iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000004974.2	ENSPPYT00000005892.2	ENSPPYP00000005675.2
ENSPPYG00000004974.2	ENSPPYT00000005893.2	ENSPPYP00000005676.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.40e-80	269.7	4047	4407

Active Site

Position(s)	Description	Evidence
4381	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.......lysendketlqpnpdsglknpehlklFeflGrllgkalq 83
           d ++ ++++f+gEe+++++G++r+fl++++kelq+++l+l+       ++++++k+ l+p+p ++     +++l +flG+llg+a++
   Q: 4047 DPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLllcpssaVNKNKGKYILTPSPITY----GEEQLLHFLGQLLGIAIR 4129
           5667788*********************************9999999888888***********9....789*************** PP
   S: 84   dgrlldlplsksfyklllgkklsl.edleevdpelyks.lkeikenaesdieelgldltfs..vseei...............lget 151
            + +l+l+l +sf+k+l+g++l+  +dl+e d  +y++ +k+ + n+e+++e+l+++++++  +  ++                 + 
   Q: 4130 ADVPLPLDLLPSFWKTLVGEPLDPeQDLQEADILTYNYvKKFESINDETELEALCAEIASQhlA--TEspdspnkpccrftylTMTG 4214
           ************************9*************56666677789999999999999532..33468999*******655555 PP
   S: 152  keeeLkpgGenipVtneNkeeYvklvveyrlke.gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykg 237
           +e+eL+++G++i V++eNk+ Y  ++ ++rl+e +  e+v+a+r+G+ ++ipl+ll+ +++ e+el +cG ++i++e lk++t+y+ 
   Q: 4215 EEVELCSRGRHILVAWENKDIYAAAIRSLRLRElQNVECVTAVRAGLGSIIPLQLLTTLSPLEMELRTCGLPYINLEFLKAHTMYQV 4301
           6667*****************************9***************************************************** PP
   S: 238  gytedspaiqwFwevleefsseerkafLqFvTgssrlPl......gGfaelk....prlfvirk...dasddrlPssnTCfnyLkLP 311
           g++e++++i++Fw +le+f++ee ++f++F+++++r+P+      gG ++ +    p+++  ++    + d+r+++++TC++++kLP
   Q: 4302 GLMETDQHIEFFWGALEMFTQEELCKFIKFACNQERIPFtcpckdGGPDTAHvppyPMKIAPPDgtaGSPDSRYIRVETCMFMIKLP 4388
           *********************************************99999999988888888889955555**************** PP
   S: 312  eYsskeilkekLlyAieet 330
           +Yss ei+ ekL++Ai+++
   Q: 4389 QYSSLEIMLEKLRCAIHYR 4407
           ****************986 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MGSSAAAAAA AAAAADSAQW LSVKEETIFL HDGLIRVTDL AELPSEILGA PEAADTDLEI 60
LTFETKNPSE LAERLRSVCG NQSNAYARLL EYRLNALRGL WNAQRQLALE EQHERESSGD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACCCCGCCC CCAACATGGC GTCTCACTGA CAGTTGGCTG CCGAGCGGCA GAGGCGGATC 60
CTGCTCCTGA GGGCGGCGGC GGCGGCGGCG GGGCCGGGGT CTCCCGGGCC GGGGTCGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002256	Ailuropoda melanoleuca	96.60	0.00e+00	7209.00
IUUC-Apl-004161	Anas platyrhynchos	92.53	0.00e+00	5166.00
IUUC-Aca-005341	Anolis carolinensis	88.56	0.00e+00	6620.00
IUUC-Ame-011574	Astyanax mexicanus	80.97	0.00e+00	5011.00
IUUC-Bta-012514	Bos taurus	97.59	0.00e+00	1945.00
IUUC-Cja-019148	Callithrix jacchus	98.38	0.00e+00	5340.00
IUUC-Cfa-020499	Canis familiaris	97.94	0.00e+00	7749.00
IUUC-Cpo-021894	Cavia porcellus	96.97	0.00e+00	2750.00
IUUC-Csa-023079	Chlorocebus sabaeus	99.43	0.00e+00	8056.00
IUUC-Cho-024415	Choloepus hoffmanni	92.92	0.00e+00	5068.00
IUUC-Dre-027452	Danio rerio	79.27	0.00e+00	5029.00
IUUC-Dno-029595	Dasypus novemcinctus	97.16	0.00e+00	7902.00
IUUC-Dor-030849	Dipodomys ordii	97.70	0.00e+00	1799.00
IUUC-Ete-032563	Echinops telfairi	90.23	0.00e+00	1607.00
IUUC-Eca-034202	Equus caballus	96.71	0.00e+00	7133.00
IUUC-Eeu-035175	Erinaceus europaeus	97.11	0.00e+00	1074.00
IUUC-Fca-036295	Felis catus	97.60	0.00e+00	7093.00
IUUC-Fal-037003	Ficedula albicollis	92.91	0.00e+00	6716.00
IUUC-Gmo-038579	Gadus morhua	84.34	0.00e+00	2845.00
IUUC-Gga-040961	Gallus gallus	92.98	0.00e+00	7726.00
IUUC-Gac-041899	Gasterosteus aculeatus	84.07	0.00e+00	2878.00
IUUC-Ggo-045099	Gorilla gorilla	99.35	0.00e+00	6484.00
IUUC-Hsa-046331	Homo sapiens	99.39	0.00e+00	7939.00
IUUC-Itr-048190	Ictidomys tridecemlineatus	96.84	0.00e+00	2150.00
IUUC-Lch-049923	Latimeria chalumnae	84.17	0.00e+00	2642.00
IUUC-Loc-052630	Lepisosteus oculatus	84.05	0.00e+00	4018.00
IUUC-Laf-053394	Loxodonta africana	97.31	0.00e+00	7594.00
IUUC-Mcc-055763	Macaca mulatta	98.98	0.00e+00	8080.00
IUUC-Meu-056039	Macropus eugenii	89.07	0.00e+00	5062.00
IUUC-Mga-059500	Meleagris gallopavo	91.42	0.00e+00	6939.00
IUUC-Mmr-060868	Microcebus murinus	95.10	0.00e+00	7791.00
IUUC-Mdo-062772	Monodelphis domestica	94.55	0.00e+00	7844.00
IUUC-Mmu-063606	Mus musculus	96.91	0.00e+00	7990.00
IUUC-Mpu-065860	Mustela putorius furo	94.70	0.00e+00	7080.00
IUUC-Mlu-067376	Myotis lucifugus	96.13	0.00e+00	5324.00
IUUC-Nle-069693	Nomascus leucogenys	97.11	0.00e+00	7703.00
IUUC-Opr-071065	Ochotona princeps	96.17	0.00e+00	1228.00
IUUC-Ont-072470	Oreochromis niloticus	82.07	0.00e+00	4616.00
IUUC-Oan-073693	Ornithorhynchus anatinus	92.52	0.00e+00	5192.00
IUUC-Ocu-074032	Oryctolagus cuniculus	96.78	0.00e+00	8031.00
IUUC-Ola-087433	Oryzias latipes	83.28	0.00e+00	1583.00
IUUC-Oga-088546	Otolemur garnettii	98.43	0.00e+00	6995.00
IUUC-Oar-089643	Ovis aries	91.89	0.00e+00	763.00
IUUC-Ptr-090504	Pan troglodytes	98.39	0.00e+00	7382.00
IUUC-Pan-092543	Papio anubis	99.29	0.00e+00	8038.00
IUUC-Psi-093952	Pelodiscus sinensis	89.38	0.00e+00	6822.00
IUUC-Pfo-096356	Poecilia formosa	81.04	0.00e+00	6789.00
IUUC-Pca-100994	Procavia capensis	97.74	0.00e+00	3007.00
IUUC-Pva-102263	Pteropus vampyrus	95.63	0.00e+00	7112.00
IUUC-Rno-104888	Rattus norvegicus	96.78	0.00e+00	7487.00
IUUC-Sha-106944	Sarcophilus harrisii	92.55	0.00e+00	7071.00
IUUC-Sar-113556	Sorex araneus	83.25	0.00e+00	976.00
IUUC-Ssc-116187	Sus scrofa	97.91	0.00e+00	5166.00
IUUC-Tgu-116655	Taeniopygia guttata	92.35	0.00e+00	5112.00
IUUC-Tru-118093	Takifugu rubripes	83.17	0.00e+00	2982.00
IUUC-Tni-119739	Tetraodon nigroviridis	83.38	0.00e+00	1606.00
IUUC-Tbe-127962	Tupaia belangeri	93.37	0.00e+00	1221.00
IUUC-Ttr-128819	Tursiops truncatus	93.15	0.00e+00	2872.00
IUUC-Vpa-130482	Vicugna pacos	94.43	0.00e+00	4447.00
IUUC-Xtr-132222	Xenopus tropicalis	86.18	0.00e+00	6575.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence