iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-063018

UUCD1 version

UUC-MoD-01125

Ensembl Protein ID

ENSMODP00000010101.2

UniProt Accession

F7ELW8; F7ELW8_MONDO

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP44

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000008126.3	ENSMODT00000010296.2	ENSMODP00000010101.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.50e-97	324.9	272	680

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...kkkeklneenp............................................ 42
           tGl+NlgNtCYmNS+LQ+Ls++  +r+++l+   ++++      +                                            
   Q: 272  TGLRNLGNTCYMNSILQVLSHLLIFRQCFLKldlNQTQ------Ellataasgktrssckhppvidsmfhikesqekyrgspgsrrpsl 354
           7******************************5552233......223345578888888889999999999999999999999999999 PP
   S: 43   ......................kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkk 109
                                 +++  +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld+++ el  
   Q: 355  ssglsggasksrsmeliqprepSSKYISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKVQHEL-- 441
           999999999999888888888777777************************************************************.. PP
   S: 110  eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke........slqdc 190
                  e+++++  +l  ++++k  k+  ++++++F+gql sq++cl+cdn+s++ epf+dlsl++p++ +++ +         ++++
   Q: 442  -------ETTGTRYPALIPSSQKKLIKQVLNVVNTIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFPERYHCNGKemaaqypcLVTEM 523
           .......77888888999999***********************************************9999988799999**9***** PP
   S: 191  Lesftkeeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctsp 268
           L++ft++e leg+  y c++c+ k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c ++
   Q: 524  LAKFTETEALEGKI-YVCDQCNTKRRkfsskpvilteAQKQLMVCRLPQVLRLHLKRFRWSGR-NHREKIGVHVGFDEILNMEPYCYRE 610
           ***********965.*******999999999999999***********************997.8889********************9 PP
   S: 269  eekqke..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           + k+ +  + +Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk + ++ eev++   ++aY+lfY++
   Q: 611  SLKSLRpdCFIYDLSAVVMHHGkGFGSGHYTAYCYNSEGGfWVHCNDSKLNMCTLEEVCK---AQAYILFYTQ 680
           988877779***************************9999********************...********98 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MDKCKHVGRL RLAQDHSILN PQKWHCVDCN TTDSVWACLS CSHVACGRYI EEHALKHFQD 60
SNHPVALEVN ELYVFCYLCD DYVLNDNATG DLKLLRSTLS AIKSQNYDCT TRSGRILRSM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCAGAGCCC TCAAAGACAT GGCCTACAAC ACTTTCAGGT TCTGCCCAAA CAACATTAAA 60
AGGTAATTGG GAAATATTTA ACAAAATATA CAATAAAACG CATTTAAATT TTAAAACTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:1904667--P:negative regulation of ubiquitin protein ligase activity
GO:0016579--P:protein deubiquitination
GO:0090231--P:regulation of spindle checkpoint
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mdo:100017189

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	80.17	0.00e+00	1139.00
IUUC-Apl-003673	Anas platyrhynchos	84.95	0.00e+00	1145.00
IUUC-Aca-004434	Anolis carolinensis	81.59	0.00e+00	1129.00
IUUC-Ame-010986	Astyanax mexicanus	68.24	0.00e+00	911.00
IUUC-Bta-012774	Bos taurus	79.18	0.00e+00	1129.00
IUUC-Cja-019619	Callithrix jacchus	79.49	0.00e+00	1117.00
IUUC-Cfa-020957	Canis familiaris	79.46	0.00e+00	1142.00
IUUC-Csa-023177	Chlorocebus sabaeus	79.49	0.00e+00	1123.00
IUUC-Cho-024877	Choloepus hoffmanni	77.04	0.00e+00	717.00
IUUC-Cin-025587	Ciona intestinalis	48.46	2.00e-115	410.00
IUUC-Csv-025814	Ciona savignyi	43.16	6.00e-152	531.00
IUUC-Dre-027878	Danio rerio	69.72	0.00e+00	872.00
IUUC-Dno-029832	Dasypus novemcinctus	80.03	0.00e+00	1141.00
IUUC-Ete-032627	Echinops telfairi	78.08	0.00e+00	1102.00
IUUC-Eca-033863	Equus caballus	77.04	0.00e+00	1080.00
IUUC-Eeu-035225	Erinaceus europaeus	75.04	0.00e+00	1052.00
IUUC-Fca-036288	Felis catus	79.46	0.00e+00	1132.00
IUUC-Fal-037207	Ficedula albicollis	83.72	0.00e+00	1120.00
IUUC-Gga-040457	Gallus gallus	84.23	0.00e+00	1100.00
IUUC-Ggo-044926	Gorilla gorilla	79.49	0.00e+00	1117.00
IUUC-Hsa-046079	Homo sapiens	79.49	0.00e+00	1116.00
IUUC-Itr-048737	Ictidomys tridecemlineatus	79.68	0.00e+00	1108.00
IUUC-Lch-050260	Latimeria chalumnae	75.25	0.00e+00	995.00
IUUC-Loc-051981	Lepisosteus oculatus	80.37	0.00e+00	718.00
IUUC-Laf-054491	Loxodonta africana	79.89	0.00e+00	1089.00
IUUC-Mcc-055694	Macaca mulatta	79.35	0.00e+00	1122.00
IUUC-Mga-059523	Meleagris gallopavo	83.94	0.00e+00	1124.00
IUUC-Mmr-060885	Microcebus murinus	81.24	0.00e+00	1144.00
IUUC-Mmu-064012	Mus musculus	70.66	0.00e+00	957.00
IUUC-Mpu-066207	Mustela putorius furo	79.89	0.00e+00	1147.00
IUUC-Mlu-066929	Myotis lucifugus	76.65	0.00e+00	1053.00
IUUC-Nle-069313	Nomascus leucogenys	70.63	0.00e+00	956.00
IUUC-Opr-070375	Ochotona princeps	74.93	0.00e+00	1020.00
IUUC-Ont-071637	Oreochromis niloticus	69.73	0.00e+00	906.00
IUUC-Oan-073030	Ornithorhynchus anatinus	88.81	0.00e+00	946.00
IUUC-Ocu-074836	Oryctolagus cuniculus	76.73	0.00e+00	1060.00
IUUC-Oga-088367	Otolemur garnettii	80.48	0.00e+00	1117.00
IUUC-Oar-089953	Ovis aries	79.32	0.00e+00	1140.00
IUUC-Ptr-090980	Pan troglodytes	79.49	0.00e+00	1117.00
IUUC-Pan-092748	Papio anubis	79.89	0.00e+00	1132.00
IUUC-Psi-094078	Pelodiscus sinensis	86.14	0.00e+00	941.00
IUUC-Pab-098514	Pongo abelii	80.20	0.00e+00	1127.00
IUUC-Pva-102984	Pteropus vampyrus	79.80	0.00e+00	1135.00
IUUC-Rno-106019	Rattus norvegicus	71.53	0.00e+00	1008.00
IUUC-Sha-106965	Sarcophilus harrisii	95.23	0.00e+00	1318.00
IUUC-Ssc-115299	Sus scrofa	80.03	0.00e+00	1151.00
IUUC-Tgu-117160	Taeniopygia guttata	82.94	0.00e+00	1121.00
IUUC-Tru-118156	Takifugu rubripes	68.28	0.00e+00	891.00
IUUC-Tni-119733	Tetraodon nigroviridis	65.06	0.00e+00	878.00
IUUC-Tbe-128084	Tupaia belangeri	76.52	0.00e+00	1085.00
IUUC-Ttr-128928	Tursiops truncatus	80.45	0.00e+00	1148.00
IUUC-Vpa-130706	Vicugna pacos	80.17	0.00e+00	1134.00
IUUC-Xtr-132061	Xenopus tropicalis	80.21	0.00e+00	1024.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence