iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-073293

UUCD1 version

UUC-OrA-00584

Ensembl Protein ID

ENSOANP00000007416.2

UniProt Accession

F7EBA1; F7EBA1_ORNAN

Protein Name

Katanin p80 WD40 repeat-containing subunit B1; p80 katanin

Gene Name

KATNB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000004682.2	ENSOANT00000007418.2	ENSOANP00000007416.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.60e-46	153.8	154	189
UBD/Beta-Prp	9.30e-62	209.1	24	303

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gHt  v+cl+f +d + l+s++dD+t+k+WDl+ g+
   Q: 154  GHTQAVRCLRFsPDgKWLASAADDHTVKLWDLTAGK 189
           8***********999*****************9997 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
           ++ +h ++v + v  + +++llatg++d ++ +w++ +++++ sl gh+++v +v+++  ++++v gs+ + i+vwdl++ k+++tl g
   Q: 24   EIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMG 112
           67788888999888899************************************************************************ PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtd 181
           h+++++sl+f+p+g++++sGs+d  i++wd++ + c+    +gh+++v+c++++pdg+ l+s+++D tv+lWdl  gk++ ++ g ht+
   Q: 113  HKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVF-RYRGHTQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPG-HTG 199
           *************************************9.9********************************************9.*** PP
   S: 182  svyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisv 270
           +v  ++f++n   l+sgs d+t+++wdl++ ++v   +g   +v+s+ f p++  l+sgs+D s+r++  +   +  ++q    +v   
   Q: 200  PVSVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSILFNPDGCCLYSGSQD-SLRVYGWEPERCFDMVQVNWGKVADL 287
           ***********************************************************977.78888889999999999977666655 PP
   S: 271  avlsfgdnvlvlgse.dsk 288
           a     +n l+ +s+  s+
   Q: 288  AI---CNNQLIGVSFsQSN 303
           55...44444444443344 PP

Organism

Ornithorhynchus anatinus

Functional Description
(View)

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.

Protein Sequence
(Fasta)

MQEKALPLEM AAPVITKTAW KLQEIVAHAS NVSSLVLGKA SGRLLATGGD DCRVNLWSIN 60
KPNCIMSLTG HTSPVESVRL NTPEELIVAG SQSGSIRVWD LEAAKILRTL MGHKANICSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGACGGCTCT TCTTGCCTCT TAAATTGAAA CCGTGATTTC TGTCTTACAG CCAATCGCCA 60
CGCTAAAATG GACCGGATCT GACACTCCCC AGCCCGGGCC GTGTTGGAAA GCCGAGCCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR003143--Cyt_cd1_C
IPR020472--G-protein_beta_WD-40_rep
IPR026962--Katanin_bsu1
IPR028021--Katanin_C-terminal
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF13925--Katanin_con80
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030424--C:axon
GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0008352--C:katanin complex
GO:0005874--C:microtubule
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0000922--C:spindle pole
GO:0008568--F:microtubule-severing ATPase activity
GO:0051301--P:cell division
GO:0051013--P:microtubule severing
GO:0007079--P:mitotic chromosome movement towards spindle pole
GO:0007026--P:negative regulation of microtubule depolymerization
GO:0031117--P:positive regulation of microtubule depolymerization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000954	Aegilops tauschii	48.16	8.00e-87	315.00
IUUC-Aml-002187	Ailuropoda melanoleuca	83.46	0.00e+00	995.00
IUUC-Atr-002899	Amborella trichopoda	55.14	6.00e-104	371.00
IUUC-Apl-003305	Anas platyrhynchos	77.26	0.00e+00	952.00
IUUC-Aca-004635	Anolis carolinensis	79.77	0.00e+00	896.00
IUUC-Aly-005711	Arabidopsis lyrata	52.16	5.00e-103	368.00
IUUC-Ath-007606	Arabidopsis thaliana	52.16	7.00e-103	367.00
IUUC-Ame-010870	Astyanax mexicanus	54.90	2.00e-80	291.00
IUUC-Bta-012527	Bos taurus	88.71	0.00e+00	1047.00
IUUC-Bdi-014652	Brachypodium distachyon	53.85	1.00e-104	373.00
IUUC-Bol-015242	Brassica oleracea	49.53	4.00e-101	362.00
IUUC-Bra-017390	Brassica rapa	51.50	2.00e-101	363.00
IUUC-Cja-019706	Callithrix jacchus	88.62	0.00e+00	996.00
IUUC-Cfa-020139	Canis familiaris	73.21	0.00e+00	701.00
IUUC-Cpo-021710	Cavia porcellus	89.59	0.00e+00	1060.00
IUUC-Cre-022746	Chlamydomonas reinhardtii	42.47	2.00e-70	259.00
IUUC-Csa-023546	Chlorocebus sabaeus	89.92	0.00e+00	968.00
IUUC-Cin-025156	Ciona intestinalis	43.02	2.00e-146	511.00
IUUC-Csv-025962	Ciona savignyi	50.34	1.00e-89	322.00
IUUC-Dre-028215	Danio rerio	62.90	0.00e+00	812.00
IUUC-Dno-029314	Dasypus novemcinctus	87.97	0.00e+00	1016.00
IUUC-Dor-030482	Dipodomys ordii	89.11	0.00e+00	1055.00
IUUC-Dme-032188	Drosophila melanogaster	40.78	9.00e-62	231.00
IUUC-Eca-034143	Equus caballus	88.46	0.00e+00	1032.00
IUUC-Fca-035924	Felis catus	88.94	0.00e+00	1011.00
IUUC-Fal-037387	Ficedula albicollis	79.51	0.00e+00	974.00
IUUC-Gmo-038692	Gadus morhua	63.92	4.00e-156	544.00
IUUC-Gga-040597	Gallus gallus	79.48	0.00e+00	991.00
IUUC-Gac-042004	Gasterosteus aculeatus	60.48	0.00e+00	780.00
IUUC-Gma-044134	Glycine max	53.82	6.00e-103	367.00
IUUC-Ggo-044761	Gorilla gorilla	89.92	0.00e+00	1002.00
IUUC-Hsa-045698	Homo sapiens	89.92	0.00e+00	1018.00
IUUC-Hvu-047649	Hordeum vulgare	53.85	1.00e-104	374.00
IUUC-Itr-048697	Ictidomys tridecemlineatus	88.94	0.00e+00	1037.00
IUUC-Lch-049674	Latimeria chalumnae	69.23	0.00e+00	883.00
IUUC-Lpe-051554	Leersia perrieri	50.00	3.00e-107	382.00
IUUC-Loc-052623	Lepisosteus oculatus	68.88	0.00e+00	875.00
IUUC-Laf-054587	Loxodonta africana	89.76	0.00e+00	1042.00
IUUC-Mcc-055851	Macaca mulatta	90.08	0.00e+00	1002.00
IUUC-Meu-056704	Macropus eugenii	90.88	0.00e+00	1129.00
IUUC-Mtr-058053	Medicago truncatula	53.49	1.00e-106	380.00
IUUC-Mga-059608	Meleagris gallopavo	78.92	0.00e+00	981.00
IUUC-Mmr-061154	Microcebus murinus	88.64	0.00e+00	1013.00
IUUC-Mdo-062365	Monodelphis domestica	87.32	0.00e+00	1061.00
IUUC-Mmu-063754	Mus musculus	89.11	0.00e+00	1045.00
IUUC-Mac-064667	Musa acuminata	53.24	6.00e-102	363.00
IUUC-Mpu-066245	Mustela putorius furo	88.29	0.00e+00	1018.00
IUUC-Mlu-067692	Myotis lucifugus	89.80	0.00e+00	1014.00
IUUC-Nle-070051	Nomascus leucogenys	87.44	0.00e+00	989.00
IUUC-Opr-070855	Ochotona princeps	89.59	0.00e+00	1052.00
IUUC-Ont-071883	Oreochromis niloticus	59.70	0.00e+00	784.00
IUUC-Ocu-074644	Oryctolagus cuniculus	90.24	0.00e+00	1065.00
IUUC-Oba-075448	Oryza barthii	55.18	1.00e-107	383.00
IUUC-Obr-076385	Oryza brachyantha	49.15	1.00e-106	380.00
IUUC-Ogl-077427	Oryza glaberrima	50.00	5.00e-108	385.00
IUUC-Ogu-079022	Oryza glumaepatula	49.20	4.00e-98	352.00
IUUC-Oin-079811	Oryza indica	48.08	8.00e-105	374.00
IUUC-Olo-080245	Oryza longistaminata	48.08	5.00e-105	375.00
IUUC-Ome-081239	Oryza meridionalis	50.29	7.00e-105	374.00
IUUC-Oni-082640	Oryza nivara	55.18	1.00e-107	383.00
IUUC-Opu-083748	Oryza punctata	54.85	4.00e-107	382.00
IUUC-Oru-084609	Oryza rufipogon	55.18	1.00e-107	383.00
IUUC-Osa-086267	Oryza sativa	49.20	3.00e-98	352.00
IUUC-Ola-087483	Oryzias latipes	56.13	0.00e+00	650.00
IUUC-Oga-087964	Otolemur garnettii	89.11	0.00e+00	1037.00
IUUC-Oar-089483	Ovis aries	87.58	0.00e+00	1021.00
IUUC-Ptr-091387	Pan troglodytes	89.92	0.00e+00	1019.00
IUUC-Pan-092623	Papio anubis	90.08	0.00e+00	1002.00
IUUC-Psi-093830	Pelodiscus sinensis	82.33	0.00e+00	999.00
IUUC-Pma-094135	Petromyzon marinus	43.50	5.00e-40	156.00
IUUC-Ppa-095379	Physcomitrella patens	55.82	6.00e-100	358.00
IUUC-Pfo-096755	Poecilia formosa	58.95	0.00e+00	772.00
IUUC-Pab-097564	Pongo abelii	88.23	0.00e+00	924.00
IUUC-Pop-099149	Populus trichocarpa	53.16	1.00e-105	376.00
IUUC-Pca-100357	Procavia capensis	97.62	3.00e-125	441.00
IUUC-Ppe-101237	Prunus persica	53.16	2.00e-105	375.00
IUUC-Pva-102397	Pteropus vampyrus	84.39	0.00e+00	940.00
IUUC-Rno-105349	Rattus norvegicus	89.43	0.00e+00	1053.00
IUUC-Smo-109409	Selaginella moellendorffii	53.07	4.00e-103	368.00
IUUC-Sit-110360	Setaria italica	55.18	2.00e-107	382.00
IUUC-Sly-111307	Solanum lycopersicum	50.15	2.00e-100	359.00
IUUC-Stu-112053	Solanum tuberosum	52.19	2.00e-100	360.00
IUUC-Sar-112953	Sorex araneus	80.26	4.00e-107	381.00
IUUC-Sbi-114389	Sorghum bicolor	46.64	3.00e-94	339.00
IUUC-Ssc-115949	Sus scrofa	85.15	0.00e+00	731.00
IUUC-Tgu-117461	Taeniopygia guttata	78.14	0.00e+00	963.00
IUUC-Tru-117865	Takifugu rubripes	58.73	0.00e+00	756.00
IUUC-Tsy-119036	Tarsius syrichta	97.64	2.00e-69	255.00
IUUC-Tni-120903	Tetraodon nigroviridis	61.33	0.00e+00	739.00
IUUC-Tca-121185	Theobroma cacao	52.16	9.00e-103	367.00
IUUC-Tae-125263	Triticum aestivum	54.18	5.00e-105	375.00
IUUC-Tur-126181	Triticum urartu	48.30	4.00e-95	342.00
IUUC-Tbe-127518	Tupaia belangeri	72.17	2.00e-147	515.00
IUUC-Ttr-128172	Tursiops truncatus	88.13	0.00e+00	1028.00
IUUC-Vvi-131489	Vitis vinifera	53.82	6.00e-106	377.00
IUUC-Xtr-132915	Xenopus tropicalis	73.16	0.00e+00	912.00
IUUC-Xma-134133	Xiphophorus maculatus	58.64	0.00e+00	761.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence