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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063700
UUCD1 version UUC-MuM-00355
Ensembl Protein ID ENSMUSP00000080278.4
UniProt Accession Q02395; Q05C61; Q569Z8; Q6PG89; Q8BGP9; Q8BSJ7; MTF2_MOUSE
Genbank Protein ID BAC28027.1; BAC28039.1; BAC27390.1; BAE24103.1; AAH57163.1; AAH92237.1; AAI00341.1; AAH24889.1; AAH29076.1; AAC34714.1
Protein Name Metal-response element-binding transcription factor 2; Metal regulatory transcription factor 2; Metal-response element DNA-binding protein M96; Polycomb-like protein 2; Zinc-regulated factor 1
Genbank Nucleotide ID AK032798; AK032819; AK031409; AK139685; BC057163; BC092237; BC100340; BC024889; BC029076; S78454
Gene Name Mtf2; Pcl2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000029267.17 ENSMUST00000124195.7 ENSMUSP00000126297.1
ENSMUSG00000029267.17 ENSMUST00000134026.7 ENSMUSP00000128797.1
ENSMUSG00000029267.17 ENSMUST00000143412.7 ENSMUSP00000132596.1
ENSMUSG00000029267.17 ENSMUST00000081567.10 ENSMUSP00000080278.4
ENSMUSG00000029267.17 ENSMUST00000112626.7 ENSMUSP00000108245.1
ENSMUSG00000029267.17 ENSMUST00000137996.7 ENSMUSP00000121697.1
ENSMUSG00000029267.17 ENSMUST00000129921.2 ENSMUSP00000137843.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDPINAHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 8.90e-11 42.9 103 155
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedek.slveCekCrewfHpaClklsveeelpnsek.wiCpkCr 52
           +vC +C+e++++   ++v C+kC + +H+ C+ + +++++ +s++ w C++C 
   Q: 103  MVCTICQEEYSEAPnEMVICDKCGQGYHQLCHTPHIDSSVIDSDEkWLCRQCV 155
           79********987569********************9999888777******7 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter.
 Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter.
Protein Sequence
(Fasta)
MRDSTGAGNS LVHKRSPLRR NQKTSASLNK LSLQDGHKAK KPACKFEEGQ DVLARWSDGL 60
FYLGTIKKIN ILKQSCFIIF EDSSKSWVLW KDIQTGATGS GEMVCTICQE EYSEAPNEMV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063700|E3,PHD|Mus musculus
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Nucleotide Sequence
(Fasta)
ATTCGGCCCC GGAGTAGCTC CGCGCTCCCA GAATGCACCG CTAGTCCGCG GGAAACCAAA 60
ATGGCGAAGG GCTGTTGCGA AGTGGTCTGT GTTTGAGGCC GGTGTGAGCA CGCACATTCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063700|E3,PHD|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR025894--Mtf2_C_dom
IPR002999--Tudor
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF14061--Mtf2_C
PF00628--PHD
SMART

SM00249--PHD
SM00333--TUDOR
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0035064--F:methylated histone binding
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0061086--P:negative regulation of histone H3-K27 methylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0061087--P:positive regulation of histone H3-K27 methylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0007379--P:segment specification
GO:0048863--P:stem cell differentiation
GO:0019827--P:stem cell population maintenance
KEGG mmu:17765
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001293 Ailuropoda melanoleuca 97.64 0.00e+00 1157.00
IUUC-Apl-004128 Anas platyrhynchos 89.77 0.00e+00 1095.00
IUUC-Aca-004646 Anolis carolinensis 87.92 0.00e+00 972.00
IUUC-Bta-012598 Bos taurus 97.56 0.00e+00 956.00
IUUC-Cja-019930 Callithrix jacchus 97.81 0.00e+00 1180.00
IUUC-Cfa-020413 Canis familiaris 97.47 0.00e+00 1155.00
IUUC-Csa-023605 Chlorocebus sabaeus 97.64 0.00e+00 1157.00
IUUC-Csv-026067 Ciona savignyi 52.30 9.00e-99 353.00
IUUC-Dre-028327 Danio rerio 62.72 0.00e+00 703.00
IUUC-Dno-029487 Dasypus novemcinctus 94.09 0.00e+00 1111.00
IUUC-Dme-031808 Drosophila melanogaster 32.74 5.00e-47 183.00
IUUC-Eca-034332 Equus caballus 96.97 0.00e+00 1172.00
IUUC-Fca-036088 Felis catus 97.47 0.00e+00 1154.00
IUUC-Fal-036851 Ficedula albicollis 89.68 0.00e+00 911.00
IUUC-Gmo-038940 Gadus morhua 64.80 1.00e-143 503.00
IUUC-Gga-041162 Gallus gallus 89.58 0.00e+00 1090.00
IUUC-Gac-041758 Gasterosteus aculeatus 53.01 1.00e-141 496.00
IUUC-Ggo-044658 Gorilla gorilla 97.64 0.00e+00 1157.00
IUUC-Hsa-045895 Homo sapiens 97.64 0.00e+00 1157.00
IUUC-Itr-047940 Ictidomys tridecemlineatus 97.64 0.00e+00 1180.00
IUUC-Lch-050577 Latimeria chalumnae 79.63 0.00e+00 890.00
IUUC-Loc-051747 Lepisosteus oculatus 69.22 0.00e+00 789.00
IUUC-Laf-054500 Loxodonta africana 97.47 0.00e+00 1177.00
IUUC-Mcc-055738 Macaca mulatta 97.64 0.00e+00 1154.00
IUUC-Mga-059203 Meleagris gallopavo 89.43 0.00e+00 1090.00
IUUC-Mmr-061070 Microcebus murinus 96.96 0.00e+00 1148.00
IUUC-Mdo-061878 Monodelphis domestica 94.11 0.00e+00 946.00
IUUC-Mpu-066250 Mustela putorius furo 97.30 0.00e+00 1155.00
IUUC-Mlu-067694 Myotis lucifugus 96.79 0.00e+00 1170.00
IUUC-Nle-069777 Nomascus leucogenys 97.30 0.00e+00 1177.00
IUUC-Ont-072183 Oreochromis niloticus 54.95 5.00e-166 577.00
IUUC-Oan-073204 Ornithorhynchus anatinus 96.28 2.00e-142 497.00
IUUC-Ocu-074279 Oryctolagus cuniculus 97.30 0.00e+00 1176.00
IUUC-Ola-087332 Oryzias latipes 55.76 9.00e-136 477.00
IUUC-Oga-089023 Otolemur garnettii 51.31 4.00e-115 408.00
IUUC-Oar-089543 Ovis aries 97.30 0.00e+00 1157.00
IUUC-Ptr-090676 Pan troglodytes 97.64 0.00e+00 1157.00
IUUC-Pan-092568 Papio anubis 97.81 0.00e+00 1157.00
IUUC-Psi-092976 Pelodiscus sinensis 89.41 0.00e+00 1094.00
IUUC-Pma-094138 Petromyzon marinus 64.16 1.00e-134 472.00
IUUC-Pfo-097187 Poecilia formosa 58.02 4.00e-138 485.00
IUUC-Pab-097543 Pongo abelii 97.64 0.00e+00 1157.00
IUUC-Pca-100289 Procavia capensis 86.47 0.00e+00 838.00
IUUC-Pva-103007 Pteropus vampyrus 54.95 3.00e-103 369.00
IUUC-Rno-105075 Rattus norvegicus 97.81 0.00e+00 1182.00
IUUC-Sha-106522 Sarcophilus harrisii 95.71 3.00e-120 423.00
IUUC-Ssc-116220 Sus scrofa 97.47 0.00e+00 1157.00
IUUC-Tgu-117230 Taeniopygia guttata 88.11 0.00e+00 1052.00
IUUC-Tru-118228 Takifugu rubripes 53.70 1.00e-158 553.00
IUUC-Tsy-119045 Tarsius syrichta 96.95 0.00e+00 1137.00
IUUC-Tni-120342 Tetraodon nigroviridis 56.47 3.00e-176 611.00
IUUC-Ttr-128691 Tursiops truncatus 97.13 0.00e+00 1152.00
IUUC-Vpa-130085 Vicugna pacos 57.04 1.00e-48 186.00
IUUC-Xtr-132767 Xenopus tropicalis 74.50 0.00e+00 883.00
IUUC-Xma-133635 Xiphophorus maculatus 50.73 8.00e-158 550.00
Created Date 25-Jun-2017

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