iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033969

UUCD1 version

UUC-EqC-00347

Ensembl Protein ID

ENSECAP00000018073.1

UniProt Accession

F6VSQ2; F6VSQ2_HORSE

Protein Name

Uncharacterized protein

Gene Name

FBXW4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000020477.1	ENSECAT00000021901.1	ENSECAP00000018073.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.40e-18	64.8	181	214
UBD/Beta-Prp	1.40e-40	139.5	252	390

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           H+ +v+c++  ++++vsGs+D t kvW l +g+l
   Q: 181  HEQEVNCVDCKGGIIVSGSRDRTAKVWPLASGRL 214
           99*******9449***************999875 PP

UBD/Beta-Prp

   S: 161  vrlWdlktgkllrtltgghtdsvyslsfdsng.kelvsgsldgtvklwdlq..tgecvrtlng.htdnvksvrfspnderlvsgs.sDg 244
           +r+Wdl++g+l+++l ++  +    l++ +++ + l+s+++d++v++wdl+    +cv+++++ h+++ ++++++  +++l++gs   g
   Q: 252  LRIWDLNSGQLMTHLGSDFPPGAGVLDVMYESpFTLLSCGYDTYVRYWDLRtsVRKCVMEWEEpHDSTLYCLQTD-GNHLLATGSsYYG 339
           79*************99999*******9999989*****************88789*****9999**********.999999999789* PP
   S: 245  siriWdlrsgdllktlqlhn.ssvisvavlsfgdnvlvlgsedskvniwklk 295
           ++r+Wd r++ +l+++ l+    +++v +l+f+ ++l+++ +  ++++++++
   Q: 340  VVRLWDRRQRACLHAFPLTStPLSSPVYCLRFTTKHLYAALS-YNLHVLDFQ 390
           ******************99667889***********99866.467777665 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

RPAAGPALWR LPEELLLLIC SYLDMQALGR LAQVCRWLRR FTSCDLLWRR IARASLNSGF 60
TRLGTDLMPS VPVKERVKVS QNWKLGHCRE GILLKWRCSQ MPWMQLEGDS LYISQANFIL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCATGGGGC GCATCGCGGG GCCAGGGGTG GTCATGGCGG CGGCGGCCGA GGAGGAGGCG 60
GCGACTCGGG AGCCGTCCGC CGGCCCGCGG CGGGGCCCGC GCTCTGGCGC CTGCCGGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0019005--C:SCF ubiquitin ligase complex
GO:0051216--P:cartilage development
GO:0042733--P:embryonic digit morphogenesis
GO:0002053--P:positive regulation of mesenchymal cell proliferation
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002129	Ailuropoda melanoleuca	97.59	0.00e+00	761.00
IUUC-Apl-003837	Anas platyrhynchos	71.74	5.00e-142	496.00
IUUC-Aca-004776	Anolis carolinensis	67.39	3.00e-140	491.00
IUUC-Ame-010651	Astyanax mexicanus	62.04	5.00e-115	407.00
IUUC-Bta-013495	Bos taurus	97.06	0.00e+00	722.00
IUUC-Cja-018901	Callithrix jacchus	98.37	0.00e+00	723.00
IUUC-Cfa-021251	Canis familiaris	97.06	0.00e+00	755.00
IUUC-Cpo-021750	Cavia porcellus	93.54	0.00e+00	642.00
IUUC-Csa-024026	Chlorocebus sabaeus	97.56	0.00e+00	752.00
IUUC-Cho-024496	Choloepus hoffmanni	75.61	2.00e-158	551.00
IUUC-Cin-025142	Ciona intestinalis	31.50	5.00e-26	110.00
IUUC-Csv-025883	Ciona savignyi	36.36	7.00e-65	240.00
IUUC-Dre-027447	Danio rerio	59.38	2.00e-133	468.00
IUUC-Dno-029572	Dasypus novemcinctus	81.79	3.00e-173	601.00
IUUC-Dor-030982	Dipodomys ordii	89.16	0.00e+00	670.00
IUUC-Dme-031804	Drosophila melanogaster	22.70	9.00e-12	64.30
IUUC-Ete-032917	Echinops telfairi	94.77	0.00e+00	650.00
IUUC-Eeu-034850	Erinaceus europaeus	85.64	0.00e+00	649.00
IUUC-Fca-036182	Felis catus	92.25	0.00e+00	689.00
IUUC-Fal-037391	Ficedula albicollis	68.80	5.00e-149	520.00
IUUC-Gmo-038632	Gadus morhua	57.55	2.00e-130	458.00
IUUC-Gga-040783	Gallus gallus	73.32	7.00e-162	563.00
IUUC-Gac-042314	Gasterosteus aculeatus	57.11	3.00e-114	404.00
IUUC-Ggo-044739	Gorilla gorilla	97.56	0.00e+00	750.00
IUUC-Hsa-046705	Homo sapiens	98.10	0.00e+00	722.00
IUUC-Itr-048014	Ictidomys tridecemlineatus	98.62	2.00e-171	594.00
IUUC-Loc-052397	Lepisosteus oculatus	65.71	9.00e-141	493.00
IUUC-Laf-054544	Loxodonta africana	94.64	0.00e+00	659.00
IUUC-Meu-056363	Macropus eugenii	58.46	1.00e-101	362.00
IUUC-Mga-059275	Meleagris gallopavo	73.04	1.00e-143	502.00
IUUC-Mmr-060906	Microcebus murinus	97.56	0.00e+00	750.00
IUUC-Mdo-062400	Monodelphis domestica	77.54	9.00e-176	609.00
IUUC-Mmu-063556	Mus musculus	92.14	0.00e+00	713.00
IUUC-Mpu-066500	Mustela putorius furo	97.33	0.00e+00	758.00
IUUC-Mlu-068074	Myotis lucifugus	97.54	0.00e+00	664.00
IUUC-Nle-069601	Nomascus leucogenys	97.83	0.00e+00	752.00
IUUC-Opr-070904	Ochotona princeps	88.30	1.00e-146	512.00
IUUC-Ont-072679	Oreochromis niloticus	56.52	2.00e-124	439.00
IUUC-Oan-073434	Ornithorhynchus anatinus	72.43	3.00e-85	307.00
IUUC-Ocu-074649	Oryctolagus cuniculus	95.66	0.00e+00	727.00
IUUC-Ola-087336	Oryzias latipes	50.26	5.00e-107	380.00
IUUC-Oga-088590	Otolemur garnettii	94.58	0.00e+00	699.00
IUUC-Oar-090178	Ovis aries	94.40	0.00e+00	674.00
IUUC-Pan-092881	Papio anubis	97.83	0.00e+00	751.00
IUUC-Pfo-096176	Poecilia formosa	56.23	1.00e-116	412.00
IUUC-Pab-098285	Pongo abelii	97.83	0.00e+00	754.00
IUUC-Pca-100888	Procavia capensis	90.91	0.00e+00	693.00
IUUC-Pva-102184	Pteropus vampyrus	82.66	3.00e-177	613.00
IUUC-Rno-105668	Rattus norvegicus	92.95	0.00e+00	718.00
IUUC-Sha-106629	Sarcophilus harrisii	77.33	2.00e-154	537.00
IUUC-Ssc-116183	Sus scrofa	98.66	0.00e+00	767.00
IUUC-Tgu-116630	Taeniopygia guttata	71.73	2.00e-168	585.00
IUUC-Tru-118761	Takifugu rubripes	52.89	2.00e-118	418.00
IUUC-Tni-120651	Tetraodon nigroviridis	51.98	2.00e-59	221.00
IUUC-Ttr-128582	Tursiops truncatus	96.26	0.00e+00	713.00
IUUC-Vpa-130431	Vicugna pacos	77.06	3.00e-98	351.00
IUUC-Xtr-132655	Xenopus tropicalis	67.48	8.00e-150	523.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence