iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000027078.14	ENSMUST00000102642.8	ENSMUSP00000099702.2
ENSMUSG00000027078.14	ENSMUST00000150325.1	ENSMUSP00000119507.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	3.40e-37	128.4	6	141

Active Site

Position(s)	Description	Evidence
86	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkee 89
           R++kel++l+k+ p++++   +d++++  w++l+l p++ pY  ++F+++i+fp++YPfkPP+++f+tki+hPnv e+G vCl ++ ++
   Q: 6    RVAKELESLSKELPPYLRQLSSDDANVLVWHMLLL-PDQLPYGLKAFQVRIDFPREYPFKPPTLRFTTKIYHPNVREDGLVCLPLI-SN 92
           899********************************.**************************************************.59 PP
   S: 90   ekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           e+W+p ++  +vl +++ l+++pn e+p++ e a+ll++n+e+++kk++
   Q: 93   ENWKPYTKPYQVLEALNVLVSKPNLEEPVRLELADLLTQNPEMFRKKAE 141
           **********************************************986 PP

Organism

Mus musculus

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.

Protein Sequence
(Fasta)

MMASKRVAKE LESLSKELPP YLRQLSSDDA NVLVWHMLLL PDQLPYGLKA FQVRIDFPRE 60
YPFKPPTLRF TTKIYHPNVR EDGLVCLPLI SNENWKPYTK PYQVLEALNV LVSKPNLEEP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGGCGGGG CTCGGGAGCT GCAGTTCAGA GAGCGGTGTC CTGCTGGAAT CTGCTGGTGC 60
CCCACGCTCC AACCCGAGAT GATGGCCAGC AAGCGAGTGG CGAAAGTAAG CCTATGTAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005524--F:ATP binding
GO:0042296--F:ISG15 transferase activity
GO:0043130--F:ubiquitin binding
GO:0019787--F:ubiquitin-like protein transferase activity
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process
GO:0016567--P:protein ubiquitination

KEGG

mmu:56791

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001818	Ailuropoda melanoleuca	69.93	4.00e-61	226.00
IUUC-Bta-012539	Bos taurus	67.97	8.00e-58	215.00
IUUC-Cja-019456	Callithrix jacchus	78.43	2.00e-67	248.00
IUUC-Cfa-021275	Canis familiaris	71.24	2.00e-62	231.00
IUUC-Cpo-022261	Cavia porcellus	66.67	1.00e-58	218.00
IUUC-Csa-023794	Chlorocebus sabaeus	74.34	2.00e-63	234.00
IUUC-Cho-024821	Choloepus hoffmanni	73.61	2.00e-57	214.00
IUUC-Dno-029632	Dasypus novemcinctus	73.86	1.00e-62	231.00
IUUC-Dor-030595	Dipodomys ordii	58.17	1.00e-45	175.00
IUUC-Eca-033746	Equus caballus	71.24	6.00e-61	226.00
IUUC-Fca-035417	Felis catus	71.24	6.00e-61	226.00
IUUC-Ggo-045537	Gorilla gorilla	75.82	2.00e-65	241.00
IUUC-Hsa-045943	Homo sapiens	76.47	3.00e-66	243.00
IUUC-Itr-048889	Ictidomys tridecemlineatus	71.24	7.00e-60	222.00
IUUC-Laf-053524	Loxodonta africana	67.32	1.00e-52	198.00
IUUC-Mcc-054818	Macaca mulatta	74.34	4.00e-63	233.00
IUUC-Meu-055936	Macropus eugenii	60.00	2.00e-33	133.00
IUUC-Mmr-060799	Microcebus murinus	77.63	4.00e-65	239.00
IUUC-Mpu-066122	Mustela putorius furo	70.27	4.00e-59	219.00
IUUC-Mlu-067283	Myotis lucifugus	71.90	5.00e-60	223.00
IUUC-Nle-069829	Nomascus leucogenys	75.82	2.00e-65	241.00
IUUC-Opr-071062	Ochotona princeps	73.20	3.00e-62	230.00
IUUC-Oan-073297	Ornithorhynchus anatinus	69.00	1.00e-34	138.00
IUUC-Ocu-074709	Oryctolagus cuniculus	73.79	5.00e-59	219.00
IUUC-Oga-088256	Otolemur garnettii	75.66	9.00e-64	235.00
IUUC-Oar-089370	Ovis aries	67.59	5.00e-54	202.00
IUUC-Ptr-091324	Pan troglodytes	76.47	3.00e-66	243.00
IUUC-Pan-092601	Papio anubis	73.79	3.00e-60	223.00
IUUC-Pab-098184	Pongo abelii	77.12	4.00e-67	246.00
IUUC-Pca-101080	Procavia capensis	70.14	8.00e-56	208.00
IUUC-Pva-102211	Pteropus vampyrus	67.89	2.00e-39	154.00
IUUC-Rno-104863	Rattus norvegicus	88.89	1.00e-77	281.00
IUUC-Sha-107162	Sarcophilus harrisii	58.82	1.00e-47	182.00
IUUC-Ssc-115506	Sus scrofa	72.55	1.00e-61	228.00
IUUC-Tsy-118811	Tarsius syrichta	61.81	3.00e-46	177.00
IUUC-Ttr-129266	Tursiops truncatus	74.51	2.00e-63	234.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence