iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-033615

Ensembl Protein ID

ENSECAP00000006426.1

UniProt Accession

F6U6A9; F6U6A9_HORSE

Protein Name

Histone-lysine N-methyltransferase 2A

Gene Name

KMT2A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000007743.1	ENSECAT00000008563.1	ENSECAP00000006426.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	9.00e-26	90.0	1449	1502

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCrsk 54
           k+C+vCg++++ +k+l+eC+kCr+ +Hp+Cl+++ ++++p+++k  wiC+kC ++
   Q: 1449 KFCHVCGRQHQATKQLLECNKCRNSYHPECLGPN-YPTKPTKKKkvWICTKCVRC 1502
           58********************************.*****99999*******876 PP

Organism

Equus caballus

Functional Description
(View)

Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis. Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer. Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin.

Protein Sequence
(Fasta)

PRQSITALLL PPGPPVGGGG PEAPPSPPAV AAAAAAAGSS GAGVPGGAAA ASAASSSSAS 60
SSSSSSSSAS SGPALLRVGP GFDAALQVSA AIGTNLRRFR AVFGESGGGG GSGEDEQFLG 120

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Nucleotide Sequence
(Fasta)

GCGGCAGAGG CGGGGGACGC CCAGGGCCTA AGGGAAGCAC CCGCGGCAGA GCATCACGGC 60
CCTGCTGCTT CCACCCGGGC CCCCGGTCGG CGGCGGCGGT CCCGAGGCGC CCCCCTCCCC 120

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Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001487--Bromodomain
IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR016569--MeTrfase_trithorax
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50014--BROMODOMAIN_2
PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET
PF02008--zf-CXXC

SMART

SM00297--BROMO
SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0005829--C:cytosol
GO:0071339--C:MLL1 complex
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0045322--F:unmethylated CpG binding
GO:0008270--F:zinc ion binding
GO:0009952--P:anterior/posterior pattern specification
GO:0032922--P:circadian regulation of gene expression
GO:0060216--P:definitive hemopoiesis
GO:0006306--P:DNA methylation
GO:0035162--P:embryonic hemopoiesis
GO:0035640--P:exploration behavior
GO:0044648--P:histone H3-K4 dimethylation
GO:0080182--P:histone H3-K4 trimethylation
GO:0043984--P:histone H4-K16 acetylation
GO:0048873--P:homeostasis of number of cells within a tissue
GO:0008285--P:negative regulation of cell proliferation
GO:0018026--P:peptidyl-lysine monomethylation
GO:2001040--P:positive regulation of cellular response to drug
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032411--P:positive regulation of transporter activity
GO:0009791--P:post-embryonic development
GO:0006461--P:protein complex assembly
GO:0071440--P:regulation of histone H3-K14 acetylation
GO:1901674--P:regulation of histone H3-K27 acetylation
GO:2000615--P:regulation of histone H3-K9 acetylation
GO:0048172--P:regulation of short-term neuronal synaptic plasticity
GO:0048536--P:spleen development
GO:0006351--P:transcription, DNA-templated
GO:0008542--P:visual learning

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001054	Aegilops tauschii	34.74	7.00e-13	69.30
IUUC-Aml-002274	Ailuropoda melanoleuca	95.82	0.00e+00	6219.00
IUUC-Atr-002455	Amborella trichopoda	48.10	7.00e-39	156.00
IUUC-Apl-003478	Anas platyrhynchos	79.39	0.00e+00	4008.00
IUUC-Aca-005086	Anolis carolinensis	66.00	0.00e+00	3627.00
IUUC-Aly-006448	Arabidopsis lyrata	48.10	3.00e-39	157.00
IUUC-Ath-006690	Arabidopsis thaliana	47.40	4.00e-37	150.00
IUUC-Ame-011195	Astyanax mexicanus	44.00	0.00e+00	810.00
IUUC-Bta-012974	Bos taurus	95.04	0.00e+00	6116.00
IUUC-Bol-016540	Brassica oleracea	48.05	1.00e-37	152.00
IUUC-Cja-019226	Callithrix jacchus	93.52	0.00e+00	6070.00
IUUC-Cfa-021049	Canis familiaris	95.45	0.00e+00	6134.00
IUUC-Cpo-021459	Cavia porcellus	93.17	0.00e+00	4348.00
IUUC-Cre-022891	Chlamydomonas reinhardtii	50.00	1.00e-38	156.00
IUUC-Csa-023434	Chlorocebus sabaeus	95.20	0.00e+00	5591.00
IUUC-Cho-024652	Choloepus hoffmanni	90.84	0.00e+00	3971.00
IUUC-Cin-025724	Ciona intestinalis	54.46	1.00e-96	348.00
IUUC-Csv-026268	Ciona savignyi	36.96	4.00e-133	469.00
IUUC-Cme-027224	Cyanidioschyzon merolae	34.18	3.00e-12	67.40
IUUC-Dre-028180	Danio rerio	65.77	0.00e+00	1166.00
IUUC-Dno-029068	Dasypus novemcinctus	91.23	0.00e+00	5819.00
IUUC-Dor-030550	Dipodomys ordii	87.05	0.00e+00	5110.00
IUUC-Ete-032834	Echinops telfairi	85.51	0.00e+00	2839.00
IUUC-Eeu-035136	Erinaceus europaeus	82.78	0.00e+00	1188.00
IUUC-Fca-036453	Felis catus	93.80	0.00e+00	2776.00
IUUC-Fal-037256	Ficedula albicollis	79.04	0.00e+00	5028.00
IUUC-Gmo-038641	Gadus morhua	71.31	0.00e+00	1090.00
IUUC-Gga-040828	Gallus gallus	79.50	0.00e+00	4937.00
IUUC-Gac-041452	Gasterosteus aculeatus	70.49	0.00e+00	1160.00
IUUC-Gma-043554	Glycine max	49.02	3.00e-38	154.00
IUUC-Ggo-045124	Gorilla gorilla	91.91	0.00e+00	5773.00
IUUC-Hsa-046143	Homo sapiens	95.50	0.00e+00	6073.00
IUUC-Itr-049024	Ictidomys tridecemlineatus	93.15	0.00e+00	5321.00
IUUC-Lch-049704	Latimeria chalumnae	64.28	0.00e+00	3881.00
IUUC-Loc-052181	Lepisosteus oculatus	78.51	0.00e+00	1312.00
IUUC-Laf-053946	Loxodonta africana	95.14	0.00e+00	5947.00
IUUC-Mcc-055508	Macaca mulatta	95.66	0.00e+00	6067.00
IUUC-Meu-056485	Macropus eugenii	82.62	0.00e+00	3134.00
IUUC-Mtr-058327	Medicago truncatula	41.52	9.00e-39	155.00
IUUC-Mga-059943	Meleagris gallopavo	76.59	0.00e+00	4588.00
IUUC-Mmr-061178	Microcebus murinus	93.82	0.00e+00	6070.00
IUUC-Mdo-063031	Monodelphis domestica	86.85	0.00e+00	4096.00
IUUC-Mmu-063650	Mus musculus	89.81	0.00e+00	4216.00
IUUC-Mpu-066495	Mustela putorius furo	95.25	0.00e+00	4143.00
IUUC-Mlu-068045	Myotis lucifugus	86.32	0.00e+00	5500.00
IUUC-Nle-069064	Nomascus leucogenys	95.69	0.00e+00	6075.00
IUUC-Opr-071043	Ochotona princeps	87.88	0.00e+00	4404.00
IUUC-Ont-072556	Oreochromis niloticus	69.71	0.00e+00	1129.00
IUUC-Oan-073324	Ornithorhynchus anatinus	77.46	0.00e+00	2157.00
IUUC-Ocu-074190	Oryctolagus cuniculus	92.48	0.00e+00	5885.00
IUUC-Oba-075647	Oryza barthii	49.36	2.00e-38	154.00
IUUC-Olo-080577	Oryza longistaminata	47.71	8.00e-36	145.00
IUUC-Ome-081214	Oryza meridionalis	49.36	2.00e-38	154.00
IUUC-Oni-083000	Oryza nivara	49.36	2.00e-38	154.00
IUUC-Opu-083842	Oryza punctata	49.36	2.00e-38	154.00
IUUC-Oru-084361	Oryza rufipogon	49.36	3.00e-38	154.00
IUUC-Ola-087176	Oryzias latipes	64.70	0.00e+00	1136.00
IUUC-Olu-087718	Ostreococcus lucimarinus	37.50	2.00e-35	145.00
IUUC-Oga-088208	Otolemur garnettii	94.34	0.00e+00	5984.00
IUUC-Oar-090152	Ovis aries	95.14	0.00e+00	6188.00
IUUC-Ptr-091127	Pan troglodytes	95.56	0.00e+00	6038.00
IUUC-Pan-092679	Papio anubis	94.95	0.00e+00	4844.00
IUUC-Psi-094059	Pelodiscus sinensis	80.24	0.00e+00	5084.00
IUUC-Pma-094258	Petromyzon marinus	60.30	0.00e+00	684.00
IUUC-Pfo-096536	Poecilia formosa	68.60	0.00e+00	1121.00
IUUC-Pab-098262	Pongo abelii	95.68	0.00e+00	6105.00
IUUC-Pca-100358	Procavia capensis	89.55	0.00e+00	5527.00
IUUC-Pva-102522	Pteropus vampyrus	90.67	0.00e+00	4865.00
IUUC-Rno-105200	Rattus norvegicus	90.04	0.00e+00	4111.00
IUUC-Sha-107174	Sarcophilus harrisii	86.62	0.00e+00	5504.00
IUUC-Smo-109164	Selaginella moellendorffii	51.95	1.00e-40	162.00
IUUC-Sly-111176	Solanum lycopersicum	48.37	4.00e-36	146.00
IUUC-Stu-112529	Solanum tuberosum	48.37	1.00e-38	154.00
IUUC-Sar-113503	Sorex araneus	83.67	0.00e+00	3158.00
IUUC-Sbi-114254	Sorghum bicolor	26.92	8.00e-11	62.40
IUUC-Tgu-117047	Taeniopygia guttata	79.48	0.00e+00	4992.00
IUUC-Tru-118328	Takifugu rubripes	65.64	0.00e+00	1145.00
IUUC-Tsy-118953	Tarsius syrichta	89.20	0.00e+00	3135.00
IUUC-Tni-120837	Tetraodon nigroviridis	65.75	0.00e+00	1135.00
IUUC-Tbe-127950	Tupaia belangeri	88.95	0.00e+00	2924.00
IUUC-Ttr-128643	Tursiops truncatus	94.12	0.00e+00	5925.00
IUUC-Vpa-130660	Vicugna pacos	90.58	0.00e+00	2018.00
IUUC-Vvi-131476	Vitis vinifera	46.75	2.00e-39	157.00
IUUC-Xtr-132869	Xenopus tropicalis	62.03	0.00e+00	2289.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence