iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037256

Ensembl Protein ID

ENSFALP00000010386.1

UniProt Accession

U3K5T2; U3K5T2_FICAL

Genbank Protein ID

ENSFALP00000010386

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AGTO01011842

Gene Name

KMT2A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000009959.1	ENSFALT00000010427.1	ENSFALP00000010386.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	4.70e-26	90.4	1274	1327

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCrsk 54
           k+C+vCg++++ +k+l+eC+kCr+ +Hp+Cl+++ ++++p+++k  wiC+kC ++
   Q: 1274 KFCHVCGRQHQATKQLLECNKCRNSYHPECLGPN-YPTKPTKKKkvWICTKCVRC 1327
           58********************************.*****99999*******876 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MEKVKKKESK SGEKRRGRPP TLTSVKFKLS QEKDTSDIQK GSKDEKESLK KIKRSPSTTF 60
QQATKIKKLR TSKLSPLKSK FKPGAKLQIG RKSVQMVRRR GRPPSSERLK TSSALVINSQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCAACATTA ATATCCATGT CCTCAAACTT TCACCTGCTT TCTCATTGCA GGATGAACAG 60
TTTTTAGGTT TTGGTTCAGA TGAAGAAGTC AAAGTACGAA GTCCCACCAG GTCCCCCACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001487--Bromodomain
IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR016569--MeTrfase_trithorax
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50014--BROMODOMAIN_2
PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET
PF02008--zf-CXXC

SMART

SM00297--BROMO
SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0005829--C:cytosol
GO:0071339--C:MLL1 complex
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0045322--F:unmethylated CpG binding
GO:0008270--F:zinc ion binding
GO:0009952--P:anterior/posterior pattern specification
GO:0032922--P:circadian regulation of gene expression
GO:0060216--P:definitive hemopoiesis
GO:0006306--P:DNA methylation
GO:0035162--P:embryonic hemopoiesis
GO:0035640--P:exploration behavior
GO:0044648--P:histone H3-K4 dimethylation
GO:0080182--P:histone H3-K4 trimethylation
GO:0043984--P:histone H4-K16 acetylation
GO:0048873--P:homeostasis of number of cells within a tissue
GO:0008285--P:negative regulation of cell proliferation
GO:0018026--P:peptidyl-lysine monomethylation
GO:2001040--P:positive regulation of cellular response to drug
GO:0051571--P:positive regulation of histone H3-K4 methylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032411--P:positive regulation of transporter activity
GO:0009791--P:post-embryonic development
GO:0006461--P:protein complex assembly
GO:0071440--P:regulation of histone H3-K14 acetylation
GO:1901674--P:regulation of histone H3-K27 acetylation
GO:2000615--P:regulation of histone H3-K9 acetylation
GO:0048172--P:regulation of short-term neuronal synaptic plasticity
GO:0048536--P:spleen development
GO:0006351--P:transcription, DNA-templated
GO:0008542--P:visual learning

KEGG

fab:101813917

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001054	Aegilops tauschii	34.74	6.00e-13	69.30
IUUC-Aml-002274	Ailuropoda melanoleuca	79.55	0.00e+00	4899.00
IUUC-Atr-002455	Amborella trichopoda	48.10	2.00e-39	158.00
IUUC-Apl-003478	Anas platyrhynchos	91.15	0.00e+00	4672.00
IUUC-Aca-005086	Anolis carolinensis	67.80	0.00e+00	3694.00
IUUC-Aly-006448	Arabidopsis lyrata	48.10	6.00e-40	159.00
IUUC-Ath-006690	Arabidopsis thaliana	47.40	1.00e-37	151.00
IUUC-Ame-011195	Astyanax mexicanus	44.97	0.00e+00	832.00
IUUC-Bta-012974	Bos taurus	79.00	0.00e+00	4913.00
IUUC-Bdi-014882	Brachypodium distachyon	31.90	4.00e-26	112.00
IUUC-Bol-016540	Brassica oleracea	48.05	3.00e-38	154.00
IUUC-Cja-019226	Callithrix jacchus	78.06	0.00e+00	4891.00
IUUC-Cfa-021049	Canis familiaris	79.75	0.00e+00	4934.00
IUUC-Cpo-021459	Cavia porcellus	79.45	0.00e+00	3584.00
IUUC-Cre-022891	Chlamydomonas reinhardtii	50.78	2.00e-39	159.00
IUUC-Csa-023434	Chlorocebus sabaeus	78.32	0.00e+00	3615.00
IUUC-Cho-024652	Choloepus hoffmanni	75.63	0.00e+00	3222.00
IUUC-Cin-025724	Ciona intestinalis	54.78	2.00e-96	347.00
IUUC-Csv-026268	Ciona savignyi	37.25	6.00e-131	462.00
IUUC-Cme-027224	Cyanidioschyzon merolae	34.18	2.00e-12	67.80
IUUC-Dre-028180	Danio rerio	65.52	0.00e+00	1150.00
IUUC-Dno-029068	Dasypus novemcinctus	73.49	0.00e+00	2628.00
IUUC-Dor-030550	Dipodomys ordii	75.04	0.00e+00	4286.00
IUUC-Dme-032023	Drosophila melanogaster	46.82	1.00e-90	330.00
IUUC-Ete-032834	Echinops telfairi	69.28	0.00e+00	2208.00
IUUC-Eca-033615	Equus caballus	79.81	0.00e+00	4806.00
IUUC-Eeu-035136	Erinaceus europaeus	74.66	0.00e+00	1038.00
IUUC-Fca-036453	Felis catus	71.23	0.00e+00	1968.00
IUUC-Gmo-038641	Gadus morhua	67.79	0.00e+00	1088.00
IUUC-Gga-040828	Gallus gallus	91.08	0.00e+00	5751.00
IUUC-Gac-041452	Gasterosteus aculeatus	70.43	0.00e+00	1145.00
IUUC-Gma-043554	Glycine max	49.02	6.00e-39	156.00
IUUC-Ggo-045124	Gorilla gorilla	75.00	0.00e+00	3351.00
IUUC-Hsa-046143	Homo sapiens	78.47	0.00e+00	3586.00
IUUC-Hvu-047762	Hordeum vulgare	29.78	2.00e-19	90.50
IUUC-Itr-049024	Ictidomys tridecemlineatus	76.48	0.00e+00	4225.00
IUUC-Lch-049704	Latimeria chalumnae	66.14	0.00e+00	3959.00
IUUC-Lpe-051476	Leersia perrieri	30.09	5.00e-22	99.80
IUUC-Loc-052181	Lepisosteus oculatus	78.51	0.00e+00	1292.00
IUUC-Laf-053946	Loxodonta africana	80.11	0.00e+00	4783.00
IUUC-Mcc-055508	Macaca mulatta	78.31	0.00e+00	3599.00
IUUC-Meu-056485	Macropus eugenii	75.50	0.00e+00	2766.00
IUUC-Mtr-058327	Medicago truncatula	41.96	1.00e-39	158.00
IUUC-Mga-059943	Meleagris gallopavo	88.58	0.00e+00	5331.00
IUUC-Mmr-061178	Microcebus murinus	78.13	0.00e+00	4856.00
IUUC-Mdo-063031	Monodelphis domestica	80.44	0.00e+00	3719.00
IUUC-Mmu-063650	Mus musculus	77.89	0.00e+00	3500.00
IUUC-Mac-064935	Musa acuminata	33.50	4.00e-28	119.00
IUUC-Mpu-066495	Mustela putorius furo	79.65	0.00e+00	3341.00
IUUC-Mlu-068045	Myotis lucifugus	74.89	0.00e+00	4555.00
IUUC-Nle-069064	Nomascus leucogenys	79.40	0.00e+00	4887.00
IUUC-Opr-071043	Ochotona princeps	73.81	0.00e+00	3594.00
IUUC-Ont-072556	Oreochromis niloticus	65.02	0.00e+00	1109.00
IUUC-Oan-073324	Ornithorhynchus anatinus	75.91	0.00e+00	2108.00
IUUC-Ocu-074190	Oryctolagus cuniculus	77.82	0.00e+00	4788.00
IUUC-Oba-075647	Oryza barthii	49.36	7.00e-39	155.00
IUUC-Obr-076458	Oryza brachyantha	32.66	8.00e-26	111.00
IUUC-Ogl-077851	Oryza glaberrima	31.44	3.00e-25	110.00
IUUC-Ogu-078706	Oryza glumaepatula	31.84	1.00e-25	111.00
IUUC-Oin-079802	Oryza indica	29.13	5.00e-20	92.80
IUUC-Olo-080577	Oryza longistaminata	47.71	2.00e-36	147.00
IUUC-Ome-081214	Oryza meridionalis	49.36	7.00e-39	155.00
IUUC-Oni-083000	Oryza nivara	49.36	9.00e-39	155.00
IUUC-Opu-083842	Oryza punctata	49.36	8.00e-39	155.00
IUUC-Oru-084361	Oryza rufipogon	49.36	9.00e-39	155.00
IUUC-Osa-085421	Oryza sativa	32.14	1.00e-24	107.00
IUUC-Ola-087176	Oryzias latipes	62.91	0.00e+00	1127.00
IUUC-Oga-088208	Otolemur garnettii	78.62	0.00e+00	4791.00
IUUC-Oar-090152	Ovis aries	79.45	0.00e+00	4949.00
IUUC-Ptr-091127	Pan troglodytes	78.51	0.00e+00	3567.00
IUUC-Pan-092679	Papio anubis	78.47	0.00e+00	3601.00
IUUC-Psi-094059	Pelodiscus sinensis	85.36	0.00e+00	5487.00
IUUC-Pma-094258	Petromyzon marinus	59.36	0.00e+00	676.00
IUUC-Ppa-095221	Physcomitrella patens	33.33	1.00e-27	117.00
IUUC-Pfo-096536	Poecilia formosa	67.65	0.00e+00	1111.00
IUUC-Pab-098262	Pongo abelii	79.56	0.00e+00	4874.00
IUUC-Pop-099585	Populus trichocarpa	31.63	3.00e-25	110.00
IUUC-Pca-100358	Procavia capensis	75.46	0.00e+00	4543.00
IUUC-Ppe-101920	Prunus persica	33.65	3.00e-26	114.00
IUUC-Pva-102522	Pteropus vampyrus	74.30	0.00e+00	3860.00
IUUC-Rno-105200	Rattus norvegicus	77.27	0.00e+00	3449.00
IUUC-Sha-107174	Sarcophilus harrisii	80.77	0.00e+00	5003.00
IUUC-Smo-109164	Selaginella moellendorffii	51.30	7.00e-41	162.00
IUUC-Sit-110552	Setaria italica	31.90	7.00e-27	115.00
IUUC-Sly-111176	Solanum lycopersicum	48.37	1.00e-36	148.00
IUUC-Stu-112529	Solanum tuberosum	48.37	7.00e-39	155.00
IUUC-Sar-113503	Sorex araneus	70.98	0.00e+00	2633.00
IUUC-Sbi-114254	Sorghum bicolor	26.92	4.00e-10	59.70
IUUC-Ssc-115509	Sus scrofa	51.17	0.00e+00	757.00
IUUC-Tgu-117047	Taeniopygia guttata	96.39	0.00e+00	6175.00
IUUC-Tru-118328	Takifugu rubripes	65.71	0.00e+00	1146.00
IUUC-Tsy-118953	Tarsius syrichta	71.07	0.00e+00	2350.00
IUUC-Tni-120837	Tetraodon nigroviridis	66.26	0.00e+00	1132.00
IUUC-Tca-121624	Theobroma cacao	32.14	6.00e-26	112.00
IUUC-Tae-124647	Triticum aestivum	28.98	5.00e-19	89.00
IUUC-Tbe-127950	Tupaia belangeri	71.16	0.00e+00	2212.00
IUUC-Ttr-128643	Tursiops truncatus	78.05	0.00e+00	4702.00
IUUC-Vpa-130660	Vicugna pacos	79.58	0.00e+00	1765.00
IUUC-Vvi-131476	Vitis vinifera	46.75	4.00e-40	159.00
IUUC-Xtr-132869	Xenopus tropicalis	60.08	0.00e+00	3606.00
IUUC-Xma-133393	Xiphophorus maculatus	63.89	0.00e+00	1062.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence