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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064403
UUCD1 version UUC-MuM-00856
Ensembl Protein ID ENSMUSP00000031434.6
UniProt Accession Q99KR6; Q3UV45; RNF34_MOUSE
Genbank Protein ID AAL30770.1; BAC32461.1; BAC32666.1; BAC32697.1; BAC36693.1; BAE21109.1; BAE23428.1; BAE30005.1; BAE35344.1; AAH04042.1
Protein Name E3 ubiquitin-protein ligase RNF34; Phafin-1; RING finger protein 34; RING-type E3 ubiquitin transferase RNF34
Genbank Nucleotide ID AF434815; AK045696; AK046274; AK046381; AK077221; AK132330; AK137606; AK150976; AK159753; BC004042
Gene Name Rnf34
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000029474.7 ENSMUST00000031434.7 ENSMUSP00000031434.6
ENSMUSG00000029474.7 ENSMUST00000198602.1 ENSMUSP00000143603.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
UniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 87.77 2.00e-157 552.00 IUUC-Hsa-046299
E3 activity/RING/RING 93.96 1.00e-169 592.00 IUUC-Rno-105481
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation.
 E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation.
Protein Sequence
(Fasta)
MKAGATSMWA SCCGLLNEVM GTGAVRGQQA GFPGSTGPFR FTPSSDFPTY PPAATEGPNI 60
VCKACGLSFS VFRKKHVCCD CKKDFCSLCS VSQENLRRCS TCHLLQETAF QRPQLMRLKV 120
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Protein Fasta Sequence


>IUUC-Mmu-064403|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
TTTCATTGGC TTTGGTGATC GGGCCCCCCG AAGACCCGCT TCGGATTGGT GGGCTCCGCC 60
CGCCGCTCGG CGTCTTCCCG GGGCGTGAGC CGAGCGTGGC CATGCCCCCT TACGTAGGGA 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064403|E3,RING|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0053--Apoptosis
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003034--SAP_dom
IPR011011--Znf_FYVE_PHD
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0012505--C:endomembrane system
GO:0016604--C:nuclear body
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0002039--F:p53 binding
GO:1901981--F:phosphatidylinositol phosphate binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0070417--P:cellular response to cold
GO:2001271--P:negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1901797--P:negative regulation of signal transduction by p53 class mediator
GO:0035872--P:nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000374--P:regulation of oxygen metabolic process
KEGG mmu:80751
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002341 Ailuropoda melanoleuca 86.97 5.00e-163 566.00
IUUC-Apl-003398 Anas platyrhynchos 73.74 1.00e-139 489.00
IUUC-Aca-005050 Anolis carolinensis 69.81 2.00e-77 281.00
IUUC-Bta-012886 Bos taurus 88.03 8.00e-164 569.00
IUUC-Cja-019045 Callithrix jacchus 88.30 8.00e-166 576.00
IUUC-Cfa-020037 Canis familiaris 85.99 3.00e-155 541.00
IUUC-Cpo-021618 Cavia porcellus 78.99 5.00e-147 513.00
IUUC-Csa-023303 Chlorocebus sabaeus 88.27 8.00e-166 576.00
IUUC-Cho-024671 Choloepus hoffmanni 78.67 5.00e-159 553.00
IUUC-Dre-027887 Danio rerio 58.14 4.00e-96 344.00
IUUC-Dno-029136 Dasypus novemcinctus 87.77 4.00e-174 603.00
IUUC-Dor-030596 Dipodomys ordii 84.00 5.00e-154 536.00
IUUC-Ete-032684 Echinops telfairi 85.03 8.00e-147 513.00
IUUC-Eca-033598 Equus caballus 88.89 2.00e-166 578.00
IUUC-Eeu-034878 Erinaceus europaeus 87.20 2.00e-162 565.00
IUUC-Fca-036370 Felis catus 86.65 6.00e-164 570.00
IUUC-Fal-036937 Ficedula albicollis 73.14 8.00e-135 473.00
IUUC-Gga-040411 Gallus gallus 72.70 6.00e-124 437.00
IUUC-Gac-042281 Gasterosteus aculeatus 61.79 8.00e-114 403.00
IUUC-Ggo-044752 Gorilla gorilla 87.47 5.00e-163 566.00
IUUC-Hsa-046299 Homo sapiens 87.77 3.00e-164 571.00
IUUC-Itr-047907 Ictidomys tridecemlineatus 88.59 1.00e-171 595.00
IUUC-Loc-052099 Lepisosteus oculatus 60.35 2.00e-119 422.00
IUUC-Laf-054103 Loxodonta africana 84.04 1.00e-160 559.00
IUUC-Mcc-055295 Macaca mulatta 88.83 1.00e-166 578.00
IUUC-Mga-059584 Meleagris gallopavo 72.43 2.00e-126 445.00
IUUC-Mmr-061766 Microcebus murinus 88.16 7.00e-170 589.00
IUUC-Mdo-062738 Monodelphis domestica 74.80 1.00e-130 459.00
IUUC-Mpu-066021 Mustela putorius furo 87.50 2.00e-165 575.00
IUUC-Mlu-067144 Myotis lucifugus 88.33 2.00e-161 561.00
IUUC-Nle-070133 Nomascus leucogenys 87.64 1.00e-152 532.00
IUUC-Opr-070683 Ochotona princeps 81.28 2.00e-153 535.00
IUUC-Ont-072065 Oreochromis niloticus 59.60 2.00e-109 388.00
IUUC-Oan-073504 Ornithorhynchus anatinus 75.98 3.00e-134 471.00
IUUC-Ocu-074382 Oryctolagus cuniculus 85.11 4.00e-167 580.00
IUUC-Ola-087022 Oryzias latipes 60.68 1.00e-115 409.00
IUUC-Oga-087963 Otolemur garnettii 87.40 1.00e-172 599.00
IUUC-Oar-089439 Ovis aries 88.56 4.00e-164 570.00
IUUC-Ptr-091616 Pan troglodytes 88.03 2.00e-162 565.00
IUUC-Pan-092754 Papio anubis 88.27 2.00e-164 572.00
IUUC-Psi-093217 Pelodiscus sinensis 67.75 6.00e-123 433.00
IUUC-Pno-094968 Phaeosphaeria nodorum 32.35 4.00e-09 58.50
IUUC-Pab-098124 Pongo abelii 88.27 4.00e-164 570.00
IUUC-Pca-100954 Procavia capensis 87.23 4.00e-165 573.00
IUUC-Pva-102588 Pteropus vampyrus 86.67 9.00e-163 566.00
IUUC-Pte-104027 Pyrenophora teres 32.35 2.00e-09 59.30
IUUC-Rno-105481 Rattus norvegicus 93.96 1.00e-176 612.00
IUUC-Sha-106640 Sarcophilus harrisii 77.66 9.00e-140 489.00
IUUC-Sit-110649 Setaria italica 39.66 2.00e-08 52.00
IUUC-Sar-113331 Sorex araneus 88.50 1.00e-165 575.00
IUUC-Tgu-117252 Taeniopygia guttata 73.54 2.00e-131 461.00
IUUC-Tsy-118891 Tarsius syrichta 61.14 2.00e-58 219.00
IUUC-Tni-119741 Tetraodon nigroviridis 56.02 5.00e-107 380.00
IUUC-Tbe-127380 Tupaia belangeri 87.70 1.00e-167 582.00
IUUC-Ttr-128999 Tursiops truncatus 88.53 1.00e-166 578.00
Created Date 25-Jun-2017

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