilops tauschii	38.83	3.00e-126	447.00
IUUC-Aml-001502	Ailuropoda melanoleuca	95.20	0.00e+00	3563.00
IUUC-Atr-002821	Amborella trichopoda	37.59	3.00e-116	414.00
IUUC-Apl-003531	Anas platyrhynchos	88.57	0.00e+00	3230.00
IUUC-Aly-005962	Arabidopsis lyrata	38.94	6.00e-114	406.00
IUUC-Ath-006636	Arabidopsis thaliana	41.92	2.00e-113	404.00
IUUC-Ago-007875	Ashbya gossypii	35.87	1.00e-81	298.00
IUUC-Acl-008242	Aspergillus clavatus	35.53	3.00e-113	404.00
IUUC-Afl-008736	Aspergillus flavus	38.88	7.00e-111	396.00
IUUC-Afu-008812	Aspergillus fumigatus	35.10	9.00e-114	405.00
IUUC-Ani-009407	Aspergillus nidulans	36.82	7.00e-110	392.00
IUUC-Ang-009763	Aspergillus niger	39.78	8.00e-106	379.00
IUUC-Aor-009941	Aspergillus oryzae	30.88	7.00e-113	402.00
IUUC-Ate-010459	Aspergillus terreus	36.31	5.00e-86	313.00
IUUC-Ame-011761	Astyanax mexicanus	83.13	0.00e+00	2767.00
IUUC-Bgr-012265	Blumeria graminis	34.86	3.00e-103	370.00
IUUC-Bta-013070	Bos taurus	93.82	0.00e+00	3399.00
IUUC-Bci-013890	Botrytis cinerea	39.92	2.00e-102	368.00
IUUC-Bdi-014046	Brachypodium distachyon	38.62	2.00e-121	431.00
IUUC-Bol-015942	Brassica oleracea	41.38	7.00e-114	406.00
IUUC-Bra-016849	Brassica rapa	41.38	2.00e-113	404.00
IUUC-Cja-019046	Callithrix jacchus	93.74	0.00e+00	3504.00
IUUC-Cfa-020521	Canis familiaris	93.25	0.00e+00	3414.00
IUUC-Cre-022767	Chlamydomonas reinhardtii	39.88	3.00e-89	322.00
IUUC-Csa-023231	Chlorocebus sabaeus	93.67	0.00e+00	3501.00
IUUC-Cho-024380	Choloepus hoffmanni	86.59	0.00e+00	3189.00
IUUC-Cin-025482	Ciona intestinalis	51.21	1.00e-159	556.00
IUUC-Csv-026121	Ciona savignyi	47.55	0.00e+00	1445.00
IUUC-Cgl-026716	Colletotrichum gloeosporioides	40.26	5.00e-110	393.00
IUUC-Cne-026857	Cryptococcus neoformans	39.89	3.00e-94	340.00
IUUC-Cme-027226	Cyanidioschyzon merolae	35.14	3.00e-74	274.00
IUUC-Dre-028174	Danio rerio	83.33	0.00e+00	2822.00
IUUC-Dor-030939	Dipodomys ordii	83.88	0.00e+00	2636.00
IUUC-Dse-031444	Dothistroma septosporum	37.29	5.00e-105	376.00
IUUC-Dme-032162	Drosophila melanogaster	55.06	1.00e-126	449.00
IUUC-Ete-032345	Echinops telfairi	91.84	0.00e+00	2299.00
IUUC-Eca-033229	Equus caballus	94.52	0.00e+00	3447.00
IUUC-Eeu-035205	Erinaceus europaeus	83.89	0.00e+00	2469.00
IUUC-Fca-036444	Felis catus	94.23	0.00e+00	3498.00
IUUC-Fal-037131	Ficedula albicollis	89.09	0.00e+00	3302.00
IUUC-Fox-038035	Fusarium oxysporum	38.50	2.00e-109	389.00
IUUC-Fso-038320	Fusarium solani	37.22	5.00e-110	393.00
IUUC-Gmo-039497	Gadus morhua	84.32	0.00e+00	2850.00
IUUC-Ggr-040057	Gaeumannomyces graminis	35.05	1.00e-107	385.00
IUUC-Gga-041021	Gallus gallus	89.72	0.00e+00	3321.00
IUUC-Gac-042474	Gasterosteus aculeatus	78.47	0.00e+00	2894.00
IUUC-Gma-043060	Glycine max	38.78	1.00e-120	429.00
IUUC-Ggo-044855	Gorilla gorilla	93.79	0.00e+00	3506.00
IUUC-Hsa-046147	Homo sapiens	91.58	0.00e+00	3400.00
IUUC-Hvu-047775	Hordeum vulgare	38.83	2.00e-124	441.00
IUUC-Itr-048131	Ictidomys tridecemlineatus	91.55	0.00e+00	3321.00
IUUC-Kpa-049098	Komagataella pastoris	37.90	2.00e-85	311.00
IUUC-Lch-049818	Latimeria chalumnae	80.06	0.00e+00	2882.00
IUUC-Lpe-051017	Leersia perrieri	38.18	6.00e-118	419.00
IUUC-Loc-051777	Lepisosteus oculatus	83.41	0.00e+00	3114.00
IUUC-Lma-052990	Leptosphaeria maculans	39.74	3.00e-111	397.00
IUUC-Laf-053727	Loxodonta africana	94.66	0.00e+00	3510.00
IUUC-Mcc-055799	Macaca mulatta	92.27	0.00e+00	3410.00
IUUC-Meu-056065	Macropus eugenii	93.70	0.00e+00	2100.00
IUUC-Mor-057054	Magnaporthe oryzae	34.80	9.00e-107	382.00
IUUC-Mpo-057417	Magnaporthe poae	39.74	8.00e-109	389.00
IUUC-Mtr-057849	Medicago truncatula	37.50	7.00e-113	402.00
IUUC-Mla-058870	Melampsora laricipopulina	42.77	4.00e-106	380.00
IUUC-Mga-059580	Meleagris gallopavo	90.17	0.00e+00	2865.00
IUUC-Mvi-060507	Microbotryum violaceum	39.81	5.00e-112	400.00
IUUC-Mmr-060816	Microcebus murinus	93.67	0.00e+00	3494.00
IUUC-Mdo-062866	Monodelphis domestica	88.99	0.00e+00	3182.00
IUUC-Mmu-063906	Mus musculus	91.06	0.00e+00	3382.00
IUUC-Mac-064675	Musa acuminata	41.08	1.00e-110	394.00
IUUC-Mpu-066199	Mustela putorius furo	92.27	0.00e+00	3396.00
IUUC-Mlu-067110	Myotis lucifugus	91.16	0.00e+00	3371.00
IUUC-Nfi-068482	Neosartorya fischeri	35.10	1.00e-113	405.00
IUUC-Ncr-068906	Neurospora crassa	38.85	7.00e-109	389.00
IUUC-Nle-069410	Nomascus leucogenys	94.52	0.00e+00	3496.00
IUUC-Opr-070401	Ochotona princeps	83.42	0.00e+00	2940.00
IUUC-Ont-072100	Oreochromis niloticus	79.03	0.00e+00	2921.00
IUUC-Oan-073121	Ornithorhynchus anatinus	89.91	0.00e+00	3446.00
IUUC-Ocu-074623	Oryctolagus cuniculus	91.74	0.00e+00	3416.00
IUUC-Oba-075380	Oryza barthii	36.36	1.00e-112	401.00
IUUC-Obr-076915	Oryza brachyantha	37.50	4.00e-118	420.00
IUUC-Ogl-077055	Oryza glaberrima	38.44	2.00e-117	417.00
IUUC-Ogu-078892	Oryza glumaepatula	40.77	6.00e-112	399.00
IUUC-Oin-079256	Oryza indica	38.26	2.00e-116	414.00
IUUC-Olo-080343	Oryza longistaminata	38.26	8.00e-117	416.00
IUUC-Ome-081422	Oryza meridionalis	37.97	2.00e-116	414.00
IUUC-Oni-083047	Oryza nivara	40.95	7.00e-114	405.00
IUUC-Opu-083641	Oryza punctata	36.07	6.00e-110	392.00
IUUC-Oru-084439	Oryza rufipogon	40.77	1.00e-112	401.00
IUUC-Osa-085972	Oryza sativa	38.44	5.00e-116	411.00
IUUC-Ola-087173	Oryzias latipes	76.86	0.00e+00	2849.00
IUUC-Olu-087871	Ostreococcus lucimarinus	36.50	5.00e-88	318.00
IUUC-Oga-087908	Otolemur garnettii	93.65	0.00e+00	3507.00
IUUC-Oar-090277	Ovis aries	92.35	0.00e+00	3402.00
IUUC-Ptr-091543	Pan troglodytes	91.63	0.00e+00	3405.00
IUUC-Pan-092243	Papio anubis	92.22	0.00e+00	3409.00
IUUC-Psi-093150	Pelodiscus sinensis	91.25	0.00e+00	3422.00
IUUC-Pno-094891	Phaeosphaeria nodorum	41.09	2.00e-112	400.00
IUUC-Ppa-095181	Physcomitrella patens	42.33	2.00e-106	380.00
IUUC-Pfo-096267	Poecilia formosa	78.83	0.00e+00	2885.00
IUUC-Pab-098072	Pongo abelii	94.81	0.00e+00	3507.00
IUUC-Pop-099190	Populus trichocarpa	41.34	8.00e-116	412.00
IUUC-Pca-100311	Procavia capensis	87.65	0.00e+00	3131.00
IUUC-Ppe-101284	Prunus persica	37.66	1.00e-115	412.00
IUUC-Pva-102215	Pteropus vampyrus	88.94	0.00e+00	1231.00
IUUC-Pgr-103694	Puccinia graminis	40.68	1.00e-103	372.00
IUUC-Ptt-103916	Puccinia triticina	38.80	1.00e-97	352.00
IUUC-Pte-104346	Pyrenophora teres	39.44	2.00e-109	391.00
IUUC-Pyt-104508	Pyrenophora triticirepentis	39.51	1.00e-109	391.00
IUUC-Rno-105315	Rattus norvegicus	91.74	0.00e+00	3357.00
IUUC-Sce-106273	Saccharomyces cerevisiae	35.19	4.00e-71	263.00
IUUC-Sha-106835	Sarcophilus harrisii	91.45	0.00e+00	3464.00
IUUC-Sja-107943	Schizosaccharomyces japonicus	37.78	3.00e-94	340.00
IUUC-Spo-108081	Schizosaccharomyces pombe	38.74	1.00e-94	342.00
IUUC-Ssl-108560	Sclerotinia sclerotiorum	40.12	6.00e-106	379.00
IUUC-Smo-109590	Selaginella moellendorffii	42.91	2.00e-111	398.00
IUUC-Sit-110717	Setaria italica	37.80	2.00e-119	424.00
IUUC-Sly-111469	Solanum lycopersicum	38.97	9.00e-121	429.00
IUUC-Stu-112896	Solanum tuberosum	38.22	1.00e-104	374.00
IUUC-Sar-113224	Sorex araneus	82.20	0.00e+00	1755.00
IUUC-Sbi-114313	Sorghum bicolor	38.16	2.00e-123	437.00
IUUC-Sre-114993	Sporisorium reilianum	33.86	1.00e-99	359.00
IUUC-Ssc-115535	Sus scrofa	87.45	0.00e+00	3257.00
IUUC-Tgu-117493	Taeniopygia guttata	89.51	0.00e+00	2597.00
IUUC-Tru-118669	Takifugu rubripes	79.09	0.00e+00	2902.00
IUUC-Tsy-119373	Tarsius syrichta	93.70	0.00e+00	1856.00
IUUC-Tni-120049	Tetraodon nigroviridis	77.80	0.00e+00	867.00
IUUC-Tca-121779	Theobroma cacao	38.76	6.00e-115	409.00
IUUC-Tre-122195	Trichoderma reesei	36.10	4.00e-105	377.00
IUUC-Tvi-122650	Trichoderma virens	36.08	1.00e-108	389.00
IUUC-Tae-123580	Triticum aestivum	38.73	2.00e-124	439.00
IUUC-Tur-126295	Triticum urartu	38.69	4.00e-125	443.00
IUUC-Tme-126964	Tuber melanosporum	40.67	4.00e-105	377.00
IUUC-Tbe-128149	Tupaia belangeri	81.32	0.00e+00	1457.00
IUUC-Ttr-128165	Tursiops truncatus	91.94	0.00e+00	2917.00
IUUC-Uma-129365	Ustilago maydis	35.89	8.00e-88	320.00
IUUC-Vda-129725	Verticillium dahliae	41.28	1.00e-108	389.00
IUUC-Vpa-130678	Vicugna pacos	96.24	0.00e+00	2546.00
IUUC-Vvi-131147	Vitis vinifera	39.23	3.00e-121	431.00
IUUC-Xtr-132636	Xenopus tropicalis	83.31	0.00e+00	3078.00
IUUC-Xma-133458	Xiphophorus maculatus	78.98	0.00e+00	2927.00
IUUC-Yli-134481	Yarrowia lipolytica	39.36	2.00e-97	351.00
IUUC-Zma-135782	Zea mays	37.09	3.00e-117	417.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence