iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062563

UUCD1 version

UUC-MoD-00523

Ensembl Protein ID

ENSMODP00000016994.2

UniProt Accession

F7AVX2; F7AVX2_MONDO

Protein Name

Uncharacterized protein

Gene Name

KLHL40

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000013585.3	ENSMODT00000017308.3	ENSMODP00000016994.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	1.10e-20	73.9	34	98
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	1.00e-07	31.2	131	161

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 2    DvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkldene 69
           D++++v+++ef++h++vLaa+S++F+a+fl++ e  +   ++ +++v+pev+  +l++lYt+++d+ne
   Q: 34   DCVVKVKDQEFPCHRLVLAACSPYFRAMFLKDSEGIQ---EISLEEVSPEVMAKVLHYLYTSEIDLNE 98
           9****************************99999887...999***********************97 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 2    eNclgilrfAdlydcpdLkdaaldfilkhFk 32
            Ncl+++r++ ++dc +L+ aa+dfi++ F+
   Q: 131  ANCLAVFRLGLMLDCARLAVAARDFICDRFP 161
           6****************************96 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MAQSLDQMEE QRLYQQTLLQ DGLKDMLDHG KFLDCVVKVK DQEFPCHRLV LAACSPYFRA 60
MFLKDSEGIQ EISLEEVSPE VMAKVLHYLY TSEIDLNEDN VQDLFAAANL FQIPSIFTIC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCCAGA GTTTGGACCA AATGGAAGAA CAGAGACTCT ACCAGCAGAC CCTCCTTCAA 60
GATGGTCTGA AGGACATGCT AGACCATGGC AAGTTCTTGG ACTGTGTTGT CAAGGTGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030607--KLHL40
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031672--C:A band
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0031674--C:I band
GO:0032435--P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031397--P:negative regulation of protein ubiquitination
GO:0016567--P:protein ubiquitination
GO:0048741--P:skeletal muscle fiber development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001792	Ailuropoda melanoleuca	71.07	0.00e+00	674.00
IUUC-Apl-003748	Anas platyrhynchos	73.63	0.00e+00	733.00
IUUC-Aca-005275	Anolis carolinensis	74.21	0.00e+00	734.00
IUUC-Ame-011294	Astyanax mexicanus	60.55	5.00e-166	577.00
IUUC-Bta-012801	Bos taurus	77.36	0.00e+00	758.00
IUUC-Cja-019795	Callithrix jacchus	75.53	0.00e+00	721.00
IUUC-Cfa-021245	Canis familiaris	77.13	0.00e+00	691.00
IUUC-Cpo-022436	Cavia porcellus	75.32	0.00e+00	753.00
IUUC-Csa-023105	Chlorocebus sabaeus	77.22	0.00e+00	751.00
IUUC-Cin-025237	Ciona intestinalis	28.75	6.00e-56	212.00
IUUC-Dre-028077	Danio rerio	60.13	2.00e-165	575.00
IUUC-Dno-030015	Dasypus novemcinctus	64.01	5.00e-157	548.00
IUUC-Dor-030850	Dipodomys ordii	46.12	2.00e-65	242.00
IUUC-Ete-032697	Echinops telfairi	51.93	9.00e-141	493.00
IUUC-Eca-034393	Equus caballus	76.42	0.00e+00	730.00
IUUC-Eeu-035245	Erinaceus europaeus	53.22	5.00e-139	488.00
IUUC-Fca-035823	Felis catus	63.69	2.00e-172	598.00
IUUC-Fal-037632	Ficedula albicollis	74.30	0.00e+00	734.00
IUUC-Gmo-039697	Gadus morhua	59.24	4.00e-165	574.00
IUUC-Gga-040525	Gallus gallus	73.74	0.00e+00	731.00
IUUC-Gac-042421	Gasterosteus aculeatus	59.92	2.00e-171	595.00
IUUC-Ggo-045596	Gorilla gorilla	76.37	0.00e+00	749.00
IUUC-Hsa-046235	Homo sapiens	76.58	0.00e+00	751.00
IUUC-Itr-048612	Ictidomys tridecemlineatus	76.89	0.00e+00	760.00
IUUC-Lch-050123	Latimeria chalumnae	66.31	0.00e+00	669.00
IUUC-Loc-051824	Lepisosteus oculatus	67.51	0.00e+00	668.00
IUUC-Laf-053485	Loxodonta africana	74.94	0.00e+00	628.00
IUUC-Mcc-054909	Macaca mulatta	76.58	0.00e+00	751.00
IUUC-Meu-055972	Macropus eugenii	89.59	0.00e+00	892.00
IUUC-Mga-059451	Meleagris gallopavo	74.37	0.00e+00	740.00
IUUC-Mmr-060736	Microcebus murinus	77.22	0.00e+00	753.00
IUUC-Mmu-063549	Mus musculus	76.37	0.00e+00	753.00
IUUC-Mpu-066262	Mustela putorius furo	77.78	0.00e+00	760.00
IUUC-Mlu-067210	Myotis lucifugus	76.89	0.00e+00	753.00
IUUC-Nle-069300	Nomascus leucogenys	75.57	0.00e+00	687.00
IUUC-Opr-070384	Ochotona princeps	72.06	0.00e+00	677.00
IUUC-Ont-071273	Oreochromis niloticus	60.76	7.00e-173	600.00
IUUC-Oan-073476	Ornithorhynchus anatinus	53.22	1.00e-141	496.00
IUUC-Ocu-074499	Oryctolagus cuniculus	76.88	0.00e+00	751.00
IUUC-Ola-087175	Oryzias latipes	60.13	1.00e-170	593.00
IUUC-Oga-088855	Otolemur garnettii	75.95	0.00e+00	751.00
IUUC-Oar-089342	Ovis aries	66.82	8.00e-159	553.00
IUUC-Ptr-091028	Pan troglodytes	75.51	0.00e+00	676.00
IUUC-Pan-091827	Papio anubis	76.79	0.00e+00	751.00
IUUC-Psi-092998	Pelodiscus sinensis	75.74	0.00e+00	738.00
IUUC-Pma-094586	Petromyzon marinus	56.95	6.00e-72	263.00
IUUC-Pfo-096216	Poecilia formosa	59.28	2.00e-169	588.00
IUUC-Pab-097656	Pongo abelii	76.10	3.00e-174	603.00
IUUC-Pca-100495	Procavia capensis	53.22	3.00e-139	488.00
IUUC-Pva-102331	Pteropus vampyrus	77.57	0.00e+00	755.00
IUUC-Rno-105613	Rattus norvegicus	77.00	0.00e+00	749.00
IUUC-Sha-107091	Sarcophilus harrisii	91.77	0.00e+00	895.00
IUUC-Sar-112941	Sorex araneus	74.10	2.00e-168	585.00
IUUC-Ssc-116276	Sus scrofa	77.99	0.00e+00	761.00
IUUC-Tgu-116494	Taeniopygia guttata	75.21	0.00e+00	749.00
IUUC-Tru-118614	Takifugu rubripes	61.60	1.00e-173	603.00
IUUC-Tsy-119499	Tarsius syrichta	72.63	4.00e-159	554.00
IUUC-Tni-119776	Tetraodon nigroviridis	61.18	7.00e-172	597.00
IUUC-Tbe-127806	Tupaia belangeri	78.11	0.00e+00	772.00
IUUC-Ttr-128813	Tursiops truncatus	76.47	0.00e+00	744.00
IUUC-Vpa-130127	Vicugna pacos	75.13	5.00e-168	583.00
IUUC-Xtr-132942	Xenopus tropicalis	67.51	0.00e+00	657.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence