iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-036311

Ensembl Protein ID

ENSFCAP00000005933.3

UniProt Accession

M3W5T8; M3W5T8_FELCA

Genbank Protein ID

ENSFCAP00000005933

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AANG02178610

Gene Name

KMT2B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000006381.3	ENSFCAT00000006383.3	ENSFCAP00000005933.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	9.70e-29	99.4	1259	1312

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCrsk 54
           k+C+vCg++g+++k+l+eCe+Cr+++HpaCl++s ++++ ++++  wiC+ C ++
   Q: 1259 KFCHVCGRKGRGSKHLLECERCRHAYHPACLGPS-YPTRATRKRrhWICSACVRC 1312
           58********************************.88888877777******876 PP

Organism

Felis catus

Protein Sequence
(Fasta)

MAAAAGGGSC PGPGSARGRF PGRPRGSGGG GGRGGRGSGA ERVRVAPGRG GGRGASKGLG 60
GPEGWREEAR FSGSLRRDGG ALRIGLGGDR LHGGVGAKGL RKWVEKPGCS WALGPEAHPA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGCGG CGGCGGGCGG CGGCAGTTGC CCCGGGCCTG GCTCCGCGCG GGGCCGCTTC 60
CCGGGCCGGC CGCGGGGCTC CGGCGGGGGC GGGGGCCGCG GCGGACGGGG CAGCGGAGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001487--Bromodomain
IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET
PF02008--zf-CXXC

SMART

SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0035097--C:histone methyltransferase complex
GO:0003677--F:DNA binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0008270--F:zinc ion binding
GO:0016458--P:gene silencing
GO:0080182--P:histone H3-K4 trimethylation
GO:0007613--P:memory
GO:0009994--P:oocyte differentiation
GO:0001541--P:ovarian follicle development
GO:0030728--P:ovulation
GO:0051569--P:regulation of histone H3-K4 methylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002367	Ailuropoda melanoleuca	95.40	0.00e+00	3339.00
IUUC-Atr-002455	Amborella trichopoda	48.10	5.00e-37	150.00
IUUC-Aca-004718	Anolis carolinensis	57.93	0.00e+00	1988.00
IUUC-Aly-006448	Arabidopsis lyrata	48.10	7.00e-37	149.00
IUUC-Ath-006690	Arabidopsis thaliana	44.16	4.00e-35	143.00
IUUC-Ame-010705	Astyanax mexicanus	47.88	0.00e+00	791.00
IUUC-Bta-013578	Bos taurus	96.35	0.00e+00	3003.00
IUUC-Bdi-014882	Brachypodium distachyon	33.00	5.00e-27	115.00
IUUC-Bol-016540	Brassica oleracea	44.81	9.00e-36	145.00
IUUC-Bra-017422	Brassica rapa	33.01	3.00e-27	117.00
IUUC-Cja-019138	Callithrix jacchus	89.59	0.00e+00	3234.00
IUUC-Cfa-020020	Canis familiaris	96.55	0.00e+00	3289.00
IUUC-Cpo-021552	Cavia porcellus	88.50	0.00e+00	3176.00
IUUC-Cre-022891	Chlamydomonas reinhardtii	53.12	1.00e-37	152.00
IUUC-Csa-024216	Chlorocebus sabaeus	91.25	0.00e+00	3271.00
IUUC-Cin-025724	Ciona intestinalis	54.52	2.00e-95	344.00
IUUC-Csv-026268	Ciona savignyi	39.05	3.00e-129	456.00
IUUC-Dre-027440	Danio rerio	44.78	0.00e+00	912.00
IUUC-Dno-029583	Dasypus novemcinctus	94.71	0.00e+00	3064.00
IUUC-Dor-030903	Dipodomys ordii	87.86	0.00e+00	2178.00
IUUC-Dme-032023	Drosophila melanogaster	47.28	2.00e-92	336.00
IUUC-Eca-034026	Equus caballus	97.37	0.00e+00	1963.00
IUUC-Eeu-034687	Erinaceus europaeus	93.98	0.00e+00	1149.00
IUUC-Gmo-039265	Gadus morhua	44.72	0.00e+00	815.00
IUUC-Gac-042202	Gasterosteus aculeatus	48.34	0.00e+00	748.00
IUUC-Gma-043554	Glycine max	47.06	8.00e-36	145.00
IUUC-Ggo-044791	Gorilla gorilla	94.19	0.00e+00	2133.00
IUUC-Hsa-046988	Homo sapiens	91.16	0.00e+00	3177.00
IUUC-Hvu-047762	Hordeum vulgare	35.82	8.00e-20	91.70
IUUC-Itr-048907	Ictidomys tridecemlineatus	92.75	0.00e+00	3358.00
IUUC-Lpe-051476	Leersia perrieri	31.05	9.00e-24	105.00
IUUC-Loc-052252	Lepisosteus oculatus	53.59	0.00e+00	779.00
IUUC-Laf-053703	Loxodonta africana	94.40	0.00e+00	2198.00
IUUC-Mcc-054782	Macaca mulatta	89.30	0.00e+00	2487.00
IUUC-Meu-056046	Macropus eugenii	86.96	0.00e+00	1729.00
IUUC-Mtr-058327	Medicago truncatula	40.44	2.00e-36	147.00
IUUC-Mmr-061316	Microcebus murinus	92.00	0.00e+00	2836.00
IUUC-Mdo-062648	Monodelphis domestica	80.06	0.00e+00	2005.00
IUUC-Mmu-063579	Mus musculus	89.41	0.00e+00	3232.00
IUUC-Mac-064935	Musa acuminata	32.87	2.00e-29	124.00
IUUC-Mpu-066710	Mustela putorius furo	96.46	0.00e+00	3341.00
IUUC-Mlu-067559	Myotis lucifugus	90.92	0.00e+00	3264.00
IUUC-Nle-070085	Nomascus leucogenys	87.64	0.00e+00	2181.00
IUUC-Opr-071148	Ochotona princeps	88.34	0.00e+00	3183.00
IUUC-Ont-071626	Oreochromis niloticus	45.14	0.00e+00	891.00
IUUC-Oan-073324	Ornithorhynchus anatinus	48.58	0.00e+00	930.00
IUUC-Ocu-074475	Oryctolagus cuniculus	89.20	0.00e+00	3123.00
IUUC-Obr-076458	Oryza brachyantha	33.99	1.00e-27	118.00
IUUC-Ogl-077851	Oryza glaberrima	35.71	8.00e-28	118.00
IUUC-Ogu-078706	Oryza glumaepatula	35.71	5.00e-28	119.00
IUUC-Oin-079802	Oryza indica	30.95	7.00e-23	102.00
IUUC-Olo-080577	Oryza longistaminata	46.41	1.00e-33	138.00
IUUC-Osa-085421	Oryza sativa	35.71	1.00e-27	118.00
IUUC-Ola-086609	Oryzias latipes	51.47	0.00e+00	755.00
IUUC-Oga-088140	Otolemur garnettii	91.34	0.00e+00	3221.00
IUUC-Oar-089447	Ovis aries	94.82	0.00e+00	2078.00
IUUC-Ptr-090902	Pan troglodytes	91.07	0.00e+00	3199.00
IUUC-Pan-091930	Papio anubis	91.25	0.00e+00	3273.00
IUUC-Pma-094258	Petromyzon marinus	49.29	2.00e-146	512.00
IUUC-Ppa-095221	Physcomitrella patens	35.55	2.00e-30	127.00
IUUC-Pfo-096884	Poecilia formosa	45.19	0.00e+00	891.00
IUUC-Pab-098404	Pongo abelii	83.33	0.00e+00	2417.00
IUUC-Pop-099585	Populus trichocarpa	33.89	4.00e-26	113.00
IUUC-Pca-100949	Procavia capensis	82.48	0.00e+00	1257.00
IUUC-Ppe-101920	Prunus persica	32.06	2.00e-27	117.00
IUUC-Pva-102634	Pteropus vampyrus	93.19	0.00e+00	3377.00
IUUC-Rno-105870	Rattus norvegicus	88.67	0.00e+00	3286.00
IUUC-Smo-109164	Selaginella moellendorffii	48.70	6.00e-36	146.00
IUUC-Sit-110552	Setaria italica	33.83	2.00e-28	120.00
IUUC-Sly-111158	Solanum lycopersicum	38.32	3.00e-34	140.00
IUUC-Stu-112529	Solanum tuberosum	47.06	2.00e-36	147.00
IUUC-Sar-113289	Sorex araneus	90.71	0.00e+00	1787.00
IUUC-Ssc-115509	Sus scrofa	96.30	0.00e+00	3093.00
IUUC-Tru-117736	Takifugu rubripes	45.56	0.00e+00	835.00
IUUC-Tni-120837	Tetraodon nigroviridis	48.39	0.00e+00	730.00
IUUC-Tca-121624	Theobroma cacao	31.71	2.00e-27	117.00
IUUC-Tae-125629	Triticum aestivum	35.82	7.00e-20	92.00
IUUC-Tbe-127825	Tupaia belangeri	87.39	0.00e+00	1453.00
IUUC-Ttr-128754	Tursiops truncatus	94.95	0.00e+00	1261.00
IUUC-Xtr-132838	Xenopus tropicalis	49.59	0.00e+00	1014.00
IUUC-Xma-133119	Xiphophorus maculatus	43.48	0.00e+00	969.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence