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Tag Content
UUCD2 ID IUUC-Oan-073512
UUCD1 version UUC-OrA-00001
Ensembl Protein ID ENSOANP00000008063.3
UniProt Accession F6PFU8; F6PFU8_ORNAN
Genbank Protein ID ENSOANP00000008063
Protein Name E3 ubiquitin-protein ligase
Genbank Nucleotide ID AAPN01171225
Gene Name WWP2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSOANG00000005081.3 ENSOANT00000008065.3 ENSOANP00000008063.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 2.80e-136 454.6 589 921
Active Site
Position(s) Description Evidence
890 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 589  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 676
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+k+ +l+dle++dpe+y+s+ +iken   ++ee+gl+l f ++ eilg+++++eLk+gGe+i+Vt+eNkeeY+ l+++
   Q: 677  GFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKEN---NLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTD 762
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev ple+l++F+e+elel++cG++eid++d++k+t y++ yt++s++iqwFw+v++e+++e+r ++LqFv
   Q: 763  WRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMNDWQKNTIYRH-YTKNSKQIQWFWQVIKEMDNEKRIRLLQFV 850
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfael     p++f+i k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLlyAieet+gF++
   Q: 851  TGTCRLPVGGFAELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFGQ 921
           *********************************************************************96 PP
   
Organism Ornithorhynchus anatinus
Protein Sequence
(Fasta)
MRSGAPTSSG SGDQWGRSRE SGVAGEGGSR EGSSAVPLRL LQFFGDDMAS ASSGRAGAGL 60
PFEKSQLTLK VVSAKPKVHS RQPRINSFVE VAVDGLPSET KKTGKRIGSS ELLWNEIINL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Oan-073512|E3,HECT|Ornithorhynchus anatinus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGCATGCGC AGTGGGGCTC CCACCTCTTC CGGGTCAGGT GACCAGTGGG GGCGGTCACG 60
TGAGTCCGGG GTGGCGGGAG AAGGCGGAAG TAGAGAGGGA AGTTCGGCGG TGCCGCTCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Oan-073512|E3,HECT|Ornithorhynchus anatinus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051224--P:negative regulation of protein transport
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001575 Ailuropoda melanoleuca 88.03 0.00e+00 1498.00
IUUC-Apl-003912 Anas platyrhynchos 74.23 0.00e+00 1194.00
IUUC-Aca-004291 Anolis carolinensis 78.73 0.00e+00 1384.00
IUUC-Bta-013231 Bos taurus 85.83 0.00e+00 1483.00
IUUC-Cja-019455 Callithrix jacchus 88.34 0.00e+00 1555.00
IUUC-Cfa-021017 Canis familiaris 87.53 0.00e+00 1505.00
IUUC-Cpo-021988 Cavia porcellus 86.97 0.00e+00 1512.00
IUUC-Csa-023549 Chlorocebus sabaeus 87.89 0.00e+00 1545.00
IUUC-Dre-028513 Danio rerio 88.46 0.00e+00 1095.00
IUUC-Dno-028976 Dasypus novemcinctus 88.24 0.00e+00 1538.00
IUUC-Dor-030176 Dipodomys ordii 85.08 0.00e+00 1395.00
IUUC-Eca-033949 Equus caballus 87.66 0.00e+00 1521.00
IUUC-Eeu-034529 Erinaceus europaeus 80.28 0.00e+00 1246.00
IUUC-Fca-036236 Felis catus 88.23 0.00e+00 1524.00
IUUC-Fal-036948 Ficedula albicollis 76.28 0.00e+00 1283.00
IUUC-Gmo-038842 Gadus morhua 86.07 0.00e+00 1029.00
IUUC-Gga-040617 Gallus gallus 78.41 0.00e+00 1392.00
IUUC-Gac-041338 Gasterosteus aculeatus 68.45 0.00e+00 1225.00
IUUC-Ggo-045278 Gorilla gorilla 88.11 0.00e+00 1551.00
IUUC-Hsa-046148 Homo sapiens 88.11 0.00e+00 1552.00
IUUC-Itr-047945 Ictidomys tridecemlineatus 96.46 0.00e+00 1101.00
IUUC-Lch-050663 Latimeria chalumnae 76.44 0.00e+00 1363.00
IUUC-Loc-052604 Lepisosteus oculatus 75.95 0.00e+00 1297.00
IUUC-Laf-053944 Loxodonta africana 86.97 0.00e+00 1527.00
IUUC-Mcc-055655 Macaca mulatta 88.00 0.00e+00 1548.00
IUUC-Meu-055953 Macropus eugenii 77.83 0.00e+00 1342.00
IUUC-Mga-060190 Meleagris gallopavo 78.29 0.00e+00 1388.00
IUUC-Mmr-060896 Microcebus murinus 87.82 0.00e+00 1500.00
IUUC-Mdo-062536 Monodelphis domestica 89.14 0.00e+00 1556.00
IUUC-Mmu-064017 Mus musculus 86.86 0.00e+00 1508.00
IUUC-Mpu-066608 Mustela putorius furo 85.63 0.00e+00 1453.00
IUUC-Mlu-067623 Myotis lucifugus 84.93 0.00e+00 1466.00
IUUC-Nle-069496 Nomascus leucogenys 85.84 0.00e+00 1499.00
IUUC-Opr-071054 Ochotona princeps 77.61 0.00e+00 1303.00
IUUC-Ont-071279 Oreochromis niloticus 70.78 0.00e+00 1236.00
IUUC-Ocu-074271 Oryctolagus cuniculus 86.54 0.00e+00 1484.00
IUUC-Ola-087237 Oryzias latipes 66.77 0.00e+00 1184.00
IUUC-Oga-088164 Otolemur garnettii 88.11 0.00e+00 1540.00
IUUC-Oar-089698 Ovis aries 88.23 0.00e+00 1491.00
IUUC-Ptr-091306 Pan troglodytes 86.86 0.00e+00 1521.00
IUUC-Pan-092814 Papio anubis 84.25 0.00e+00 1459.00
IUUC-Pfo-096709 Poecilia formosa 70.51 0.00e+00 1233.00
IUUC-Pab-098494 Pongo abelii 85.08 0.00e+00 1489.00
IUUC-Pca-100596 Procavia capensis 97.49 0.00e+00 992.00
IUUC-Pva-103154 Pteropus vampyrus 83.69 0.00e+00 1426.00
IUUC-Rno-104954 Rattus norvegicus 86.22 0.00e+00 1284.00
IUUC-Sha-106781 Sarcophilus harrisii 89.37 0.00e+00 1611.00
IUUC-Ssc-116307 Sus scrofa 76.21 0.00e+00 1311.00
IUUC-Tgu-116530 Taeniopygia guttata 73.16 0.00e+00 1131.00
IUUC-Tru-118287 Takifugu rubripes 86.97 0.00e+00 1038.00
IUUC-Tsy-119097 Tarsius syrichta 74.94 0.00e+00 1098.00
IUUC-Tni-120801 Tetraodon nigroviridis 68.39 0.00e+00 1164.00
IUUC-Tbe-127793 Tupaia belangeri 76.69 0.00e+00 1304.00
IUUC-Ttr-128275 Tursiops truncatus 92.78 0.00e+00 1127.00
IUUC-Xtr-132866 Xenopus tropicalis 79.45 0.00e+00 1095.00
IUUC-Xma-133757 Xiphophorus maculatus 86.41 0.00e+00 1054.00
Created Date 25-Jun-2017

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